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Handbook of Stem Cell Transplantation and Cellular Therapy Management [Minkštas viršelis]

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  • Formatas: Paperback / softback, 352 pages, aukštis x plotis: 203x127 mm, weight: 360 g, 40 Illustrations
  • Išleidimo metai: 04-Sep-2020
  • Leidėjas: Springer Publishing Co Inc
  • ISBN-10: 0826139930
  • ISBN-13: 9780826139931
Kitos knygos pagal šią temą:
  • Formatas: Paperback / softback, 352 pages, aukštis x plotis: 203x127 mm, weight: 360 g, 40 Illustrations
  • Išleidimo metai: 04-Sep-2020
  • Leidėjas: Springer Publishing Co Inc
  • ISBN-10: 0826139930
  • ISBN-13: 9780826139931
Kitos knygos pagal šią temą:

Handbook of Stem Cell Transplantation and Cellular Therapy Management provides an evidence-based practical guide for clinicians and practitioners who treat cancer patients with these challenging and innovative techniques. The handbook begins with chapters on autologous transplantation for myeloma and lymphoma, and allogenic transplantation for leukemia, lymphoma and myelodysplastic syndrome. Further chapters cover the standards of care for managing adverse events related to acute graft-versus-host disease, chronic graft-versus-host disease, infections of bacterial, fungal, and viral nature, lymphoproliferative disease, pulmonary complications, renal complications, treatment of cancer relapse, as well as quality of life and long-term survivorship issues. Concluding chapters address new CAR-T therapies, including their mechanisms of action, indications, and unique associated toxicities such as cytokine release syndrome, in addition to a chapter dedicated to biostatistics and clinical trials. Throughout the book, extensive tables, flow diagrams and other figures highlight, simplify and illustrate key concepts.

Written by experienced clinicians at the world-renowned Dana Farber Cancer Center and Harvard Medical School in Boston and leading experts at other renowned institutions, this stem cell transplantation handbook combines the clinical knowledge, expertise and practical application of these potential life-saving cell therapies s in one quick, point-of-care reference . With real-world clinical vignettes interwoven among the chapters, this handbook is an essential resource for anyone managing patients being treated with stem cell transplantation or cellular therapies.

