Contributors |
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xiii | |
Preface |
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xxvii | |
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1 Milestones in the History of Pulmonary Medicine |
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2 | (18) |
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PART 2 Scientific Basis of Lung Function in Health and Disease |
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Section 1 Genetic, Cellular, and Structural Basis of Normal Lung Function |
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2 Functional Design of the Human Lung for Gas Exchange |
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20 | (43) |
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3 The Respiratory Muscles |
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63 | (10) |
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4 Molecular Regulation of Lung Development |
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73 | (10) |
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5 Pulmonary Surfactant and Disorders of Surfactant Homeostasis |
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83 | (10) |
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93 | (11) |
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7 The Genetic Basis of Respiratory Disorders |
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104 | (13) |
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8 Stem Cells and Respiratory Disease: Prospects for the Future |
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117 | (7) |
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9 Personalized Pulmonary Medicine |
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124 | (13) |
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Section 2 Physiological Principles of Normal Lung Function |
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137 | (11) |
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11 Control of Ventilation |
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148 | (10) |
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12 Circadian Rhythms and Sleep Biology |
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158 | (9) |
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167 | (16) |
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14 Ventilation, Pulmonary Blood Flow, and Ventilation--Perfusion Relationships |
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183 | (12) |
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195 | (4) |
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16 Diffusion, Chemical Reactions, and Diffusing Capacity |
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199 | (8) |
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207 | (12) |
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Section 3 The Lungs in Different Physiological States |
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18 Respiratory System Response to Exercise in Health |
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219 | (14) |
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19 Aging of the Respiratory System |
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233 | (13) |
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Section 4 Lung Immunology |
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20 Innate and Adaptive Immunity in the Lung |
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246 | (13) |
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21 Lymphocyte- and Macrophage-Mediated Inflammation in the Lung |
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259 | (16) |
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22 Mast Cells and Eosinophils |
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275 | (17) |
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23 Leukocyte Accumulation in Pulmonary Disease |
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292 | (11) |
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24 Antibody-Mediated Lung Defenses and Humoral Immunodeficiency |
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303 | (15) |
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Section 5 Lung Injury and Repair |
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25 T Lymphocytes in the Lung |
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318 | (9) |
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26 Chemokines, Adipokines, and Growth Factors in the Lung |
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327 | (14) |
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27 Redox Signaling and Oxidative Stress in Lung Diseases |
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341 | (18) |
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28 Fibroblasts in Lung Homeostasis and Disease |
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359 | (15) |
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PART 3 Symptoms and Signs of Respiratory Disease |
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Section 6 Clinical Approach to the Patient |
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29 Approach to the Patient with Respiratory Symptoms |
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374 | (38) |
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Section 7 Diagnostic Procedures |
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30 Modern Approach to Thoracic Imaging Diagnosis |
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412 | (56) |
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Eduardo J. Mortani Barbosa Jr. |
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31 Thoracic Ultrasonography |
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468 | (9) |
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32 Physiologic and Metabolic Study of Pulmonary Disorders Using Conventional Imaging Techniques and Positron Emission Tomography |
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477 | (25) |
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33 Pulmonary Function Testing |
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502 | (35) |
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34 Principles and Applications of Cardiopulmonary Exercise Testing |
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537 | (16) |
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35 Diagnostic Bronchoscopy, Transthoracic Needle Biopsy, and Related Procedures |
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553 | (19) |
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36 Interventional Bronchoscopy |
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572 | (11) |
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37 Diagnostic Thoracic Surgical Procedures: Thoracoscopy, VATS, and Thoracotomy |
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583 | (3) |
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38 Evaluation of Respiratory Impairment and Disability |
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586 | (14) |
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PART 4 Obstructive Lung Diseases |
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Section 8 Chronic Obstructive Pulmonary Disease |
