An introduction to the Fundamentals of Biomedical Science series |
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vii | |
Contributors |
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xi | |
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xiii | |
Abbreviations |
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xv | |
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1 Haematology and Haemopoiesis |
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1 | (68) |
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1 Introduction to haematology |
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3 | (14) |
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3 | (1) |
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1.2 A classification of haematology |
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4 | (2) |
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1.3 The role of the biomedical scientist in the haematology laboratory |
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6 | (2) |
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1.4 Additional roles of biomedical scientists |
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8 | (2) |
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1.5 The role of haematology in the provision of healthcare |
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10 | (2) |
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1.6 The overlap with other pathology disciplines |
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12 | (2) |
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1.7 The role of the professional body |
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14 | (3) |
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2 Major haematology parameters and basic techniques |
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17 | (31) |
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2.1 Obtaining a blood sample |
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17 | (1) |
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18 | (2) |
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20 | (5) |
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25 | (2) |
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27 | (8) |
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35 | (2) |
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37 | (6) |
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43 | (2) |
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45 | (3) |
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3 Haemopoiesis and the bone marrow |
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48 | (21) |
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3.1 Overview of the cellular constituents of the blood |
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48 | (1) |
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3.2 Ontogeny of haemopoiesis |
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49 | (1) |
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3.3 Bone marrow architecture and cellularity |
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50 | (1) |
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3.4 Models of differentiation, stem cells, and growth factors |
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50 | (5) |
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3.5 Specific lineage haemopoiesis |
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55 | (7) |
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3.6 Bone marrow sampling and analysis |
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62 | (7) |
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2 Peripheral Blood Cells in Health and Disease |
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69 | (192) |
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4 The physiology of the red blood cell |
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71 | (33) |
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4.1 The development of the red blood cell: erythropoiesis |
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72 | (5) |
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4.2 The red blood cell membrane |
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77 | (5) |
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4.3 The cytoplasm of the red blood cell |
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82 | (14) |
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4.4 The death of the red cell |
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96 | (2) |
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4.5 The red blood cell under the microscope |
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98 | (6) |
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5 The pathology of the red blood cell: Part 1 |
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104 | (39) |
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5.1 Diseases of the red blood cell |
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104 | (4) |
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5.2 Anaemia arising from changes in the bone marrow |
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108 | (5) |
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113 | (13) |
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5.4 Anaemia arising from lack of vitamins |
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126 | (10) |
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5.5 Anaemia of chronic disease (ACD) |
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136 | (7) |
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6 The pathology of the red blood cell: Part 2 |
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143 | (47) |
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6.1 Immune-mediated and other `extrinsic' causes of haemolytic anaemia |
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144 | (10) |
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154 | (23) |
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6.3 Membrane and enzyme defects |
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177 | (7) |
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6.4 Erythrocytosis and polycythaemia |
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184 | (6) |
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190 | (36) |
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190 | (1) |
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191 | (21) |
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212 | (2) |
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214 | (3) |
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217 | (2) |
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219 | (7) |
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8 White blood cells in health and disease |
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226 | (35) |
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227 | (1) |
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227 | (15) |
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242 | (2) |
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244 | (11) |
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255 | (6) |
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3 Haematological Malignancies |
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261 | (172) |
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9 An introduction to haematological malignancies |
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263 | (41) |
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9.1 A background to haematological malignancies |
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264 | (5) |
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269 | (1) |
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9.3 An introduction to the cell cycle |
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270 | (6) |
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9.4 Chromosomes and nomenclature |
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276 | (3) |
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9.5 An introduction to genetic mutation |
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279 | (10) |
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289 | (2) |
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291 | (4) |
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9.8 Mechanisms of oncogenesis |
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295 | (1) |
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9.9 Inheritance and leukaemia |
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296 | (2) |
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9.10 Environmental causes of haematological malignancies |
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298 | (6) |
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10 The laboratory investigation of haematological malignancies |
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304 | (37) |
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10.1 Patient presentation |
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305 | (2) |
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10.2 The full blood count |
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307 | (2) |
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309 | (3) |
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10.4 Bone marrow assessment |
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312 | (8) |
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320 | (3) |
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323 | (8) |
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10.7 Cytogenetic analysis |
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331 | (6) |
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10.8 Molecular techniques |
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337 | (4) |
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11 An introduction to classification systems: myeloid neoplasms |
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341 | (40) |
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11.1 Why is classification important? |
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342 | (1) |
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11.2 The main classification systems |
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342 | (19) |
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11.3 Myelodysplastic syndrome |
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361 | (8) |
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11.4 Myelodysplastic/myeloproliferative diseases |
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369 | (2) |
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11.5 Myeloproliferative neoplasms |
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371 | (10) |
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12 An introduction to classification systems: lymphoid neoplasms |
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381 | (52) |
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12.1 The history of lymphoid classification |
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382 | (9) |
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12.2 Acute lymphoblastic leukaemias (ALL) |
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391 | (4) |
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12.3 Precursor lymphoid neoplasms |
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395 | (3) |
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12.4 Mature B-cell neoplasms |
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398 | (26) |
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12.5 Mature T-cell and NK-cell neoplasms |
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424 | (4) |
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428 | (5) |
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4 Haemostasis in Health and Disease |
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433 | (180) |
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435 | (42) |
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13.1 Introduction to haemostasis |
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435 | (1) |
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436 | (13) |
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13.3 Secondary haemostasis |
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449 | (19) |
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468 | (9) |
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14 Bleeding disorders and their laboratory investigation |
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477 | (51) |
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477 | (3) |
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14.2 Von Willebrand's disease |
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480 | (2) |
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14.3 Laboratory investigation of a suspected bleeding disorder |
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482 | (26) |
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14.4 Diagnosis of platelet disorders |
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508 | (20) |
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528 | (38) |
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528 | (1) |
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15.2 Natural anticoagulants |
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529 | (12) |
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15.3 Antiphospholipid antibodies |
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541 | (19) |
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560 | (6) |
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16 Haemostasis and anticoagulation |
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566 | (47) |
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16.1 Reasons for anticoagulation therapy |
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566 | (6) |
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16.2 Current therapeutic anticoagulant pharmaceuticals for VTE |
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572 | (10) |
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16.3 Current therapeutic anticoagulant pharmaceuticals for arterial thrombosis |
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582 | (2) |
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16.4 Laboratory monitoring of anticoagulant therapy |
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584 | (19) |
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16.5 Management of oral anticoagulant therapy |
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603 | (10) |
Glossary |
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613 | (17) |
References |
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630 | (1) |
Index |
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631 | |