| Contributors |
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xvii | |
| Preface |
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xxxi | |
| Acknowledgments |
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xxxiii | |
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Section 1 General Considerations |
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1 The Epidemiology and Burden of Skin Disease |
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1 | (8) |
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2 Evidence-Based Dermatology |
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9 | (6) |
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3 Global Health in Dermatology |
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15 | (6) |
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4 Public Health in Dermatology |
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21 | (5) |
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Section 2 Approach to Dermatologic Diagnosis |
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5 Structure of Skin Lesions and Fundamentals of Clinical Diagnosis |
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26 | (16) |
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6 Basic Pathologic Reactions of the Skin |
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42 | (16) |
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Section 3 Overview of Biology, Development, and Structure of Skin |
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7 Development and Structure of Skin |
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58 | (17) |
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8 Genetics in Relation to the Skin |
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75 | (16) |
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9 Racial Considerations: Skin of Color |
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91 | (14) |
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PART 2 DISORDERS PRESENTING IN SKIN AND MUCOUS MEMBRANES |
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Section 4 Inflammatory Disorders Based on T-Cell Reactivity and Dysregulation |
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10 Innate and Adaptive Immunity in the Skin |
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105 | (21) |
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126 | (16) |
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142 | (10) |
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13 Allergic Contact Dermatitis |
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152 | (13) |
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Mari Paz Castanedo-Tardan |
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14 Atopic Dermatitis (Atopic Eczema) |
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165 | (17) |
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15 Nummular Eczema, Lichen Simplex Chronicus, and Prurigo Nodularis |
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182 | (5) |
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16 Vesicular Palmoplantar Eczema |
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187 | (7) |
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17 Autosensitization Dermatitis |
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194 | (3) |
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197 | (35) |
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232 | (11) |
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243 | (10) |
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21 Pustular Eruptions of Palms and Soles |
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253 | (6) |
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259 | (7) |
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23 Exfoliative Dermatitis |
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266 | (13) |
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24 Pityriasis Rubra Pilaris |
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279 | (6) |
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25 Parapsoriasis and Pityriasis Lichenoides |
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285 | (11) |
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296 | (16) |
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312 | (4) |
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28 Graft-Versus-Host Disease |
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316 | (14) |
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29 Skin Disease in Acute and Chronic Immunosuppression |
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330 | (15) |
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Section 5 Inflammatory Diseases Based on Neutrophils and Eosinophils |
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30 Regulation of the Production and Activation of Neutrophils |
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345 | (6) |
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31 Regulation of the Production and Activation of Eosinophils |
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351 | (11) |
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32 Acute Febrile Neutrophilic Dermatosis (Sweet Syndrome) |
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362 | (9) |
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371 | (9) |
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380 | (3) |
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35 Subcorneal Pustular Dermatosis (Sneddon--Wilkinson Disease) |
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383 | (3) |
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36 Eosinophils in Cutaneous Diseases |
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386 | (15) |
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Section 6 Inflammatory Diseases Based on Abnormal Humoral Reactivity and Other Inflammatory Diseases |
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37 Humoral Immunity and Complement |
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401 | (13) |
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38 Urticaria and Angioedema |
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414 | (17) |
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431 | (8) |
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40 Epidermal Necrolysis (Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis) |
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439 | (10) |
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41 Cutaneous Reactions to Drugs |
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449 | (9) |
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458 | (5) |
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43 Erythema Annulare Centrifugum and Other Figurate Erythemas |
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463 | (4) |
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467 | (6) |
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Section 7 Disorders of Epidermal Differentiation and Keratinization |
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473 | (5) |
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46 Epidermal Growth and Differentiation |
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478 | (8) |
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47 Skin as an Organ of Protection |
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486 | (13) |
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48 Irritant Contact Dermatitis |
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499 | (8) |
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507 | (31) |
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50 Inherited Palmoplantar Keratodermas |
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538 | (12) |
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Maurice A. M. van Steensel |
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51 Acantholytic Disorders of the Skin |
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550 | (13) |
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563 | (6) |
