Contributors |
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xix | |
Preface |
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xl | |
Part 1 The Profession of Medicine |
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1 The Practice of Medicine |
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1 | (7) |
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8 | (5) |
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3 Decision-Making in Clinical Medicine |
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13 | (9) |
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4 Screening and Prevention of Disease |
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22 | (5) |
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5 Health Care Systems in Developed Countries |
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27 | (6) |
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6 The Safety and Quality of Health Care |
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33 | (4) |
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7 Racial and Ethnic Disparities in Health Care |
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37 | (7) |
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8 Ethical Issues in Clinical Medicine |
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44 | (3) |
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9 Palliative and End-of-Life Care |
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47 | (18) |
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Part 2 Cardinal Manifestations and Presentation of Diseases |
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10 Pain: Pathophysiology and Management |
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65 | (8) |
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73 | (8) |
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81 | (4) |
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85 | (4) |
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89 | (13) |
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Section 2 Alterations in Body Temperature |
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102 | (3) |
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105 | (9) |
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17 Fever of Unknown Origin |
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114 | (8) |
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Chantal P. Bleeker-Rovers |
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Section 3 Nervous System Dysfunction |
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122 | (7) |
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129 | (3) |
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132 | (3) |
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21 Neurologic Causes of Weakness and Paralysis |
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135 | (4) |
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22 Numbness, Tingling, and Sensory Loss |
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139 | (4) |
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23 Gait Disorders, Imbalance and Falls |
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143 | (4) |
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24 Confusion and Delirium |
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147 | (5) |
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152 | (5) |
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26 Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes and Other Cerebral Disorders |
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157 | (9) |
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166 | (11) |
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Section 4 Disorders of Eyes, Ears, Nose and Throat |
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177 | (17) |
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29 Disorders of Smell and Taste |
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194 | (6) |
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200 | (8) |
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31 Sore Throat, Earache and Upper Respiratory Symptoms |
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208 | (11) |
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32 Oral Manifestations of Disease |
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219 | (7) |
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Section 5 Alterations in Circulatory and Respiratory Functions |
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226 | (4) |
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230 | (2) |
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232 | (2) |
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234 | (3) |
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237 | (3) |
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38 Approach to the Patient with a Heart Murmur |
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240 | (9) |
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249 | (1) |
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Section 6 Alterations in Gastrointestinal Function |
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249 | (4) |
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41 Nausea, Vomiting and Indigestion |
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253 | (6) |
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42 Diarrhea and Constipation |
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259 | (11) |
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43 Unintentional Weight Loss |
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270 | (2) |
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44 Gastrointestinal Bleeding |
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272 | (4) |
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276 | (5) |
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46 Abdominal Swelling and Ascites |
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281 | (4) |
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Section 7 Alterations in Renal and Urinary Tract Function |
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47 Dysuria, Bladder Pain and the Interstitial Cystitis/Bladder Pain Syndrome |
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285 | (3) |
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48 Azotemia and Urinary Abnormalities |
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288 | (7) |
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49 Fluid and Electrolyte Disturbances |
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295 | (17) |
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50 Hypercalcemia and Hypocalcemia |
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312 | (3) |
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51 Acidosis and Alkalosis |
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315 | (9) |
