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El. knyga: Handbook of Hematologic Malignancies

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  • Formatas: 500 pages
  • Išleidimo metai: 19-Dec-2020
  • Leidėjas: Springer Publishing Co Inc
  • Kalba: eng
  • ISBN-13: 9780826149770
  • Formatas: 500 pages
  • Išleidimo metai: 19-Dec-2020
  • Leidėjas: Springer Publishing Co Inc
  • Kalba: eng
  • ISBN-13: 9780826149770

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"The 2nd edition of Handbook of Hematologic Malignancies encompasses the hard work and effort of many fellows and residents, working under the mentorship and guidance of attending staff physicians at world-renowned cancer centers throughout the country, not only at Moffitt Cancer Center, but also many others including Harvard, Mayo Clinic, and Memorial Sloan Kettering Cancer Center. Specifically, the editors would like acknowledge Dr. Kenian Liu from the Cytogenetic Laboratory (Moffitt) for providing FISH images and Drs. Lugen Chen (Tampa General Hospital), Wilfredo Chamizo (All Children Hospital at St Petersburg), Haipeng Shao (Moffitt), Xiaohui Zhang (Moffitt), and Jane Messina (Moffitt) for sharing unique cases to the book. The quality of their work and their willingness to contribute to make this textbook one that can serve the needs of readers across disciplines, made working on this project a rewarding experience for us all"--

This revised and updated second edition of Handbook of Hematologic Malignancies continues to be an essential and "go-to" resource for the busy hematologist, hematologic oncologist, hematopathologist, oncology advanced practice provider, oncology nurse, and trainee. Concisely organized, each chapter provides the most current, need-to-know points of diagnosis, prognosis, therapeutic management, and clinical trial opportunities for each hematological malignancy. Chapters are complete with richly illustrated figures to highlight the hematopathologic characteristics of diseases in addition to helpful tables on differential diagnosis, prognostic scoring systems, molecular profiles, and therapeutic options. A new case-based chapter concludes the handbook with clinical cases designed to test a clinician's knowledge of pathologic diagnosis and clinical presentation of diseases covered in the book. With over twenty new FDA-approved indications since publication of the first edition, including breakthroughs with CAR-T therapy, and other evidence-based treatment options for patients with hematologic disease, this book serves as quick reference to practice changing information on challenging diagnostic dilemmas, frontline and refractory treatment scenarios, and more.

The subspecialty field of hematologic oncology is ever-changing and expanding with available treatment options and this second edition keeps the busy clinician abreast of recent findings and their impact on evidence-based treatment and management. Written by experienced clinicians at the world-renowned Moffitt Cancer Center in Tampa, Florida, as well as contributions from leading academicians, hematologists, and oncologists throughout the country, this unique handbook is packed with authoritative knowledge and clinical insight into all known hematologic cancers.

