Contributors |
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xviii | |
Preface |
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xxxix | |
Harrison's Related Resources |
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xl | |
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PART 1 The Profession of Medicine |
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1 The Practice of Medicine |
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1 | (7) |
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8 | (5) |
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3 Vaccine Opposition and Hesitancy |
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13 | (8) |
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4 Decision-Making in Clinical Medicine |
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21 | (9) |
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5 Precision Medicine and Clinical Care |
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30 | (7) |
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6 Screening and Prevention of Disease |
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37 | (5) |
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7 Global Diversity of Health System Financing and Delivery |
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42 | (8) |
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8 The Safety and Quality of Health Care |
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50 | (4) |
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9 Diagnosis: Reducing Errors and Improving Quality |
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54 | (5) |
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10 Racial and Ethnic Disparities in Health Care |
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59 | (8) |
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11 Ethical Issues in Clinical Medicine |
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67 | (5) |
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12 Palliative and End-of-Life Care |
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72 | (19) |
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PART 2 Cardinal Manifestations and Presentation of Diseases |
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13 Pain: Pathophysiology and Management |
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91 | (9) |
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100 | (8) |
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108 | (4) |
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112 | (5) |
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117 | (13) |
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SECTION 2 Alterations in Body Temperature |
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130 | (3) |
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133 | (12) |
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20 Fever of Unknown Origin |
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145 | (7) |
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Chantal P. Bleeker-Rovers |
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Catharina M. Mulders-Manders |
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SECTION 3 Nervous System Dysfunction |
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152 | (7) |
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159 | (3) |
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162 | (3) |
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24 Neurologic Causes of Weakness and Paralysis |
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165 | (3) |
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25 Numbness, Tingling, and Sensory Loss |
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168 | (5) |
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26 Gait Disorders, Imbalance, and Falls |
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173 | (5) |
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27 Confusion and Delirium |
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178 | (5) |
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183 | (6) |
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189 | (6) |
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30 Aphasia, Memory Loss, and Other Cognitive Disorders |
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195 | (9) |
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204 | (11) |
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SECTION 4 Disorders of Eyes, Ears, Nose, and Throat |
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215 | (17) |
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33 Disorders of Smell and Taste |
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232 | (6) |
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238 | (9) |
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35 Upper Respiratory Symptoms, Including Earache, Sinus Symptoms, and Sore Throat |
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247 | (9) |
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36 Oral Manifestations of Disease |
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256 | (7) |
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SECTION 5 Alterations in Circulatory and Respiratory Functions |
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263 | (4) |
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267 | (3) |
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270 | (2) |
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272 | (3) |
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275 | (3) |
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42 Approach to the Patient with a Heart Murmur |
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278 | (8) |
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286 | (1) |
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SECTION 6 Alterations in Gastrointestinal Function |
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287 | (4) |
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45 Nausea, Vomiting, and Indigestion |
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291 | (6) |
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46 Diarrhea and Constipation |
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297 | (12) |
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47 Unintentional Weight Loss |
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309 | (2) |
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48 Gastrointestinal Bleeding |
