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Greenberger's CURRENT Diagnosis & Treatment Gastroenterology, Hepatology, & Endoscopy, Fourth Edition 4th edition [Minkštas viršelis]

  • Formatas: Paperback / softback, 704 pages, aukštis x plotis x storis: 231x185x33 mm, weight: 1077 g, 250 Illustrations
  • Išleidimo metai: 06-Jul-2022
  • Leidėjas: McGraw-Hill Education
  • ISBN-10: 1260473430
  • ISBN-13: 9781260473438
Kitos knygos pagal šią temą:
  • Formatas: Paperback / softback, 704 pages, aukštis x plotis x storis: 231x185x33 mm, weight: 1077 g, 250 Illustrations
  • Išleidimo metai: 06-Jul-2022
  • Leidėjas: McGraw-Hill Education
  • ISBN-10: 1260473430
  • ISBN-13: 9781260473438
Kitos knygos pagal šią temą:

The peerless guide to clinical management of digestive and liver diseases—updated to reflect the latest research and treatments

  • Authoritative coverage of the entire spectrum of gastroenterology and hepatology conditions, including therapeutic advances in Barrett’s esophagus, eosinophilic esophagitis, acute diarrheal disorders, peptic ulcer disease, hereditary gastrointestinal cancer syndromes, upper and lower gastrointestinal bleeding
  • Written by expert faculty physicians at Harvard Medical School and Brigham and Women's Hospital
  • Presented in a streamlined style that makes learning and retaining key information effortless
  • More than 90 full-color endoscopic and radiographic images enhance clinical decision-making and clarify imaging techniques
  • Logical organization begins with a section on general concerns such as acute abdominal pain, then progresses to specific disease categories
  • “Essentials of Diagnosis” bulleted lists deliver instant guidance on identifying both common and rare digestive disorders
  • Updated references to recently-published clinically relevant articles
  • Key information from related fields, including gastrointestinal surgery, and subspecialties such as liver transplantation, advanced endoscopy, bariatric surgery, inflammatory bowel disease, mast cell disease, toxicities of oncologic therapy, intestinal malabsorption, nutrition, and state of the art imaging
  • High-yield overview of effective treatment approaches for both acute and chronic viral hepatitis provides key perspectives on improving patient outcomes

Authors ix
Preface xv
Section I General Concerns
1 Acute Abdominal Pain: Basic Principles & Current Challenges
1(12)
Molly L. Perencevich
Frederick L. Makrauer
Evaluation of the Acute Abdomen
4(4)
Acute Appendicitis
8(3)
Unique Presentations of Appendicitis
11(2)
2 Inflammatory Bowel Disease: Immunologic Considerations & Therapeutic Implications
13(16)
Vanessa Mitsialis
Scott B. Snapper
Richard S. Blumberg
General Principles of Gut-Associated Lymphoid Tissues and the Mucosal Immune Response
14(3)
Pathogenesis of Inflammatory Bowel Disease
17(3)
Mucosal Inflammatory Signatures of IBD
20(3)
Cytokines in IBD and Therapeutic Implications
23(3)
Additional Therapeutic Targets in IBD
26(3)
3 Inflammatory Bowel Disease: Medical Considerations
29(11)
Rachel W. Winter
Sonia Friedman
General Considerations
29(1)
Epidemiology
29(1)
Etiology
29(1)
Clinical Findings
30(1)
Radiographic Findings
31(1)
Endoscopic Examination
