Contributors |
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xiii | |
Preface |
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xxix | |
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1 Milestones in the History of Pulmonary Medicine |
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2 | (20) |
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PART 2 Scientific Basis of Lung Function in Health and Disease |
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SECTION 1 Genetic, Cellular, and Structural Basis of Normal Lung Function |
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2 Functional Design of the Human Lung for Gas Exchange |
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22 | (43) |
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3 The Respiratory Muscles |
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65 | (11) |
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4 Molecular Regulation of Lung Development |
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76 | (14) |
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5 Pulmonary Surfactant and Disorders of Surfactant Homeostasis |
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90 | (11) |
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101 | (17) |
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7 The Genetic Basis of Respiratory Disorders |
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118 | (17) |
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8 Stem Cells and Respiratory Disease: Prospects for the Future |
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135 | (10) |
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Konstantinos-Dionysios Alysandratos |
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9 Personalized Pulmonary Medicine |
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145 | (16) |
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SECTION 2 Physiological Principles of Normal Lung Function |
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161 | (12) |
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11 Control of Ventilation |
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173 | (10) |
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12 Sleep and Circadian Rhythms |
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183 | (10) |
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13 The Pulmonary Circulation |
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193 | (18) |
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14 Ventilation, Pulmonary Blood Flow, and Ventilation--Perfusion Relationships |
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211 | (13) |
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224 | (5) |
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16 Diffusion, Chemical Reactions, and Diffusing Capacity |
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229 | (7) |
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236 | (12) |
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18 Aging of the Respiratory System |
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248 | (14) |
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SECTION 3 Lung Immunology |
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19 Innate and Adaptive Immunity in the Lung |
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262 | (15) |
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20 Macrophages and Lymphocytes in the Lung |
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277 | (13) |
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21 Mast Cells and Eosinophils |
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290 | (23) |
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22 Antibody-Mediated Lung Defenses and Humoral Immunodeficiency |
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313 | (16) |
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SECTION 4 Lung Injury and Repair |
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23 T Cell Responses in the Lung |
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329 | (10) |
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24 Chemokines, Adipokines, and Growth Factors in the Lung |
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339 | (17) |
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25 Redox Signaling and Oxidative Stress in Lung Diseases |
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356 | (20) |
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26 Fibroblasts in Lung Homeostasis and Disease |
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376 | (18) |
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PART 3 Symptoms and Signs of Respiratory Disease |
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SECTION 5 Clinical Approach to the Patient |
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27 Approach to the Patient with Respiratory Symptoms |
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394 | (39) |
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SECTION 6 Diagnostic Procedures |
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28 Modern Approach to Thoracic Imaging Diagnosis |
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433 | (68) |
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Eduardo J. Mortani Barbosa Jr. |
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29 Thoracic Ultrasonography |
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501 | (10) |
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30 Physiologic and Metabolic Assessment of Pulmonary Disorders Using Conventional Imaging Techniques and Positron Emission Tomography |
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511 | (33) |
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31 Pulmonary Function Testing |
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544 | (35) |
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32 Principles and Application of Cardiopulmonary Exercise Testing |
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579 | (18) |
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33 Diagnostic Bronchoscopy, Transthoracic Needle Biopsy, and Related Procedures |
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597 | (23) |
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34 Interventional Pulmonology |
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620 | (12) |
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35 Diagnostic Thoracic Surgical Procedures: Thoracoscopy, VATS, RATS, and Thoracotomy |
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632 | (4) |
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36 Evaluation of Respiratory Impairment and Disability |
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636 | (14) |
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PART 4 Obstructive Lung Diseases |
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SECTION 7 Chronic Obstructive Pulmonary Disease |
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37 Pathology of Chronic Obstructive Pulmonary Disease: Diagnostic Features and Differential Diagnosis |
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650 | (14) |