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311 | (4) |
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315 | (6) |
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50 Abdominal Swelling and Ascites |
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321 | (4) |
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SECTION 7 Alterations in Renal and Urinary Tract Function |
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51 Interstitial Cystitis/Bladder Pain Syndrome |
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325 | (6) |
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52 Azotemia and Urinary Abnormalities |
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331 | (7) |
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53 Fluid and Electrolyte Disturbances |
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338 | (18) |
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54 Hypercalcemia and Hypocalcemia |
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356 | (3) |
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55 Acidosis and Alkalosis |
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359 | (10) |
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SECTION 8 Alterations in the Skin |
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56 Approach to the Patient with a Skin Disorder |
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369 | (5) |
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57 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders |
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374 | (9) |
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58 Skin Manifestations of Internal Disease |
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383 | (17) |
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59 Immunologically Mediated Skin Diseases |
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400 | (7) |
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60 Cutaneous Drug Reactions |
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407 | (10) |
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61 Photosensitivity and Other Reactions to Sunlight |
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417 | (7) |
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SECTION 9 Hematologic Alterations |
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62 Interpreting Peripheral Blood Smears |
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424 | (7) |
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63 Anemia and Polycythemia |
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431 | (8) |
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64 Disorders of Granulocytes and Monocytes |
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439 | (11) |
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65 Bleeding and Thrombosis |
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450 | (7) |
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66 Enlargement of Lymph Nodes and Spleen |
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457 | (8) |
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67 Principles of Clinical Pharmacology |
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465 | (9) |
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474 | (7) |
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PART 4 Oncology and Hematology |
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SECTION 1 Neoplastic Disorders |
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69 Approach to the Patient with Cancer |
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481 | (9) |
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70 Prevention and Early Detection of Cancer |
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490 | (8) |
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498 | (10) |
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508 | (21) |
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73 Principles of Cancer Treatment |
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529 | (27) |
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74 Infections in Patients with Cancer |
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556 | (9) |
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565 | (13) |
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578 | (12) |
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77 Head and Neck Cancer s |
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590 | (4) |
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594 | (17) |
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611 | (15) |
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80 Upper Gastrointestinal Tract Cancers |
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626 | (10) |
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81 Lower Gastrointestinal Cancers |
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636 | (7) |
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82 Tumors of the Liver and Biliary Tree |
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643 | (14) |
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657 | (6) |
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84 Gastrointestinal Neuroendocrine Tumors |
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663 | (10) |
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673 | (3) |
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86 Cancer of the Bladder and Urinary Tract |
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676 | (5) |
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87 Benign and Malignant Diseases of the Prostate |
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681 | (8) |
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689 | (6) |
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89 Gynecologic Malignancies |
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695 | (6) |
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90 Primary and Metastatic Tumors of the Nervous System |
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701 | (11) |
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91 Soft Tissue and Bone Sarcomas and Bone Metastases |
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712 | (4) |
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92 Carcinoma of Unknown Primary |
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716 | (5) |
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93 Paraneoplastic Syndromes: Endocrinologic/Hematologic |