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Section 8 Disorders of Epidermal and Dermal--Epidermal Adhesion and Vesicular and Bullous Disorders |
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53 Epidermal and Epidermal--Dermal Adhesion |
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569 | (17) |
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586 | (14) |
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55 Paraneoplastic Pemphigus |
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600 | (8) |
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608 | (9) |
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57 Cicatricial Pemphigoid |
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617 | (6) |
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58 Linear Immunoglobulin A Dermatosis and Chronic Bullous Disease of Childhood |
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623 | (7) |
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59 Pemphigoid Gestationis (Herpes Gestationis) |
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630 | (4) |
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60 Epidermolysis Bullosa Acquisita |
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634 | (8) |
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61 Dermatitis Herpetiformis |
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642 | (7) |
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62 Inherited Epidermolysis Bullosa |
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649 | (17) |
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Section 9 Disorders of the Dermal Connective Tissue |
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63 Collagens, Elastic Fibers, and Other Extracellular Matrix Proteins of the Dermis |
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666 | (26) |
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692 | (10) |
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702 | (5) |
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66 Dermal Hypertrophies and Benign Fibroblastic/Myofibroblastic Tumors |
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707 | (11) |
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67 Anetoderma and Other Atrophic Disorders of the Skin |
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718 | (6) |
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68 Ainhum and Pseudoainhum |
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724 | (3) |
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69 Acquired Perforating Disorders |
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727 | (5) |
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Section 10 Disorders of Subcutaneous Tissue |
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732 | (23) |
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755 | (10) |
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Section 11 Disorders of Melanocytes |
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72 Biology of Melanocytes |
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765 | (16) |
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73 Albinism and Other Genetic Disorders of Pigmentation |
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781 | (11) |
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792 | (12) |
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75 Hypomelanoses and Hypermelanoses |
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804 | (23) |
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Section 12 Disorders of the Oral and Genital Integument |
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76 Biology and Pathology of the Oral Cavity |
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827 | (25) |
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77 Diseases and Disorders of the Male Genitalia |
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852 | (26) |
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78 Diseases and Disorders of the Female Genitalia |
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878 | (15) |
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PART 3 DISORDERS OF THE SKIN APPENDAGES |
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Section 13 Disorders of the Sebaceous Glands |
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79 Biology of Sebaceous Glands |
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893 | (4) |
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80 Acne Vulgaris and Acneiform Eruptions |
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897 | (21) |
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918 | (7) |
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925 | (4) |
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Section 14 Disorders of the Eccrine and Apocrine Glands |
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83 Biology of Eccrine and Apocrine Glands |
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929 | (7) |
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84 Disorders of the Eccrine Sweat Glands and Sweating |
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936 | (11) |
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85 Disorders of the Apocrine Sweat Glands |
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947 | (13) |
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Section 15 Disorders of the Hair and Nails |
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86 Biology of Hair Follicles |
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960 | (13) |
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87 Keratosis Pilaris and Other Inflammatory Follicular Keratotic Syndromes |
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973 | (6) |
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979 | (30) |
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89 Biology of Nails and Nail Disorders |
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1009 | (22) |
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PART 4 DISORDERS DUE TO THE ENVIRONMENT |
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Section 16 Disorders Due to Ultraviolet Radiation |
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90 Fundamentals of Cutaneous Photobiology and Photoimmunology |
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1031 | (18) |
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91 Abnormal Responses to Ultraviolet Radiation: Idiopathic, Probably Immunologic, and Photoexacerbated |
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1049 | (17) |
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92 Abnormal Responses to Ultraviolet Radiation: Photosensitivity Induced by Exogenous Agents |
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1066 | (9) |
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Section 17 Skin Changes Due to Other Physical and Chemical Factors |
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1075 | (4) |
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1079 | (10) |
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Claudine Pierard-Franchimont |
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1089 | (6) |
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96 Skin Problems in Amputees |
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1095 | (9) |
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97 Skin Problems in Ostomates |
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1104 | (7) |
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1111 | (4) |
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1115 | (6) |
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100 Decubitus (Pressure) Ulcers |
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1121 | (8) |
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1129 | (8) |
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PART 5 NEUROCUTANEOUS AND PSYCHOCUTANEOUS ASPECTS OF SKIN DISEASE |
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Section 18 Neurocutaneous and Psychocutaneous Skin Disease |
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102 Neurobiology of the Skin |
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1137 | (9) |
