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El. knyga: Functionalised Cardiovascular Stents

Edited by (Wroclaw Medical University, Wrocla), Edited by (Department of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology, Wroclaw, Poland), Edited by (National University of Ireland, Galway, Ireland)
  • Formatas: EPUB+DRM
  • Išleidimo metai: 06-Feb-2018
  • Leidėjas: Woodhead Publishing Ltd
  • Kalba: eng
  • ISBN-13: 9780081004982
  • Formatas: EPUB+DRM
  • Išleidimo metai: 06-Feb-2018
  • Leidėjas: Woodhead Publishing Ltd
  • Kalba: eng
  • ISBN-13: 9780081004982

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Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis.

This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo.

  • Provides a specific focus on cardiovascular stents
  • Includes a range of topics covering the fundamentals, surface modification and biofunctionalization
  • Provides essential knowledge for researchers on advances in the field

Daugiau informacijos

Explores the technologies that functionalize cardiovascular stents
List of contributors
ix
Preface xiii
Acknowledgments xv
Part One Fundamentals of cardiovascular stents
1(134)
1 Overview of cardiovascular stent designs
3(24)
C. McCormick
1.1 Introduction
3(1)
1.2 Percutaneous coronary interventions
4(1)
1.3 Bare metal stents
4(4)
1.4 Drug-eluting stents
8(9)
1.5 Bioresorbable stents
17(1)
1.6 Summary of current state of the art and future perspective
18(9)
References
19(7)
Further reading
26(1)
2 Fundamentals of bare-metal stents
27(18)
A.R. Saraf
S.P. Yadav
2.1 Clinical study of bare-metal stents
27(1)
2.2 Complimentary manufacturing of bare-metal stents
28(2)
2.3 Validation of mechanical properties of metals for bare-metal stent
30(1)
2.4 Material selection
31(7)
2.5 Finite element analysis of stents
38(4)
2.6 Conclusions
42(3)
References
43(2)
3 Development of drug-eluting stents (DES)
45(12)
M. Wawrzynska
J. Arkowski
A. Wlodarczak
M. Kopaczynska
D. Bialy
3.1 First coronary intervention and development of stents
45(1)
3.2 Pathophysiology of restenosis
46(1)
3.3 Methods of testing stent performance and their limitations
46(1)
3.4 First-generation drug-eluting stents
47(1)
3.5 Second-generation DES
48(2)
3.6 Next-generation DES
50(4)
3.7 Conclusion
54(3)
References
54(3)
4 Polymer-free drug-eluting stents
57(18)
C. McCormick
4.1 Introduction
57(1)
4.2 Moving beyond polymer controlled stent drug release
57(1)
4.3 Direct coating of drug
58(2)
4.4 Stent platform modifications
60(6)
4.5 Role of stent surface in vessel healing
66(1)
4.6 Summary and future perspectives
67(8)
References
68(6)
Online sources
74(1)
5 Fundamentals of bioresorbable stents
75(24)
H.Y. Ang
J. Ng
H. Bulluck
P. Wong
S. Venkatraman
Y. Huang
N. Foin
5.1 Introduction
75(4)
5.2 Current bioresorbable stents technology
79(13)
5.3 Future perspectives
92(7)
References
93(4)
Further reading
97(2)
6 Bioabsorbable metallic stents
99(36)
Y.F. Zheng
6.1 Introduction
99(1)
6.2 General design criterions of bioabsorbable metallic stents
100(2)
6.3 Development of Mg-based bioabsorbable metallic stents
102(11)
6.4 Development of Fe-based bioabsorbable metallic stents
113(9)
6.5 Development of Zn-based bioabsorbable metallic stents
122(6)
6.6 Challenges and opportunities for bioabsorbable metallic stents
128(7)
References
129(6)
Part Two Coatings and surface modification of cardiovascular stents
135(94)
7 Physico-chemical stent surface modifications
137(12)
A. Foerster
M. Duda
H. Kraskiewicz
M. Wawrzynska
H. Podbielska
M. Kopaczynska
7.1 Introduction
137(1)
7.2 Stent surface functionalization
138(3)
7.3 Thiol groups functionalized surface
141(3)
7.4 Conclusion
144(5)
References
144(5)
8 Chemical vapor deposition of cardiac stents
149(6)
P. Sojitra
8.1 Introduction
149(1)
8.2 Chemical vapor deposition
150(1)
8.3 CVD passivation process evaluation
151(1)
8.4 Discussion
152(1)
8.5 Conclusion
152(3)
References
152(2)
Further reading
154(1)
9 Polymer coatings for biocompatibility and reduced nonspecific adsorption
155(44)
M.C. Ramkumar
P. Cools
A. Arunkumar
N. De Geyter
R. Morent
V. Kumar
S. Udaykumar
P. Gopinath
S.K. Jaganathan
K.N. Pandiyaraj
9.1 Introduction
156(2)
9.2 Classification of plasma
158(9)
9.3 Added value of nonthermal plasma for stent applications: Polymer coatings
167(20)
9.4 Conclusion
187(12)
Acknowledgments
188(1)
References
188(11)
10 Coating stability for stents
199(12)
V. Montano-Machado
E.C. Michel
D. Mantovani
10.1 Static tests
199(3)
10.2 Dynamic tests
202(2)
10.3 Adhesion
204(1)
10.4 DES and biodegradable polymers
205(1)
10.5 Stability tests involving endothelial cells
206(1)
10.6 Conclusions and perspectives
207(4)
References
207(4)
11 Simple one-step covalent immobilization of bioactive agents without use of chemicals on plasma-activated low thrombogenic stent coatings
211(18)
M. Santos
A. Waterhouse
B.S.L. Lee
A.H.P. Chan
R.P. Tan
P.L. Michael
E.C. Filipe
J. Hung
S.G. Wise
M.M.M. Bilek
