Preface |
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ix | |
Acronyms |
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xvii | |
Summary |
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1 | (10) |
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2 | (1) |
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2 | (1) |
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3 | (1) |
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Considerations in Identifying and Evaluating the Literature |
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4 | (2) |
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Primary and Secondary Studies |
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4 | (1) |
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Categories of Association |
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5 | (1) |
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6 | (1) |
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6 | (1) |
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7 | (2) |
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9 | (2) |
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11 | (12) |
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11 | (1) |
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12 | (3) |
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13 | (1) |
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13 | (1) |
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Environmental and Chemical Exposures |
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13 | (1) |
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Threat of Chemical and Biologic Warfare |
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14 | (1) |
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15 | (1) |
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Committee's Approach to Its Charge |
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16 | (1) |
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Complexities in Resolving Gulf War and Health Issues |
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17 | (1) |
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Multiple Exposures and Chemical Interactions |
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17 | (1) |
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Limitations of Exposure Information |
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17 | (1) |
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18 | (1) |
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18 | (2) |
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Organization of the Report |
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20 | (1) |
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20 | (3) |
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2 Considerations in Identifying and Evaluating the Literature |
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23 | (16) |
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Identification of the Literature |
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23 | (2) |
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25 | (3) |
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25 | (1) |
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Associations in Epidemiologic Studies |
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25 | (2) |
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27 | (1) |
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Types of Epidemiologic Studies |
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28 | (3) |
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28 | (1) |
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29 | (1) |
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30 | (1) |
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Standardized Mortality Studies |
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31 | (1) |
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31 | (2) |
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32 | (1) |
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32 | (1) |
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Health Outcome Assessment |
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32 | (1) |
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Considerations in Assessing the Strength of Evidence |
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33 | (2) |
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Categories of Association |
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33 | (2) |
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Additional Considerations |
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35 | (1) |
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35 | (1) |
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35 | (1) |
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35 | (1) |
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36 | (1) |
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Limitations of Gulf War Veteran Studies |
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36 | (1) |
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36 | (3) |
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39 | (32) |
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General Limitations of Gulf War Cohort Studies and Derivative Studies |
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39 | (2) |
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Organization of this Chapter |
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41 | (22) |
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Department of Veterans Affairs Study |
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45 | (4) |
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The Iowa Persian Gulf Study |
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49 | (2) |
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United Kingdom Veteran Studies |
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51 | (3) |
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Australian Veteran Studies |
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54 | (2) |
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Danish Peacekeeper Studies |
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56 | (1) |
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Oregon and Washington Veteran Studies |
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57 | (1) |
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Canadian Gulf War Veterans Study |
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58 | (1) |
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58 | (1) |
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Fort Devens and New Orleans Cohort Studies |
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59 | (1) |
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60 | (2) |
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Pennsylvania Air National Guard Study |
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62 | (1) |
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Hawaii and Pennsylvania Active Duty and Reserve Study |
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62 | (1) |
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New Orleans Reservist Studies |
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63 | (1) |
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63 | (8) |
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71 | (184) |
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Organization of the Chapter |
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71 | (2) |
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73 | (10) |
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73 | (2) |
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Updated and Supplemental Literature |
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75 | (3) |
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78 | (5) |
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Diseases of the Blood and Blood-Forming Organs |
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83 | (6) |
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Updated and Supplemental Literature |
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83 | (2) |
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85 | (4) |
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Endocrine, Nutritional, and Metabolic Diseases |
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89 | (10) |
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89 | (2) |
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91 | (1) |
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92 | (1) |
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93 | (2) |
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95 | (1) |
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95 | (4) |
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Mental and Behavioral Disorders |
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99 | (16) |
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101 | (4) |
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Updated and Supplemental Literature |
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105 | (3) |
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108 | (7) |
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Neurocognitive and Neurobehavioral Outcomes |
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115 | (6) |
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115 | (1) |
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Updated and Supplemental Literature |
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116 | (2) |
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118 | (3) |
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Diseases of the Nervous System |
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121 | (14) |
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Peripheral Neuropathy and Myopathy |
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121 | (3) |
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124 | (2) |
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Amyotrophic Lateral Sclerosis |
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126 | (3) |
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Other Neurodegenerative Diseases |
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129 | (1) |
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Other Neurological Outcomes |
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130 | (5) |
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Diseases of the Circulatory System |
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135 | (10) |
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135 | (1) |
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Updated and Supplemental Literature |
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136 | (4) |
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140 | (5) |
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Diseases of the Respiratory System |
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145 | (9) |
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145 | (2) |
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Updated and Supplemental Literature |
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147 | (2) |
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149 | (5) |
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Diseases of the Digestive System |
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154 | (10) |
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155 | (1) |
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Updated and Supplemental Epidemiologic Literature |
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156 | (3) |
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159 | (5) |
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164 | (5) |
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164 | (1) |
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Updated and Supplemental Literature |
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165 | (2) |
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167 | (2) |
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Diseases of the Musculoskeletal System |
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169 | (6) |
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169 | (1) |
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Updated and Supplemental Literature |
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170 | (1) |
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171 | (4) |
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Fibromyalgia and Chronic Widespread Pain |
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175 | (5) |
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175 | (1) |
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Updated and Supplemental Literature |
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176 | (2) |
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178 | (2) |
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Diseases of the Genitourinary System |
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180 | (9) |
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180 | (3) |
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Hospitalization for Genitourinary System Diseases |
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183 | (1) |
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184 | (5) |
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Adverse Reproductive and Perinatal Outcomes |
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189 | (15) |
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189 | (4) |
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Adverse Pregnancy Outcomes |
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193 | (2) |
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195 | (3) |
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198 | (6) |
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204 | (17) |
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Factor Analyses and Surveys |
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204 | (3) |
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207 | (1) |
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208 | (2) |
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210 | (1) |
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210 | (11) |
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External Causes of Mortality |
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221 | (7) |
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221 | (1) |
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Updated and Supplemental Literature |
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222 | (2) |
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224 | (4) |
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228 | (7) |
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228 | (1) |
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229 | (2) |
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231 | (1) |
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Military Sexual Assault and Harassment |
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232 | (1) |
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Hospitalization and Mortality |
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233 | (1) |
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234 | (1) |
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235 | (20) |
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5 Conclusions and Recommendations |
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255 | (10) |
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258 | (1) |
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Possible Causes of Multisymptom Illness in Veterans |
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259 | (1) |
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260 | (5) |
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APPENDIX A CHOLINESTERASE INHIBITORS AND MULTISYMPTOM ILLNESSES |
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265 | (20) |
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Exposures to Cholinesterase Inhibitors and Other Pesticides During the Gulf War |
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266 | (4) |
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266 | (4) |
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Long-Term Effects of Low Doses of Cholinesterase Inhibitors |
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270 | (1) |
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Studies in Gulf War Populations |
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271 | (4) |
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275 | (1) |
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Genetic Susceptibility to Cholinesterase Inhibitors |
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276 | (2) |
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The Role of Cholinesterase Inhibitors and Pesticides in Multisymptom Illness |
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278 | (1) |
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279 | (6) |
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APPENDIX B COMMITTEE BIOGRAPHICAL SKETCHES |
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285 | (4) |
Index |
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289 | |