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38 Chronic Obstructive Pulmonary Disease: Epidemiology, Pathophysiology, Pathogenesis |
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664 | (19) |
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39 Chronic Obstructive Pulmonary Disease and al-Antitrypsin Deficiency |
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683 | (10) |
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40 Course and Treatment of Chronic Obstructive Pulmonary Disease |
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693 | (15) |
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41 Cigarette Smoking, Smoking Cessation, and Electronic Cigarettes |
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708 | (17) |
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42 Rehabilitation in Chronic Obstructive Pulmonary Disease and Other Respiratory Disorders |
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725 | (9) |
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734 | (16) |
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44 The Epidemiology of Asthma |
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750 | (17) |
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45 Asthma: Clinical Presentation and Management |
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767 | (18) |
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46 Allergic Bronchopulmonary Aspergillosis (Mycosis) and Severe Asthma with Fungal Sensitivity |
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785 | (9) |
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SECTION 9 Other Obstructive Disorders |
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47 Upper Airway Obstruction in Adults |
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794 | (21) |
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815 | (27) |
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842 | (7) |
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849 | (13) |
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862 | (10) |
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PART 5 Interstitial and Inflammatory Lung Diseases |
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52 Interstitial Lung Disease: A Clinical Overview and General Approach |
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872 | (19) |
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Danielle E. Antin-Ozerkis |
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891 | (24) |
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54 Idiopathic Pulmonary Fibrosis |
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915 | (17) |
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55 Idiopathic Interstitial Pneumonias Other Than Idiopathic Pulmonary Fibrosis |
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932 | (24) |
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56 Hypersensitivity Pneumonitis |
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956 | (10) |
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966 | (21) |
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58 Pulmonary Manifestations of the Collagen Vascular Diseases |
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987 | (19) |
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59 Pulmonary Langerhans Cell Histiocytosis |
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1006 | (9) |
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60 Pulmonary Lymphangioleiomyomatosis |
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1015 | (15) |
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61 Diffuse Cystic Lung Diseases |
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1030 | (24) |
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Kathryn A. Wikenheiser-Brokamp |
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62 Benign Metastasizing Leiomyoma |
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1054 | (11) |
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Gustavo Pacheco-Rodriguez |
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63 Depositional Lung Disorders: Amyloidosis, Pulmonary Calcification, and Pulmonary Ossification |
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1065 | (9) |
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PART 6 Drug-Induced Lung Diseases |
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64 Pulmonary Toxicity Related to Systemic Treatments for Cancer |
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1074 | (26) |
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65 Drug-induced Pulmonary Disease Due to Nonchemotherapeutic Agents |
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1100 | (19) |
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66 Lung Injury Associated with Recreational Drug Use |
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1119 | (17) |
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PART 7 Other Infiltrative and Airspace Disorders |
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67 The Lungs in Patients with Inborn Errors of Metabolism |
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1136 | (8) |
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68 Alveolar Hemorrhage Syndromes |
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1144 | (20) |
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69 Aspiration-Related Pulmonary Disorders |
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1164 | (11) |
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70 Pulmonary Alveolar Proteinosis Syndrome |
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1175 | (11) |
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71 Eosinophilic Lung Diseases |
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1186 | (25) |
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72 Pulmonary Arterial Hypertension |
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1211 | (47) |
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PART 8 Disorders of the Pulmonary Circulation |
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73 Pulmonary Thromboembolic Disease |
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1258 | (29) |
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1287 | (19) |
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75 Pulmonary Arteriovenous Malformations |
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1306 | (14) |
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Josanna M. Rodriguez-Lopez |
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PART 9 Disorders of the Pleural Space |
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76 Nonmalignant Pleural Effusions |
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1320 | (19) |
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77 Malignant Pleural Effusions |
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1339 | (12) |
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78 Malignant Mesothelioma and Other Primary Pleural Tumors |
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1351 | (24) |
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1375 | (23) |