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Section 8 Alterations in the Skin |
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52 Approach to the Patient with a Skin Disorder |
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324 | (5) |
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53 Eczema, Psoriasis, Cutaneous Infections, Acne and Other Common Skin Disorders |
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329 | (10) |
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54 Skin Manifestations of Internal Disease |
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339 | (16) |
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55 Immunologically Mediated Skin Diseases |
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355 | (7) |
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56 Cutaneous Drug Reactions |
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362 | (10) |
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57 Photosensitivity and Other Reactions to Light |
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372 | (7) |
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Section 9 Hematologic Alterations |
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58 Interpreting Peripheral Blood Smears |
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379 | (6) |
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59 Anemia and Polycythemia |
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385 | (9) |
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60 Disorders of Granulocytes and Monocytes |
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394 | (10) |
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61 Bleeding and Thrombosis |
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404 | (7) |
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62 Enlargement of Lymph Nodes and Spleen |
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411 | (8) |
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Part 3 Pharmacology |
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63 Principles of Clinical Pharmacology |
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419 | (10) |
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429 | (6) |
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Part 4 Oncology and Hematology |
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Section 1 Neoplastic Disorders |
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65 Approach to the Patient with Cancer |
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435 | (8) |
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66 Prevention and Early Detection of Cancer |
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443 | (9) |
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452 | (9) |
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461 | (19) |
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69 Principles of Cancer Treatment |
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480 | (22) |
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70 Infections in Patients with Cancer |
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502 | (9) |
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511 | (11) |
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522 | (10) |
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532 | (5) |
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537 | (18) |
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555 | (11) |
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76 Upper Gastrointestinal Tract Cancers |
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566 | (6) |
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77 Lower Gastrointestinal Cancers |
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572 | (6) |
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78 Tumors of the Liver and Biliary Tree |
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578 | (13) |
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591 | (5) |
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80 Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas |
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596 | (20) |
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616 | (3) |
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82 Cancer of the Bladder and Urinary Tract |
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619 | (4) |
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83 Benign and Malignant Diseases of the Prostate |
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623 | (9) |
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632 | (5) |
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85 Gynecologic Malignancies |
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637 | (6) |
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86 Primary and Metastatic Tumors of the Nervous System |
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643 | (10) |
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87 Soft Tissue and Bone Sarcomas and Bone Metastases |
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653 | (4) |
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88 Carcinoma of Unknown Primary |
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657 | (5) |
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89 Paraneoplastic Syndromes: Endocrinologic/Hematologic |
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662 | (6) |
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90 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis |
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668 | (6) |
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91 Late Consequences of Cancer and Its Treatment |
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674 | (5) |
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Section 2 Hematopoietic Disorders |
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92 Hematopoietic Stem Cells |
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679 | (4) |
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93 Iron Deficiency and Other Hypoproliferative Anemias |
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683 | (7) |
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94 Disorders of Hemoglobin |
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690 | (8) |
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698 | (10) |
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708 | (15) |
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97 Anemia Due to Acute Blood Loss |
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723 | (1) |
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98 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia |
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723 | (10) |
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99 Polycythemia Vera and Other Myeloproliferative Neoplasms |
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733 | (6) |
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100 Acute Myeloid Leukemia |
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739 | (9) |
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101 Chronic Myeloid Leukemia |
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748 | (9) |
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102 Acute Lymphoid Leukemia |
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757 | (6) |
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103 Chronic Lymphocytic Leukemia |
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763 | (6) |
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104 Non-Hodgkin's Lymphoma |
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769 | (11) |
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780 | (3) |
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106 Less Common Hematologic Malignancies |
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783 | (10) |
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107 Plasma Cell Disorders |
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793 | (10) |
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803 | (6) |
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109 Transfusion Biology and Therapy |
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809 | (7) |
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110 Hematopoietic Cell Transplantation |
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816 | (6) |
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Section 3 Disorders of Hemostasis |
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111 Disorders of Platelets and Vessel Wall |
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822 | (8) |
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112 Coagulation Disorders |
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830 | (9) |
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113 Arterial and Venous Thrombosis |
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839 | (4) |
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114 Antiplatelet, Anticoagulant and Fibrinolytic Drugs |
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843 | (16) |
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Part 5 Infectious Diseases |
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Section 1 Basic Considerations in Infectious Diseases |
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115 Approach to the Patient with an Infectious Disease |
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859 | (7) |
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116 Molecular Mechanisms of Microbial Pathogenesis |
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866 | (11) |
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117 Approach to the Acutely Ill Infected Febrile Patient |
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877 | (7) |
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118 Immunization Principles and Vaccine Use |
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884 | (8) |
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119 Health Recommendations for International Travel |
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892 | (8) |
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120 Climate Change and Infectious Disease |
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900 | (8) |
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Section 2 Clinical Syndromes: Community-Acquired Infections |
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908 | (11) |
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919 | (2) |
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123 Infective Endocarditis |
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921 | (12) |
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124 Infections of the Skin, Muscles and Soft Tissues |
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933 | (6) |
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939 | (5) |
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944 | (8) |
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127 Intraabdominal Infections and Abscesses |
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952 | (7) |
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128 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning |
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959 | (5) |
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129 Clostridium difficile Infection, Including Pseudomembranous Colitis |
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964 | (4) |
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130 Urinary Tract Infections, Pyelonephritis and Prostatitis |
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968 | (8) |
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131 Sexually Transmitted Infections: Overview and Clinical Approach |
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976 | (15) |
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991 | (7) |
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998 | (9) |
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134 Chronic and Recurrent Meningitis |
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1007 | (6) |
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135 Brain Abscess and Empyema |
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1013 | (6) |
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136 Infectious Complications of Bites |
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1019 | (3) |
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Section 3 Clinical Syndromes: Health Care-Associated Infections |
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137 Infections Acquired in Health Care Facilities |
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1022 | (8) |
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138 Infections in Transplant Recipients |
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1030 | (12) |
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Section 4 Therapy for Bacterial Diseases |
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139 Treatment and Prophylaxis of Bacterial Infections |
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1042 | (15) |
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140 Bacterial Resistance to Antimicrobial Agents |
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1057 | (5) |
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Section 5 Diseases Caused by Gram-Positive Bacteria |
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141 Pneumococcal Infections |
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1062 | (9) |
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142 Staphylococcal Infections |
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1071 | (10) |
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143 Streptococcal Infections |
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1081 | (8) |
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144 Enterococcal Infections |
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1089 | (6) |
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145 Diphtheria and Other Corynebacterial Infections |
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1095 | (5) |
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146 Listeria monocytogenes Infections |
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1100 | (2) |
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1102 | (3) |
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1105 | (4) |
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149 Gas Gangrene and Other Clostridial Infections |
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1109 | (5) |
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Section 6 Diseases Caused by Gram-Negative Bacteria |
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150 Meningococcal Infections |
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1114 | (8) |
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151 Gonococcal Infections |
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1122 | (7) |
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152 Haemophilus and Moraxella Infections |
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1129 | (5) |
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153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria |
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1134 | (3) |
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154 Legionella Infections |
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1137 | (5) |
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155 Pertussis and Other Bordetella Infections |
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1142 | (4) |
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156 Diseases Caused by Gram-Negative Enteric Bacilli |
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1146 | (12) |
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157 Acinetobacter Infections |
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1158 | (4) |
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158 Helicobacter pylori Infections |
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1162 | (5) |
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159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species |
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1167 | (6) |
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1173 | (7) |
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1180 | (4) |
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162 Infections Due to Campylobacter and Related Organisms |
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1184 | (2) |
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163 Cholera and Other Vibrioses |
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1186 | (6) |
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1192 | (4) |
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1196 | (4) |
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166 Plague and Other Yersinia Infections |
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1200 | (9) |
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167 Bartonella Infections, Including Cat-Scratch Disease |
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1209 | (5) |
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1214 | (1) |
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Section 7 Miscellaneous Bacterial Infections |
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1215 | (5) |
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1220 | (3) |
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1223 | (4) |
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172 Infections Due to Mixed Anaerobic Organisms |
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1227 | (9) |
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Section 8 Mycobacterial Diseases |
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1236 | (23) |
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1259 | (7) |
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175 Nontuberculous Mycobacterial Infections |
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1266 | (4) |
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176 Antimycobacterial Agents |
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1270 | (9) |
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Section 9 Spirochetal Diseases |
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1279 | (7) |
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178 Endemic Treponematoses |
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1286 | (4) |
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1290 | (5) |
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1295 | (3) |
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1298 | (5) |
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Section 10 Diseases Caused by Rickettsiae, Mycoplasmas and Chlamydiae |
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1303 | (10) |
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183 Infections Due to Mycoplasmas |
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1313 | (3) |
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184 Chlamydial Infections |
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1316 | (9) |
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Section 11 Viral Diseases: General Considerations |
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1325 | (9) |
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186 Antiviral Chemotherapy, Excluding Antiretroviral Drugs |
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1334 | (11) |
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Section 12 Infections Due to DNA Viruses |
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187 Herpes Simplex Virus Infections |
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1345 | (9) |
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188 Varicella-Zoster Virus Infections |
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1354 | (4) |
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189 Epstein-Barr Virus Infections, Including Infectious Mononucleosis |
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1358 | (3) |
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190 Cytomegalovirus and Human Herpesvirus Types 6, 7 and 8 |
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1361 | (5) |
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191 Molluscum Contagiosum, Monkeypox and Other Poxvirus Infections |
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1366 | (1) |
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192 Parvovirus Infections |
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1367 | (3) |
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193 Human Papillomavirus Infections |
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1370 | (5) |
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Section 13 Infections Due to DNA and RNA Respiratory Viruses |
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194 Common Viral Respiratory Infections |
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1375 | (7) |
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1382 | (6) |
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Section 14 Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses |
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196 The Human Retroviruses |
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1388 | (5) |
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197 Human Immunodeficiency Virus Disease: AIDS and Related Disorders |
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1393 | (70) |
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Section 15 Infections Due to RNA Viruses |
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198 Viral Gastroenteritis |
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1463 | (5) |
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199 Enterovirus, Parechovirus and Reovirus Infections |
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1468 | (6) |
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1474 | (4) |
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201 Rubella (German Measles) |
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1478 | (3) |
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1481 | (3) |
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203 Rabies and Other Rhabdovirus Infections |
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1484 | (5) |
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204 Arthropod-Borne and Rodent-Borne Virus Infections |
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1489 | (20) |
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205 Ebolavirus and Marburgvirus Infections |
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1509 | (6) |
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Section 16 Fungal Infections |
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206 Diagnosis and Treatment of Fungal Infections |
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1515 | (3) |
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1518 | (3) |
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1521 | (3) |
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1524 | (2) |
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1526 | (3) |
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1529 | (3) |
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1532 | (5) |
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1537 | (4) |
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214 Superficial Mycoses and Less Common Systemic Mycoses |
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1541 | (6) |
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215 Pneumocystis Infections |
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1547 | (4) |
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Section 17 Protozoal and Helminthic Infections: General Considerations |
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216 Introduction to Parasitic Infections |
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1551 | (5) |
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217 Agents Used to Treat Parasitic Infections |
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1556 | (12) |
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Section 18 Protozoal Infections |
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218 Amebiasis and Infection with Free-Living Amebae |
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1568 | (7) |
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1575 | (15) |
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1590 | (4) |
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1594 | (7) |
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222 Chagas Disease and African Trypanosomiasis |
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1601 | (8) |
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223 Toxoplasma Infections |
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1609 | (6) |
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224 Protozoal Intestinal Infections and Trichomoniasis |
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1615 | (5) |
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Section 19 Helminthic Infections |
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225 Introduction to Helminthic Infections |
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1620 | (1) |
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226 Trichinellosis and Other Tissue Nematode Infections |
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1621 | (4) |
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227 Intestinal Nematode Infections |
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1625 | (4) |
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228 Filarial and Related Infections |
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1629 | (6) |
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229 Schistosomiasis and Other Trematode Infections |
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1635 | (6) |
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Birgitte Jyding Vennervald |
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1641 | (8) |
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Part 6 Disorders of the Cardiovascular System |
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Section 1 Introduction to Cardiovascular Disorders |
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231 Approach to the Patient with Possible Cardiovascular Disease |
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1649 | (2) |
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232 Basic Biology of the Cardiovascular System |
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1651 | (11) |
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233 Epidemiology of Cardiovascular Disease |
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1662 | (4) |
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Section 2 Diagnosis of Cardiovascular Disorders |
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234 Physical Examination of the Cardiovascular System |
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1666 | (9) |
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1675 | (8) |
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236 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology and Magnetic Resonance/Computed Tomography Imaging |
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1683 | (26) |
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237 Diagnostic Cardiac Catheterization and Coronary Angiography |
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1709 | (7) |
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Section 3 Disorders of Rhythm |
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238 Principles of Electrophysiology |
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1716 | (6) |
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239 The Bradyarrhythmias: Disorders of the Sinoatrial Node |
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1722 | (5) |
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240 The Bradyarrhythmias: Disorders of the Atrioventricular Node |
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1727 | (6) |
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241 Approach to Supraventricular Tachyarrhythmias |
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1733 | (2) |
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242 Physiologic and Nonphysiologic Sinus Tachycardia |
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1735 | (1) |
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243 Focal Atrial Tachycardia |
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1736 | (3) |
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|
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244 Paroxysmal Supraventricular Tachycardias |
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1739 | (4) |
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245 Common Atrial Flutter, Macroreentrant and Multifocal Atrial Tachycardias |
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1743 | (3) |
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1746 | (4) |
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|
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247 Approach to Ventricular Arrhythmias |
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1750 | (5) |
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248 Premature Ventricular Beats, Non-Sustained Ventricular Tachycardia and Idioventricular Rhythm |
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1755 | (2) |
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|
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249 Sustained Ventricular Tachycardia |
|
|
1757 | (2) |
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|
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250 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation |
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1759 | (3) |
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|
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251 Electrical Storm and Incessant VT |
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1762 | (1) |
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Section 4 Disorders of the Heart |
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|
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252 Heart Failure: Pathophysiology and Diagnosis |
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1763 | (6) |
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253 Heart Failure: Management |
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1769 | (10) |
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254 Cardiomyopathy and Myocarditis |
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1779 | (18) |
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255 Cardiac Transplantation and Prolonged Assisted Circulation |
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1797 | (5) |
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1802 | (7) |
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1809 | (4) |
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1813 | (5) |
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1818 | (3) |
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260 Mitral Valve Prolapse |
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1821 | (2) |
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261 Tricuspid Valve Disease |
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1823 | (3) |
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|
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262 Pulmonic Valve Disease |
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|
1826 | (1) |
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|
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263 Multiple and Mixed Valvular Heart Disease |
|
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1827 | (2) |
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264 Congenital Heart Disease in the Adult |
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1829 | (12) |
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1841 | (6) |
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266 Atrial Myxoma and Other Cardiac Tumors |
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1847 | (3) |
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|
Section 5 Coronary and Peripheral Vascular Disease |
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267 Ischemic Heart Disease |
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1850 | (16) |
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268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina) |
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1866 | (6) |
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|
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269 ST-Segment Elevation Myocardial Infarction |
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1872 | (13) |
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|
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270 Percutaneous Coronary Interventions and Other Interventional Procedures |
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1885 | (5) |
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|
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271 Hypertensive Vascular Disease |
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1890 | (16) |
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|
1906 | (4) |
|
|
273 Deep Venous Thrombosis and Pulmonary Thromboembolism |
|
|
1910 | (7) |
|
|
274 Diseases of the Aorta |
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1917 | (6) |
|
|
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275 Arterial Diseases of the Extremities |
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1923 | (7) |
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|
|
276 Chronic Venous Disease and Lymphedema |
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|
1930 | (5) |
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277 Pulmonary Hypertension |
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|
1935 | (8) |
|
|
Part 7 Disorders of the Respiratory System |
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|
Section 1 Diagnosis of Respiratory Disorders |
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278 Approach to the Patient with Disease of the Respiratory System |
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|
1943 | (2) |
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279 Disturbances of Respiratory Function |
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1945 | (6) |
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280 Diagnostic Procedures in Respiratory Disease |
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|
1951 | (6) |
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Section 2 Diseases of the Respiratory System |
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1957 | (13) |
|
|
282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia |
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|
1970 | (6) |
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|
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283 Occupational and Environmental Lung Disease |
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|
1976 | (7) |
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1983 | (3) |
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|
1986 | (4) |
|
|
286 Chronic Obstructive Pulmonary Disease |
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|
1990 | (9) |
|
|
|
|
287 Interstitial Lung Disease |
|
|
1999 | (7) |
|
|
|
288 Disorders of the Pleura |
|
|
2006 | (3) |
|
|
289 Disorders of the Mediastinum |
|
|
2009 | (1) |
|
|
290 Disorders of Ventilation |
|
|
2010 | (3) |
|
|
|
|
|
2013 | (5) |
|
|
|
|
2018 | (5) |
|
Part 8 Critical Care Medicine |
|
|
Section 1 Respiratory Critical Care |
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|
|
293 Approach to the Patient with Critical Illness |
|
|
2023 | (7) |
|
|
|
294 Acute Respiratory Distress Syndrome |
|
|
2030 | (5) |
|
|
|
295 Mechanical Ventilatory Support |
|
|
2035 | (4) |
|
|
Section 2 Shock and Cardiac Arrest |
|
|
|
296 Approach to the Patient with Shock |
|
|
2039 | (5) |
|
|
297 Sepsis and Septic Shock |
|
|
2044 | (8) |
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|
|
298 Cardiogenic Shock and Pulmonary Edema |
|
|
2052 | (7) |
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|
|
299 Cardiovascular Collapse, Cardiac Arrest and Sudden Cardiac Death |
|
|
2059 | (9) |
|
|
|
Section 3 Neurologic Critical Care |
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|
|
|
2068 | (6) |
|
|
|
|
301 Severe Acute Encephalopathies and Critical Care Weakness |
|
|
2074 | (10) |
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|
|
|
|
302 Subarachnoid Hemorrhage |
|
|
2084 | (5) |
|
|
|
Part 9 Disorders of the Kidney and Urinary Tract |
|
|
303 Cellular and Molecular Biology of the Kidney |
|
|
2089 | (10) |
|
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|
2099 | (12) |
|
|
|
305 Chronic Kidney Disease |
|
|
2111 | (10) |
|
|
|
306 Dialysis in the Treatment of Renal Failure |
|
|
2121 | (5) |
|
|
|
307 Transplantation in the Treatment of Renal Failure |
|
|
2126 | (6) |
|
|
|
|
|
|
2132 | (18) |
|
|
|
309 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development |
|
|
2150 | (7) |
|
|
|
310 Tubulointerstitial Diseases of the Kidney |
|
|
2157 | (7) |
|
|
|
311 Vascular Injury to the Kidney |
|
|
2164 | (4) |
|
|
|
|
2168 | (5) |
|
|
313 Urinary Tract Obstruction |
|
|
2173 | (4) |
|
Part 10 Disorders of the Gastrointestinal System |
|
|
Section 1 Disorders of the Alimentary Tract |
|
|
|
314 Approach to the Patient with Gastrointestinal Disease |
|
|
2177 | (5) |
|
|
|
315 Gastrointestinal Endoscopy |
|
|
2182 | (27) |
|
Louis Michel Wong Kee Song |
|
|
|
316 Diseases of the Esophagus |
|
|
2209 | (11) |
|
|
|
317 Peptic Ulcer Disease and Related Disorders |
|
|
2220 | (24) |
|
|
318 Disorders of Absorption |
|
|
2244 | (14) |
|
|
319 Inflammatory Bowel Disease |
|
|
2258 | (18) |
|
|
|
320 Irritable Bowel Syndrome |
|
|
2276 | (7) |
|
|
321 Diverticular Disease and Common Anorectal Disorders |
|
|
2283 | (8) |
|
|
|
322 Mesenteric Vascular Insufficiency |
|
|
2291 | (3) |
|
|
|
323 Acute Intestinal Obstruction |
|
|
2294 | (4) |
|
|
324 Acute Appendicitis and Peritonitis |
|
|
2298 | (5) |
|
|
|
|
325 Nutrient Requirements and Dietary Assessment |
|
|
2303 | (6) |
|
|
326 Vitamin and Trace Mineral Deficiency and Excess |
|
|
2309 | (10) |
|
|
|
327 Malnutrition and Nutritional Assessment |
|
|
2319 | (5) |
|
|
328 Enteral and Parenteral Nutrition |
|
|
2324 | (8) |
|
|
|
|
Section 3 Liver and Biliary Tract Disease |
|
|
|
329 Approach to the Patient with Liver Disease |
|
|
2332 | (6) |
|
|
|
330 Evaluation of Liver Function |
|
|
2338 | (4) |
|
|
331 The Hyperbilirubinemias |
|
|
2342 | (5) |
|
|
332 Acute Viral Hepatitis |
|
|
2347 | (19) |
|
|
333 Toxic and Drug-Induced Hepatitis |
|
|
2366 | (9) |
|
|
|
|
2375 | (24) |
|
|
335 Alcoholic Liver Disease |
|
|
2399 | (2) |
|
|
|
336 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis |
|
|
2401 | (4) |
|
|
|
337 Cirrhosis and Its Complications |
|
|
2405 | (9) |
|
|
338 Liver Transplantation |
|
|
2414 | (8) |
|
|
|
339 Diseases of the Gallbladder and Bile Ducts |
|
|
2422 | (11) |
|
|
|
Section 4 Disorders of the Pancreas |
|
|
|
340 Approach to the Patient with Pancreatic Disease |
|
|
2433 | (4) |
|
|
|
|
341 Acute and Chronic Pancreatitis |
|
|
2437 | (14) |
|
|
|
Part 11 Immune-Mediated, Inflammatory and Rheumatologic Disorders |
|
|
Section 1 The Immune System in Health and Disease |
|
|
|
342 Introduction to the Immune System |
|
|
2451 | (29) |
|
|
|
|
343 The Major Histocompatibility Complex |
|
|
2480 | (8) |
|
|
344 Primary Immune Deficiency Diseases |
|
|
2488 | (10) |
|
|
Section 2 Disorders of Immune-Mediated Injury |
|
|
|
345 Urticaria, Angioedema, and Allergic Rhinitis |
|
|
2498 | (8) |
|
|
|
|
2506 | (2) |
|
|
|
|
2508 | (2) |
|
|
|
348 Autoimmunity and Autoimmune Diseases |
|
|
2510 | (5) |
|
|
|
349 Systemic Lupus Erythematosus |
|
|
2515 | (11) |
|
|
350 Antiphospholipid Syndrome |
|
|
2526 | (1) |
|
Haralampos M. Moutsopoulos |
|
|
|
2527 | (14) |
|
|
|
352 Acute Rheumatic Fever |
|
|
2541 | (5) |
|
|
353 Systemic Sclerosis (Scleroderma) and Related Disorders |
|
|
2546 | (14) |
|
|
|
2560 | (3) |
|
Haralampos M. Moutsopoulos |
|
|
355 The Spondyloarthritides |
|
|
2563 | (11) |
|
|
356 The Vasculitis Syndromes |
|
|
2574 | (15) |
|
|
|
|
2589 | (1) |
|
Haralampos M. Moutsopoulos |
|
|
358 Inflammatory Myopathies |
|
|
2590 | (7) |
|
|
|
359 Relapsing Polychondritis |
|
|
2597 | (3) |
|
|
|
2600 | (7) |
|
|
|
|
2607 | (3) |
|
|
362 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases |
|
|
2610 | (4) |
|
|
Section 3 Disorders of the Joints and Adjacent Tissues |
|
|
|
363 Approach to Articular and Musculoskeletal Disorders |
|
|
2614 | (10) |
|
|
|
2624 | (7) |
|
|
|
365 Gout and Other Crystal-Associated Arthropathies |
|
|
2631 | (5) |
|
|
|
|
2636 | (3) |
|
|
367 Arthritis Associated with Systemic Disease, and Other Arthritides |
|
|
2639 | (7) |
|
|
|
368 Periarticular Disorders of the Extremities |
|
|
2646 | (3) |
|
Part 12 Endocrinology and Metabolism |
|
|
|
|
369 Approach to the Patient with Endocrine Disorders |
|
|
2649 | (4) |
|
|
370 Mechanisms of Hormone Action |
|
|
2653 | (6) |
|
|
371 Physiology of Anterior Pituitary Hormones |
|
|
2659 | (5) |
|
|
|
|
2664 | (6) |
|
|
|
373 Pituitary Tumor Syndromes |
|
|
2670 | (14) |
|
|
|
374 Disorders of the Neurohypophysis |
|
|
2684 | (8) |
|
|
375 Thyroid Gland Physiology and Testing |
|
|
2692 | (6) |
|
|
|
|
|
2698 | (5) |
|
|
|
|
|
2703 | (7) |
|
|
|
|
378 Thyroid Nodular Disease and Thyroid Cancer |
|
|
2710 | (9) |
|
|
|
|
379 Disorders of the Adrenal Cortex |
|
|
2719 | (20) |
|
|
|
2739 | (7) |
|
|
381 Multiple Endocrine Neoplasia |
|
|
2746 | (10) |
|
|
382 Autoimmune Polyendocrine Syndromes |
|
|
2756 | (4) |
|
|
|
Section 2 Sex- and Gender-Based Medicine |
|
|
|
383 Disorders of Sex Development |
|
|
2760 | (9) |
|
|
|
384 Disorders of the Testes and Male Reproductive System |
|
|
2769 | (18) |
|
|
|
385 Disorders of the Female Reproductive System |
|
|
2787 | (7) |
|
|
386 Menstrual Disorders and Pelvic Pain |
|
|
2794 | (5) |
|
|
|
2799 | (4) |
|
|
388 Menopause and Postmenopausal Hormone Therapy |
|
|
2803 | (7) |
|
|
|
389 Infertility and Contraception |
|
|
2810 | (6) |
|
|
|
2816 | (7) |
|
|
|
2823 | (5) |
|
|
|
2828 | (7) |
|
|
|
393 Lesbian, Gay, Bisexual and Transgender (LGBT) Health |
|
|
2835 | (2) |
|
|
|
Section 3 Obesity, Diabetes Mellitus and Metabolic Syndrome |
|
|
|
394 Pathobiology of Obesity |
|
|
2837 | (6) |
|
|
Elef Iberia Maratos-Flier |
|
|
395 Evaluation and Management of Obesity |
|
|
2843 | (7) |
|
|
396 Diabetes Mellitus: Diagnosis, Classification and Pathophysiology |
|
|
2850 | (9) |
|
|
|
|
397 Diabetes Mellitus: Management and Therapies |
|
|
2859 | (16) |
|
|
|
|
398 Diabetes Mellitus: Complications |
|
|
2875 | (8) |
|
|
|
|
|
2883 | (6) |
|
|
|
400 Disorders of Lipoprotein Metabolism |
|
|
2889 | (14) |
|
|
|
401 The Metabolic Syndrome |
|
|
2903 | (6) |
|
|
Section 4 Disorders of Bone and Mineral Metabolism |
|
|
|
402 Bone and Mineral Metabolism in Health and Disease |
|
|
2909 | (12) |
|
|
|
|
403 Disorders of the Parathyroid Gland and Calcium Homeostasis |
|
|
2921 | (21) |
|
|
|
|
2942 | (17) |
|
|
|
405 Paget's Disease and Other Dysplasias of Bone |
|
|
2959 | (8) |
|
|
|
Section 5 Disorders of Intermediary Metabolism |
|
|
|
406 Heritable Disorders of Connective Tissue |
|
|
2967 | (10) |
|
|
|
|
2977 | (5) |
|
|
|
2982 | (2) |
|
|
|
2984 | (13) |
|
|
|
410 Disorders of Purine and Pyrimidine Metabolism |
|
|
2997 | (6) |
|
|
|
411 Lysosomal Storage Diseases |
|
|
3003 | (6) |
|
|
|
412 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism |
|
|
3009 | (6) |
|
|
|
413 Inherited Disorders of Amino Acid Metabolism in Adults |
|
|
3015 | (5) |
|
|
414 Inherited Defects of Membrane Transport |
|
|
3020 | (5) |
|
Part 13 Neurologic Disorders |
|
|
Section 1 Diagnosis of Neurologic Disorders |
|
|
|
415 Approach to the Patient with Neurologic Disease |
|
|
3025 | (5) |
|
|
|
|
416 Neuroimaging in Neurologic Disorders |
|
|
3030 | (9) |
|
|
417 Pathobiology of Neurologic Diseases |
|
|
3039 | (11) |
|
|
|
|
Section 2 Diseases of the Central Nervous System |
|
|
|
418 Seizures and Epilepsy |
|
|
3050 | (18) |
|
|
419 Cerebrovascular Diseases |
|
|
3068 | (11) |
|
|
|
|
|
3079 | (12) |
|
|
|
|
421 Intracranial Hemorrhage |
|
|
3091 | (5) |
|
|
|
|
422 Migraine and Other Primary Headache Disorders |
|
|
3096 | (12) |
|
|
|
3108 | (7) |
|
|
|
424 Frontotemporal Dementia |
|
|
3115 | (3) |
|
|
|
|
3118 | (1) |
|
|
|
|
426 Dementia with Lewy Bodies |
|
|
3119 | (1) |
|
|
|
|
|
3120 | (12) |
|
|
|
|
428 Tremor, Chorea and Other Movement Disorders |
|
|
3132 | (9) |
|
|
|
|
429 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases |
|
|
3141 | (7) |
|
|
|
3148 | (6) |
|
|
|
|
3154 | (4) |
|
|
432 Disorders of the Autonomic Nervous System |
|
|
3158 | (8) |
|
|
|
433 Trigeminal Neuralgia, Bell's Palsy and Other Cranial Nerve Disorders |
|
|
3166 | (6) |
|
|
|
434 Diseases of the Spinal Cord |
|
|
3172 | (11) |
|
|
435 Concussion and Other Traumatic Brain Injuries |
|
|
3183 | (5) |
|
|
|
|
|
3188 | (14) |
|
|
|
|
3202 | (2) |
|
|
|
Section 3 Nerve and Muscle Disorders |
|
|
|
438 Peripheral Neuropathy |
|
|
3204 | (21) |
|
|
|
439 Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies |
|
|
3225 | (7) |
|
|
|
440 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction |
|
|
3232 | (7) |
|
|
441 Muscular Dystrophies and Other Muscle Diseases |
|
|
3239 | (15) |
|
|
|
Section 4 Chronic Fatigue Syndrome |
|
|
|
442 Chronic Fatigue Syndrome |
|
|
3254 | (2) |
|
|
|
Section 5 Psychiatric and Addiction Disorders |
|
|
|
443 Biology of Psychiatric Disorders |
|
|
3256 | (6) |
|
|
|
|
444 Psychiatric Disorders |
|
|
3262 | (15) |
|
|
445 Alcohol and Alcohol Use Disorders |
|
|
3277 | (7) |
|
|
446 Opioid-Related Disorders |
|
|
3284 | (3) |
|
|
|
447 Cocaine and Other Commonly Used Drugs |
|
|
3287 | (5) |
|
|
|
|
3292 | (5) |
|
Part 14 Poisoning, Drug Overdose and Envenomation |
|
|
449 Heavy Metal Poisoning |
|
|
3297 | (3) |
|
|
450 Poisoning and Drug Overdose |
|
|
3300 | (13) |
|
|
451 Disorders Caused by Venomous Snakebites and Marine Animal Exposures |
|
|
3313 | (11) |
|
|
|
|
|
452 Ectoparasite Infestations and Arthropod Injuries |
|
|
3324 | (9) |
|
|
Part 15 Disorders Associated with Environmental Exposures |
|
|
|
3333 | (5) |
|
|
|
454 Hypothermia and Peripheral Cold Injuries |
|
|
3338 | (5) |
|
|
455 Heat-Related Illnesses |
|
|
3343 | (4) |
|
Part 16 Genes, the Environment and Disease |
|
|
456 Principles of Human Genetics |
|
|
3347 | (22) |
|
|
|
457 The Practice of Genetics in Clinical Medicine |
|
|
3369 | (6) |
|
|
|
|
458 Gene and Cell Based Therapy in Clinical Medicine |
|
|
3375 | (4) |
|
|
|
|
3379 | (12) |
|
|
Part 17 Global Medicine |
|
|
460 Global Issues in Medicine |
|
|
3391 | (10) |
|
|
|
461 Worldwide Changes in Patterns of Infectious Disease |
|
|
3401 | (3) |
|
|
|
462 Primary Care and Global Health |
|
|
3404 | (9) |
|
|
Part 18 Aging |
|
|
|
3413 | (7) |
|
|
|
464 Clinical Problems Associated with the Aging Process |
|
|
3420 | (19) |
|
|
Part 19 Consultative Medicine |
|
|
465 Approach to Medical Consultation |
|
|
3439 | (1) |
|
|
|
466 Medical Disorders During Pregnancy |
|
|
3440 | (6) |
|
|
|
467 Medical Evaluation of the Surgical Patient |
|
|
3446 | (7) |
|
|
Part 20 Frontiers |
|
|
468 Behavioral Economics and Health |
|
|
3453 | (9) |
|
|
|
|
469 Complementary, Alternative and Integrative Health Approaches |
|
|
3462 | (4) |
|
|
|
3466 | (5) |
|
|
|
471 The Role of Epigenetics in Disease and Treatment |
|
|
3471 | (5) |
|
|
|
472 Mitochondrial DNA and Heritable Traits and Diseases |
|
|
3476 | (12) |
|
|
|
473 Applications of Stem Cell Biology in Clinical Medicine |
|
|
3488 | (3) |
|
|
474 Microbial Genomics and Infectious Disease |
|
|
3491 | (13) |
|
|
|
|
475 The Role of Circadian Biology in Health and Disease |
|
|
3504 | (11) |
|
|
|
|
476 Network Medicine: Systems Biology in Health and Disease |
|
|
3515 | (7) |
|
|
477 Emerging Neurotherapeutic Technologies |
|
|
3522 | |
|
|
Index |
|
I-1 | |