Nearly 90 percent of the 117 international specialists contributing to this new edition are new to the text, which has expanded from the original 46 chapters to 55. The 1992 text has been almost completely rewritten, reflecting advances in diseases whose genetic knowledge was rudimentary ten years ago. New chapters on specific diseases cover gallstones, hemochromatosis, osteoporosis, spondyloarthrophies, lupus erythematosis, mental retardation, common skin diseases and skin cancer, prostate cancer, hearing loss, and migraine. New general chapters cover genetic counseling, evolution and disease, genetic effects of therapy, pharmacogentics, and the role of mitochondrial variation. Annotation (c) Book News, Inc., Portland, OR (booknews.com)
Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult diseases, and we now have a better understanding of the molecular processes involved in genetic susceptibility and diseases mechanisms. The second edition fully incorporates these advances. The entire book has been updated and twelve new chapters have been added. Most of these chapters deal with diseases such as gallstones, osteoporosis, osteoarthritis, skin cancer, other common skin diseases, prostate cancer and migraine headaches that are seen by all physicians. Others address the genetic and molecular basis of spondylarthropathies, lupus, hemochromatosis, IgA deficiency, mental retardation, hearing loss, and the role of mitochondrial variation in adult diseases. Chapters on the evolution of human genetic disease and on animal models add important background on the omplexities of these diseases. Unique clinical applications of genetics to common diseases are covered in the additional new chapters on genetic counseling, pharmacogenetics, and the genetic consequences of modern therapeutics.