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39 Pathology of Chronic Obstructive Pulmonary Disease: Diagnostic Features and Differential Diagnosis |
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600 | (13) |
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40 Chronic Obstructive Pulmonary Disease: Epidemiology, Pathophysiology, Pathogenesis, and α1-Antitrypsin Deficiency |
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613 | (23) |
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41 Cigarette Smoking and Smoking Cessation |
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636 | (14) |
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42 Course and Treatment of Chronic Obstructive Pulmonary Disease |
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650 | (14) |
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43 Rehabilitation in Chronic Obstructive Pulmonary Disease and Other Respiratory Disorders |
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664 | (9) |
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673 | (14) |
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687 | (13) |
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46 Asthma: Clinical Presentation and Management |
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700 | (15) |
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47 Aspirin- and Exercise-Induced Asthma |
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715 | (15) |
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48 Allergic Bronchopulmonary Aspergillosis (Mycosis) and Severe Asthma with Fungal Sensitivity |
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730 | (8) |
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Section 10 Other Obstructive Disorders |
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49 Upper Airway Obstruction in Adults |
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738 | (19) |
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757 | (21) |
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778 | (9) |
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52 Bullous Disease of the Lung |
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787 | (13) |
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800 | (10) |
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PART 5 Interstitial and Inflammatory Lung Diseases |
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Section 11 Immunologic and Interstitial Diseases |
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54 Interstitial Lung Disease: A Clinical Overview and General Approach |
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810 | (13) |
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823 | (19) |
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56 Idiopathic Pulmonary Fibrosis |
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842 | (17) |
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57 Idiopathic Interstitial Pneumonias Other Than Idiopathic Pulmonary Fibrosis |
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859 | (16) |
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58 Hypersensitivity Pneumonitis |
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875 | (8) |
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883 | (19) |
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60 Pulmonary Manifestations of the Collagen Vascular Diseases |
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902 | (17) |
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61 Pulmonary Langerhans' Cell Histiocytosis |
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919 | (9) |
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62 Pulmonary Lymphangioleiomyomatosis |
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928 | (11) |
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Angelo M. Taveira-DaSilva |
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63 Benign Metastasizing Leiomyoma |
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939 | (6) |
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Gustavo Pacheco-Rodriguez |
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Angelo M. Taveira-DaSilva |
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64 Depositional Diseases of the Lungs |
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945 | (11) |
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PART 6 Drug-Induced Lung Diseases |
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65 Pulmonary Toxicity Related to Chemotherapeutic Agents |
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956 | (19) |
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66 Drug-Induced Pulmonary Disease Due to Nonchemotherapeutic Agents |
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975 | (19) |
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PART 7 Other Infiltrative and Airspace Disorders |
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67 The Lungs in Patients with Inborn Errors of Metabolism |
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994 | (7) |
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68 Alveolar Hemorrhage Syndromes |
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1001 | (17) |
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69 Aspiration-Related Pulmonary Disorders |
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1018 | (10) |
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70 Pulmonary Alveolar Proteinosis Syndrome |
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1028 | (9) |
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71 The Eosinophilic Pneumonias |
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1037 | (27) |
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PART 8 Disorders of the Pulmonary Circulation |
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72 Pulmonary Arterial Hypertension |
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1064 | (46) |
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73 Pulmonary Thromboembolic Disease |
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1110 | (24) |
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1134 | (14) |
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75 Pulmonary Arteriovenous Malformations |
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1148 | (16) |
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PART 9 Disorders of the Pleural Space |
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76 Nonmalignant Pleural Effusions |
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1164 | (24) |
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77 Malignant Pleural Effusions |
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1188 | (9) |
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1197 | (19) |
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PART 10 Diseases of the Mediastinum |
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79 Malignant Mesothelioma and Other Primary Pleural Tumors |
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1216 | (20) |
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80 Nonneoplastic Disorders of the Mediastinum |
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1236 | (12) |