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721 | (7) |
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94 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis |
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728 | (8) |
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95 Cancer Survivorship and the Long-Term Impact of Cancer and Its Treatment |
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736 | (7) |
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SECTION 2 Hematopoietic Disorders |
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96 Hematopoietic Stem Cells |
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743 | (4) |
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97 Iron Deficiency and Other Hypoproliferative Anemias |
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747 | (7) |
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98 Disorders of Hemoglobin |
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754 | (12) |
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766 | (10) |
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776 | (15) |
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101 Anemia Due to Acute Blood Loss |
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791 | (1) |
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102 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia |
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792 | (10) |
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103 Polycythemia Vera and Other Myeloproliferative Neoplasms |
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802 | (7) |
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104 Acute Myeloid Leukemia |
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809 | (9) |
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105 Chronic Myeloid Leukemia |
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818 | (10) |
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106 Acute Lymphoid Leukemia |
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828 | (6) |
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107 Chronic Lymphocytic Leukemia |
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834 | (7) |
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108 Non-Hodgkin's Lymphoma |
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841 | (11) |
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852 | (3) |
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110 Less Common Lymphoid and Myeloid Malignancies |
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855 | (11) |
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111 Plasma Cell Disorders |
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866 | (12) |
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878 | (6) |
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113 Transfusion Therapy and Biology |
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884 | (13) |
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114 Hematopoietic Cell Transplantation |
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897 | (6) |
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SECTION 3 Disorders of Hemostasis |
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115 Disorders of Platelets and Vessel Wall |
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903 | (7) |
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116 Coagulation Disorders |
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910 | (9) |
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117 Arterial and Venous Thrombosis |
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919 | (5) |
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118 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs |
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924 | (17) |
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PART 5 Infectious Diseases |
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SECTION 1 Basic Considerations in Infectious Diseases |
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119 Approach to the Patient with an Infectious Disease |
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941 | (7) |
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120 Molecular Mechanisms of Microbial Pathogenesis |
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948 | (12) |
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121 Microbial Genomics and Infectious Disease |
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960 | (13) |
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122 Approach to the Acutely 111 Infected Febrile Patient |
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973 | (8) |
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123 Immunization Principles and Vaccine Use |
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981 | (8) |
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124 Health Recommendations for International Travel |
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989 | (12) |
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125 Climate Change and Infectious Disease |
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1001 | (8) |
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SECTION 2 Clinical Syndromes: Community-Acquired Infections |
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1009 | (11) |
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1020 | (2) |
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128 Infective Endocarditis |
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1022 | (12) |
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129 Infections of the Skin, Muscles, and Soft Tissues |
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1034 | (6) |
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1040 | (6) |
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Nongnooch Poowanawittayakom |
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1046 | (8) |
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132 Intraabdominal Infections and Abscesses |
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1054 | (7) |
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133 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning |
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1061 | (5) |
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134 Clostridioides difficile Infection, Including Pseudomembranous Colitis |
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1066 | (4) |
