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PART I MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY |
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1 | (92) |
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Anatomy and Physiology of the Gene |
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3 | (13) |
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Genomic Approaches to the Study of Hematologic Science |
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16 | (9) |
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Protein Synthesis, Processing, and Trafficking |
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25 | (9) |
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Protein Degradation in Cells |
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34 | (8) |
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Protein Architecture: Relationship of Form and Function |
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42 | (7) |
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Regulation of Cellular Response |
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49 | (12) |
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61 | (11) |
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72 | (9) |
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Pharmacogenomics and Hematologic Diseases |
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81 | (12) |
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PART II IMMUNOLOGIC BASIS OF HEMATOLOGY |
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93 | (92) |
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Overview and Compartmentalization of the Immune System |
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95 | (10) |
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105 | (12) |
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117 | (12) |
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Natural Killer Cell Immunity |
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129 | (6) |
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135 | (9) |
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Zbigniew M. Szczepiorkowski |
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Regulation of Activation of B and T Lymphocytes |
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144 | (17) |
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161 | (8) |
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Cell Trafficking and Chemokines |
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169 | (7) |
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Tolerance and Autoimmunity |
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176 | (9) |
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PART III BIOLOGY OF STEM CELLS AND DISORERS OF HEMATOPOIESIS |
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185 | (484) |
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Overview of Stem Cell Biology |
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187 | (13) |
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Cellular Biology of Hematopoiesis |
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200 | (13) |
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Transcription Facors in Normal and Malignant Hematopoiesis |
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213 | (18) |
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Nonhematopoietic Stem Cells Originating Within the Bone Marrow |
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231 | (14) |
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Interactions Between Hematopoietic Stem/Progenitor Cells and the Bone Marrow: The Biology of Stem Cell Homing and Mobilization |
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245 | (8) |
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The Humoral Regulation of Hematopoiesis |
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253 | (23) |
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Biology of Erythropoiesis, Erythroid Differentiation, and Maturation |
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276 | (19) |
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Granulocytopoiesis and Monocytopoiesis |
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295 | (10) |
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305 | (14) |
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Inherited Forms of Bone Marrow Failure |
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319 | (40) |
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359 | (26) |
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Paroxysmal Nocturnal Hemoglobinuria |
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385 | (10) |
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Acquired Disorders of Red Cell and White Cell Production |
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395 | (16) |
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Thrombocytopenia Due to Decreased Platelet Production |
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411 | (16) |
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Pathobiology of the Human Erythrocyte and Its Hemoglobins |
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427 | (12) |
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Approach to Anemia in the Adult and Child |
