Fundamentals of Brain Organoids for Neurological Diseases provides a practical resource for researchers on how to utilize and apply brain organoids. This book is organized into nine distinct sections, guiding the reader through each step from advanced overview of what organoids are to the use of brain organoids in various neurodevelopmental disorders and neurodegenerative diseases. In later sections, this book reviews the necessary methods involved in organoid development including the elements and challenges involved. This book will serve as a valuable tool for researchers, helping to advance the understanding of brain biology and disease mechanisms.
Researchers use brain organoids to study the formation of neural tissues, investigate the processes involved in brain development, and gain a better understanding of neurological disorders and diseases. Brain organoids are particularly useful in studying developmental disorders, neurodegenerative diseases, and infectious diseases that affect the brain.
Section I An overview about Organoids
1. What are organoids?
2. Past, Present and Future scenario of organoids
Section II Neurological diseases
3. A brief introduction about Neurodevelopmental disorders
4. An overview of Neurodegenerative diseases
Section III Brain organoids for Neurodevelopmental disorders
5. Use of brain organoids for Autism
6. Role of brain organoids in Rett Syndrome
7. Role of brain organoids in Bipolar disorder
Section IV Brain organoids for Neurodegenerative diseases
8. Use of brain organoids for Parkinsons disease (PD)
9. Role of brain organoids in Alzheimers disease (AD)
10. Application of brain organoids in Huntingtons disease (HD)
Section V Methods involved in organoids development
11. How HiPSCs are derived into organoids
12. Elements required for organoid generation
13. Days involved in organoid generation
14. Challenges while constructing organoids
Section VI Ongoing Clinical trials
15. Ongoing clinical trials on use of Brain organoids for neurodevelopmental
disorders
16. Ongoing clinical trials on use of Brain organoids for neurodegenerative
diseases
Section VII Application and advancement of Brain organoids
17. Brain organoids A promising disease model
18. Existing drug targeting using Brain organoids
19. New drug research by brain organoids
Section VII - Ethical consideration while conducting organoids research
Section IX - Future Direction and Conclusion
Dr Mahalaxmi Balachandar has experience in handling neurological disorder patients and has conducted genetic and epigenetic studies. She has experience in handling bone marrow-derived mesenchymal stem cells (BM-MSCs) as a promising therapeutic agent for LHON disease. Further, Dr Mahalaxmi Balachandar has generated Brain organoids from various neurodevelopmental diseases. Her role in terms of research is to continually engage in research and update my knowledge to inspire the students to do their own original research. She has published almost 50 review and research articles in several internationally reputed SCI journals. Her articles in reputable international journals demonstrate how performing cutting-edge research is made possible by updating current research technologies.
Dr. Balachandar Vellingiri mainly works on neurological diseases and analyzing its genetic impact. He is working on various neurological diseases to investigate the molecular mechanism and developing human induced pluripotent stem cells (HiPSCs), and generating patient-derived Brain organoids as a promising disease model for various neurological diseases because understanding the inside mechanism of neurological diseases is always a difficult task. Exploring the cutting-edge molecular, cellular, and translational neuroscience approaches, he aims to unravel disease mechanisms, identify therapeutic targets, and develop innovative interventions to slow or reverse neurological diseases. He is well-expertise in techniques such as molecular cytogenetics, pathway analysis, and techniques in developing HiPSCs and Brain organoids, especially for neurological diseases. He has published over 100 research and review articles in various Internationally reputed SCI journals, 12 Book chapters and one book on Autism Spectrum Disorder.