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PART 10 Diseases of the Mediastinum |
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80 Nonneoplastic Disorders of the Mediastinum |
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1398 | (14) |
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81 Congenital Cysts of the Mediastinum: Bronchopulmonary Foregut Anomalies |
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1412 | (11) |
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82 Primary Benign and Malignant Neoplasms of the Mediastinum |
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1423 | (17) |
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PART 11 Disorders of the Chest Wall, Diaphragm, and Spine |
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83 Nonmuscular Diseases of the Chest Wall |
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1440 | (19) |
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84 Effects of Neuromuscular Diseases on Ventilation |
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1459 | (29) |
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PART 12 Occupational and Environmental Disorders |
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SECTION 10 Occupational Disorders |
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85 Asbestos-Related Lung Disease |
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1488 | (14) |
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86 Chronic Beryllium Disease and Hard-Metal Lung Diseases |
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1502 | (11) |
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87 Coal Workers' Lung Diseases and Silicosis |
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1513 | (19) |
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88 Occupational Asthma, Byssinosis, and Industrial Bronchitis |
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1532 | (7) |
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SECTION 11 Environmental Disorders |
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89 Indoor and Outdoor Air Pollution |
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1539 | (20) |
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90 Acute and Chronic Responses to Toxic Inhalations |
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1559 | (22) |
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91 High-Altitude Physiology and Clinical Disorders |
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1581 | (12) |
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92 Diving Physiology and Dysbarism |
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1593 | (10) |
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Christopher E. Winstead-Derlega |
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93 Thermal Lung Injury and Acute Smoke Inhalation |
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1603 | (17) |
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PART 13 Pulmonary Complications of Nonpulmonary Disorders |
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94 Noninfectious Pulmonary Complications of Hematopoietic Stem Cell and Solid Organ Transplantation |
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1620 | (24) |
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95 Pulmonary Complications of Sickle Cell Disease |
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1644 | (19) |
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96 Pulmonary Disorders and Pregnancy |
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1663 | (22) |
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97 Pulmonary Complications of Intra-abdominal Disease |
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1685 | (15) |
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PART 14 Sleep and Sleep Disorders |
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98 Sleep Apnea Syndromes: Central and Obstructive |
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1700 | (51) |
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99 Sleep-related Hypoventilation Syndromes |
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1751 | (14) |
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100 Changes in the Cardiorespiratory System During Sleep |
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1765 | (8) |
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101 Differential Diagnosis and Evaluation of Sleepiness |
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1773 | (13) |
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PART 15 Surgical Aspects of Pulmonary Medicine |
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102 Perioperative Respiratory Considerations in the Surgical Patient |
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1786 | (15) |
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103 Acute Respiratory Failure in the Surgical Patient |
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1801 | (15) |
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1816 | (8) |
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105 Developmental Disorders of the Lung |
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1824 | (19) |
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1843 | (21) |
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PART 16 Cancer and Other Malignancies of the Lungs |
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107 Genetic and Molecular Changes in Lung Cancer: Prospects for a Personalized Pharmacologic Approach to Treatment |
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1864 | (18) |
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108 Epidemiology of Lung Cancer |
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1882 | (22) |
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109 Lung Cancer Screening |
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1904 | (7) |
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110 Approach to the Patient with Pulmonary Nodules |
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1911 | (18) |
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111 The Pathology of Bronchogenic Carcinoma |
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1929 | (21) |
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112 Clinical Evaluation, Diagnosis, and Staging of Lung Cancer |
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1950 | (14) |
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113 Treatment of Non-Small-Cell Lung Cancer: Surgery |
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1964 | (13) |
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114 Treatment of Non-Small-Cell Lung Cancer: Chemotherapy and Immunotherapy |
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1977 | (15) |
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115 Treatment of Non-Small-Cell Lung Cancer: Radiation Therapy |
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1992 | (10) |
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116 Small Cell Lung Cancer: Diagnosis, Treatment, and Natural History |
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2002 | (20) |