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103 Pathophysiology and Clinical Aspects of Pruritus |
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1146 | (12) |
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104 Psychocutaneous Skin Disease |
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1158 | (8) |
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105 Cutaneous Manifestations of Drug Abuse |
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1166 | (11) |
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106 Skin Signs of Physical Abuse |
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1177 | (8) |
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PART 6 SKIN CHANGES ACROSS THE SPAN OF LIFE |
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Section 19 From Birth to Old Age |
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107 Neonatal, Pediatric, and Adolescent Dermatology |
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1185 | (19) |
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108 Skin Changes and Diseases in Pregnancy |
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1204 | (9) |
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1213 | (14) |
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Section 20 Carcinogenesis |
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110 Genome Instability, DNA Repair, and Cancer |
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1227 | (12) |
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111 Chemical Carcinogenesis |
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1239 | (12) |
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112 Ultraviolet Radiation Carcinogenesis |
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1251 | (10) |
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Section 21 Epidermal and Appendageal Tumors |
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113 Epithelial Precancerous Lesions |
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1261 | (22) |
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114 Squamous Cell Carcinoma |
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1283 | (11) |
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1294 | (10) |
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116 Basal Cell Nevus Syndrome |
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1304 | (8) |
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1312 | (7) |
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118 Benign Epithelial Tumors, Hamartomas, and Hyperplasias |
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1319 | (18) |
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119 Appendage Tumors and Hamartomas of the Skin |
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1337 | (25) |
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120 Merkel Cell Carcinoma |
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1362 | (9) |
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121 Mammary and Extramammary Paget's Disease |
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1371 | (6) |
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Section 22 Melanocytic Tumors |
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122 Benign Neoplasias and Hyperplasias of Melanocytes |
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1377 | (33) |
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123 Atypical (Dysplastic) Melanocytic Nevi |
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1410 | (6) |
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1416 | (29) |
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Section 23 Tumors and Hyperplasias of the Dermis and Subcutaneous Fat |
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125 Malignant Fibrous, Fibrohistiocytic, and Histiocytic Tumors of the Dermis |
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1445 | (11) |
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Bernadette Liegl-Atzwanger |
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1456 | (14) |
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127 Neoplasias and Hyperplasias of Muscular and Neural Origin |
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1470 | (11) |
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128 Kaposi's Sarcoma and Angiosarcoma |
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1481 | (8) |
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129 Neoplasms of Subcutaneous Fat |
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1489 | (10) |
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PART 8 THE SKIN IN SYSTEMIC DISEASE |
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Section 24 Skin in Nutritional, Metabolic, and Heritable Disease |
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130 Cutaneous Changes in Nutritional Disease |
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1499 | (26) |
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131 Cutaneous Changes in Errors of Amino Acid Metabolism |
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1525 | (13) |
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1538 | (36) |
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133 Amyloidosis of the Skin |
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1574 | (10) |
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134 Systemic Autoinflammatory Diseases |
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1584 | (16) |
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135 Xanthomatoses and Lipoprotein Disorders |
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1600 | (13) |
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1613 | (11) |
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137 Lipoid Proteinosis and Heritable Disorders of Connective Tissue |
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1624 | (25) |
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138 Cutaneous Mineralization and Ossification |
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1649 | (5) |
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139 Hereditary Disorders of Genome Instability and DNA Repair |
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1654 | (17) |
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140 Tuberous Sclerosis Complex |
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1671 | (9) |
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141 The Neurofibromatoses |
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1680 | (11) |
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142 Ectodermal Dysplasias |
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1691 | (12) |
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143 Genetic Immunodeficiency Diseases |
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1703 | (23) |
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Section 25 Skin Manifestations of Bone Marrow or Blood Chemistry Disorders |
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1726 | (19) |
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1745 | (22) |
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146 Inflammatory Diseases That Simulate Lymphomas: Cutaneous Pseudolymphomas |
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1767 | (15) |
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147 Cutaneous Langerhans Cell Histiocytosis |
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1782 | (13) |
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148 Non-Langerhans Cell Histiocytosis |
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1795 | (14) |
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1809 | (10) |
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Section 26 Skin Manifestations of Internal Organ Disorders |
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150 The Skin and Disorders of the Alimentary Tract, the Hepatobiliary System, the Kidney, and the Cardiopulmonary System |
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1819 | (21) |
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151 Diabetes Mellitus and Other Endocrine Diseases |
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1840 | (29) |