32(1)
Extraintestinal Manifestations
32(1)
Complications
33(1)
Differential Diagnosis of IBD
34(1)
Medical Therapy of Crohn's Disease and Ulcerative Colitis
35(2)
Treatment of Acute Inflammation
37(1)
Cyclosporine and Tacrolimus
37(1)
Surgical Management of IBD
38(2)
4 Inflammatory Bowel Disease: Surgical Considerations
40(12)
Jennifer L. Irani
Ronald Bleday
Ulcerative Colitis
40(5)
Crohn's Disease
45(7)
5 Acute Diarrheal Disorders
52(23)
Rahul S. Dalai
Jerry S. Trier
Jessica R. Allegretti
Acute Diarrhea
52(5)
Acute Diarrheal Disease Caused by Specific Infections
57(18)
6 Mesenteric Vascular Disease
75(11)
Navin L. Kumar
Kunal Jajoo
Mesenteric Ischemia
75(1)
Acute Mesenteric Ischemia
76(4)
Chronic Mesenteric Ischemia
80(2)
Acute Colonic Ischemia
82(4)
7 Gastrointestinal & Biliary Complications of Pregnancy
86(34)
Punyanganie S. de Silva
Gastroesophageal Reflux Disease
86(3)
Nausea & Vomiting
89(3)
Hyperemesis Gravidarum
92(1)
Constipation
93(1)
Diarrhea
94(2)
Hemorrhoids
96(1)
Irritable Bowel Syndrome
97(1)
Fecal Incontinence
98(1)
Inflammatory Bowel Disease
99(8)
Abdominal Pain
107(2)
Peptic Ulcer Disease
109(1)
Biliary Disease
110(1)
Pancreatitis
110(1)
Appendicitis
111(1)
Intestinal Obstruction, Pseudo-Obstruction, & Gastrointestinal Cancer
112(1)
Endoscopy In Pregnancy
113(7)
8 Liver Disease in Pregnancy
120(8)
Rachel Placzek
Anna Rutherford
Interpretation of Liver Biochemical Tests During Pregnancy
120(1)
Hepatic Conditions Unique to Pregnancy
121(3)
Conditions Not Unique to Pregnancy
124(4)
9 State-of-the-Art Imaging of the Gastrointestinal System
128(37)
Francesco Alessandrino
Alan J. Cubre
Gastrointestinal Tract Imaging
129(17)
Liver Imaging
146(7)
Biliary Imaging
153(5)
Pancreatic Imaging
158(5)
Summary of Current Recommendations
163(2)
10 Acute and Chronic Gastrointestinal Toxicities of Oncologic Therapy
165(10)
Lawrence Kogan
Shilpa Graver
Acute Complications
165(9)
Chronic Gastrointestinal Complications
174(1)
11 Mast Cell Disorders
175(7)
Matthew J. Hamilton
Mariana Castells
General Considerations
175(1)
Classifications of Mast Cell Disorders
176(1)
Pathogenesis of Mast Cell Disorders
177(1)
Clinical Findings
178(1)
Differential Diagnosis
179(1)
Treatment
180(1)
Clinical Course & Prognosis
181(1)
Unresolved Issues
181(1)
Section II Esophageal Diseases
182(45)
12 Gastroesophageal Reflux Disease
182(11)
Walter W. Chan
General Considerations
182(1)
Clinical Findings
183(4)
Complications
187(1)
Treatment
188(3)
Course & Prognosis
191(2)
13 Barrett Esophagus
193(7)
Kunal Jajoo
General Considerations
193(1)
Clinical Findings
194(2)
Treatment
196(3)
Course & Prognosis
199(1)
14 Oropharyngeal & Esophageal Motility Disorders
200(22)
Hiroshi Mashimo
Oropharyngeal Dysphagia
200(3)
Impaired Ues Relaxation, Cricopharyngeal Spasms, & Cricopharyngeal Bar
203(2)
Zenker Diverticulum
205(1)
Globus Pharyngeus
205(1)
Esophageal Motility Disorders
206(1)
Esophageal Motor Dysphagia
207(2)
Gastroesophageal Reflux Disease
209(2)
Esophageal Chest Pain
211(3)
Disorders of Inhibitory Innervation
214(5)
Disorders of Excitatory Nerves and Smooth Muscles
219(3)
15 Eosinophilic Esophagitis
222(5)
Wai-Kit Lo
Matthew J. Hamilton
General Considerations
222(1)
Epidemiology
222(1)
Pathogenesis
222(1)
