Haematology in Critical Care: A Practical Handbook Edited by Jecko Thachil MRCP FRC Path Consultant Haematologist Central Manchester University Hospitals NHS Foundation Trust Manchester, UK Quentin. A Hill MRCP FRCPath Consultant Haematologist Leeds Teaching Hospitals NHS Trust Leeds, UK Issues of thrombosis, bleeding, and transfusion are extremely common, and often complex, in critically ill patients. Haematology in Critical Care: A Practical Handbook provides a dependable source of expert guidance on how to handle common haematological problems seen in the critical care setting, as well as the acute care of patients with a primary haematological disorder. Full-time clinical haematologists, regularly attending on intensive care, the editors begin with an approach to abnormal laboratory tests, following with a disease-orientated approach to topics such as coagulation and haematological malignancy. Other key topics include paediatric and neonatal care, transfusion, point of care testing and the emergency presentation of haematological disease. This title brings together two of the most highly scientific specialties in clinical practice, delivering a practical approach to these problems, and guiding the clinician through the diagnosis and management of common scenarios encountered in the ICU. Titles of Related Interest Postgraduate Haematology, 6th edition Hoffbrand, ISBN 9781405191807.
List of Contributors, v Preface, ix Acknowledgements, x Section 1
Approach to Abnormal Blood Tests 1 Diagnostic Approach to Anaemia in
Critical Care, 3 Stephen F. Hawkins and Quentin A. Hill 2 Leukopenia, 9
Stephen F. Hawkins, Jecko Thachil and Quentin A. Hill 3 Thrombocytopenia in
the Intensive Care Unit, 12 Jecko Thachil 4 High Blood Counts, 16 Quentin
A. Hill 5 The Abnormal Clotting Profile, 26 Jecko Thachil 6
Understanding the Blood Film, 31 Stephen F. Hawkins and Quentin A. Hill
Section 2 Approach to Coagulation Problems 7 Venous Thromboembolism in
Intensive Care, 39 Sarah A. Bennett and Roopen Arya 8 Reversal and
Monitoring of Anticoagulants, 45 Joost J. van Veen 9 Disseminated
Intravascular Coagulation, 52 Jecko Thachil 10 Heparin-Induced
Thrombocytopenia, 58 Jerrold H. Levy and Anne M. Winkler 11 Thrombotic
Microangiopathies, 62 Mari Thomas and Marie Scully 12 Critical Care of
Patients with a Congenital Bleeding Disorder, 69 Vanessa Martlew Section
3 Approach to Transfusion Problems 13 Blood Components and Their Contents,
77 Shubha Allard 14 Transfusion Reactions, 86 Therese A. Callaghan 15
The Management of Non-traumatic Massive Haemorrhage, 93 Nicola S. Curry and
Simon J. Stanworth 16 Plasma Exchange, 100 Khaled El-Ghariani Section 4
Approach to Red Cell Problems 17 Appropriate Haemoglobin in Intensive Care,
107 Jonathan Wallis and Stephen Wright 18 Sickle Cell Disease and
Thalassaemia in the Critical Care Setting, 112 Andrew Retter and Jo Howard
19 Management of Patients Who Refuse Blood Transfusion, 118 Derek R. Norfolk
and Fran Hartley Section 5 Approach to White Cell Problems 20 Infectious
Complications in the Immunosuppressed Patient, 125 Tim Collyns and
Elankumaran Paramasivam 21 Haematopoietic Stem Cell Transplantation (HSCT),
135 John Snowden and Stephen Webber 22 Multiple Myeloma and Hyperviscosity
Syndrome, 144 Amin Rahemtulla and Joydeep Chakrabartty, 23 Palliative Care
for the Patient with Haematological Malignancy in Intensive Care, 148
Suzanne Kite Section 6 Admission to Intensive Care 24 Haematological
Malignancy Outside Intensive Care: Current Practice and Outcomes, 159
Charlotte Kallmeyer 25 Early Care of the Unstable Patient: Preventing
Admission to the Intensive Care Unit, 165 Andrew Breen 26 Decisions to
Intensify Treatment: Who Will Benefit from Intensive Care?, 171 Quentin A.
Hill and Peter A. Hampshire Section 7 Point-of-Care Testing 27 The
Relevance of Thromboelastography in Intensive Care Patients, 179 Jon Bailey
and Nicola S. Curry Section 8 Haematology Drugs in Critical Care 28
Recombinant Activated Coagulation Factor VII (rFVIIa) in Critical Care, 187
Leon Cloherty and Richard Wenstone 29 The Use of Haemostatic Drugs in
Post-operative Bleeding, 192 Catharina Hartman and Nigel Webster 30
Delivering Chemotherapy on Intensive Care, 196 Arvind Arumainathan and
Daniel Collins Section 9 Haematology in Paediatric and Neonatal Intensive
Care 31 Neonatal Anaemia, 207 Michael Richards 32 Haemolysis, 213
Michael Richards 33 Approach to Thrombocytopenia, 219 Amrana Qureshi 34
Blood Component Therapy in Children and Neonates, 224 Anne Kelly, Simon J.
Stanworth and Helen V. New Section 10 Haematological Emergencies 35
Haematological Emergencies, 235 Quentin A. Hill and Amin Rahemtulla
Appendix A: Adult, Paediatric and Neonatal Haematology Reference Intervals,
243 Quentin A. Hill Index, 249