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135 Urinary Tract Infections, Pyelonephritis, and Prostatitis |
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1070 | (8) |
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136 Sexually Transmitted Infections: Overview and Clinical Approach |
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1078 | (16) |
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1094 | (6) |
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1100 | (10) |
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139 Chronic and Recurrent Meningitis |
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1110 | (7) |
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140 Brain Abscess and Empyema |
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1117 | (7) |
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141 Infectious Complications of Bites |
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1124 | (4) |
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SECTION 3 Clinical Syndromes: Health Care-Associated Infections |
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142 Infections Acquired in Health Care Facilities |
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1128 | (8) |
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143 Infections in Transplant Recipients |
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1136 | (12) |
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SECTION 4 Therapy for Bacterial Diseases |
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144 Treatment and Prophylaxis of Bacterial Infections |
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1148 | (15) |
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145 Bacterial Resistance to Antimicrobial Agents |
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1163 | (6) |
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SECTION 5 Diseases Caused by Gram-Positive Bacteria |
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146 Pneumococcal Infections |
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1169 | (9) |
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147 Staphylococcal Infections |
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1178 | (10) |
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148 Streptococcal Infections |
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1188 | (9) |
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149 Enterococcal Infections |
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1197 | (6) |
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150 Diphtheria and Other Corynebacterial Infections |
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1203 | (5) |
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151 Listeria monocytogenes Infections |
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1208 | (3) |
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1211 | (3) |
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1214 | (6) |
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154 Gas Gangrene and Other Clostridial Infections |
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1220 | (5) |
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SECTION 6 Diseases Caused by Gram-Negative Bacteria |
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155 Meningococcal Infections |
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1225 | (9) |
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156 Gonococcal Infections |
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1234 | (7) |
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157 Haemophilus and Moraxella Infections |
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1241 | (5) |
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158 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria |
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1246 | (3) |
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159 Legionella Infections |
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1249 | (8) |
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160 Pertussis and Other Bordetella Infections |
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1257 | (4) |
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161 Diseases Caused by Gram-Negative Enteric Bacilli |
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1261 | (14) |
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162 Acinetobacter Infections |
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1275 | (4) |
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163 Helicobacter pylori Infections |
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1279 | (5) |
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164 Infections Due to Pseudomonas, Burkbolderia, and Stenotrophomonas Species |
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1284 | (7) |
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1291 | (7) |
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1298 | (4) |
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167 Infections Due to Campylobacter and Related Organisms |
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1302 | (3) |
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168 Cholera and Other Vibrioses |
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1305 | (5) |
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1310 | (4) |
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1314 | (6) |
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171 Plague and Other Yersinia Infections |
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1320 | (8) |
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172 Bartonella Infections, Including Cat-Scratch Disease |
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1328 | (6) |
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1334 | (1) |
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SECTION 7 Miscellaneous Bacterial Infections |
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1335 | (5) |
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1340 | (4) |
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1344 | (3) |
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177 Infections Due to Mixed Anaerobic Organisms |
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1347 | (10) |
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SECTION 8 Mycobacterial Diseases |
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1357 | (25) |
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1382 | (10) |