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81 Congenital Cysts of the Mediastinum: Bronchopulmonary Foregut Anomalies |
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1248 | (11) |
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82 Benign and Malignant Neoplasms of the Mediastinum |
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1259 | (15) |
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PART 11 Disorders of the Chest Wall, Diaphragm, and Spine |
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83 Nonmuscular Diseases of the Chest Wall |
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1274 | (15) |
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84 Effects of Neuromuscular Diseases on Ventilation |
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1289 | (24) |
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85 Management of Neuromuscular Respiratory Muscle Dysfunction |
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1313 | (9) |
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PART 12 Occupational and Environmental Disorders |
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Section 12 Occupational Disorders |
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86 Asbestos-Related Lung Disease |
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1322 | (12) |
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87 Chronic Beryllium Disease and Hard-Metal Lung Diseases |
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1334 | (8) |
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88 Coal Workers' Lung Diseases and Silicosis |
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1342 | (18) |
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89 Occupational Asthma, Byssinosis, and Industrial Bronchitis |
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1360 | (9) |
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90 Acute and Chronic Responses to Toxic Inhalations |
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1369 | (17) |
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Section 13 Environmental Disorders |
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91 Indoor and Outdoor Air Pollution |
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1386 | (26) |
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92 High-Altitude Physiology and Clinical Disorders |
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1412 | (8) |
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93 Diving Injuries and Air Embolism |
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1420 | (8) |
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94 Thermal Lung Injury and Acute Smoke Inhalation |
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1428 | (14) |
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PART 13 Pulmonary Complications of Nonpulmonary Disorders |
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95 Noninfectious Pulmonary Complications of Hematopoietic Stem Cell and Solid Organ Transplantation |
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1442 | (21) |
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96 Pulmonary Complications of Sickle Cell Disease |
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1463 | (16) |
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97 Pulmonary Disorders and Pregnancy |
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1479 | (17) |
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98 Pulmonary Complications of Intra-abdominal Disease |
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1496 | (14) |
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PART 14 Sleep and Sleep Disorders |
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99 Sleep Apnea Syndromes: Central and Obstructive |
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1510 | (41) |
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100 Sleep-Related Hypoventilation Syndromes |
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1551 | (10) |
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101 Changes in the Cardiorespiratory System During Sleep |
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1561 | (6) |
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102 Differential Diagnosis and Evaluation of Sleepiness |
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1567 | (11) |
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PART 15 Surgical Aspects of Pulmonary Medicine |
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103 Perioperative Respiratory Considerations in the Surgical Patient |
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1578 | (14) |
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104 Acute Respiratory Failure in the Surgical Patient |
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1592 | (14) |
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105 Perioperative Care of the Patient Undergoing Lung Resection |
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1606 | (12) |
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1618 | (6) |
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1624 | (28) |
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PART 16 Neoplasms of the Lungs |
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108 Genetic and Molecular Changes in Lung Cancer: Prospects for a Personalized Pharmacological Approach to Treatment |
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1652 | (15) |
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109 Epidemiology of Lung Cancer |
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1667 | (17) |
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110 Approach to the Patient with Pulmonary Nodules |
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1684 | (16) |
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111 The Pathology of Bronchogenic Carcinoma |
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1700 | (22) |
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112 Clinical Evaluation, Diagnosis, and Staging of Lung Cancer |
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1722 | (11) |
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113 Treatment of Non--Small-Cell Lung Cancer: Surgery |
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1733 | (14) |
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114 Treatment of Non--Small-Cell Lung Cancer: Chemotherapy |
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1747 | (11) |
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115 Treatment of Non--Small-Cell Lung Cancer: Radiation Therapy |
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1758 | (12) |
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116 Small Cell Lung Cancer: Diagnosis, Treatment, and Natural History |
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1770 | (16) |
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117 Primary Lung Tumors Other than Bronchogenic Carcinoma: Benign and Malignant |
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1786 | (11) |
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118 Extrapulmonary Syndromes Associated with Lung Tumors |
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1797 | (13) |