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439 | (8) |
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Pathology of Iron Metabolism |
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447 | (6) |
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Disorders of Iron Metabolism: Iron Deficiency and Iron Overload |
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453 | (16) |
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Anemia of Chronic Diseases |
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469 | (6) |
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Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias |
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475 | (16) |
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491 | (34) |
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Laboratory Diagnosis of Hemoglobinopathies and Thalassemias |
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525 | (10) |
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535 | (30) |
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Pathobiology of Sickle Cell Disease |
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565 | (12) |
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Sickle Cell Disease---Clinical Features and Management |
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577 | (26) |
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Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias |
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603 | (8) |
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Red Blood Cell Enzymopathies |
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611 | (12) |
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Red Blood Cell Membrane Disorders |
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623 | (22) |
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Autoimmune Hemolytic Anemia |
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645 | (14) |
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Extrinsic Nonimmune Hemolytic Anemias |
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659 | (10) |
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PART V HOST DEFENSE AND ITS DISORDERS |
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669 | (120) |
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Complement and Immunoglobulin Biology |
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671 | (16) |
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Disorders of Phagocyte Function and Number |
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687 | (34) |
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Disorders of Lymphocyte Function |
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721 | (26) |
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747 | (14) |
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Lysosomal Storage Diseases: Perspectives and Principles |
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761 | (18) |
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Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases |
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779 | (10) |
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PART VI HEMATOLOGIC MALIGNANCIES |
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789 | (980) |
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Conventional and Molecular Cytogenetic Basis of Hematologic Malignancies |
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791 | (48) |
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Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies |
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839 | (60) |
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Radiation Therapy in the Treatment of Hematologic Malignancies |
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899 | (8) |
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Clinical Use of Hematopoietic Growth Factors |
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907 | (14) |
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Pathobiology of Acute Myeloid Leukemia |
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921 | (12) |
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Clinical Manifestations of Acute Myeloid Leukemia |
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933 | (32) |
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Therapy for Acute Myeloid Leukemia |
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965 | (26) |
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Acute Myeloid Leukemia in Children |
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991 | (12) |
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Pathobiology of Acute Lymphoblastic Leukemia |
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1003 | (16) |
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Clinical Manifestations of Acute Lymphoblastic Leukemia |
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1019 | (8) |
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Treatment of Childhood Acute Lymphoblastic Leukemia |
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1027 | (6) |
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Acute Lymphocytic Leukemia in Adults |
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1033 | (18) |
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Myelodysplastic Syndromes: Biology and Treatment |
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1051 | (22) |
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1073 | (36) |
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1109 | (16) |
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1125 | (24) |
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Essential Thrombocythemia |
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1149 | (18) |
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Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes |
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1167 | (20) |
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Mast Cells and Systemic Mastocytosis |
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1187 | (12) |
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Myelodysplastic and Myeloproliferative Syndrome in Children |
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1199 | (8) |
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Pathobiology of Non-Hodgkin Lymphoma |
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1207 | (14) |
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Pathobiology of Hodgkin Lymphoma |
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1221 | (18) |
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Hodgkin Lymphoma: Clinical Manifestations, Staging, and Therapy |
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1239 | (26) |
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The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas |
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1265 | (16) |
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Clinical Manifestations, Staging, and Treatment of Indolent Non-Hodgkin Lymphoma |
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1281 | (12) |
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Diagnosis and Treatment of Non-Hodgkin Lymphoma (Aggressive) |
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1293 | (10) |
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Malignant Lymphomas in Childhood |
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1303 | (12) |
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Radioimmunotherapy for B-Cell and Non-Hodgkin Lymphoma |
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1315 | (12) |
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Chronic Lymphocytic Leukemia |
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1327 | (22) |
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1349 | (10) |
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Cutaneous T-Cell Lymphomas |
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1359 | (18) |
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1377 | (10) |
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1387 | (26) |
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Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma |
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1413 | (12) |
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Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis) |
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1425 | (24) |
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Atypical Immune Lymphoproliferations |
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1449 | (12) |
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Clinical Approach to Infections in the Compromised Host |
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1461 | (14) |
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Nutritional Support of Patients with Hematologic Malignancies |
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1475 | (16) |
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Psychosocial Aspects of Hematologic Disorders |
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1491 | (10) |
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Pain Management and Antiemetic Therapy in Hematologic Disorders |
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1501 | (16) |
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1517 | (8) |
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Indwelling Access Devices |
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1525 | (14) |
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Late Complications of Hematologic Diseases and Their Therapies |
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1539 | (16) |
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Overview of Cell- and Immune-Based Therapies |
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1555 | (6) |
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Hematopoietic Stem Cell Transplantation for Acquired Nonmalignant Diseases and Myelodysplastic Syndrome |
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1561 | (16) |
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Hematopoietic Stem Cell Transplantation for Immune Deficiencies and Genetic Diseases |
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1577 | (10) |
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Outcomes of Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults |
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1587 | (18) |
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Autologous Transplantation for Hematologic Malignancies |
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1605 | (14) |
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Unrelated Donor Hematopoietic Cell Transplantation |
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1619 | (14) |
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Haploidentical Hematopoietic Cell Transplantation |
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1633 | (10) |
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Umbilical Cord Blood Transplantation |
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1643 | (22) |
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Preparative Regimens for Hematopoietic Cell Transplantation |
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1665 | (12) |
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Graft-versus-Host Disease and Graft-versus-Leukemia Responses |
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1677 | (18) |
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Practical Aspects of Stem Cell Collection |
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1695 | (18) |
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Graft Engineering and Cell Processing |
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1713 | (10) |
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Gene Transfer for Hematologic Disorders |
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1723 | (12) |
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Experimental Cell Therapy |
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1735 | (12) |
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Stem Cells for Tissue Repair |
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1747 | (8) |
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Complications After Hematopoietic Cell Transplantation |
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1755 | (14) |
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PART VIII HEMOSTASIS AND THROMBOSIS |
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1769 | (392) |
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Megakaryocyte and Platelet Structure |
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1771 | (10) |
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The Molecular Basis for Platelet Function |
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1781 | (12) |
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The Molecular Basis of Platelet Activation |
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1793 | (12) |
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1805 | (14) |
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Molecular Basis of Blood Coagulation |
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1819 | (18) |
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Molecular and Cellular Basis of Fibrinolysis |
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1837 | (6) |
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Regulatory Mechanisms in Hemostasis: Natural Anticoagulants |
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1843 | (8) |
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Clinical Evaluation of Hemorrhagic Disorders: The Bleeding History and Differential Diagnosis of Purpura |
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1851 | (26) |
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Laboratory Evaluation of Hemostatic amd Thrombotic Disorders |
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1877 | (8) |
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Structure, Biology, and Genetics of Factor VIII |
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1885 | (14) |
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Biochemistry of Factor IX and Molecular Biology of Hemophilia B |
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1899 | (12) |
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Clinical Aspects and Therapy of Hemophilia |
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1911 | (20) |
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Inhibitors in Hemophilia A and B |
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1931 | (8) |
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Rare Coagulation Factor Deficiencies |
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1939 | (14) |
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Structure, Biology, and Genetics of Von Willebrand Factor |
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1953 | (8) |
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Von Willebrand Disease: Clinical Aspects and Therapy |
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1961 | (12) |
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Vitamin K: Metabolism and Disorders |
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1973 | (6) |
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Lupus Anticoagulant and Acquired Inhibitors of Blood Coagulation |
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1979 | (20) |
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Disseminated Intravascular Coagulation |
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1999 | (11) |
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Disorders of Coagulation in the Neonate |
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2010 | (11) |
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2021 | (22) |
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2043 | (12) |
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2055 | (12) |
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2067 | (16) |
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Immune Thrombocytopenic Purpura, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura |
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2083 | (16) |
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Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome |
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2099 | (14) |
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Thrombocytopenia Due to Platelet Destruction and Hypersplenism |
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2113 | (20) |
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Hereditary Disorders of Platelet Function |
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2133 | (12) |
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Acquired Disorders of Platelet Function |
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2145 | (16) |
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PART IX TRANSFUSION MEDICINE |
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2161 | (140) |
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Human Blood Group Antigens and Antibodies |
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2163 | (16) |
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2179 | (12) |
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Human Leukocyte Antigen and Human Neutrophil Antigen Systems |
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2191 | (18) |
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Principles of Red Blood Cell Transfusion |
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2209 | (10) |
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Principles of Platelet Transfusion Therapy |
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2219 | (6) |
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Principles of Neutrophil (Granulocyte) Transfusions |
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2225 | (6) |
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Transfusion of Plasma Derivatives: Fresh-Frozen Plasma, Cryoprecipitate, Albumin, and Immunoglobulins |
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2231 | (8) |
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Preparation of Plasma-Derived and Recombinant Human Plasma Proteins |
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2239 | (8) |
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Transfusion Therapy for Coagulation Factor Deficiencies |
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2247 | (10) |
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Hemapheresis and Cellular Therapy |
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2257 | (10) |
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2267 | (10) |
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Transfusion-Transmitted Diseases |
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2277 | (14) |
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Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation |
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2291 | (10) |
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PART X CONSULTATIVE HEMATOLOGY |
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2301 | (142) |
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Hematologic Manifestations of Systemic Disease: Liver and Renal Disease |
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2303 | (6) |
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Hematologic Manifestations of Systemic Disease: Infection, Chronic Inflammation, and Cancer |
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2309 | (12) |
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Hematologic Manifestations of AIDS |
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2321 | (20) |
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Hematologic Aspects of Parasitic Diseases |
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2341 | (28) |
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Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis |
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2369 | (16) |
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Hematologic Changes of Pregnancy |
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2385 | (12) |
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Hematologic Manifestations of Childhood Illness |
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2397 | (22) |
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The Spleen and Its Disorders |
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2419 | (12) |
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Appendix: Normal Blood Values: Selected Reference Values for Neonatal, Pediatric, and Adult Populations |
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2431 | (12) |
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| Index |
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2443 | |
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1 | (22) |
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Molecular and Cellular Biology of the Cell |
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1 | (1) |
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Compartmentalization of the Cell |
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1 | (1) |
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1 | (4) |
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Gene Transcription and mRNA Translation: The Production and Journey of mRNA |
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5 | (4) |
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DNA Mutations Can Alter Protein Synthesis by a Number of Mechanisms |
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9 | (1) |
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Transcriptional Control of Gene Expression |
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9 | (4) |
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CIS-Elements and Transcription Factors |
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10 | (1) |
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Chromatin and Epigenetic Control of Gene Expression |
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11 | (2) |
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Transcription Factors, Control of Gene Expression, and Lineage Commitment |
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13 | (1) |
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14 | (1) |
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DNA Replication and Telomeres |
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14 | (2) |
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Mutations and How They Result in Disease |
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16 | (2) |
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18 | (1) |
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19 | (2) |
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21 | (1) |
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21 | (1) |
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21 | (1) |
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22 | (1) |
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Cellular Basis of Hematopoiesis |
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23 | (8) |
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Road Maps of Hematopoiesis: Cellular Pathways as HSCs Differentiate into Terminally Mature Cells |
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24 | (3) |
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Transcriptional Control of Hematopoiesis |
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27 | (1) |
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28 | (3) |
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31 | (12) |
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Signaling at Different Stages of Hematopoiesis |
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31 | (5) |
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36 | (1) |
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Signaling Pathways Downstream of Receptors |
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36 | (5) |
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36 | (1) |
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Cytokine Signaling Pathways |
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37 | (1) |
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The RAS/MAPK Kinase Pathway |
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38 | (1) |
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39 | (1) |
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39 | (2) |
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Mutations in Signaling Components Leading to Clonal Hematologic Disorders |
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|
41 | (2) |
|
Maturation of Blood Cells and their Examination in Peripheral Blood and Bone Marrow |
|
|
43 | (32) |
|
Examination of Peripheral Blood and the Bone Marrow |
|
|
44 | (2) |
|
Erythroid Cells in the Bone Marrow and Peripheral Blood |
|
|
46 | (3) |
|
Megakaryocyte and Platelet Production |
|
|
49 | (1) |
|
Granulopoiesis and Monocyte Production |
|
|
50 | (7) |
|
|
|
52 | (5) |
|
Mononuclear Phagocytic System |
|
|
57 | (1) |
|
Reticuloendothelial System |
|
|
57 | (2) |
|
Lymphokines, Monokines, Chemokines |
|
|
59 | (3) |
|
|
|
59 | (1) |
|
|
|
59 | (1) |
|
|
|
59 | (1) |
|
|
|
59 | (1) |
|
|
|
59 | (2) |
|
|
|
61 | (1) |
|
Interleukin-10, 12, and 15 |
|
|
61 | (1) |
|
|
|
61 | (1) |
|
|
|
61 | (1) |
|
Lymphocytes and Plasma Cells |
|
|
62 | (7) |
|
|
|
62 | (3) |
|
|
|
65 | (2) |
|
|
|
67 | (2) |
|
Lymphocyte Proliferation and Differentiation |
|
|
69 | (3) |
|
Somatic Hypermutation in Normal B Cells |
|
|
72 | (1) |
|
|
|
72 | (1) |
|
|
|
72 | (3) |
|
|
|
75 | (18) |
|
|
|
75 | (1) |
|
|
|
76 | (1) |
|
|
|
76 | (1) |
|
|
|
77 | (1) |
|
|
|
77 | (7) |
|
Blood and Bone Marrow Appearances |
|
|
79 | (1) |
|
Causes of Iron Deficiency |
|
|
80 | (4) |
|
|
|
84 | (6) |
|
|
|
90 | (1) |
|
|
|
90 | (1) |
|
Differential Diagnosis of Hypochromic Microcytic Anemias |
|
|
91 | (2) |
|
The Porphyrias and Iron Overload |
|
|
93 | (6) |
|
Congenital Erythropoietic Porphyria |
|
|
93 | (1) |
|