    Key Features:
  • Includes seven new chapters covering CAR-T and novel therapeutic options including CD19 CAR-T therapy, novel cellular therapies, cytokine release syndrome, cancer associated thrombosis, and more
  • Comprises compact and updated disease-site chapters describing new standards of care and management considerations in bullet point format with key references
  • Highlights important diagnostic tools that assist with conducting key differential diagnoses and unveiling answers to diagnostic dilemmas
  • Provides updates of potential practice-changing clinical trials and paradigm shifting treatment considerations in each disease-based chapter
  • Purchase includes digital access for use on most mobile devices or computers
Contributors xi
Preface xix
Abbreviations xxi
Part I INTRODUCTION AND OVERVIEW
1 Normal Hematopoiesis and Diagnosis Algorithms for Cytopenias and Cytoses
7(4)
Onyee Chan
Ling Zhang
2 Familial/Inherited Mutations and Risks of Hematologic Malignancies
11(1)
Sophia C. Korotev
Lucy A. Godley
Amy M. Trottier
3 Diagnostic Approaches to Hematologic Malignancies
17(22)
Johnny Nguyen
Rohit Sharma
Ling Zhang
4 Minimal Residual Disease Assays
39(6)
Pukhraz Basra
Silvia Tse Bunting
Part II MYELOPROLIFERATIVE NEOPLASMS
5 Polycythemia Vera
45(12)
Misty Dawn Shields
Kenneth S. Zuckerman
6 Essential Thrombocythemia
57(4)
Nikesh N. Shah
Kenneth S. Zuckerman
7 Primary Myelofibrosis
61(8)
Carmelo J. Blanquicett
Andrew Kuykendall
8 Chronic Myelogenous Leukemia
69(8)
Chetasi Talati
Dasom Caroline Lee
Javier Pinilla-Ibarz
9 Chronic Neutrophilic Leukemia
77(6)
Yenny Alejandra Moreno Vanegas
Arun Kadamkulam Syriac
Utkarsh Acharya
10 Systemic Mastocytosis
83(6)
Kristen Gonter-Aubin
Andrew Kuykendall
11 PDGFRA/PDGFRB/FGFRI1 Myeloid Neoplasms
89(6)
Joseph Clara
Eric Padron
Part III MYELODYSPLASTIC AND BONE MARROW FAILURE SYNDROMES
12 Myelodysplastic Syndromes
95(8)
Anthony M. Hunter
David A. Sallman
Rami Komrokji
13 Aplastic Anemia
103(6)
Jae Chung
Rami Komrokji
14 Paroxysmal Nocturnal Hemoglobinuria
109(6)
Hilda Ding
Part IV MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS
15 Myelodysplastic/Myeloproliferative Overlap Syndromes
115(6)
Virginia O. Volpe
Jennifer Eatrides
Eric Padron
16 Chronic Myelomonocytic Leukemia
121(8)
Alexandra Gomez-Aneaga
Justin M. Watts
Part V ACUTE MYELOID LEUKEMIA AND RELATED SYNDROMES
17 Acute Myeloid Leukemia
129(6)
David M. Swoboda
Kendra Sweet
18 Secondary AML and AML-MRC
135(6)
Seongseok Yun
David A. Sallman
Jeffrey E. Lancet
19 Acute Promyelocyte Leukemia
141(8)
Virginia O. Volpe
Jeffrey E. Lancet
20 Blastic Plasmacytoid Dendritic Cell Neoplasm
149(6)
Justin Taylor
Andrew A. Lane
Part VI ACUTE LYMPHOID LEUKEMIA
21 B-Lymphoblastic Leukemia/Lymphoma
155(1)
Fernando Vargas
Bijal Shah
22 BCR-ABL1+ B-Lymphoblastic Leukemia
155(16)
Yehuda Deutsch
Bijal Shah
23 T-Cell Acute Lymphoblastic Leukemia/Lymphoma
171(6)
Muhammad Sardar
Ravitharan Krishnadasan
Keri Maher
Part VII ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE
24 Acute Leukemia of Ambiguous Lineage
177(4)
Muhammad Sardar
Ravitharan Krishnadasan
Keri Maher
Part VIII MATURE T-AND NK-CELL LEUKEMIA
25 T-Cell Prolymphocytic Leukemia
181(4)
Pei Zhang
Abhijeet Kumar
26 T-Cell Large Granular Lymphocytic Leukemia
185(6)
Ning Dong
Magali Van den Bergh
Lubomir Sokol
27 Aggressive Natural Killer Cell Leukemia
191(6)
Emilie Wang
Mintallah Haider
Lubomir Sokol
Part IX PLASMA CELL DISORDERS
28 Monoclonal Gammopathy of Unknown Significance, Smoldering Myeloma, and Plasmacytomas
197(8)
Hannah Asghari
Brandon Blue
29 Multiple Myeloma
205(14)
Shonali Midha
Patrick Griffin
Rachid Baz
30 Waldenstrom Macroglobulinemia
219(10)
Ariel Grajales-Cruz
