In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant and readily applicable information. Among the areas covered are graft manipulation and methods to control T-cell alloreactivity, the nature of the ideal graft and donor, haploidentical transplantation in pediatric and adult patients with malignant and nonmalignant diseases, immunologic reconstitution following transplantation, complications, and the prevention and treatment of relapse post transplantation. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. The book will provide practical support for hematologists and transplant physicians as they attempt to provide optimal care in this exciting but increasingly complex medical specialty.
Historical perspective and current trends in haploidentical
transplantion.- Part 1: Graft manipulation and methods to control T-cell
alloreactivity. -Positive CD34+ cell selection.- Selective allo-depletion:
and CD19+ cell T cell depletion.- T cell addback in T- cell depleted
haploidentical transplant.- Hematopoietic myeloid growth factor primed bone
marrow and peripheral blood hematopoietic progenitor cells.- Photodepletion
of allo-reactive T cells.- Post-transplant cyclophosphamide in haploidentical
transplant.- Part 2: Ideal graft & donor.- Graft source: Marrow versus
peripheral blood with PTCy- Does it matter?.- Anti-HLA antibodies: Assessment
and mitigating strategies.- Selection of haploidentical donors: What is the
art?.- Myeloablative versus non-myeloablative conditioning regimen- Does it
matter and how best to select?.- Part 3: Disease-specific pediatric
population.- Nonmalignant diseases in children.-
en.-="" part="" 4:="" disease-specific="" adult="" population.-=""
non-malignant="" adults.-="" acute="" myelogenous="" leukemia=""
lymphomas-="" parameswaran="" hari.-="" chronic="" leukemias="" and=""
myeloproliferative="" neoplasms.-="" immunologic="" reconstitution=""
after="" haploidentical="" transplantation.-="" prevention="" treatment=""
of="" relapse="" transplant.-="" unique="" complications="" limitations=""
future="" prospects="" transplantation
Stefan Ciurea is Associate Professor in the Department of Stem Cell Transplantation and Cellular Therapy at the University of Texas MD Anderson Cancer Center and leader of the Haploidentical Transplant Program at this institution. Dr. Ciurea received his medical degree from the Gr. T Popa University of Medicine and Pharmacy Iasi, Romania, and had Internal Medicine training at Harrisburg Hospital/PennState University, Fellowship in Hematology/Oncology at the University of Illinois at Chicago and Fellowship in Hematopoietic Stem Cell Transplantation and the University of Texas MD Anderson Cancer Center. He developed a Haploidentical Transplant Program at this institution with the goal to expand safe transplantation to all patients in need. Dr. Ciurea has made significant contributions in this field, primarily in identifying HLA antibodies as major cause of graft failure in mismatched transplantation and improving outcomes for patients with myeloid malignancies treated with hapl
oidentical transplantation, and is principal investigator on multiple clinical trials.
Rupert Handgretinger is Professor of Pediatrics, Chairman of the Department of General Pediatrics and Hematology/Oncology and Medical Director of the Childrens University Hospital Tübingen. He received his medical degree from the Eberhard-Karls-University in Tübingen in 1986 and was trained at the Children's University Hospital Tübingen in General Pediatrics and Hematology/Oncology. In 2000, he was appointed as director of the Division of Stem Cell Transplantation at St. Jude Childrens Research Hospital in Memphis, USA, where he served as a full faculty member and Professor of Pediatrics at the University of Tennessee, Memphis, until 2005. He returned to Tübingen in 2005 when he was appointed as Chairman of the Department of General Pediatrics and Hematology/Oncology at the Children's University Hospital Tübingen. His main research interests are cellular im
munotherapeutic approaches to the treatment of children with various forms of cancer in the context of allogeneic stem cell transplantation. He is especially interested in the establishment of graft engineering techniques to introduce new concepts in haploidentical transplantation and in the elucidation of mechanisms of graft-mediated anti-tumor effects induced by Natural Killer and other effector cells.
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