Clinical Findings
223(1)
Differential Diagnosis
224(1)
Treatment
224(1)
Course & Prognosis
225(1)
Unresolved Issues
226(1)
Section III Diseases of the Stomach
16 Peptic Ulcer Disease
227(13)
Edward Lew
General Considerations
227(1)
Pathogenesis
228(2)
Clinical Findings
230(2)
Differential Diagnosis
232(1)
Complications
232(1)
Treatment
232(8)
17 Zollinger-Ellison Syndrome (Gastrinoma)
240(7)
Edward Lew
General Considerations
240(1)
Pathogenesis
240(1)
Classification
240(1)
Clinical Findings
241(4)
Treatment
245(1)
Prognosis
246(1)
18 Functional Dyspepsia
247(10)
Molly L. Perencevich
General Considerations
247(1)
Pathogenesis
248(2)
Clinical Findings
250(2)
Differential Diagnosis
252(1)
Treatment
253(3)
Course & Prognosis
256(1)
19 Disorders of Gastric & Small Bowel Motility
257(11)
Jennifer X. Cai
Walter W. Chan
Gastroparesis & Chronic Intestinal Pseudo-Obstruction
258(9)
Dumping Syndrome & Accelerated Gastric Emptying
267(1)
Rapid Transit Dysmotility of the Small Bowel
267(1)
20 Acute Upper Gastrointestinal Bleeding
268(21)
John R. Saltzman
Nonvariceal Bleeding
277(6)
Less Common Causes of Nonvariceal Bleeding
283(2)
Variceal Bleeding
285(4)
Section IV Small Bowel Diseases
21 Intestinal Malabsorption & Nutrition
289(24)
Walter M. Kim
Joshua R. Korzenik
Diseases Associated with Intraluminal Maldigestion
297(1)
Diseases Associated with Impaired Mucosal Digestion & Absorption
298(11)
Diseases Caused by Impairment of both Intraluminal Digestion & Mucosal Digestion/Absorption
309(2)
Diseases Caused by Impaired Postmucosal Transport
311(2)
Section V Colorectal Diseases
22 Chronic Constipation & Fecal Incontinence
313(13)
Nayna A. Lodhia
Walter W. Chan
Chronic Constipation
313(9)
Fecal Incontinence
322(4)
23 Diverticular Disease of the Colon
326(12)
Navin L. Kumar
Benjamin N. Smith
Diverticulosis
326(4)
Acute Diverticulitis
330(4)
Diverticular Hemorrhage
334(4)
24 Colorectal Cancer Screening
338(13)
Nicolette J. Rodriguez
Ramona Lim
Sapna Syngal
Risk Stratification
339(1)
Screening & Surveillance Recommendations
340(6)
Screening Modalities
346(3)
Additional Screening Modalities
349(1)
Summary of Recommendations
350(1)
25 Hereditary Gastrointestinal Cancer Syndromes
351(13)
Nicolette J. Rodriguez
Sapna Syngal
Elena M. Stoffel
Hereditary Colorectal Cancer Syndromes
351(7)
Hamartomatous Polyposis Syndromes
358(2)
Serrated Polyposis Syndrome
360(1)
Colorectal Polyposis Not Otherwise Specified
360(1)
Other Gastrointestinal Cancer Syndromes
361(3)
26 Irritable Bowel Syndrome
364(13)
Anne F. Liu
Sonia Friedman
General Considerations
364(1)
Pathogenesis
365(2)
Clinical Findings
367(2)
Differential Diagnosis
369(4)
Complications
373(1)
Treatment
373(4)
27 Acute Lower Gastrointestinal Bleeding
377(9)
John R. Saltzman
Evaluation of Lower GI Bleeding
377(5)
Specific Causes of Acute Lower GI Bleeding
382(4)
Section VI Pancreatic Diseases
28 Acute Pancreatitis
386(8)
David X. Jin
Darwin Conwell
Peter A. Banks
Genetal Considerations
386(1)
Pathogenesis
387(1)
Clinical Findings
387(4)
Differential Diagnosis
391(1)
Treatment
391(1)
Prognosis
392(2)
29 Chronic Pancreatitis
394(9)
Julia McNabb-Baltar
Peter A. Banks
General Considerations
394(1)
Pathogenesis
394(1)
Clinical Findings
395(4)
Differential Diagnosis