Rachid Baz
31 Immunoglobulin Light Chain Amyloidosis
229(6)
Taxiarchis Kourelis
Morie A. Gertz
Part X HODGKIN LYMPHOMA
32 Hodgkin Lymphoma
235(8)
Anju Nair
Part XI NON-HODGKIN LYMPHOMA
33 Diagnosis and Classification of Non-Hodgkin Lymphomas
243(6)
Johnny Nguyen
Haipeng Shao
Ling Zhang
Part XII MATURE B-CELL LYMPHOMA
Very Aggressive
34 Burkitt Lymphoma
249(6)
Anju Nair
Aggressive
35 Diffuse Large B-Cell Lymphoma
255(8)
Jose D. Sandoval-Sus
Julio C. Chavez
36 Double-Hit Lymphoma
263(4)
Nikhil Mukhi
37 Mantle Cell Lymphoma
267(6)
Ruchi Desai
Bijal Shah
38 Primary Mediastinal Large B-Cell Lymphoma
273(6)
Vania Phuoc
Andreas Saltos
Julio C. Chavez
39 Primary Central Nervous System Lymphoma
279(8)
Tony Kurian
Liliana Bustamante
Peter Forsyth
Solmaz Sahebjam
40 HIV-Related Lymphomas
287(8)
Danny Nguyen
Nishan Tchekmedyian
Jeremy S. Abramson Indolent
41 Follicular Lymphoma
295(8)
Jori Kaplan
Celeste Bello
42 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
303(8)
Emilie Wang
Ateefa Chaudhury
Javier Pinilla-Ibarz
43 Hairy Cell Leukemia
311(6)
Justin Taylor
Omar Abdel-Wahab
44 Marginal Zone Lymphoma
317(6)
Nishan Tchekmedyian
Danny Nguyen
Hayder Saeed
Celeste Bello
45 Mucosa-Associated Lymphoid Tissue Lymphoma
323(8)
Nishan Tchekmedyian
Danny Nguyen
Hayder Saeed
Part XIII MATURET-AND NK-CELL LYMPHOMA
46 Adult T-Cell Leukemia/Lymphoma
331(6)
Nikhil Mukhi
Lubomir Sokol
47 Anaplastic Large Cell Lymphoma
337(6)
Poorvi Desai
Ling Zhang
Lubomir Sokol
48 Extranodal Natural Killer/T-Cell Lymphoma
343(14)
Joseph Clara
Lubomir Sokol
49 Mycosis Fungoides
357(2)
Vania Phuoc
Lubomir Sokol
50 Hepatosplenic T-Cell Lymphoma
359(8)
Walter Hanel
Narendranath Epperla
Part XIV HISTIOCYTIC/DENDRITIC CELL NEOPLASMS
51 Langerhans Cell Histiocytosis, Erdheim-Chester Disease, Rosai-Dorfman Disease, and Histiocytic Sarcoma
367(8)
Sameem Abedin
Ehab Ataliah
52 Hemophagocytic Lymphohistiocytosis
375(8)
Hilda Ding
Lubomir Sokol
Part XV BONE MARROW TRANSPLANTATION
53 Autologous Hematopoietic Cell Transplantation
383(10)
Hemant S. Murthy
Mohamed A. Kharfan-Dabaja
54 Allogeneic Hematopoietic Cell Transplantation
393(14)
Hemant S. Murthy
Taiga Nishihori
Mohamed A. Kharfan-Dabaja
Part XVI NEW CELLULAR IMMUNOTHERAPY
55 CAR-T Overview and Novel Cellular Therapeutic Options, Including TCR Gene Transfers
407(8)
Cristian I. Rodriguez Arocho
Marco L. Davila
David A. Sallman
56 CD19 CART-Cell Therapy
415(6)
Michael D. Jain
Brigett D. Brandjes
Frederick L. Locke
57 Cytokine Release Syndrome and Other Toxicities Associated With Novel Cellular-Therapies
421(8)
Jennifer M. Logue
Estelle Cervantes
Christina A. Bachmeier
Marco L. Davila
Part XVII EMERGENCIES IN HEMATOLOGY
58 Cancer-Associated Thrombosis in Hematologic Malignancies
429(8)
Karen Feghali
Arun Kadamkulam Syriac
Utkarsh Acharya
59 Tumor Lysis Syndrome
437(4)
Mintallah Haider
Michael Jaglal
60 Thrombotic Microangiopathy
441(16)
Jonathan R. Day
Ljiljana V. Vasovic
Ruchika Goel
61 Therapeutic Apheresis Indications
457(1)
Ljiljana V. Vasovic
Jonathan R. Day
Ruchika Goel
Part XVIII NEW CLINICAL CASES IN MALIGNANT HEMATOLOGY
62 Challenging Case Vignettes With Follow-Up Questions
457(40)
Appendix: Pathology Supplement 497(14)
Index 511
David A. Sallman, MD, Associate Member, Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, University of South Florida Morsani College of Medicine, Tampa, Florida

Ateefa Chaudhury, MD, Hematologist, New Mexico Cancer Center, Albuquerque, New Mexico

Johnny Nguyen, MD is a Pathology Resident, Department of Pathology, Morsani College of Medicine, University of South Florida, Tampa, FL.

Ling Zhang, MD, Senior Member, Professor, Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida