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El. knyga: Fishman's Pulmonary Diseases and Disorders, 2-Volume Set, Sixth Edition

  • Formatas: EPUB+DRM
  • Išleidimo metai: 22-Oct-2022
  • Leidėjas: McGraw-Hill Education
  • Kalba: eng
  • ISBN-13: 9781260474060
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  • Formatas: EPUB+DRM
  • Išleidimo metai: 22-Oct-2022
  • Leidėjas: McGraw-Hill Education
  • Kalba: eng
  • ISBN-13: 9781260474060
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"A presentation of pulmonary and critical care medicine with the underlying basic and applied science upon which the clinical material is based. The book includes relevant respiratory biology and underlying cellular and molecular mechanisms, and incorporates of a number of videos designed to complement and, at times, accentuate information contained within the text"--

The definitive guide to the clinical and scientific aspects of pulmonary medicine fully updated with the latest advances in the field

Fishman’s Pulmonary Diseases and Disorders delivers unparalleled coverage of pulmonary medicine. With nearly 2500 illustrations, 60 videos, and 22,000 references, this peerless, two-volume resource provides a comprehensive overview of the scientific basis of lung function in health and disease.

You’ll find detailed coverage of the broad array of disorders affecting the respiratory system, including obstructive and restrictive diseases, pulmonary vascular disorders, sleep-disordered breathing, lung neoplasms, respiratory infections, and respiratory failure. In addition, you’ll learn about all the latest advances, including molecular development of the lung, stem cells and respiratory disease, the genetics of pulmonary disease, the growth of personalized medicine, technical advances in lung transplantation, and much more.

Notable new content in the 6th edition includes discussion of the respiratory effects of vaping, detailed consideration of the idiopathic interstitial pneumonitides, state-of the-art discussion of lung nodules, a summary of the use of immunotherapy in the treatment of lung cancer, COVID-19-related lung disease and its management, and a comprehensive discussion of noninvasive ventilation, including its use in ambulatory and ICU settings. In addition, new chapters on cystic lung disease, lung cancer screening, the lung microbiome, developmental lung disorders, nocardiosis and actinomycosis, and application of ECMO are included.

Contributors xiii
Preface xxix
VOLUME 1
PART 1 Perspectives
1 Milestones in the History of Pulmonary Medicine
2(20)
Michael A. Grippi
PART 2 Scientific Basis of Lung Function in Health and Disease
SECTION 1 Genetic, Cellular, and Structural Basis of Normal Lung Function
2 Functional Design of the Human Lung for Gas Exchange
22(43)
Matthias Ochs
3 The Respiratory Muscles
65(11)
Ghislaine Gayan-Ramirez
Daniel Hanger
Marc Decramer
4 Molecular Regulation of Lung Development
76(14)
Wellington V. Cardoso
Ying Yang
Jining Lu
5 Pulmonary Surfactant and Disorders of Surfactant Homeostasis
90(11)
Jeffrey A. Whitsett
James P. Bridges
Timothy E. Weaver
6 Mucociliary Clearance
101(17)
Thomas W. Ferkol
John D. Dickinson
Burton F. Dickey
7 The Genetic Basis of Respiratory Disorders
118(17)
Micheala A. Aldred
8 Stem Cells and Respiratory Disease: Prospects for the Future
135(10)
Konstantinos-Dionysios Alysandratos
Michael J. Herriges
Darrell N. Kotton
9 Personalized Pulmonary Medicine
145(16)
Benjamin A. Raby
Kelan G. Tantisira
SECTION 2 Physiological Principles of Normal Lung Function
10 Pulmonary Mechanics
161(12)
Allan I. Pack
Michael A. Grippi
11 Control of Ventilation
173(10)
Frank J. Jacono
Atul Malhotra
12 Sleep and Circadian Rhythms
183(10)
Allan I. Pack
13 The Pulmonary Circulation
193(18)
Robert Naeije
14 Ventilation, Pulmonary Blood Flow, and Ventilation--Perfusion Relationships
211(13)
Peter D. Wagner
15 Blood Gas Transport
224(5)
Adrian Shifren
Robert A. Klocke
16 Diffusion, Chemical Reactions, and Diffusing Capacity
229(7)
Robert A. Klocke
Adrian Shifren
17 Acid-Base Balance
236(12)
Stanley Goldfarb
18 Aging of the Respiratory System
248(14)
Edward J. Campbell
Corrine R. Kliment
SECTION 3 Lung Immunology
19 Innate and Adaptive Immunity in the Lung
262(15)
Clemente J. Britto
Charles S. Dela Cruz
20 Macrophages and Lymphocytes in the Lung
277(13)
Katrina E. Traberl
Joseph P. Mizgerd
David M. Center
21 Mast Cells and Eosinophils
290(23)
Edward S. Schulman
Peter H.S. Sporn
Amali E. Samarasinghe
22 Antibody-Mediated Lung Defenses and Humoral Immunodeficiency
313(16)
Homer L. Twigg
SECTION 4 Lung Injury and Repair
23 T Cell Responses in the Lung
329(10)
Lauren Cohn
24 Chemokines, Adipokines, and Growth Factors in the Lung
339(17)
Marcus W. Butler
Paul McLoughlin
Michael P. Keane
25 Redox Signaling and Oxidative Stress in Lung Diseases
356(20)
Jessy Deshane
Victor J. Thannickal
26 Fibroblasts in Lung Homeostasis and Disease
376(18)
Yong Zhou
Victor J. Thannickal
PART 3 Symptoms and Signs of Respiratory Disease
SECTION 5 Clinical Approach to the Patient
27 Approach to the Patient with Respiratory Symptoms
394(39)
Michael A. Grippi
Jeffrey P. Callen
SECTION 6 Diagnostic Procedures
28 Modern Approach to Thoracic Imaging Diagnosis
433(68)
Eduardo J. Mortani Barbosa Jr.
Leonid Roshkovan
29 Thoracic Ultrasonography
501(10)
Andrew Weber
Fiore Mastroianni
Paul H. Mayo
30 Physiologic and Metabolic Assessment of Pulmonary Disorders Using Conventional Imaging Techniques and Positron Emission Tomography
511(33)
Ghassan El-Haddad
Søren Hess
Abass Alavi
31 Pulmonary Function Testing
544(35)
Michael A. Grippi
Gregory Tino
32 Principles and Application of Cardiopulmonary Exercise Testing
579(18)
Marco Guazzi
Alice Moroni
33 Diagnostic Bronchoscopy, Transthoracic Needle Biopsy, and Related Procedures
597(23)
David M. DiBardino
Daniel H. Sterman
Anil Vachani
34 Interventional Pulmonology
620(12)
Daniel G. Dunlap
Andrew R. Haas
Daniel H. Sterman
35 Diagnostic Thoracic Surgical Procedures: Thoracoscopy, VATS, RATS, and Thoracotomy
632(4)
Robert E. Merritt
36 Evaluation of Respiratory Impairment and Disability
636(14)
Lisa Ruvuna
Akshay Sood
PART 4 Obstructive Lung Diseases
SECTION 7 Chronic Obstructive Pulmonary Disease
37 Pathology of Chronic Obstructive Pulmonary Disease: Diagnostic Features and Differential Diagnosis
650(14)
Joanne L. Wright
Andrew Churg
38 Chronic Obstructive Pulmonary Disease: Epidemiology, Pathophysiology, Pathogenesis
664(19)
Takudzwa Mkorombindo
Mark T. Dransfield
39 Chronic Obstructive Pulmonary Disease and al-Antitrypsin Deficiency
683(10)
Darrell N. Kotton
Andrew A. Wilson
40 Course and Treatment of Chronic Obstructive Pulmonary Disease
693(15)
M. Bradley Drummond
Robert A. Wise
41 Cigarette Smoking, Smoking Cessation, and Electronic Cigarettes
708(17)
Stephen R. Baldassarri
Stephen I. Rennard
42 Rehabilitation in Chronic Obstructive Pulmonary Disease and Other Respiratory Disorders
725(9)
Andrew L. Ries
Duc M. Ha
SECTION 8 Asthma
43 The Biology of Asthma
734(16)
Geoffrey L. Chupp
Matthew C. Bell
William W. Basse
44 The Epidemiology of Asthma
750(17)
Kathleen A. Lee-Sarwar
Scott T. Weiss
Augusto A. Litonjua
45 Asthma: Clinical Presentation and Management
767(18)
Omar S. Usmani
Peter J. Barnes
46 Allergic Bronchopulmonary Aspergillosis (Mycosis) and Severe Asthma with Fungal Sensitivity
785(9)
Geoffrey L. Chupp
SECTION 9 Other Obstructive Disorders
47 Upper Airway Obstruction in Adults
794(21)
Erin DeBiasil
Christine Won
Meir Kryger
48 Cystic Fibrosis
815(27)
Judith A. Voynow
Andrea Kelly
Flora K. Szabo
Thomas F. Scanlin
49 Bronchiolitis
842(7)
Garv R. Eoler
50 Bullous Lung Disease
849(13)
Fernando J. Martinez
51 Bronchiectasis
862(10)
Gregory Tino
PART 5 Interstitial and Inflammatory Lung Diseases
52 Interstitial Lung Disease: A Clinical Overview and General Approach
872(19)
Aditi Mathur
Danielle E. Antin-Ozerkis
53 Systemic Sarcoidosis
891(24)
Edward S. Chen
54 Idiopathic Pulmonary Fibrosis
915(17)
Tanzira Zaman
Giuliana Cerro Chiang
Paul W. Noble
55 Idiopathic Interstitial Pneumonias Other Than Idiopathic Pulmonary Fibrosis
932(24)
Kelly M. Hager
Ami Rubinowitz
Mridu Gulati
56 Hypersensitivity Pneumonitis
956(10)
Prerna Mota
Richard I. Enelow
57 Radiation Pneumonitis
966(21)
James H. Laird
Kenneth B. Roberts
Roy H. Decker
Henry S. Park
58 Pulmonary Manifestations of the Collagen Vascular Diseases
987(19)
Kevin P. Toole
Gregory P. Cosgrove
59 Pulmonary Langerhans Cell Histiocytosis
1006(9)
Sergio Harari
Davide Elia
Joel Moss
Abdellatif Tazi
60 Pulmonary Lymphangioleiomyomatosis
1015(15)
Arnold S. Kristof
Joel Moss
61 Diffuse Cystic Lung Diseases
1030(24)
Nishant Gupta
Tami J. Bang
Kathryn A. Wikenheiser-Brokamp
62 Benign Metastasizing Leiomyoma
1054(11)
Gustavo Pacheco-Rodriguez
Olga I. Astapova
Stephen R. Hammes
Joel Moss
63 Depositional Lung Disorders: Amyloidosis, Pulmonary Calcification, and Pulmonary Ossification
1065(9)
Robert J. Homer
Christopher Gangei
Natalia Neparidze
PART 6 Drug-Induced Lung Diseases
64 Pulmonary Toxicity Related to Systemic Treatments for Cancer
1074(26)
Jennifer D. Possick
Erin DeBiasi
Lynn T. Tanoue
65 Drug-induced Pulmonary Disease Due to Nonchemotherapeutic Agents
1100(19)
Hilary C. Cain
66 Lung Injury Associated with Recreational Drug Use
1119(17)
Timothy E. Albertson
Patrick Mangialardi