    Key Features:
  • Provides latest insights and recommendations for managing challenging treatment complications and adverse events
  • Consolidates key information such as diagnosis criteria, disease staging, common complications, and more using detailed tables and helpful diagrams
  • Shares real-world clinical vignette examples which provide insight into clinical assessment, treatment, and management
  • Emphasizes patient management and best practices
  • Discusses short and long-term risks for stem cell transplantation and cellular therapy
  • Includes access to downloadable eBook for anytime access
Contributors xi
Preface xv
1 Introduction to Hematopoietic Stem Cell Transplantation and CellularTherapy
1(12)
Rushdia Yusuf
Edwin P. Alyea
Allogeneic and Autologous Transplants
1(1)
Classification of Allogeneic Transplants
2(4)
Complications of Allogeneic Transplants
6(4)
Conclusion
10(1)
References
10(3)
2 Autologous and Allogeneic Transplantation for Lymphoma
13(38)
Austin Kim
Eric D. Jacobsen
I Autologous Stem Cell Transplantation (Austin Kim)
13(1)
Classic HL
13(2)
B-Cell NHL
15(2)
T-Cell NHL
17(3)
References
20(3)
II Allogeneic Stem Cell Transplantation (Eric D. Jacobsen)
23(1)
B-Cell NHL
23(8)
Hodgkin's Lymphoma
31(3)
Peripheral T-Cell Lymphoma
34(2)
AlloSCT in Less Common PTCL Subtypes
36(2)
T-Cell Prolymphocyte Leukemia (T-PLL)
38(1)
Adult T-Cell Leukemia Lymphoma (ATLL)
39(1)
Cutaneous T-Cell Lymphoma (CTCL)
40(2)
Conclusion
42(1)
References
42(7)
Resources
49(2)
3 Autologous Transplantation for Multiple Myeloma
51(10)
Omar Nadeem
Jacob P. Laubach
Introduction
51(1)
ASCT in Management of Multiple Myeloma
52(2)
Mobilization and Conditioning
54(2)
Consolidation and Maintenance Therapy
56(1)
Tandem Transplantation
57(1)
Future Directions
58(1)
References
58(3)
4 Allogeneic Hematopoietic Stem Cell Transplantation for Acute and Chronic Leukemias
61(8)
Mahasweta Gooptu
Introduction
61(1)
Diagnosis
61(3)
Special Issues
64(4)
References
68(1)
5 Allogeneic Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome
69(12)
Cindy Lynn Hickey
Corey S. Cutler
Introduction
69(1)
Diagnosis
69(1)
Prognosis
70(1)
Treatment
71(6)
References
77(4)
6 Conditioning Regimen, Graft Sources, and Alternative Donor Transplantation
81(12)
Michael J. Slade
Rizwan Romee
Introduction
81(1)
Donor Classification and Selection
81(5)
Graft Source
86(1)
Conditioning Regimens
87(3)
Future Directions
90(1)
Clinical Vignette and Self-Assessment
91(1)
Questions
91(1)
Answers
92(1)
Resources
92(1)
7 Acute Graft-Versus-Host Disease
93(614)
Phuong Vo
Marco Mielcarek
Introduction
93(1)
Diagnosis
93(2)
Risk Factors
95(2)
Prevention
97(1)
Treatment
98(3)
Potential Practice Changing Clinical Trials
101(1)
Clinical Vignettes and Self-Assessment
102(1)
Questions
102(1)
Answers
103(2)
References
105(2)
8 Chronic Graft-Versus-Host Disease
107(1)
Jennifer Whangbo
John Koreth
Introduction
107(1)
Diagnosis
108(1)
Prognosis
108(1)
Treatment
108(20)
Clinical Vignettes and Self-Assessment
128(1)
Questions
128(1)
Answers
129(1)
References
129(4)
9 Bacterial and Fungal Infections in Hematopoietic Stem Cell Transplantation Recipients
133(1)
Sheila A. Bond
Lindsey R. Baden
Introduction
133(5)
Prevention
138(2)
Diagnosis
140(5)
Treatment
145(3)
References
148(1)
10 Viral Infections After Hematopoietic Stem Cell Transplantation
149(1)
Sarah R. Hammond
Francisco M. Marty
Introduction
149(1)
Diagnosis
150(1)
Prognosis
150(5)
Treatment and Prevention
150(1)
Special Issues
150(1)
Resources
150(13)
11 Pulmonary Complications After Hematopoietic Stem Cell Transplantation
163(1)
Julie Ng
Raja-Elie Abdulnour
Introduction
163(1)
Infectious Pulmonary Complications
163(5)
Noninfectious Pulmonary Complications
168(5)
Late Noninfectious Complications
173(3)
Clinical Vignettes and Self-Assessment
176(3)
Questions
176(2)
Answers
178(1)
References
179(2)
12 Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome
181(1)
Lindsey E. Roeker
Vincent T. Ho
Introduction
181(3)
Diagnosis
184(4)
Treatment and Supportive Care
188(2)
References
190(3)
13 Thrombotic Microangiopathy and Kidney Injury After Hematopoietic Stem Cell Transplantation
193(1)
Fazilet Yilmaz
Vivek Kasinath
Merve Postalcioglu
Vincent! Ho
Reza Abdi
Introduction
193(1)
Diagnosis
193(1)
Pathogenesis and Risk Factors
194(2)
Signs and Symptoms
196(1)
Incidence and Prognosis
197(1)
Treatment
197(2)
References
199(2)
14 Hematologic and Transfusion Issues After Hematopoietic Stem Cell Transplantation
201(1)
Michael Kennah
Natasha Kekre
Introduction
201(1)
Anemia
201(3)
Neutropenia
204(1)
Thrombocytopenia
205(2)
Thrombosis and Bleeding
207(2)
Conclusion
209(1)
Clinical Vignettes and Self-Assessment
209(1)
Questions
209(2)
Answers
211(1)
Resources
211(2)
15 Posttransplant Lymphoproliferative Disorders
213(1)
Jennifer L. Crombie
Ann S. LaCasce
Introduction
213(1)
Diagnosis
213(1)
Presentation
214(1)
Risk Factors
214(2)
Prognosis
216(1)
Treatment
216(1)
Emerging Therapies
217(2)
Conclusion
219(1)
References
219(2)
16 Graft Failure
221(1)
Shaikha Alotaibi
Saud Alhayli
Mahmoud Deeb Saeed Al Jurf
Introduction
221(1)
Diagnosis
221(1)
Causes
222(1)
Disease-Related Factors
222(2)
Transplant-Related Factors
224(2)
Risk Score
226(1)
Treatment
226(2)
References
228(3)
17 Treatment of Disease Relapse After Allogeneic Transplantation
231(1)
Marlise R. Luskin
Edwin P. Alyea
Introduction
231(1)
Predicting Risk of Relapse Using Pretransplant Data
231(2)
Predicting Risk of Relapse With Posttransplant Monitoring
233(1)
Treating Relapsed Disease: Timing and Approach to Chemotherapy
233(2)
Treating Relapsed Disease: Enhancing Graft-Versus-Leukemia
235(3)
Conclusion
238(1)
References
238(5)
18 Chimeric Antigen Receptor T Therapy: Rational and Clinical Applications
243(1)
Eleni Stavrou
Caron A. Jacobson
Introduction
243(2)
Current Applications and Indications
245(1)
Practice Changing Trials
245(3)
B-Cell Acute Lymphoblastic Leukemia
248(1)
Chronic Lymphocytic Leukemia (CLL)
249(2)
Special Issues: Toxicities
251(3)
Resistance
254(4)
Future Directions
258(1)
Conclusion
259(1)
References
260(3)
19 Management of Cytokine Release Syndrome
263(1)
Utkarsh Acharya
Ayse Ece Call Daylan
Prashant Nageshwar
Introduction
263(1)
Pathogenesis
263(1)
Epidemiology
264(1)
Clinical Presentation
265(1)
Diagnosis
265(2)
Treatment
267(4)
Resources
271(2)
20 Cellular Therapy Neurotoxicity: Diagnosis and Management
273(1)
Daniel B. Rubin
Lauren Spendley
Henrikas Vaitkevicius
Introduction
273(1)
Diagnosis
273(12)
Prognosis
285(3)
Treatment
288(1)
Special Considerations
289(2)
Clinical Vignettes and Self-Assessment
291(3)
Questions
291(2)
Answers
293(1)
Resources
294(3)
21 Quality of Life and Long-Term Survivor Issues: A Review of Recommendations of Long-Term Management
297(1)
Ibrahim N. Muhsen
Shahrukh K. Hashmi
Introduction
297(1)
Late Effects of HCT: Prevention and Follow-Up
297(7)
The Role of LTFU Clinics
304(2)
Future Research and Directions
306(1)
Clinical Vignettes and Self-Assessment
307(1)
Questions
307(1)
Answers
308(1)
References
308(1)
Resources
308(1)
22 Biostatisties and Clinical Trials
309(1)
Haesook T. Kim
Introduction
309(1)
Clinical Trials
309(11)
References 320(3)
Index 323