399(1)
Complications
399(1)
Treatment
400(2)
Course & Prognosis
402(1)
30 Autoimmune Pancreatitis
403(6)
Alice A. Lee
David X. Jin
General Considerations
403(1)
Type 1 Autoimmune Pancreatitis
403(1)
Epidemiology
403(1)
Clinical Findings
403(3)
Type 2 Autoimmune Pancreatitis
406(1)
Diagnosis & Differential Diagnoses
406(1)
Treatment
407(1)
Course & Prognosis
408(1)
31 Tumors of the Pancreas
409(12)
Julia McNabb-Baltar
Pancreatic Cancer
409(7)
Cystic Neoplasms of the Pancreas
416(4)
Pancreatic Lymphoma
420(1)
Section VII Therapeutic Endoscopy & Diagnostic Techniques
32 Polypectomy
421(5)
Sanchit Gupta
Kunal Jajoo
Equipment
421(1)
Polypectomy for Sessile Polyps
422(1)
Polypectomy for Pedunculated Polyps
423(1)
Endoscopic Mucosal Resection
423(1)
Endoscopic Submucosal Dissection
424(1)
Endoscopic Full-Thickness Resection
424(2)
33 Endoscopic Management of Acute Biliary & Pancreatic Conditions
426(10)
Russell D. Dolan
Andrew C. Storm
Christopher C. Thompson
Acute Cholangitis
426(2)
Gallstone Pancreatitis
428(2)
Bile Duct Injuries
430(2)
Pancreatic Duct Injuries
432(1)
Hemorrhagic Biliary & Pancreatic Conditions
433(3)
34 Endoscopic Retrograde Cholangiopancreatography (ERCP)
436(13)
Russell D. Dolan
David L. Carr-Locke
Christopher C. Thompson
Disorders of the Major Duodenal Papilla
436(2)
Biliary System
438(5)
Pancreas
443(6)
35 Video Capsule Endoscopy & Deep Small Bowel Enteroscopy
449(13)
Daniel J. Stein
Ramona M. Lim
Video Capsule Endoscopy
449(9)
Deep Small Bowel Enteroscopy
458(4)
36 Gastrointestinal Foreign Bodies
462(7)
Russell D. Dolan
Andrew C. Storm
Christopher C. Thompson
General Considerations
462(1)
Clinical Findings
462(2)
Treatment
464(5)
37 Endoscopic Ultrasound
469(17)
Russell D. Dolan
Linda Lee
Cancer Staging
471(4)
Nonmalignant Lesions
475(5)
Therapeutic Endoscopic Ultrasound
480(2)
Future Directions
482(4)
38 Endoscopic & Surgical Treatment of Obesity
486(18)
Pichamol Jirapinyo
Colston Edgerton
Malcolm K. Robinson
Treatment of Obesity
487(2)
Endoscopic Bariatric & Metabolic Therapies
489(1)
Metabolic Surgery
490(3)
Metabolic Surgical Procedures
493(3)
Postoperative Care & Complications
496(2)
Gastroenterology Evaluation & Treatment
498(3)
Long-Term Outcomes of Metabolic Surgery
501(2)
Weight Regain
503(1)
Recommendations & Caveats
503(1)
Section VIII Liver Diseases
39 Approach to Abnormal Liver Tests
504(8)
Jordan Sack
Gyorgy Baffy
General Considerations
504(1)
Pathogenesis
505(1)
Prevention
505(1)
Clinical Findings
505(3)
Differential Diagnosis
508(2)
Complications
510(1)
Treatment
510(1)
Prognosis
510(1)
When to Refer 8c Admit
510(2)
40 Acute Liver Failure
512(11)
Anna Rutherford
Specific Causes of Acute Liver Failure
518(5)
41 Viral Hepatitis
523(18)
Anne F. Liu
Stephen D. Zucker
Hepatitis A
526(1)
Hepatitis B
527(7)
Hepatitis C
534(3)
Hepatitis D
537(1)
Hepatitis E
538(3)
42 Autoimmune Liver Disorders
541(7)
Michael Li
Stephen D. Zucker
Autoimmune Hepatitis
541(4)
Primary Biliary Cholangitis
545(3)
43 Metabolic Liver Diseases
548(13)
Alexanders Vogel
Benjamin Smith
Hemochromatosis
548(7)
Wilson Disease
555(3)
A1-Antitrypsin Deficiency
558(3)
44 Alcohol-Associated Liver Disease
561(8)
Alexanders Vogel
Cyorgy Baffy
General Considerations
561(1)
Pathogenesis