Congenital Erythropoietic Protoporphyria |
|
|
94 | (1) |
|
|
|
94 | (5) |
|
Primary (Genetic) Hemochromatosis |
|
|
94 | (3) |
|
Rare Causes of Iron Overload |
|
|
97 | (1) |
|
Hereditary Hyperferritinemia with Autosomal Dominant Congenital Cataract Syndrome |
|
|
98 | (1) |
|
|
|
99 | (16) |
|
|
|
100 | (8) |
|
Blood Count and Blood Film Appearances |
|
|
103 | (2) |
|
|
|
105 | (3) |
|
Causes of Megaloblastic Anemia |
|
|
108 | (6) |
|
|
|
108 | (2) |
|
|
|
110 | (2) |
|
Abnormalities of Vitamin B12 or Folate Metabolism |
|
|
112 | (1) |
|
|
|
113 | (1) |
|
Treatment of Megaloblastic Anemia |
|
|
114 | (1) |
|
Causes of Macrocytosis Other Than Megaloblastic Anemia |
|
|
114 | (1) |
|
|
|
115 | (18) |
|
Hereditary Hemolytic Anemia |
|
|
117 | (8) |
|
|
|
117 | (1) |
|
Red Cell Blood Group Antigens |
|
|
118 | (1) |
|
|
|
118 | (2) |
|
Hereditary Elliptocytosis |
|
|
120 | (1) |
|
Normal Red Cell Metabolism |
|
|
121 | (1) |
|
Glucose-6-Phosphate Dehydrogenase Deficiency |
|
|
122 | (2) |
|
Pyruvate Kinase Deficiency |
|
|
124 | (1) |
|
Pyrimidine 5-Nucleotidase Deficiency |
|
|
124 | (1) |
|
Acquired Hemolytic Anemia |
|
|
125 | (8) |
|
Autoimmune Hemolytic Anemias |
|
|
125 | (1) |
|
|
|
126 | (1) |
|
Drug-Induced Immune Hemolytic Anemia |
|
|
126 | (1) |
|
Isoimmune Hemolytic Anemia |
|
|
126 | (1) |
|
Red Cell Fragmentation Syndromes |
|
|
127 | (1) |
|
Secondary Hemolytic Anemias |
|
|
128 | (1) |
|
Paroxysmal Nocturnal Hemoglobinuria |
|
|
128 | (3) |
|
|
|
131 | (2) |
|
Genetic Disorders of Hemoglobin |
|
|
133 | (26) |
|
|
|
133 | (16) |
|
|
|
136 | (8) |
|
|
|
144 | (1) |
|
|
|
145 | (1) |
|
β-Thalassemia with a Dominant Phenotype |
|
|
145 | (1) |
|
|
|
146 | (2) |
|
|
|
148 | (1) |
|
X-Linked α-Thalassemia and Mental Retardation Syndrome |
|
|
149 | (1) |
|
Structural Hemoglobin Variants |
|
|
149 | (10) |
|
|
|
149 | (7) |
|
Other Structural Hemoglobin Defects |
|
|
156 | (1) |
|
|
|
156 | (1) |
|
|
|
157 | (2) |
|
Benign Disorders of Phagocytes |
|
|
159 | (14) |
|
Hereditary Variation in White Cell Morphology |
|
|
159 | (3) |
|
|
|
159 | (1) |
|
|
|
159 | (1) |
|
|
|
159 | (1) |
|
Alder's (Alder-Reilly) Anomaly |
|
|
159 | (1) |
|
Mucopolysaccharidoses VI and VII |
|
|
160 | (1) |
|
Dorfman-Chanarin Syndrome |
|
|
160 | (1) |
|
Lysinuric Protein Intolerance |
|
|
160 | (1) |
|
Disorders of Phagocytic Function |
|
|
161 | (1) |
|
|
|
162 | (3) |
|
Neutrophil Leukocytosis (Neutrophilia) |
|
|
162 | (1) |
|
|
|
162 | (2) |
|
Eosinophil Leukocytosis (Eosinophilia) |
|
|
164 | (1) |
|
Monocytosis and Basophil Leukocytosis |
|
|
164 | (1) |
|
|
|
165 | (1) |
|
Leukoerythroblastic Reaction |
|
|
165 | (1) |
|
|
|
166 | (1) |
|
Severe Congenital Neutropenia (Kostmann's Syndrome) |
|
|
166 | (1) |
|
Clinical and Bone Marrow Findings |
|
|
166 | (1) |
|
|
|
166 | (2) |
|
|
|
168 | (1) |
|
Lysosomal Storage Diseases |
|
|
168 | (5) |
|
|
|
168 | (2) |
|
|
|
170 | (1) |
|
Sea-Blue Histiocyte Syndrome |
|
|
171 | (2) |
|
Benign Disorders of Lymphocytes |
|
|
173 | (18) |
|
|
|
173 | (3) |
|
|
|
173 | (3) |
|
|
|
176 | (5) |
|
|
|
180 | (1) |
|
Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease) (See
Chapter 16) |
|
|
180 | (1) |
|
Primary Immunodeficiency Disorders |
|
|
181 | (2) |
|
Acquired Immunodeficiency Syndrome |
|
|
183 | (7) |
|
Autoimmune Lymphoproliferative Syndrome |
|
|
190 | (1) |
|
|
|
191 | (42) |
|
|
|
194 | (6) |
|
|
|
200 | (14) |
|
|
|
200 | (6) |
|
Rare Types of Acute Myeloid Leukemia |
|
|
206 | (4) |
|
Congenital Acute Leukemia |
|
|
210 | (1) |
|
Acute Leukemia and Down Syndrome |
|
|
210 | (1) |
|
Acute Lymphoblastic Leukemia |
|
|
210 | (3) |
|
Acute Mixed Cell Leukemia |
|
|
213 | (1) |
|
|
|
214 | (2) |
|
|
|
216 | (2) |
|
|
|
218 | (4) |
|
Fluorescent in Situ Hybridization |
|
|
222 | (2) |
|
|
|
224 | (2) |
|
|
|
226 | (2) |
|
|
|
228 | (5) |
|
Chronic Myeloid Leukemias and Myelomonocytic/Myeloproliferative Disorders |
|
|
233 | (14) |
|
Chronic Myeloid Leukemia (BCR Rearrangement Positive) |
|
|
233 | (9) |
|
|
|
234 | (4) |
|
|
|
238 | (2) |
|
|
|
240 | (1) |
|
|
|
241 | (1) |
|
Philadelphia-Negative Chronic Myeloid Leukemia |
|
|
242 | (1) |
|
Chronic Neutrophilic Leukemia |
|
|
242 | (1) |
|
Chronic Eosinophilic Leukemia |
|
|
242 | (1) |
|
Chronic Myelomonocytic Leukemia |
|
|
243 | (1) |
|
Juvenile Myelomonocytic Leukemia |
|
|
244 | (3) |
|
|
|
245 | (1) |
|
|
|
246 | (1) |
|
Refractory Anemia with Ringed Sideroblasts Associated with Marked Thrombocytosis (RARS-T) |
|
|
246 | (1) |
|
Myelodysplastic Syndromes |
|
|
247 | (10) |
|
Monosomy 7 Syndrome of Childhood |
|
|
255 | (2) |
|
Myeloproliferative Disorders |
|
|
257 | (26) |
|
|
|
259 | (4) |
|
Primary Congenital Polycythemia |
|
|
263 | (1) |
|
Essential Thrombocythemia |
|
|
263 | (4) |
|
|
|
267 | (8) |
|
Leukemic Transformation of Polycythemia Vera and Myelofibrosis |
|
|
275 | (1) |
|
Myeloproliferative Disorder Unclassifiable |
|
|
275 | (1) |
|
|
|
276 | (7) |
|
|
|
276 | (1) |
|
|
|
277 | (3) |
|
|
|
280 | (1) |
|
|
|
281 | (1) |
|
Extracutaneous Mastocytoma |
|
|
282 | (1) |
|
|
|
282 | (1) |
|
|
|
283 | (16) |
|
|
|
283 | (1) |
|
|
|
283 | (3) |
|
|
|
286 | (1) |
|
|
|
287 | (1) |
|
Histiocytic and Dendritic Cell Neoplasms |
|
|
287 | (1) |
|
|
|
288 | (1) |
|
Langerhans Cell Histiocytosis |
|
|
289 | (4) |
|
|
|
293 | (1) |
|
Interdigitating Dendritic Cell Sarcoma |
|
|
294 | (1) |