James A. Chenoweth
Susan Murin
PART 7 Other Infiltrative and Airspace Disorders
67 The Lungs in Patients with Inborn Errors of Metabolism
1136(8)
Timothy Craig Allen
68 Alveolar Hemorrhage Syndromes
1144(20)
Joseph P. Lynch
Michael C. Fishbein
Tisha S. Wang
69 Aspiration-Related Pulmonary Disorders
1164(11)
Paul E. Marik
70 Pulmonary Alveolar Proteinosis Syndrome
1175(11)
Bruce C. Trapnell
Cormac McCarthy
Brenna Carey
71 Eosinophilic Lung Diseases
1186(25)
Lauren Cohn
Carolyn L. Rochester
Brian J. Clark
72 Pulmonary Arterial Hypertension
1211(47)
Nick H. Kim
Jess Mandel
Kimberly A. Smith
Jason X.-J. Yuan
PART 8 Disorders of the Pulmonary Circulation
73 Pulmonary Thromboembolic Disease
1258(29)
Timothy M. Fernandes
Peter F. Fedullo
74 Pulmonary Vasculitis
1287(19)
Rodrigo Cartin-Ceba
Ulrich Specks
75 Pulmonary Arteriovenous Malformations
1306(14)
Tyler J. Peck
Josanna M. Rodriguez-Lopez
PART 9 Disorders of the Pleural Space
76 Nonmalignant Pleural Effusions
1320(19)
Christopher M. Kapp
David Feller-Kopman
77 Malignant Pleural Effusions
1339(12)
Jeffrey C. Thompson
Kevin C. Ma
78 Malignant Mesothelioma and Other Primary Pleural Tumors
1351(24)
Daniel H. Sterman
Edmund K. Moon
Keshav Mangalick
Leslie A. Litzky
79 Pneumothorax
1375(23)
Rodolfo A. Estrada
Jay I. Peters
Nilam J. Soni
Philip G. Ong
VOLUME 2
PART 10 Diseases of the Mediastinum
80 Nonneoplastic Disorders of the Mediastinum
1398(14)
Luis F. Tapias
Cameron D. Wright
81 Congenital Cysts of the Mediastinum: Bronchopulmonary Foregut Anomalies
1412(11)
Erik E. Lewis
Daniel P. McCarthy
Malcolm M. DeCamp
82 Primary Benign and Malignant Neoplasms of the Mediastinum
1423(17)
Natalie S. Lui
Joseph B. Shrager
PART 11 Disorders of the Chest Wall, Diaphragm, and Spine
83 Nonmuscular Diseases of the Chest Wall
1440(19)
George E. Tzelepis
F. Dennis McCool
84 Effects of Neuromuscular Diseases on Ventilation
1459(29)
Gerard Joseph Criner
Nathaniel Marchetti
PART 12 Occupational and Environmental Disorders
SECTION 10 Occupational Disorders
85 Asbestos-Related Lung Disease
1488(14)
William N. Rom
Jun-Chieh J. Tsay
86 Chronic Beryllium Disease and Hard-Metal Lung Diseases
1502(11)
Shweta Sood
Mary Elizabeth Kreider
87 Coal Workers' Lung Diseases and Silicosis
1513(19)
Robert C. Stansbury
Rahul G. Sangani
John E. Parker
88 Occupational Asthma, Byssinosis, and Industrial Bronchitis
1532(7)
Shu-Yi Liao
David C. Christiani
SECTION 11 Environmental Disorders
89 Indoor and Outdoor Air Pollution
1539(20)
Coralynn Sack
Joel D. Kaufman
90 Acute and Chronic Responses to Toxic Inhalations
1559(22)
Austin J. Jolly
David A. Schwartz
91 High-Altitude Physiology and Clinical Disorders
1581(12)
Kingman P. Strohl
Cynthia M. Beall
Nikolaus C. Netzer
92 Diving Physiology and Dysbarism
1593(10)
Christopher E. Winstead-Derlega
Richard E. Moon
93 Thermal Lung Injury and Acute Smoke Inhalation
1603(17)
Perenlei Enkhbaatar
PART 13 Pulmonary Complications of Nonpulmonary Disorders
94 Noninfectious Pulmonary Complications of Hematopoietic Stem Cell and Solid Organ Transplantation
1620(24)
Hemang Yadavl
Steve G. Peters
Robert M. Kotloff
95 Pulmonary Complications of Sickle Cell Disease
1644(19)
Roberto F. Machado
Mark T. Gladwin
96 Pulmonary Disorders and Pregnancy
1663(22)
Debasree Banerjee
Andrew T. Levinson
Jeffrey Mazer
Ghada Bourjeily
97 Pulmonary Complications of Intra-abdominal Disease
1685(15)
Hilary M. DuBrock
Sonja D. Bartolome
PART 14 Sleep and Sleep Disorders