562(1)
Clinical Findings
563(1)
Differential Diagnosis
564(1)
Treatment
565(1)
Alcohol-associated Hepatitis
566(3)
45 Nonalcoholic Fatty Liver Disease
569(8)
Anne F. Liu
Kathleen Viveiros
General Considerations: Definitions
569(2)
Pathogenesis
571(1)
Clinical Findings
572(1)
Treatment
573(2)
Course & Prognosis
575(2)
46 Complications of Cirrhosis: Ascites & Hepatic Encephalopathy
577(8)
Jordan Sack
Kathleen Viveiros
Introduction
577(1)
General Considerations
577(1)
Ascites
578(4)
Hepatic Encephalopathy
582(3)
47 Portal Hypertension & Esophageal Variceal Hemorrhage
585(13)
Kathleen Viveiros
Marvin Ryou
Gastric Varices
595(1)
Portal Hypertensive Gastropathy
596(1)
Idiopathic Portal Hypertension
597(1)
Future Treatment Trends
597(1)
48 Drug-Induced Liver Injury
598(8)
Michael Li
Gyorgy Baffy
Drugs of Special Interest
602(4)
49 Liver Neoplasms
606(13)
Nikroo Hashemi
Benign Liver Tumors
606(5)
Hepatocellular Carcinoma
611(6)
Cholangiocarcinoma
617(1)
Metastatic Liver Disease
618(1)
50 Liver Transplantation
619(12)
Jordan Sack
Nikroo Hashemi
Indications for Transplantation
620(1)
Pretransplant Evaluation
621(1)
Contraindications
622(1)
Listing & Donor Liver Options
623(1)
Transplantation Procedures
623(1)
Complications
624(2)
Infection after Liver Transplantation
626(1)
Long-Term Medical Care After Liver Transplantation
626(2)
Prognosis & Disease Recurrence
628(3)
Section IX Biliary Tract Diseases
51 Primary Sclerosing Cholangitis & Congenital Disorders of the Biliary System
631(7)
Marvin Ryou
Stephen D. Zucker
General Considerations: Primary Sclerosing Cholangitis
631(1)
Pathogenesis
631(1)
Clinical Findings
632(1)
Differential Diagnosis
633(1)
Treatment
634(1)
Course & Prognosis
634(1)
General Considerations: Congenital Cystic Diseases of the Biliary System
635(2)
Pathogenesis
637(1)
Classification
637(1)
Clinical Findings
637(1)
52 Gallstone Disease
638(11)
Stephen D. Zucker
General Considerations
638(1)
Pathogenesis
638(4)
Clinical Features
642(1)
Differential Diagnosis
643(1)
Complications
643(2)
Treatment
645(4)
Index 649
Sonia Friedman, MD, is associate professor of medicine at Harvard Medical School; distinguished IBD clinician, researcher, teacher, and expert on IBD and womens health issues; and director of Womens Health at the Brigham and Womens Hospital Center for Crohns and Colitis in Boston, MA.

John Saltzman, MD, is professor of medicine, part-time at Harvard Medical School, long-term director of Endoscopy at the Brigham and Womens Hospital; and the director of the Brigham and Womens Hospital Advanced Endoscopy Fellowship Program in Boston, MA.

Richard S. Blumberg, MD, is professor of medicine, Harvard Medical School; and chief of the Division of Gastroenterology, Hepatology and Endoscopy at Brigham and Women's Hospital in Boston, MA.

Norton J. Greenberger, MD, was an attending physician and clinical professor of medicine at Harvard Medical School. He was a past president of the American Gastroenterological Association, the American College of Physicians, the Central Society for Clinical Research, and the Association of Professors of Medicine. Greenberger was the author or co-author of numerous original publications, chapters in major medical texts and textbooks.