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1869 | (11) |
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153 Cutaneous Manifestations of Internal Malignant Disease: Cutaneous Paraneoplastic Syndromes |
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1880 | (21) |
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Section 27 The Skin in Vascular and Connective Tissue and Other Autoimmune Disorders |
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154 Mechanisms of Autoimmune Disease |
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1901 | (8) |
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1909 | (17) |
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1926 | (16) |
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1942 | (15) |
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158 Scleredema and Scleromyxedema |
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1957 | (5) |
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159 Relapsing Polychondritis |
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1962 | (3) |
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160 Rheumatoid Arthritis, Rheumatic Fever, and Gout |
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1965 | (11) |
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1976 | (10) |
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Section 28 The Skin in Inflammatory and Other Vascular Disorders |
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162 Endothelium in Inflammation and Angiogenesis |
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1986 | (17) |
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163 Cutaneous Necrotizing Venulitis |
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2003 | (10) |
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164 Systemic Necrotizing Arteritis |
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2013 | (16) |
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165 Erythema Elevatum Diutinum |
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2029 | (4) |
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166 Adamantiades--Behcet Disease |
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2033 | (9) |
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2042 | (7) |
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168 Pigmented Purpuric Dermatoses |
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2049 | (6) |
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169 Cryoglobulinemia and Cryofibrinogenemia |
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2055 | (10) |
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2065 | (7) |
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171 Malignant Atrophic Papulosis (Degos Disease) |
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2072 | (4) |
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172 Vascular Malformations |
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2076 | (18) |
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173 Cutaneous Changes in Peripheral Arterial Vascular Disease |
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2094 | (16) |
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174 Cutaneous Changes in Peripheral Venous and Lymphatic Insufficiency |
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2110 | (11) |
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PART 9 DISEASE DUE TO MICROBIAL AGENTS, INFESTATIONS, BITES, AND STINGS |
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Section 29 Bacterial Disease |
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175 General Considerations of Bacterial Diseases |
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2121 | (7) |
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176 Superficial Cutaneous Infections and Pyodermas |
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2128 | (20) |
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177 Gram-Positive Infections Associated with Toxin Production |
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2148 | (12) |
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178 Non-Necrotizing Infections of the Dermis and Subcutaneous Fat: Cellulitis and Erysipelas |
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2160 | (9) |
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179 Necrotizing Soft Tissue Infections: Necrotizing Fasciitis, Gangrenous Cellulitis, and Myonecrosis |
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2169 | (9) |
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180 Gram-Negative Coccal and Bacillary Infections |
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2178 | (16) |
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181 The Skin in Infective Endocarditis, Sepsis, Septic Shock, and Disseminated Intravascular Coagulation |
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2194 | (7) |
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2201 | (9) |
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183 Miscellaneous Bacterial Infections with Cutaneous Manifestations |
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2210 | (15) |
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184 Tuberculosis and Infections with Atypical Mycobacteria |
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2225 | (16) |
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185 Actinomycosis, Nocardiosis, and Actinomycetoma |
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2241 | (12) |
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2253 | (10) |
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2263 | (14) |
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Section 30 Fungal Diseases |
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188 Superficial Fungal Infection |
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2277 | (21) |
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189 Yeast Infections: Candidiasis, Tinea (Pityriasis) Versicolor, and Malassezia (Pityrosporum) Folliculitis |
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2298 | (14) |
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190 Deep Fungal Infections |
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2312 | (17) |
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Section 31 Viral and Rickettsial Diseases |
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191 General Considerations of Viral Diseases |
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2329 | (8) |
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192 Exanthematous Viral Diseases |
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2337 | (30) |
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2367 | (16) |
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194 Varicella and Herpes Zoster |
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2383 | (19) |
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2402 | (19) |
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Sheila Fallon Friedlander |
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196 Human Papilloma Virus Infections |
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2421 | (13) |
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197 Human T-Lymphotropic Viruses |
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2434 | (5) |
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198 Cutaneous Manifestations of Human Immunodeficiency Virus Disease |
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2439 | (17) |
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199 The Rickettsioses, Ehrlichioses, and Anaplasmoses |
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2456 | (15) |
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Section 32 Sexually Transmitted Diseases |
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2471 | (22) |
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201 Endemic (Nonvenereal) Treponematoses |
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2493 | (8) |
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2501 | (4) |
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203 Lymphogranuloma Venereum |
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2505 | (5) |
