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El. knyga: Green Chemistry in Drug Discovery: From Academia to Industry

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This detailed book highlights several emerging areas in the implementation of green chemistry in medicinal chemistry drug discovery with a specific focus on their application to the expeditious discovery of new biologically active entities. Divided into three sections, the collection explores greener approaches to chemical transformations that are both prevalent and have been highlighted as challenging within the pharmaceutical industry, overall synthetic strategy, as well as the implementation and impact of a range of enabling technologies within medicinal chemistry. As a volume of the Methods in Pharmacology and Toxicology series, chapters provide the kind of key insight that can guide researchers toward greater success in the lab. 

Authoritative and practical, Green Chemistry in Drug Discovery: From Academia to Industry provides both a fundamental insight into the progress that has been made as well as some of the challenges that still exist for these techniques to be effectively implemented in the drug discovery process in a routine manner.
Preface v
Contributors xv
Part I Greener Approaches to Classical Transformations
1 Green Synthesis of Common Heterocycles
3(32)
Christian Schafer
Hyejin Cho
Bela Torok
2 Greener Methods for Amide Bond Synthesis
35(62)
Nathan J. Oldenhuis
Aaron M. Whittaker
Vy M. Dong
3 Mitsunobu Reactions in Medicinal Chemistry and Development of Practical Modifications
97(26)
Tsuyoshi Taniguchi
4 Direct Nucleophilic Substitution of Alcohols by Brønsted or Lewis Acids Activation: An Update
123(32)
Pier Giorgio Cozzi
Andrea Gualandi
Luca Mengozzi
Elisabetta Manoni
Claire Margaret Wilson
5 Friedel-Crafts Reactions
155(24)
Grigoriy Sereda
6 Ionic Liquids: Design and Applications
179(34)
Arturo Obregbn-Zuniga
Eusebio Juaristi
Part II Synthetic Strategy
7 Designing Efficient Cascade Reactions in Drug Discovery
213(24)
Chenguang Yu
He Huang
Chunquan Sheng
Wei Wang
8 Multicomponent Synthesis: Cohesive Integration of Green Chemistry Principles
237(32)
Razvan Cioc
Eelco Ruijter
Romano V. A. Orru
9 Direct C--H Functionalization Approaches to Pharmaceutically Relevant Molecules
269(28)
James J. Mousseau
Antonia F. Stepan
10 C--H Activation with Photoredox Catalysis
297(30)
Joel W. Beatty
Corey R. J. Stephenson
11 In Situ Protecting Groups for Chemoselective Transformations
327(48)
Alan Steven
Part III Enabling Technologies
12 Expanding the Biocatalysis Toolbox
375(28)
Rajesh Kumar
Carlos A. Martinez
John W. Wong
13 New Directions in Coupling Chemistry
403(86)
Gary M. Gallego
Rebecca A. Gallego
Raul F. Richardson
14 Flow Chemistry as an Enabling Technology for Synthetic Organic Chemistry
489(38)
Nicholas E. Leadbeater
15 Reaction Optimization: A High-Throughput Experimentation Approach
527(26)
Simon Berritt
Jason R. Schmink
Ana Ines Bellomo Peraza
16 Radiopharmaceutical Discovery with 11CO2-Fixation Methods Inspired by Green Chemistry
553(30)
Benjamin H. Rotstein
Neil Vasdev
Further Reading 583(20)
Index 603