98 Sleep Apnea Syndromes: Central and Obstructive
1700(51)
Grace W. Pien
Ilene M. Rosen
Barry G. Fields
99 Sleep-related Hypoventilation Syndromes
1751(14)
Jorge I. Moral
Richard J. Schwab
100 Changes in the Cardiorespiratory System During Sleep
1765(8)
Indira Gurubhagavatula
Susheel P. Patil
101 Differential Diagnosis and Evaluation of Sleepiness
1773(13)
Sritika Thapa
Mithu Sen
Meir Kryger
PART 15 Surgical Aspects of Pulmonary Medicine
102 Perioperative Respiratory Considerations in the Surgical Patient
1786(15)
Horace M. DeLisser
Michael A. Grippi
103 Acute Respiratory Failure in the Surgical Patient
1801(15)
Robert M. Kotloff
104 Thoracic Trauma
1816(8)
Seth A. Bellister
Bradley M. Dennis
105 Developmental Disorders of the Lung
1824(19)
Himanshu Deshwal
Subha Ghosh
106 Lung Transplantation
1843(21)
Ramsey R. Hachem
PART 16 Cancer and Other Malignancies of the Lungs
107 Genetic and Molecular Changes in Lung Cancer: Prospects for a Personalized Pharmacologic Approach to Treatment
1864(18)
Howard Y. Li
Jeffrey A. Kern
108 Epidemiology of Lung Cancer
1882(22)
Lynn T. Tanoue
Charles S. Dela Cruz
109 Lung Cancer Screening
1904(7)
Humberto K. Choi
Peter J. Mazzone
110 Approach to the Patient with Pulmonary Nodules
1911(18)
Moiz Salahuddin
David E. Ost
111 The Pathology of Bronchogenic Carcinoma
1929(21)
Leslie A. Litzky
112 Clinical Evaluation, Diagnosis, and Staging of Lung Cancer
1950(14)
A. Cole Burks
M. Patricia Rivera
113 Treatment of Non-Small-Cell Lung Cancer: Surgery
1964(13)
John K. Waters
Scott I. Reznik
114 Treatment of Non-Small-Cell Lung Cancer: Chemotherapy and Immunotherapy
1977(15)
Laurie L. Carr
115 Treatment of Non-Small-Cell Lung Cancer: Radiation Therapy
1992(10)
Joseph A. Miccio
Mitchell Machtay
116 Small Cell Lung Cancer: Diagnosis, Treatment, and Natural History
2002(20)
Jonathan E. Dowell
Benjamin J. Drapkin
David E. Gerberl
David H. Johnson
117 Uncommon Tumors of the Lung
2022(9)
Karen Rodriguez
Gerald F. Abbott
118 Extrapulmonary Syndromes Associated with Lung Tumors
2031(14)
Nicholas J. Pastis
Nichole T. Tanner
Gerard A. Silvestri
119 Lymphoproliferative Diseases Involving the Lung
2045(25)
Venerino Poletti
Sara Piciucchi
Silvia Asioli
PART 17 Infectious Diseases of the Lungs
SECTION 12 General Concepts
120 Pulmonary Clearance of Infectious Agents
2070(18)
Theodore J. Standiford
Gary B. Huffnagle
121 The Lung Microbiome
2088(11)
John E. McGinniss
Joshua M. Diamond
122 Approach to Pulmonary Infection in the Immunocompetent Host
2099(28)
Megan Rose Curtis
Tulip Ajit Jhaveri
Camille Nelson Kotton
123 Approach to Pulmonary Infection in the Immunocompromised Host
2127(27)
Matthew B. Roberts
Camille Nelson Kotton
124 Microbial Virulence Factors in Pulmonary Infections
2154(7)
Cart D. Britto
Gregory P. Priebe
Gerald B. Pier
125 Principles of Antibiotic Use and the Selection of Empiric Therapy for Pneumonia
2161(20)
Girish B. Nair
Michael S. Niederman
SECTION 13 Common Syndromes in Pulmonary Infectious Diseases
126 Viral Infections of the Lung and Respiratory Tract
2181(22)
John Treanor
127 Aspiration, Empyema, Lung Abscesses, and Anaerobic Infections
2203(20)
Kyle B. Enfield
Costi D. Sifri
128 Acute Bronchitis and Community-Acquired Pneumonia
2223(20)
James M. Walter
Richard G. Wunderink
129 Nosocomial Pneumonia, Including Ventilator-associated Pneumonia
2243(13)
Andrew T. Roth
Marin H. Kollef
SECTION 14 Major Pathogens in Pulmonary Infections