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119 Pulmonary Metastases: The Role of Surgical Resection |
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1810 | (6) |
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Section 15 Lymphoproliferative Disorders |
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120 Lymphoproliferative and Hematologic Diseases Involving the Lung and Pleura |
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1816 | (24) |
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PART 17 Infectious Diseases of the Lungs |
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Section 16 General Concepts |
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121 Pulmonary Clearance of Infectious Agents |
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1840 | (13) |
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122 Approach to the Patient with Pulmonary Infection |
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1853 | (27) |
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123 Pulmonary Infection in Immunocompromised Hosts |
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1880 | (36) |
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124 Microbial Virulence Factors in Pulmonary Infections |
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1916 | (6) |
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125 Principles of Antibiotic Use and the Selection of Empiric Therapy for Pneumonia |
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1922 | (15) |
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Section 17 Common Syndromes in Pulmonary Infectious Diseases |
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126 Infections of the Upper Respiratory Tract |
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1937 | (12) |
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127 Aspiration, Empyema, Lung Abscesses, and Anaerobic Infections |
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1949 | (17) |
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128 Acute Bronchitis and Community-Acquired Pneumonia |
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1966 | (15) |
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129 Healthcare-Acquired Pneumonia, Including Ventilator-Associated Pneumonia |
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1981 | (11) |
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Section 18 Major Pathogens in Pulmonary Infections |
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130 Viral Infections of the Lung and Respiratory Tract |
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1992 | (20) |
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2012 | (20) |
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132 Diseases due to Nontuberculous Mycobacteria |
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2032 | (7) |
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133 Aspergillus, Candida, and Other Opportunistic Mold Infections of the Lung |
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2039 | (30) |
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Dimitrios P. Kontoyiannis |
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134 Cryptococcosis and the Endemic Mycoses |
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2069 | (24) |
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135 Pneumocystis Pneumonia |
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2093 | (18) |
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136 Protozoan Infections of the Thorax |
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2111 | (12) |
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137 Helminthic Diseases of the Lungs |
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2123 | (12) |
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138 Zoonotic and Other Unusual Bacterial Pneumonias |
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2135 | (17) |
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PART 18 Acute Respiratory Failure |
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139 Respiratory Failure: An Overview |
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2152 | (10) |
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140 Acute Respiratory Distress Syndrome: Pathogenesis |
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2162 | (10) |
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141 Acute Lung Injury and the Acute Respiratory Distress Syndrome: Clinical Features, Management, and Outcomes |
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2172 | (24) |
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142 Sepsis, Multiple Organ Dysfunction Syndrome, and Chronic Critical Illness |
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2196 | (8) |
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Section 20 Respiratory Pump Failure |
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143 Pump Failure: The Pathogenesis of Hypercapnic Respiratory Failure in Patients with Lung and Chest Wall Disease |
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2204 | (18) |
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Section 21 Management and Therapeutic Interventions |
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144 Oxygen Therapy and Toxicity |
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2222 | (15) |
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145 Pulmonary Pharmacotherapy |
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2237 | (17) |
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146 Intubation and Upper Airway Management |
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2254 | (11) |
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147 Hemodynamic and Respiratory Monitoring in Acute Respiratory Failure |
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2265 | (13) |
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148 Principles of Mechanical Ventilation |
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2278 | (14) |
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149 Nutrition in Pulmonary Disease |
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2292 | (8) |
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150 Diagnosis and Treatment of Pain, Agitation, and Delirium in the Intensive Care Unit |
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2300 | (14) |
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151 Early Mobilization of Patients in the ICU |
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2314 | (6) |
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152 Organization of Intensive Care Units and Long-Term Acute Care Hospitals |
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2320 | (7) |
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153 Ethics and Palliative Care in Critical Care Units |
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Appendix A Terms and Symbols in Respiratory Physiology |
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2 | (3) |
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Appendix B Normal Values for a Healthy 20-Year Old Seated Man |
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5 | |
Index |
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1 | |