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117 Uncommon Tumors of the Lung |
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2022 | (9) |
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118 Extrapulmonary Syndromes Associated with Lung Tumors |
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2031 | (14) |
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119 Lymphoproliferative Diseases Involving the Lung |
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2045 | (25) |
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PART 17 Infectious Diseases of the Lungs |
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SECTION 12 General Concepts |
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120 Pulmonary Clearance of Infectious Agents |
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2070 | (18) |
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2088 | (11) |
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122 Approach to Pulmonary Infection in the Immunocompetent Host |
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2099 | (28) |
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123 Approach to Pulmonary Infection in the Immunocompromised Host |
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2127 | (27) |
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124 Microbial Virulence Factors in Pulmonary Infections |
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2154 | (7) |
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125 Principles of Antibiotic Use and the Selection of Empiric Therapy for Pneumonia |
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2161 | (20) |
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SECTION 13 Common Syndromes in Pulmonary Infectious Diseases |
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126 Viral Infections of the Lung and Respiratory Tract |
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2181 | (22) |
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127 Aspiration, Empyema, Lung Abscesses, and Anaerobic Infections |
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2203 | (20) |
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128 Acute Bronchitis and Community-Acquired Pneumonia |
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2223 | (20) |
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129 Nosocomial Pneumonia, Including Ventilator-associated Pneumonia |
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2243 | (13) |
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SECTION 14 Major Pathogens in Pulmonary Infections |
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2256 | (22) |
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131 Pulmonary Diseases Due to Nontuberculous Mycobacteria |
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2278 | (12) |
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132 Aspergillus, Candida, and Other Opportunistic Pulmonary Mycoses |
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2290 | (29) |
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Dimitrios P. Kontoyiannis |
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133 Cryptococcosis and the Endemic Mycoses: Histoplasma, Blastomyces, and Coccidioides |
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2319 | (34) |
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134 Pneumocystis Pneumonia |
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2353 | (22) |
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135 Protozoan Infections of the Thorax |
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2375 | (13) |
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136 Helminthic Diseases of the Lung |
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2388 | (13) |
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137 Nocardiosis and Actinomycosis |
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2401 | (20) |
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138 Zoonotic and Environmental Bacterial Pneumonias |
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2421 | (15) |
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PART 18 Respiratory Failure |
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139 Respiratory Failure: An Overview |
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2436 | (11) |
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140 Acute Respiratory Distress Syndrome: Pathogenesis |
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2447 | (12) |
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141 Acute Respiratory Distress Syndrome: Clinical Features, Management, and Outcomes |
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2459 | (29) |
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SECTION 16 Respiratory Pump Failure |
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142 Chronic Hypercapnic Respiratory Failure: Pathogenesis and Management |
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2488 | (19) |
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SECTION 17 Management and Therapeutic Interventions |
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143 Oxygen Therapy and Toxicity |
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2507 | (16) |
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144 Pulmonary Pharmacotherapy |
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2523 | (20) |
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145 Intubation and Upper Airway Management |
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2543 | (16) |
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146 Hemodynamic and Respiratory Monitoring in Acute Respiratory Failure |
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2559 | (14) |
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147 Principles of Mechanical Ventilation |
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2573 | (15) |
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148 Principles of Noninvasive Pressure-targeted Ventilation |
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2588 | (22) |
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149 Extracorporeal Membrane Oxygenation (ECMO) in Acute Respiratory Failure |
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2610 | (24) |
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150 Nutrition in Pulmonary Disease |
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2634 | (9) |
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151 Diagnosis and Treatment of Pain, Agitation, and Delirium in the Intensive Care Unit |
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2643 | (16) |
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152 Ethics and Palliative Care in Critical Care Units |
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Appendix A Terms and Symbols in Respiratory Physiology |
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2 | (3) |
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Appendix B Normal Values for a Healthy 20-Year Old Seated Man |
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5 | |
Index |
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1 | |