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2510 | (4) |
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205 Gonorrhea, Mycoplasma, and Vaginosis |
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2514 | (13) |
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Section 33 Infestations, Bites, and Stings |
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206 Leishmaniasis and Other Protozoan Infections |
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2527 | (17) |
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207 Helminthic Infections |
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2544 | (25) |
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208 Scabies, Other Mites, and Pediculosis |
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2569 | (9) |
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209 Bites and Stings of Terrestrial and Aquatic Life |
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2578 | (21) |
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210 Arthropod Bites and Stings |
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2599 | (12) |
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PART 10 OCCUPATIONAL SKIN DISEASES AND SKIN DISEASES DUE TO BIOLOGIC WARFARE |
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Section 34 Occupational Skin Diseases |
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211 Occupational Skin Diseases Due to Irritants and Allergens |
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2611 | (11) |
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212 Occupational Noneczematous Skin Diseases Due to Biologic, Physical, and Chemical Agents: Introduction |
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2622 | (11) |
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Section 35 The Skin in Bioterrorism and Biologic Warfare |
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213 Cutaneous Manifestations of Biologic, Chemical, and Radiologic Attacks |
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2633 | (10) |
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Section 36 Topical Therapy |
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214 Principles of Topical Therapy |
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2643 | (9) |
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215 Pharmacokinetics and Topical Applications of Drugs |
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2652 | (7) |
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216 Topical Corticosteroids |
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2659 | (6) |
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2665 | (8) |
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2673 | (4) |
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219 Topical Antifungal Agents |
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2677 | (8) |
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220 Topical and Intralesional Cytotoxic Agents |
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2685 | (5) |
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221 Topical Immunomodulators |
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2690 | (7) |
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222 Other Topical Medications |
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2697 | (10) |
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2707 | (7) |
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Section 37 Systemic Therapy |
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224 Systemic Glucocorticoids |
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2714 | (7) |
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2721 | (5) |
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2726 | (9) |
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227 Cytotoxic and Antimetabolic Agents |
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2735 | (24) |
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2759 | (8) |
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2767 | (9) |
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2776 | (11) |
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2787 | (9) |
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232 Oral Antifungal Agents |
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2796 | (11) |
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233 Immunosuppressive and Immunomodulatory Drugs |
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2807 | (7) |
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234 Immunobiologicals, Cytokines, and Growth Factors in Dermatology |
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2814 | (13) |
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235 Antiangiogenic Agents |
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2827 | (7) |
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2834 | (7) |
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Section 38 Physical Treatments |
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2841 | (10) |
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238 Photochemotherapy and Photodynamic Therapy |
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2851 | (18) |
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239 Lasers and Flashlamps in Dermatology |
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2869 | (21) |
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2890 | (9) |
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Section 39 Complementary and Alternative Dermatology |
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241 Complementary and Alternative Medicine in Dermatology |
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2899 | (6) |
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Section 40 Surgery in Dermatology |
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242 Anatomy and Approach in Dermatologic Surgery |
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2905 | (16) |
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243 Excisional Surgery and Repair, Flaps, and Grafts |
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2921 | (29) |
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244 Mohs Micrographic Surgery |
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2950 | (6) |
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2956 | (12) |
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246 Cryosurgery and Electrosurgery |
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2968 | (9) |
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247 Surgical Complications |
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2977 | (7) |
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248 Mechanisms of Wound Repair, Wound Healing, and Wound Dressing |
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2984 | (13) |
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249 Treatment for Varicose and Telangiectatic Leg Veins |
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2997 | (12) |
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Section 41 Cosmetic Dermatology |
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250 Cosmetics and Skin Care in Dermatology |
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3009 | (12) |
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251 Ablative Lasers, Chemical Peels, and Dermabrasion |
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3021 | (11) |
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252 Cosmetic Applications of Nonablative Lasers and Other Light Devices |
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3032 | (9) |
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3041 | (3) |
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254 Soft Tissue Augmentation |
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3044 | (9) |
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3053 | (8) |
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256 Hair Transplantation and Alopecia Reduction |
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3061 | |
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| Index |
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1 | |