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180 Nontuberculous Mycobacterial Infections |
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1392 | (5) |
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181 Antimycobacterial Agents |
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1397 | (9) |
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SECTION 9 Spirochetal Diseases |
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1406 | (7) |
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183 Endemic Treponematoses |
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1413 | (4) |
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1417 | (4) |
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185 Relapsing Fever and Borrelia miyamotoi Disease |
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1421 | (4) |
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1425 | (6) |
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SECTION 10 Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae |
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1431 | (10) |
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Chantal P. Bleeker-Rovers |
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188 Infections Due to Mycoplasmas |
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1441 | (3) |
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189 Chlamydial Infections |
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1444 | (9) |
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SECTION 11 Viral Diseases: General Considerations |
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190 Principles of Medical Virology |
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1453 | (7) |
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191 Antiviral Chemotherapy, Excluding Antiretroviral Drugs |
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1460 | (10) |
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SECTION 12 Infections Due to DNA Viruses |
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192 Herpes Simplex Virus Infections |
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1470 | (9) |
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193 Varicella-Zoster Virus Infections |
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1479 | (4) |
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194 Epstein-Barr Virus Infections, Including Infectious Mononucleosis |
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1483 | (4) |
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195 Cytomegalovirus and Human Herpesvirus Types 6,7, and 8 |
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1487 | (5) |
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196 Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections |
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1492 | (3) |
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197 Parvovirus Infections |
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1495 | (3) |
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198 Human Papillomavirus Infections |
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1498 | (6) |
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SECTION 13 Infections Due to DNA and RNA Respiratory Viruses |
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199 Common Viral Respiratory Infections, Including COVID-19 |
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1504 | (11) |
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1515 | (6) |
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SECTION 14 Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses |
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201 The Human Retroviruses |
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1521 | (6) |
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202 Human Immunodeficiency Virus Disease: AIDS and Related Disorders |
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1527 | (70) |
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SECTION 15 Infections Due to RNA Viruses |
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203 Viral Gastroenteritis |
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1597 | (5) |
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204 Enterovirus, Parechovirus, and Reovirus Infections |
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1602 | (6) |
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1608 | (4) |
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206 Rubella (German Measles) |
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1612 | (3) |
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1615 | (3) |
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Jessica Leung Mariel Marlow |
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208 Rabies and Other Rhabdovirus Infections |
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1618 | (6) |
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209 Arthropod-Borne and Rodent-Borne Virus Infections |
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1624 | (21) |
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210 Ebolavirus and Marburgvirus Infections |
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1645 | (7) |
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SECTION 16 Fungal Infections |
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211 Pathogenesis, Diagnosis, and Treatment of Fungal Infections |
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1652 | (6) |
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1658 | (3) |
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1661 | (3) |
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1664 | (4) |
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1668 | (3) |
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1671 | (6) |
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1677 | (4) |
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1681 | (5) |
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Brad Spellberg Ashraf S. Ibrahim |
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219 Less Common Systemic Mycoses and Superficial Mycoses |
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1686 | (5) |
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220 Pneumocystis Infections |
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1691 | (5) |
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SECTION 17 Protozoal and Helminthic Infections: General Considerations |
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221 Introduction to Parasitic Infections |
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1696 | (5) |
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222 Agents Used to Treat Parasitic Infections |
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1701 | (13) |
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SECTION 18 Protozoal Infections |
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223 Amebiasis and Infection with Free-Living Amebae |
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1714 | (6) |
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1720 | (16) |
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1736 | (5) |
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1741 | (7) |
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227 Chagas Disease and African Trypanosomiasis |
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1748 | (9) |
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228 Toxoplasma Infections |
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1757 | (7) |
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229 Protozoal Intestinal Infections and Trichomoniasis |
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1764 | (4) |
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SECTION 19 Helminthic Infections |
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230 Introduction to Helminthic Infections |
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1768 | (2) |
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231 Trichinellosis and Other Tissue Nematode Infections |
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1770 | (3) |
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232 Intestinal Nematode Infections |
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1773 | (5) |
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233 Filarial and Related Infections |
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1778 | (6) |
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234 Schistosomiasis and Other Trematode Infections |
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1784 | (6) |
|
Birgitte Jyding Vennervald |
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1790 | (7) |
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PART 6 Disorders of the Cardiovascular System |
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SECTION 1 Introduction to Cardiovascular Disorders |
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236 Approach to the Patient with Possible Cardiovascular Disease |
|
|
1797 | (2) |
|
|
237 Basic Biology of the Cardiovascular System |
|
|
1799 | (11) |
|
|
|
|
238 Epidemiology of Cardiovascular Disease |
|
|
1810 | (5) |
|
|
|
SECTION 2 Diagnosis of Cardiovascular Disorders |
|
|
|
239 Physical Examination of the Cardiovascular System |
|
|
1815 | (9) |
|
|
|
|
1824 | (8) |
|
|
241 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging |
|
|
1832 | (27) |
|
|
Raymond Y. Kwong Scott D. Solomon |
|
|
242 Diagnostic Cardiac Catheterization and Coronary Angiography |
|
|
1859 | (7) |
|
|
|
SECTION 3 Disorders of Rhythm |
|
|
|
243 Principles of Clinical Cardiac Electrophysiology |
|
|
1866 | (7) |
|
|
|
|
244 The Bradyarrhythmias: Disorders of the Sinoatrial Node |
|
|
1873 | (7) |
|
|
|
245 The Bradyarrhythmias: Disorders of the Atrioventricular Node |
|
|
1880 | (8) |
|
|
|
246 Approach to Supraventricular Tachyarrhythmias |
|
|
1888 | (3) |
|
|
|
247 Physiologic and Nonphysiologic Sinus Tachycardia |
|
|
1891 | (2) |
|
|
|
248 Focal Atrial Tachycardia |
|
|
1893 | (1) |
|
|
|
249 Paroxysmal Supraventricular Tachycardias |
|
|
1894 | (5) |
|
|
|
250 Common Atrial Flutter and Macroreentrant and Multifocal Atrial Tachycardias |
|
|
1899 | (4) |
|
|
|
|
1903 | (7) |
|
|
|
252 Approach to Ventricular Arrhythmias |
|
|
1910 | (5) |
|
|
|
253 Premature Ventricular Contractions, Nonsustained Ventricular Tachycardia, and Accelerated Idioventricular Rhythm |
|
|
1915 | (4) |
|
|
|
254 Sustained Ventricular Tachycardia |
|
|
1919 | (4) |
|
|
|
255 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation |
|
|
1923 | (4) |
|
|
|
256 Electrical Storm and Incessant Ventricular Tachycardia |
|
|
1927 | (3) |
|
|
|
SECTION 4 Disorders of the Heart, Muscles, Valves, and Pericardium |
|
|
|
257 Heart Failure: Pathophysiology and Diagnosis |
|
|
1930 | (10) |
|
|
|
258 Heart Failure: Management |
|
|
1940 | (14) |
|
|
|
259 Cardiomyopathy and Myocarditis |
|
|
1954 | (19) |
|
|
|
|
260 Cardiac Transplantation and Prolonged Assisted Circulation |
|
|
1973 | (5) |
|
|
|
1978 | (8) |
|
|
|
|
1986 | (5) |
|
|
|
|
1991 | (4) |
|
|
|
|
1995 | (4) |
|
|
|
265 Mitral Valve Prolapse |
|
|
1999 | (2) |
|
|
|
266 Tricuspid Valve Disease |
|
|
2001 | (3) |
|
|
|
267 Pulmonic Valve Disease |
|
|
2004 | (1) |
|
|
|
268 Multiple and Mixed Valvular Heart Disease |
|
|
2005 | (3) |
|
|
|
269 Congenital Heart Disease in the Adult |
|
|
2008 | (11) |
|
|
|
|
2019 | (6) |
|
|
271 Atrial Myxoma and Other Cardiac Tumors |
|
|
2025 | (3) |
|
|
|
2028 | (2) |
|
|
SECTION 5 Coronary and Peripheral Vascular Disease |
|
|
|
273 Ischemic Heart Disease |
|
|
2030 | (16) |
|
|
|
274 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina) |
|
|
2046 | (7) |
|
|
|
|
275 ST-Segment Elevation Myocardial Infarction |
|
|
2053 | (13) |
|
|
|
276 Percutaneous Coronary Interventions and Other Interventional Procedures |
|
|
2066 | (6) |
|
|
|
|
2072 | (16) |
|
|
|
2088 | (3) |
|
|
279 Deep-Venous Thrombosis and Pulmonary Thromboembolism |
|
|
2091 | (10) |
|
|
280 Diseases of the Aorta |
|
|
2101 | (6) |
|
|
|
281 Arterial Diseases of the Extremities |
|
|
2107 | (8) |
|
|
|
282 Chronic Venous Disease and Lymphedema |
|
|
2115 | (6) |
|
|
|
283 Pulmonary Hypertension |
|
|
2121 | (10) |
|
|
|
PART 7 Disorders of the Respiratory System |
|
|
|
SECTION 1 Diagnosis of Respiratory Disorders |
|
|
|
284 Approach to the Patient with Disease of the Respiratory System |
|
|
2131 | (2) |
|
|
285 Disturbances of Respiratory Function |
|
|
2133 | (7) |
|
|
|
286 Diagnostic Procedures in Respiratory Disease |
|
|
2140 | (7) |
|
|
|
|
SECTION 2 Diseases of the Respiratory System |
|
|
|
|
2147 | (13) |
|
|
288 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia |
|
|
2160 | (6) |
|
|
|
289 Occupational and Environmental Lung Disease |
|
|
2166 | (7) |
|
|
|
2173 | (3) |
|
|
|
|
|
2176 | (4) |
|
|
292 Chronic Obstructive Pulmonary Disease |
|
|
2180 | (10) |
|
|
|
|
293 Interstitial Lung Disease |
|
|
2190 | (7) |
|
|
|
294 Disorders of the Pleura |
|
|
2197 | (3) |
|
|
295 Disorders of the Mediastinum |
|
|
2200 | (1) |
|
|
296 Disorders of Ventilation |
|
|
