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Foreword |
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xvii | |
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Section 1 General Principles |
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1 The Rationale for Fetal Therapy |
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1 | (7) |
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2 A Fetal Origin of Adult Disease |
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8 | (12) |
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3 Human Embryology: Molecular Mechanisms of Embryonic Disease |
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20 | (16) |
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Guillermo Villagomez Olea |
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4 Human Genetics and Fetal Disease: Assessment of the Fetal Genome |
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36 | (12) |
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5 Interventions in Pregnancy to Reduce Risk of Stillbirth |
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48 | (13) |
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6 Fetal Therapy Choices: Uncertain and Emotional Decisions and the Doctor's Role in Parental Decision-Making |
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61 | (8) |
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Danielle R. M. Timmermans |
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7 The Ethics of Consent for Fetal Therapy |
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69 | (8) |
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8 Open Fetal Surgery: Is There Still a Role? |
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77 | (6) |
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83 | (8) |
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Section 2 Fetal Disease: Pathogenesis and Treatment |
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Blood Cell Alloimmunization |
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10 Management of Red Cell Alloimmunization |
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91 | (8) |
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11 Fetal and Neonatal Alloimmune Thrombocytopenia: Clinical Disease and Management |
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99 | (11) |
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Structural Heart Disease in the Fetus |
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12 Structural Heart Disease: Embryology |
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110 | (13) |
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Adriana C. Gittenberger-de Groot |
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13 Structural Heart Disease: Genetic Influences |
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123 | (10) |
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14 Deciphering the Mechanisms of Developmental Heart Disease: Research from Embryonic Knockout Mice |
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133 | (13) |
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15 In Utero Intervention for Cardiac Disease |
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146 | (11) |
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16 Fetal Cerebral Consequences of Structural Heart Disease: Can These Be Ameliorated? |
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157 | (9) |
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17 Fetal Supraventricular Tachyarrhythmias: Pharmacokinetics, Modes of Action, and Results of Anti-Arrhythmic Drug Therapy |
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166 | (10) |
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18 Fetal Dysrhythmias: Diagnosis and Clinical Management |
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176 | (15) |
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Manipulation of Fetal Amniotic Fluid Volume |
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19 Manipulation of Amniotic Fluid Volume: Homeostasis of Fluid Volumes in the Amniotic Cavity |
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191 | (9) |
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20 Oligohydramnios and Polyhydramnios: Therapeutic Manipulation of Amniotic Fluid Volume |
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200 | (15) |
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21 Fetal Infections: Immune Response to Infections during Fetal Life |
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215 | (9) |
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22 Fetal Infections: Clinical Management |
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224 | (24) |
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Fetal Growth and Well-being |
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23 Fetal Growth Restriction: Placental Basis and Implications for Clinical Practice |
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248 | (16) |
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24 Fetal Growth Restriction: Diagnosis and Management |
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264 | (15) |
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25 Screening and Intervention for Fetal Growth Restriction |
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279 | (8) |
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26 Maternal and Fetal Therapy: Can We Optimize Fetal Growth? |
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287 | (15) |
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Preterm Birth of the Singleton and Multiple Pregnancy |
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27 The Pathogenesis of Preterm Birth: A Guide to Potential Therapeutic Targets |
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302 | (9) |
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28 Clinical Interventions for the Prevention and Management of Spontaneous Preterm Birth in the Singleton Fetus |
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311 | (14) |
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29 Clinical Interventions to Prevent Preterm Birth in Multiple Pregnancies |
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325 | (8) |
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30 Reducing Neurologic Morbidity from Preterm Birth through Administering Therapy Prior to Delivery |
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333 | (11) |
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Complications of Monochorionic Multiple Pregnancy: Twin-to-Twin Transfusion Syndrome |
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31 Twin-to-Twin Transfusion Syndrome: Placental and Fetal Pathogenesis |
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344 | (9) |
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32 Twin-to-Twin Transfusion Syndrome: Treatment by Fetoscopic Laser Coagulation of the Placental Vascular Anastomoses on the Chorionic Plate |
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353 | (10) |
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33 Interventions for Early and Late Twin-Twin Transfusion Syndrome |
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363 | (4) |
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34 Diagnosis and Treatment in Twin Anemia Polycythemia Sequence |
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367 | (6) |
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35 Neurological and Long-Term Neurodevelopmental Outcome after Fetal Therapy in Complicated Monochorionic Twins |
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373 | (11) |
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Complications of Monochorionic Multiple Pregnancy: Fetal Growth Restriction in Monochorionic Twins |
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36 The Diagnosis and Detection of Fetal Growth Restriction in Monochorionic Twin Pregnancies |
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384 | (8) |
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37 Clinical Outcome and Management of Selective Fetal Growth Restriction in Monochorionic Twins |
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392 | (6) |
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Complications of Monochorionic Multiple Pregnancy: Twin Reversed Arterial Perfusion Sequence |
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38 Twin Reversed Arterial Perfusion Sequence: Pathophysiology and In Utero Treatment |
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398 | (6) |
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Complications of Monochorionic Multiple Pregnancy: Multifetal Reduction in Multiple Pregnancy |
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39 Fetal Reduction and Selective Termination |
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404 | (14) |
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40 Selective Termination of One Fetus in Monochorionic Twin Pregnancies |
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418 | (8) |
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Fetal Urinary Tract Obstruction |
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41 Lower Urinary Tract Obstruction: Pathophysiology, Prenatal Assessment, and In Utero Intervention |
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426 | (12) |
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Pleural Effusion and Pulmonary Pathology |
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42 Fetal Pleural Effusions and Pulmonary Pathology: Pathophysiology and Clinical Management |
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438 | (11) |
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Surgical Correction of Neural Tube Anomalies |
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43 Neural Tube Anomalies: An Update on the Pathophysiology and Prevention |
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449 | (7) |
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Regine P. M. Steegers-Theunissen |
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44 Neural Tube Anomalies: Clinical Management by Open Fetal Surgery |
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456 | (11) |
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45 Open Neural Tube Defect Repair: Development and Refinement of a Fetoscopic Technique |
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467 | (13) |
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46 Fetal Tumors: Clinical Management |
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480 | (14) |
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Congenital Diaphragmatic Hernia |
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47 Congenital Diaphragmatic Hernia: Pathophysiology and Antenatal Assessment |
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494 | (9) |
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48 Congenital Diaphragmatic Hernia: In Utero Treatment Today and Tomorrow |
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503 | (9) |
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Fetal Stem Cell Transplantation |
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49 Stem Cell Transplantation: Clinical Potential in Treating Fetal Genetic Disease |
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512 | (8) |
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50 Strategies to Repair Defects in the Fetal Membrane |
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520 | (12) |
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51 Tissue Engineering and the Fetus |
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532 | (8) |
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52 Gene Therapy: Principles and Clinical Potential |
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540 | (21) |
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53 Fetal Therapy and Translational Studies: Global Alignment, Coordination, and Collaboration in Perinatal Research -- the Global Obstetrics Network (GONet) Initiative |
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561 | (9) |
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54 Congenital Anomaly Registers: The European Experience |
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570 | (10) |
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55 A Challenge for Prenatal Diagnosis in Developing Countries: Zika Virus as an Exemplar |
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580 | (8) |
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Index |
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588 | |