130 Tuberculosis
2256(22)
Akash Gupta
Karen R. Jacobson
131 Pulmonary Diseases Due to Nontuberculous Mycobacteria
2278(12)
John S. Albin
Rocio M. Hurtado
132 Aspergillus, Candida, and Other Opportunistic Pulmonary Mycoses
2290(29)
Georgios Chamilos
Dimitrios P. Kontoyiannis
133 Cryptococcosis and the Endemic Mycoses: Histoplasma, Blastomyces, and Coccidioides
2319(34)
Marwan M. Azar
Nathan C. Bahr
Joshua Malo
Chadi A. Hage
134 Pneumocystis Pneumonia
2353(22)
Eliezer Zachary Nussbaum
Marwan M. Azar
135 Protozoan Infections of the Thorax
2375(13)
Louise C. Ivers
Edward T. Ryan
136 Helminthic Diseases of the Lung
2388(13)
Ricardo M. La Hoz
James B. Cutrell
137 Nocardiosis and Actinomycosis
2401(20)
Daniel N. Maxwell
Reuben J. Arasaratnam
Alejandro Restrepo
Tara M. Babu
138 Zoonotic and Environmental Bacterial Pneumonias
2421(15)
Camille Nelson Kotton
Howard M. Heller
PART 18 Respiratory Failure
139 Respiratory Failure: An Overview
2436(11)
Michael A. Grippi
General Concepts
SECTION 15 Lung Failure
140 Acute Respiratory Distress Syndrome: Pathogenesis
2447(12)
Asha N. Chesnutt
Michael A. Matthay
141 Acute Respiratory Distress Syndrome: Clinical Features, Management, and Outcomes
2459(29)
John P. Reilly
Jason D. Christie
SECTION 16 Respiratory Pump Failure
142 Chronic Hypercapnic Respiratory Failure: Pathogenesis and Management
2488(19)
Jennifer J. Dorsch
Jorge I. Mora
SECTION 17 Management and Therapeutic Interventions
143 Oxygen Therapy and Toxicity
2507(16)
Matthew Wemple
Erik R. Swenson
144 Pulmonary Pharmacotherapy
2523(20)
Karen J. Tietze
Scott Manaker
145 Intubation and Upper Airway Management
2543(16)
Joshua H. Atkins
Christopher H. Rassekh
146 Hemodynamic and Respiratory Monitoring in Acute Respiratory Failure
2559(14)
Hari M. Shankar
Brian J. Anderson
147 Principles of Mechanical Ventilation
2573(15)
Martin J. Tobin
148 Principles of Noninvasive Pressure-targeted Ventilation
2588(22)
Bernardo Selim
Janet Hilbert
Henry K. Yaggi
149 Extracorporeal Membrane Oxygenation (ECMO) in Acute Respiratory Failure
2610(24)
Asad Ali Usman
Jacob Gutsche
150 Nutrition in Pulmonary Disease
2634(9)
Tachira Tavarez
David S. Seres
151 Diagnosis and Treatment of Pain, Agitation, and Delirium in the Intensive Care Unit
2643(16)
Niall T. Prendergast
Timothy D. Girard
Nathan E. Brummel
152 Ethics and Palliative Care in Critical Care Units
2659
Joshua B. Kayser
Horace M. DeLisser
APPENDIXES
Appendix A Terms and Symbols in Respiratory Physiology
2(3)
Appendix B Normal Values for a Healthy 20-Year Old Seated Man
5
Index 1
Michael Grippi, MD, is Emeritus Associate Professor CE of Medicine and chief medical officer at Good Shepherd Penn Partners Specialty Hospital; and vice chair of the Department of Medicine at the University of Pennsylvania.

Danielle Antin-Ozerkis, MD, is associate professor of medicine (pulmonary) at Yale School of Medicine. 

Charles Dela Cruz, MD, PhD, is associate professor of medicine at Yale School of Medicine, and director of the Center for Pulmonary Research and Treatment (CPIRT). 

Robert Karloff, MD, is chairman of the Department of Pulmonary Medicine at the Cleveland Clinic.

Camille Nelson Kotton, MD, FIDSA, FAST is the clinical director of Transplant and Immunocompromised Host Infectious Diseases in the Infectious Diseases Division at Massachusetts General Hospital.

Alan Pack, MD, PhD, is professor of medicine at the University of Pennsylvania.