2201 | (3) |
|
|
|
|
|
2204 | (5) |
|
|
|
|
|
2209 | (5) |
|
Hilary J. Goldberg Hari R. Mallidi |
|
|
299 Interventional Pulmonary Medicine |
|
|
2214 | (3) |
|
|
|
PART 8 Critical Care Medicine |
|
|
|
SECTION 1 Respiratory Critical Care |
|
|
|
300 Approach to the Patient with Critical Illness |
|
|
2217 | (8) |
|
|
|
301 Acute Respiratory Distress Syndrome |
|
|
2225 | (5) |
|
|
|
302 Mechanical Ventilatory Support |
|
|
2230 | (5) |
|
|
SECTION 2 Shock and Cardiac Arrest |
|
|
|
303 Approach to the Patient with Shock |
|
|
2235 | (6) |
|
|
304 Sepsis and Septic Shock |
|
|
2241 | (9) |
|
|
|
|
305 Cardiogenic Shock and Pulmonary Edema |
|
|
2250 | (7) |
|
|
|
306 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death |
|
|
2257 | (10) |
|
|
|
SECTION 3 Neurologic Critical Care |
|
|
|
307 Nervous System Disorders in Critical Care |
|
|
2267 | (12) |
|
|
|
|
|
PART 9 Disorders of the Kidney and Urinary Tract |
|
|
|
308 Approach to the Patient with Renal Disease or Urinary Tract Disease |
|
|
2279 | (8) |
|
|
309 Cell Biology and Physiology of the Kidney |
|
|
2287 | (9) |
|
|
|
|
2296 | (13) |
|
|
|
311 Chronic Kidney Disease |
|
|
2309 | (11) |
|
|
|
312 Dialysis in the Treatment of Kidney Failure |
|
|
2320 | (5) |
|
|
|
313 Transplantation in the Treatment of Renal Failure |
|
|
2325 | (6) |
|
|
|
|
|
2331 | (19) |
|
|
|
315 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development |
|
|
2350 | (7) |
|
|
|
316 Tubulointerstitial Diseases of the Kidney |
|
|
2357 | (7) |
|
|
|
317 Vascular Injury to the Kidney |
|
|
2364 | (4) |
|
|
|
|
2368 | (5) |
|
|
319 Urinary Tract Obstruction |
|
|
2373 | (4) |
|
|
320 Interventional Nephrology |
|
|
2377 | (4) |
|
|
PART 10 Disorders of the Gastrointestinal System |
|
|
|
SECTION 1 Disorders of the Alimentary Tract |
|
|
|
321 Approach to the Patient with Gastrointestinal Disease |
|
|
2381 | (6) |
|
|
|
322 Gastrointestinal Endoscopy |
|
|
2387 | (36) |
|
Louis Michel Wong Kee Song Mark Topazian |
|
|
323 Diseases of the Esophagus |
|
|
2423 | (11) |
|
|
|
324 Peptic Ulcer Disease and Related Disorders |
|
|
2434 | (24) |
|
|
325 Disorders of Absorption |
|
|
2458 | (11) |
|
|
326 Inflammatory Bowel Disease |
|
|
2469 | (21) |
|
|
|
327 Irritable Bowel Syndrome |
|
|
2490 | (7) |
|
|
328 Diverticular Disease and Common Anorectal Disorders |
|
|
2497 | (9) |
|
|
329 Mesenteric Vascular Insufficiency |
|
|
2506 | (2) |
|
|
|
|
330 Acute Intestinal Obstruction |
|
|
2508 | (5) |
|
|
331 Acute Appendicitis and Peritonitis |
|
|
2513 | (4) |
|
|
|
|
332 Nutrient Requirements and Dietary Assessment |
|
|
2517 | (6) |
|
|
333 Vitamin and Trace Mineral Deficiency and Excess |
|
|
2523 | (11) |
|
|
334 Malnutrition and Nutritional Assessment |
|
|
2534 | (5) |
|
|
335 Enteral and Parenteral Nutrition |
|
|
2539 | (7) |
|
|
|
|
SECTION 3 Liver and Biliary Tract Disease |
|
|
|
336 Approach to the Patient with Liver Disease |
|
|
2546 | (7) |
|
|
|
337 Evaluation of Liver Function |
|
|
2553 | (4) |
|
|
|
338 The Hyperbilirubinemias |
|
|
2557 | (5) |
|
|
339 Acute Viral Hepatitis |
|
|
2562 | (22) |
|
|
340 Toxic and Drug-Induced Hepatitis |
|
|
2584 | (7) |
|
|
|
|
2591 | (26) |
|
|
342 Alcohol-Associated Liver Disease |
|
|
2617 | (2) |
|
|
343 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis |
|
|
2619 | (5) |
|
|
|
344 Cirrhosis and Its Complications |
|
|
2624 | (9) |
|
|
|
345 Liver Transplantation |
|
|
2633 | (8) |
|
|
|
346 Diseases of the Gallbladder and Bile Ducts |
|
|
2641 | (11) |
|
|
|
|
SECTION 4 Disorders of the Pancreas |
|
|
|
347 Approach to the Patient with Pancreatic Disease |
|
|
2652 | (5) |
|
|
|
|
348 Acute and Chronic Pancreatitis |
|
|
2657 | (14) |
|
|
|
|
PART 11 Immune-Mediated, Inflammatory, and Rheumatologic Disorders |
|
|
|
SECTION 1 The Immune System in Health and Disease |
|
|
|
349 Introduction to the Immune System |
|
|
2671 | (30) |
|
|
Kelly A. Soderberg Anthony S. Fauci |
|
|
350 Mechanisms of Regulation and Dysregulation of the Immune System |
|
|
2701 | (8) |
|
|
Kelly A. Soderberg Anthony S. Fauci |
|
|
351 Primary Immune Deficiency Diseases |
|
|
2709 | (10) |
|
|
SECTION 2 Disorders of Immune-Mediated Injury |
|
|
|
352 Urticaria, Angioedema, and Allergic Rhinitis |
|
|
2719 | (8) |
|
|
|
|
2727 | (2) |
|
David Hong Joshua A. Boyce |
|
|
|
2729 | (2) |
|
|
|
355 Autoimmunity and Autoimmune Diseases |
|
|
2731 | (5) |
|
|
|
356 Systemic Lupus Erythematosus |
|
|
2736 | (13) |
|
|
|
357 Antiphospholipid Syndrome |
|
|
2749 | (2) |
|
Haralampos M. Moutsopoulos |
|
|
|
|
2751 | (15) |
|
|
|
359 Acute Rheumatic Fever |
|
|
2766 | (5) |
|
|
|
360 Systemic Sclerosis (Scleroderma) and Related Disorders |
|
|
2771 | (16) |
|
|
|
2787 | (3) |
|
Haralampos M. Moutsopoulos |
|
|
|
|
2790 | (12) |
|
|
|
|
363 The Vasculitis Syndromes |
|
|
2802 | (15) |
|
|
|
|
2817 | (2) |
|
365 Inflammatory Myopathies |
|
|
2819 | (7) |
|
|
|
366 Relapsing Polychondritis |
|
|
2826 | (3) |
|
|
|
2829 | (8) |
|
|
|
|
2837 | (3) |
|
|
369 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases |
|
|
2840 | (4) |
|
|
SECTION 3 Disorders of the Joints and Adjacent Tissues |
|
|
|
370 Approach to Articular and Musculoskeletal Disorders |
|
|
2844 | (10) |
|
|
|
2854 | (8) |
|
|
|
372 Gout and Other Crystal-Associated Arthropathies |
|
|
2862 | (6) |
|
|
|
2868 | (3) |
|
|
374 Arthritis Associated with Systemic Disease, and Other Arthritides |
|
|
2871 | (7) |
|
|
|
375 Periarticular Disorders of the Extremities |
|
|
2878 | (3) |
|
|
PART 12 Endocrinology and Metabolism |
|
|
|
|
|
376 Approach to the Patient with Endocrine Disorders |
|
|
2881 | (3) |
|
|
377 Mechanisms of Hormone Action |
|
|
2884 | (7) |
|
|
378 Physiology of Anterior Pituitary Hormones |
|
|
2891 | (5) |
|
|
|
|
2896 | (6) |
|
|
|
380 Pituitary Tumor Syndromes |
|
|
2902 | (16) |
|
|
|
381 Disorders of the Neurohypophysis |
|
|
2918 | (8) |
|
|
|
382 Thyroid Gland Physiology and Testing |
|
|
2926 | (7) |
|
|
|
|
|
2933 | (5) |
|
|
|
|
384 Hyperthyroidism and Other Causes of Thyrotoxicosis |
|
|
2938 | (8) |
|
|
|
|
385 Thyroid Nodular Disease and Thyroid Cancer |
|
|
2946 | (9) |
|
|
|
|
386 Disorders of the Adrenal Cortex |
|
|
2955 | (21) |
|
|
|
2976 | (7) |
|
|
388 Multiple Endocrine Neoplasia Syndromes |
|
|
2983 | (9) |
|
|
389 Autoimmune Polyendocrine Syndromes |
|
|
2992 | (5) |
|
|
|
SECTION 2 Sex- and Gender-Based Medicine |
|
|
|
|
2997 | (9) |
|
|
|
|
391 Disorders of the Testes and Male Reproductive System |
|
|
3006 | (21) |
|
|
|
392 Disorders of the Female Reproductive System |
|
|
3027 | (6) |
|
|
|
393 Menstrual Disorders and Pelvic Pain |
|
|
3033 | (6) |
|
|
|
|
3039 | (4) |
|
|
395 Menopause and Postmenopausal Hormone Therapy |
|
|
3043 | (7) |
|
|
|
396 Infertility and Contraception |
|
|
3050 | (5) |
|
|
|
|
3055 | (8) |
|
|
|
3063 | (6) |
|
|
|
|
3069 | (9) |
|
|
400 Lesbian, Gay, Bisexual, and Transgender (LGBT) Health |
|
|
3078 | (2) |
|
|
|
SECTION 3 Obesity, Diabetes Mellitus, and Metabolic Syndrome |
|
|
|
401 Pathobiology of Obesity |
|
|
3080 | (7) |
|
|
|
402 Evaluation and Management of Obesity |
|
|
3087 | (7) |
|
|
403 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology |
|
|
3094 | (10) |
|
|
|
|
404 Diabetes Mellitus: Management and Therapies |
|
|
3104 | (16) |
|
|
|
|
405 Diabetes Mellitus: Complications |
|
|
3120 | (9) |
|
|
|
|
|
3129 | (6) |
|
|
|
407 Disorders of Lipoprotein Metabolism |
|
|
3135 | (15) |
|
|
408 The Metabolic Syndrome |
|
|
3150 | (7) |
|
|
SECTION 4 Disorders of Bone and Mineral Metabolism |
|
|
|
409 Bone and Mineral Metabolism in Health and Disease |
|
|
3157 | (12) |
|
|
Henry M. Kronenberg Eva S. Liu |
|
|
410 Disorders of the Parathyroid Gland and Calcium Homeostasis |
|
|
3169 | (22) |
|
|
|
|
3191 | (18) |
|
|
|
412 Paget's Disease and Other Dysplasias of Bone |
|
|
3209 | (8) |
|
|
|
SECTION 5 Disorders of Intermediary Metabolism |
|
|
|
413 Heritable Disorders of Connective Tissue |
|
|
3217 | (13) |
|
|
|
|
3230 | (5) |
|
|
|
|
3235 | (2) |
|
|
|
3237 | (11) |
|
|
|
417 Disorders of Purine and Pyrimidine Metabolism |
|
|
3248 | (6) |
|
|
|
418 Lysosomal Storage Diseases |
|
|
3254 | (7) |
|
|
|
419 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism |
|
|
3261 | (7) |
|
|
420 Inherited Disorders of Amino Acid Metabolism in Adults |
|
|
3268 | (6) |
|
|
421 Inherited Defects of Membrane Transport |
|
|
3274 | (3) |
|
|
PART 13 Neurologic Disorders |
|
|
|
SECTION 1 Diagnosis of Neurologic Disorders |
|
|
|
422 Approach to the Patient with Neurologic Disease |
|
|
3277 | (5) |
|
|
|
|
423 Neuroimaging in Neurologic Disorders |
|
|
3282 | (11) |
|
|
424 Pathobiology of Neurologic Diseases |
|
|
3293 | (12) |
|
|
|
|
SECTION 2 Diseases of the Central Nervous System |
|
|
|
425 Seizures and Epilepsy |
|
|
3305 | (19) |
|
|
|
426 Introduction to Cerebrovascular Diseases |
|
|
3324 | (11) |
|
|
|
|
|
3335 | (13) |
|
|
|
|
428 Intracranial Hemorrhage |
|
|
3348 | (5) |
|
|
|
|
429 Subarachnoid Hemorrhage |
|
|
3353 | (4) |
|
|
|
|
430 Migraine and Other Primary Headache Disorders |
|
|
3357 | (13) |
|
|
|
3370 | (8) |
|
|
|
|
432 Frontotemporal Dementia |
|
|
3378 | (3) |
|
|
|
|
3381 | (4) |
|
|
|
434 Dementia with Lewy Bodies |
|
|
3385 | (1) |
|
|
|
|
|
3386 | (14) |
|
|
|
436 Tremor, Chorea, and Other Movement Disorders |
|
|
3400 | (10) |
|
|
|
437 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases |
|
|
3410 | (6) |
|
|
|
3416 | (6) |
|
|
|
|
3422 | (5) |
|
|
440 Disorders of the Autonomic Nervous System |
|
|
3427 | (9) |
|
|
|
441 Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders |
|
|
3436 | (9) |
|
|
|
442 Diseases of the Spinal Cord |
|
|
3445 | (11) |
|
|
443 Concussion and Other Traumatic Brain Injuries |
|
|
3456 | (6) |
|
|
|
|
|
3462 | (15) |
|
|
|
|
3477 | (3) |
|
|
|
SECTION 3 Nerve and Muscle Disorders |
|
|
|
446 Peripheral Neuropathy |
|
|
3480 | (21) |
|
|
|
447 Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies |
|
|
3501 | (8) |
|
|
|
448 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction |
|
|
3509 | (7) |
|
|
449 Muscular Dystrophies and Other Muscle Diseases |
|
|
3516 | (16) |
|
|
|
SECTION 4 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
|
|
|
450 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
|
|
3532 | (2) |
|
|
|
|
SECTION 5 Psychiatric and Addiction Disorders |
|
|
|
451 Biology of Psychiatric Disorders |
|
|
3534 | (6) |
|
Robert O. Messing Eric J. Nestler |
|
|
|
452 Psychiatric Disorders |
|
|
3540 | (16) |
|
|
453 Alcohol and Alcohol Use Disorders |
|
|
3556 | (7) |
|
|
|
3563 | (4) |
|
|
455 Marijuana and Marijuana Use Disorders |
|
|
3567 | (2) |
|
|
|
|
456 Opioid-Related Disorders |
|
|
3569 | (4) |
|
|
|
457 Cocaine, Other Psychostimulants, and Hallucinogens |
|
|
3573 | (6) |
|
|
|
PART 14 Poisoning, Drug Overdose, and Envenomation |
|
|
|
458 Heavy Metal Poisoning |
|
|
3579 | (3) |
|
|
459 Poisoning and Drug Overdose |
|
|
3582 | (14) |
|
|
460 Disorders Caused by Venomous Snakebites and Marine Animal Exposures |
|
|
3596 | (12) |
|
|
|
|
461 Ectoparasite Infestations and Arthropod Injuries |
|
|
3608 | (9) |
|
|
|
PART 15 Disorders Associated with Environmental Exposures |
|
|
|
|
3617 | (6) |
|
|
|
463 Hyperbaric and Diving Medicine |
|
|
3623 | (7) |
|
|
|
464 Hypothermia and Peripheral Cold Injuries |
|
|
3630 | (5) |
|
|
465 Heat-Related Illnesses |
|
|
3635 | (4) |
|
|
PART 16 Genes, the Environment, and Disease |
|
|
|
466 Principles of Human Genetics |
|
|
3639 | (23) |
|
|
|
467 The Practice of Genetics in Clinical Medicine |
|
|
3662 | (6) |
|
|
|
|
468 Mitochondrial DNA and Heritable Traits and Diseases |
|
|
3668 | (12) |
|
|
|
|
3680 | (5) |
|
|
|
470 Gene- and Cell-Based Therapy in Clinical Medicine |
|
|
3685 | (5) |
|
|
|
|
3690 | (13) |
|
|
|
|
|
472 Global Issues in Medicine |
|
|
3703 | (10) |
|
|
|
473 Emerging and Reemerging Infectious Diseases |
|
|
3713 | (5) |
|
|
|
474 Primary Care and Global Health |
|
|
3718 | (8) |
|
|
|
475 Health Effects of Climate Change |
|
|
3726 | (7) |
|
|
|
|
|
|
|
3733 | (6) |
|
|
|
477 Caring for the Geriatric Patient |
|
|
3739 | (22) |
|
|
|
PART 19 Consultative Medicine |
|
|
|
478 Approach to Medical Consultation |
|
|
3761 | (1) |
|
|
|
479 Medical Disorders During Pregnancy |
|
|
3762 | (7) |
|
|
|
480 Medical Evaluation of the Surgical Patient |
|
|
3769 | (6) |
|
|
|
|
|
481 Behavioral Economics and Health |
|
|
3775 | (9) |
|
|
|
|
482 Complementary and Integrative Therapies and Practices |
|
|
3784 | (6) |
|
|
483 The Role of Epigenetics in Disease and Treatment |
|
|
3790 | (6) |
|
|
|
484 Applications of Stem Cell Biology in Clinical Medicine |
|
|
3796 | (4) |
|
|
485 The Role of Circadian Biology in Health and Disease |
|
|
3800 | (12) |
|
|
|
|
486 Network Medicine: Systems Biology in Health and Disease |
|
|
3812 | (7) |
|
|
487 Emerging Neurotherapeutic Technologies |
|
|
3819 | (7) |
|
|
|
488 Machine Learning and Augmented Intelligence in Clinical Medicine |
|
|
3826 | (5) |
|
|
|
|
3831 | (5) |
|
|
|
490 Circulating Nucleic Acids as Liquid Biopsies and Noninvasive Disease Biomarkers |
|
|
3836 | (10) |
|
|
|
|
491 Protein Folding Disorders |
|
|
3846 | (5) |
|
|
|
492 Novel Approaches to Diseases of Unknown Etiology |
|
|
3851 | |
|
|
|
Index |
|
1 | |