Handbook of Toxicology of Chemical Warfare Agents, Third Edition, covers every aspect of deadly toxic chemicals used in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this essential reference offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors and biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, and countermeasures.
Expanding on the second edition, Handbook of Toxicology of Chemical Warfare Agents has been completely updated, presenting the most recent advances in field. Brand new chapters include a new chapter on emergency preparedness, coverage of the chemical warfare agents used in Syria, the use of the Novichok agent in the UK, and more.
- Unites world-leading experts to bring you cutting-edge, agent-specific information on Chemical Warfare Agents (CWA) and their adverse effects on human and animal health, and the environment
- Provides you with all the information you need on CWA modes of action, detection, prevention, therapeutic treatment and countermeasures
- New to this edition: a full update to reflect the most recent advances in the field and new chapters on emergency preparedness, the chemical warfare agents used in Syria, and the use of the Novichok agent in the UK
Section I: Historical Perspective and Epidemiology
1. History of Toxicology: From Killers to Healers;
2. Historical Perspective
of Chemical Warfare Agents;
3. Global Impact of Chemical Warfare Agents Used
Before and After 1945;
4. Sarin Attacks in Japan: Acute and Delayed Health
Effects in Survivors;
5. Early and Delayed Effects of Sulfur Mustard in
Iranian Veterans After the IraqIran Conflict;
6. Epidemiology of Chemical
Warfare Agents;
7. Chemical Weapons of Mass Destruction and Terrorism: A
Threat Analysis
Section II: Agents That Can Be Used as Weapons of Mass Destruction
8. Organophosphate Nerve Agents;
9. Russian VX;
10. Novichoks;
11. Blister
Agents;
12. Riot Control Agents;
13. Phosgene oxime;
14. Psychotomimetic
Agent BZ (3-Quinuclidinyl Benzilate);
15. Fluoroacetate;
16. Strychnine;
17.
Superwarfarins;
18. PCBs, Dioxins and Furans: Human Exposure and Health
Effects;
19. Polycyclic Aromatic Hydrocarbons: Implications for
Developmental, Molecular, and Behavioral Neurotoxicity;
20. Thallium;
21.
Arsenicals: Toxicity, Their Use as Chemical Warfare Agents, and Possible
Remedial Measures;
22. Chlorine;
23. Phosgene;
24. Carbon Monoxide: Cant
See, Cant Smell, Body Looks Red But They Are Dead;
25. Acute Cyanide
Toxicity and its Treatment: The Body is Dead and Maybe Red but Does Not Stay
Red for Long;
26. Methyl Isocyanate: The Bhopal Gas;
27. Other Toxic
Chemicals as Potential Chemical Warfare Agents;
28. Ricin;
29. Botulinum
Toxin;
30. Onchidal and Fasciculins;
31. Cyanobacterial (Blue-Green Algae)
Toxins
Section III: Target Organ Toxicity
32. Chemical Warfare Agents and the Nervous System;
33. Behavioral Toxicity
of Nerve Agents;
34. The Respiratory Toxicity of Chemical Warfare Agents;
35.
Cardiovascular System as a Target of Chemical Warfare Agents;
36. Ocular
Toxicity of Chemical Warfare Agents;
37. Skeletal Muscle;
38. Dermal Toxicity
of Sulfur Mustard;
39. Reproductive Toxicity and Endocrine Disruption of
Potential Chemical Warfare Agents;
40. Liver Toxicity of Chemical Warfare
Agents;
41. Renal System;
42. Impact of Chemical Warfare Agents on the Immune
System
Section IV: Special Topics
43. Health Effects of Nuclear Weapons and Releases of Radioactive Materials;
44. Clinical and Cellular Aspects of Traumatic Brain Injury;
45. Neurological
Effects and Mechanisms of Blast Overpressure Injury;
46. Genomics and
Proteomics in Brain Complexity in Relation to Chemically-Induced PTSD;
47.
Excitotoxicity, Oxidative Stress, and Neuronal Injury;
48. BloodBrain
Barrier Damage and Dysfunction by Chemical Toxicity;
49. The Effects of
Organophosphates in the Early Stages of Human Skeletal Muscle Regeneration;
50. Experimental modeling for delayed effects of organophosphates;
51.
Alternative Animal Toxicity Testing of Chemical Warfare Agents
Section V: Toxicokinetics, Toxicodynamics and Physiologically-Based
Pharmacokinetics
52. Toxicokinetic Aspects of Nerve Agents and Vesicants;
53. Toxicokinetics
and Toxicodynamics of DFP;
54. Physiologically Based Pharmacokinetic Modeling
of Chemical Warfare Agents;
55. Biotransformation of Warfare Nerve Agents
Section VI: Analytical Methods, Biosensors and Biomarkers
56. Laboratory Analysis of Chemical Warfare Agents, Adducts, and Metabolites
in Biomedical Samples;
57. On-Site Detection of Chemical Warfare Agents;
58.
Neuropathy Target Esterase as a Biomarker and Biosensor of Delayed
Neuropathic Agents;
59. The crosslinking action of organophosphorus poisons;
implications for chronic neurotoxicity;
60. Monitoring of Blood
Cholinesterase Activity in Workers Exposed to Nerve Agents
Section VII: Risks to Animals and Wildlife
61. Potential Agents That Can Cause Contamination of Animal Feed stuff and
Terror;
62. Chemical Warfare Agents and Risks to Animal Health;
63. Threats
to Wildlife by Chemical and Warfare Agents
Section VIII: Emergency Preparedness, Prophylactic, Therapeutic and
Countermeasures
64. Pharmacological Prophylaxis Against Nerve Agent Poisoning: Experimental
Studies and Practical Implications;
65. Prophylactic and Therapeutic Measures in Nerve Agents Poisoning;
66.
Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling of
Countermeasures to Nerve Agents;
67. Research on Medical Countermeasures for
Chemical Attacks on Civilians;
68. Pyridinium Oximes in the Treatment of
Poisoning with Organophosphorus Compounds;
69. Novel Cholinesterase
Reactivators;
70. Paraoxonase (PON1), detoxication of nerve agents, and
modulation of their toxicity;
71. The role of carboxylesterases in
therapeutic interventions of nerve agent poisoning;
72. Catalytic
bioscavengers: the new generation of bioscavenger-based medical
countermeasures
Section IX: Decontamination and Detoxification
73. Rapid Decontamination of Chemical Warfare Agents from the Skin
Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimers disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including seven major books with Elsevier: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, (6) Biomarkers in Toxicology and (7) Neutraceuticals. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.