11.1 Functionalization of stents to improve their clinical performance
211(2)
11.2 Bioengineering of plasma-activated coatings for stents
213(7)
11.3 Biological properties of PAC coated stents
220(9)
References
226(3)
Part Three Biofunctionalisation of cardiovascular stent surfaces
229(104)
12 Chemistry of targeted immobilization of biomediators
231(20)
A. Srivastava
12.1 Introduction
231(3)
12.2 Targeted immobilization chemistries
234(8)
12.3 Future trends
242(9)
References
242(9)
13 Functionalized cardiovascular stents: Cardiovascular stents incorporated with stem cells
251(40)
B. Oh
C.H. Lee
13.1 Introduction
251(1)
13.2 Adventitial biology for coronary artery disease (CAD)
252(1)
13.3 Role of stem/progenitor cells in atherosclerosis
253(5)
13.4 Current treatment strategies against atherosclerosis
258(4)
13.5 Preparation and surface modification of nanofiber
262(7)
13.6 Functionalized cardiovascular stents for treatment of atherosclerosis
269(6)
13.7 Conclusion
275(16)
References
276(15)
14 Nitric oxide donor delivery
291(14)
S.A. Omar
A. de Belder
14.1 Introduction
291(1)
14.2 Nitric oxide
292(1)
14.3 Nitric oxide and vascular function
293(1)
14.4 Localized NO delivery
294(1)
14.5 Nitric oxide donor stents (the evidence)
295(1)
14.6 The future
296(1)
14.7 Conclusion
297(8)
References
297(8)
15 Immobilization of peptides on cardiovascular stent
305(14)
F. Boccafoschi
L. Fusaro
M. Cannas
15.1 Introduction: Cardiovascular materials and biocompatibility
305(2)
15.2 Metals and alloys for endovascular stent
307(1)
15.3 Immobilization of peptides: The grafting technique
308(3)
15.4 Guiding the tissue regeneration: Surface modification of cardiovascular stents
311(2)
15.5 Future trends/conclusion
313(6)
References
313(5)
Further reading
318(1)
16 Immobilization of antibodies on cardiovascular stents
319(14)
L.B. O'Connor
J.G. Wall
16.1 Introduction
319(1)
16.2 The use of antibodies in stent functionalization
320(5)
16.3 Protein-stent linking approaches
325(3)
16.4 Applications of stent-immobilized antibodies
328(4)
16.5 Future perspectives
332(1)
Acknowledgments 333(1)
References 333(10)
Index 343
Dr. Gerard Wall obtained his primary degree in Microbiology from the National University of Ireland, Galway, followed by a PhD in Molecular Immunology from the University of Aberdeen, Scotland. After a period spent engineering antibodies at the University of Zurich in Switzerland, he established his own research group in protein engineering at the University of Limerick, Ireland. He returned to NUI Galway in 2008 and is based in Microbiology and the Centre for Research in Medical Devices (CŚRAM). He has published widely on recombinant protein expression and engineering and has particular interests in the fields of antibody engineering, drug delivery, and materials functionalization. Prof. Dr. Eng. MD Halina Podbielska received her M.Sc. and Engineering Degree in Applied Physics/Optics from the Faculty of Fundamental Problems of Technology of Wroclaw University of Science and Technology (WrUST), and her Ph.D. degree in Physics from the Institute of Physics at WrUST. She also received her M.D. degree from the Faculty of Medicine of Medical University of Wrocaw. In 2002 she received the scientific title Professor of Technical Science in Biomedical Engineering. She was a visiting scientist in several scientific institutions worldwide: as an A. v. Humboldt fellow at the University of Frankfurt/Main, University of Muenster (Germany) and at the Weizmann Institute of Science, Israel. In years 2002-2005 she was a visiting professor at the Institute of Optics of Technical University in Berlin. She was also visiting scientist at the Charite Medizin University of Berlin (2005) working at the Medical Laser Technology Center LMTB, Germany. She a member of the Academic Advisory Board and Representative of Biomedical Engineering of EPMA (European Association for Predictive, Preventive and Personalized Medicine and an associate editor of EPMA Journal. Her professional experiences include biomedical engineering with emphasis on medical application of optics, nanomaterials and physical medicine. Dr. Magdalena Wawrzyn ska is an interventional cardiologist and internal medicine specialist, a member of European Society of Cardiology and the European Association of Percutaneous Interventions. She obtained her M.D. degree, followed by PhD in Internal Diseases at Wrocaw Medical University, Poland, and is currently an academic teacher at Wrocaw Medical University and practitioning clinitian Her research focus is experimental cardiology and diagnosis and advanced treatment of coronary artery diseases. She has been awarded a silver medal at the International Exhibition of Innovation, Entrepreneurship and New Technologies, Eureka Brussels in 2006 and bronze medal at the Concours Lepine International Paris in 2016. Dr Wawrzyn ska is the owner of several patent applications in the field of innovative solutions for cardiology.