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El. knyga: Gulf War and Health: Volume 11: Generational Health Effects of Serving in the Gulf War

  • Formatas: 518 pages
  • Išleidimo metai: 20-Dec-2018
  • Leidėjas: National Academies Press
  • Kalba: eng
  • ISBN-13: 9780309478267
Kitos knygos pagal šią temą:
  • Formatas: 518 pages
  • Išleidimo metai: 20-Dec-2018
  • Leidėjas: National Academies Press
  • Kalba: eng
  • ISBN-13: 9780309478267
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For the United States, the 1991 Persian Gulf War was a brief and successful military operation with few injuries and deaths. However, soon after returning from duty, a large number of veterans began reporting health problems they believed were associated with their service in the Gulf. At the request of Congress, the National Academies of Sciences, Engineering, and Medicine has been conducting an ongoing review of the evidence to determine veterans' long-term health problems and potential causes.



Some of the health effects identified by past reports include post-traumatic stress disorders, other mental health disorders, Gulf War illness, respiratory effects, and self-reported sexual dysfunction. Veterans' concerns regarding the impacts of deployment-related exposures on their health have grown to include potential adverse effects on the health of their children and grandchildren. These concerns now increasingly involve female veterans, as more women join the military and are deployed to war zones and areas that pose potential hazards.



Gulf War and Health: Volume 11 evaluates the scientific and medical literature on reproductive and developmental effects and health outcomes associated with Gulf War and Post-9/11 exposures, and designates research areas requiring further scientific study on potential health effects in the descendants of veterans of any era.

Table of Contents



Front Matter Summary 1 Introduction 2 Committee's Approach 3 Introduction to the Study of Generational Effects 4 Deployment-Related Exposures 5 Pesticides 6 Combustion Products and Fuels 7 Solvents 8 Outcomes Toward Heritable Effects 9 Health Monitoring and Research Programs 10 Pathophysiologic Research 11 Moving Forward Appendix A: Committee Biographical Sketches Appendix B: Glossary
Acronyms and Abbreviations xv
Summary 1(14)
Charge to the Committee
2(1)
The Committee's Approach
2(4)
Findings and Conclusions
6(1)
Health Monitoring and Research Program
7(4)
Pathophysiologic Studies
11(1)
Moving Forward
12(3)
1 Introduction
15(10)
The Gulf War and Post-9/11 Conflicts
16(1)
Legislative Actions
17(1)
Gulf War and Health and Related Reports
17(3)
Charge to the Committee
20(1)
Organization of the Report
20(2)
References
22(3)
2 Committee's Approach
25(16)
Exposure Considerations
26(4)
Committee's Review Process
30(8)
Categories of Association
38(1)
References
39(2)
3 Introduction to the Study of Generational Effects
41(22)
Heritable Targets for Deployment-Related Exposures
42(5)
Paradigms of Inheritance
47(2)
Timing of Exposures and Outcomes
49(7)
Epidemiologic Generational and Epigenetic Studies
56(1)
Animal Models
56(1)
Summary
57(1)
References
57(6)
4 Deployment-Related Exposures
63(38)
Deployment
63(5)
Chemical Warfare Agents
68(7)
Infectious Diseases
75(3)
Vaccines
78(6)
Depleted Uranium
84(5)
Pyridostigmine Bromide
89(1)
Hexavalent Chromium
90(7)
References
97(4)
5 Pesticides
101(92)
Organophosphates
103(37)
Carbamates
140(10)
Pyrethroids
150(21)
Lindane
171(7)
DEET (N,N-Diethyl-3-Methylbenzamide)
178(1)
References
179(14)
6 Combustion Products and Fuels
193(124)
Combustion Products
193(97)
Fuels
290(6)
References
296(21)
7 Solvents
317(80)
Benzene
321(16)
Toluene
337(8)
Xylenes
345(6)
Trichloroethylene (TCE)
351(12)
Tetrachloroethylene
363(12)
Glycols and Glycol Ethers
375(12)
References
387(10)
8 Outcomes Toward Heritable Effects
397(12)
Health Outcomes Associated with Gulf War Deployment
397(5)
Summary of Data and Knowledge Gaps
402(3)
Summary
405(1)
References
405(4)
9 Health Monitoring and Research Programs
409(52)
Overview of VA and DoD Health Care Systems
410(1)
Framework for a Health Monitoring and Research Program
411(2)
Program Scope and Study Design
413(6)
Study Populations
419(6)
Data Collection
425(9)
Data Analyses
434(8)
Leveraging Existing Resources
442(6)
Program Management
448(3)
Communication
451(2)
Program Evaluation
453(1)
Ethical Considerations
454(1)
Summary
455(2)
References
457(4)
10 Pathophysiologic Research
461(10)
Utility of Animal Studies
462(1)
Lifecourse Exposures
463(2)
Data Gaps to Be Addressed
465(1)
Effects of Genetic and Epigenetic Alterations on Descendants
466(1)
Inter- and Transgenerational Health Effects
467(2)
Summary
469(1)
References
470(1)
11 Moving Forward
471(12)
Collection of Baseline and Longitudinal Data
474(1)
Prioritization of Exposures
475(1)
Development of Biomarkers
476(2)
Funding
478(1)
Feasibility
478(2)
Summary
480(1)
References
481(2)
Appendixes
A Committee Biographical Sketches
483(6)
B Glossary
489