|
Follicular Dendritic Cell Sarcoma |
|
|
294 | (1) |
|
Indeterminate Dendritic Cell Tumor |
|
|
294 | (2) |
|
Fibroblastic Reticular Cell Tumor |
|
|
296 | (1) |
|
Blastic Plasmacytoid Dendritic Cell Neoplasm |
|
|
296 | (1) |
|
Disseminated Juvenile Xanthogranuloma |
|
|
296 | (3) |
|
Aplastic and Dyserythropoietic Anemias |
|
|
299 | (12) |
|
|
|
299 | (6) |
|
Inherited Aplastic Anemia |
|
|
300 | (5) |
|
|
|
305 | (2) |
|
Congenital Dyserythropoietic Anemias |
|
|
307 | (4) |
|
Chronic Lymphoid Leukemias |
|
|
311 | (16) |
|
|
|
311 | (11) |
|
Chronic Lymphocytic Leukemia |
|
|
311 | (8) |
|
|
|
319 | (1) |
|
|
|
319 | (3) |
|
Leukemia/Lymphoma Syndromes |
|
|
322 | (1) |
|
|
|
322 | (5) |
|
T-Cell Prolymphocytic Leukemia |
|
|
322 | (1) |
|
Large Granular Lymphocytic Leukemia |
|
|
323 | (2) |
|
Adult T-Cell Leukemia/Lymphoma |
|
|
325 | (2) |
|
Non-Hodgkin Lymphomas: Mature B-Cell Neoplasms |
|
|
327 | (34) |
|
|
|
327 | (1) |
|
|
|
328 | (1) |
|
|
|
328 | (1) |
|
|
|
329 | (7) |
|
Clinical Features and Diagnosis |
|
|
332 | (2) |
|
|
|
334 | (1) |
|
|
|
335 | (1) |
|
Small Lymphocytic Lymphoma |
|
|
336 | (1) |
|
Splenic Marginal Zone Lymphoma |
|
|
337 | (1) |
|
Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia |
|
|
338 | (2) |
|
|
|
340 | (1) |
|
Extranodal Marginal Zone B-Cell Lymphoma of Mucosa Associated Lymphoid Tissue (Malt) Lymphoma |
|
|
341 | (2) |
|
Nodal Marginal Zone B-Cell Lymphoma |
|
|
343 | (1) |
|
|
|
343 | (3) |
|
Primary Cutaneous Follicle Center Lymphoma |
|
|
346 | (1) |
|
|
|
346 | (3) |
|
Diffuse Large B-Cell Lymphoma |
|
|
349 | (4) |
|
T-Cell-Rich Diffuse Large B-Cell Lymphoma |
|
|
353 | (1) |
|
Lymphomatoid Granulomatosis |
|
|
353 | (1) |
|
Primary Mediastinal (Thymic) Large B-Cell Lymphoma |
|
|
354 | (1) |
|
Intravascular Large B-Cell Lymphoma |
|
|
354 | (1) |
|
Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type |
|
|
355 | (1) |
|
ALK-Positive Diffuse Large B-Cell Lymphoma |
|
|
355 | (1) |
|
|
|
356 | (1) |
|
Primary Effusion Lymphoma |
|
|
357 | (1) |
|
Large B-Cell Lymphoma Arising in HHV8 Associated Multicentric Castleman's Disease |
|
|
357 | (1) |
|
|
|
358 | (1) |
|
|
|
358 | (3) |
|
Peripheral T-Cell Disorders |
|
|
361 | (18) |
|
Mature T-Cell and Natural Killer-Cell Neoplasms |
|
|
361 | (1) |
|
Primary Cutaneous T-Cell Lymphomas |
|
|
361 | (1) |
|
|
|
361 | (2) |
|
|
|
363 | (1) |
|
Primary Cutaneous Anaplastic T-Cell Lymphoma |
|
|
364 | (1) |
|
|
|
365 | (1) |
|
Subcutaneous Panniculitis-Like NK-/T-Cell Lymphoma |
|
|
365 | (1) |
|
Cutaneous γδT-Cell Lymphoma |
|
|
366 | (1) |
|
Primary Cutaneous Aggressive Epidermotrophic CD8+ T-Cell Lymphoma (Provisional Category) |
|
|
367 | (1) |
|
Primary Cutaneous Small/Medium CD4+ T-Cell Lymphoma (Provisional Category) |
|
|
367 | (1) |
|
Primary Cutaneous Peripheral T-Cell Lymphoma Unspecified |
|
|
368 | (1) |
|
Extranodal NK-/T-Cell Lymphoma, Nasal Type |
|
|
368 | (1) |
|
Hydroa Vacciniforme-Like T-Cell Lymphoma |
|
|
369 | (1) |
|
Intestinal and/or Enteropathy-Associated T-Cell Lymphoma |
|
|
370 | (1) |
|
Hepatosplenic T-Cell Lymphoma |
|
|
371 | (1) |
|
Angioimmunoblastic Lymphadenopathy |
|
|
372 | (1) |
|
Anaplastic Large Cell Lymphoma:ALK Positive |
|
|
373 | (2) |
|
Anaplastic Large Cell Lymphoma:ALK Negative |
|
|
375 | (1) |
|
Peripheral T-Cell Lymphoma, Unspecified |
|
|
375 | (2) |
|
Systemic EBV+ T-Cell Lymphoproliferative Disease of Childhood |
|
|
377 | (2) |
|
|
|
379 | (16) |
|
Presentation and Evolution |
|
|
379 | (2) |
|
|
|
381 | (1) |
|
The Hodgkin Reed-Sternberg Cell |
|
|
381 | (1) |
|
Classification of Hodgkin Lymphoma |
|
|
382 | (4) |
|
Nodular Sclerosing Hodgkin Lymphoma |
|
|
382 | (1) |
|
Mixed Cellularity Hodgkin Lymphoma |
|
|
383 | (1) |
|
Lymphocyte-Rich Classic Hodgkin Lymphoma |
|
|
384 | (1) |
|
Lymphocyte-Depleted Hodgkin Lymphoma |
|
|
384 | (1) |
|
Nodular Lymphocyte-Predominant Hodgkin Lymphoma |
|
|
384 | (2) |
|
|
|
386 | (7) |
|
|
|
393 | (2) |
|
Myeloma and Related Conditions |
|
|
395 | (18) |
|
|
|
395 | (13) |
|
|
|
405 | (1) |
|
|
|
406 | (1) |
|
|
|
406 | (1) |
|
Monoclonal Immunoglobulin Deposition Diseases (MIDDs) |
|
|
407 | (1) |
|
|
|
407 | (1) |
|
|
|
408 | (1) |
|
Solitary Plasmacytoma of Bone |
|
|
408 | (1) |
|
Extraosseous (Extramedullary) Plasmacytoma |
|
|
409 | (1) |
|
|
|
409 | (1) |
|
Other Causes of Serum M-Proteins |
|
|
410 | (3) |
|
Monoclonal Gammopathy of Uncertain Significance (MGUS) |
|
|
410 | (1) |
|
|
|
411 | (1) |
|
|
|
411 | (2) |
|
Tissue Typing and Stem Cell Transplantation |
|
|
413 | (16) |
|
Human Leukocyte Antigen System |
|
|
413 | (5) |
|
Human Leukocyte Antigen Nomenclature |
|
|
414 | (1) |
|
Typing of Human Leukocyte Antigens |
|
|
414 | (4) |
|
Other Human Leukocyte Antigens |
|
|
418 | (1) |
|
Stem Cell Transplantation |
|
|
418 | (11) |
|
Nonmyeloablative (``Mini'') Transplants |
|
|
422 | (1) |
|
|
|
422 | (1) |
|
Complications of Stem Cell Transplants |
|
|
422 | (2) |
|
Graft-Versus-Host Disease |
|
|
424 | (2) |
|
Post-Transplant Lymphoproliferative Disorders |
|
|
426 | (3) |
|
Vascular and Platelet Bleeding Disorders |
|
|
429 | (16) |
|
Vascular Bleeding Disorders |
|
|
431 | (6) |
|
Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu Syndrome) |
|
|
431 | (1) |
|
|
|
432 | (1) |
|
|
|
432 | (1) |
|
|
|
432 | (1) |
|
Purpura Associated with Abnormal Proteins |
|
|
432 | (1) |
|
|
|
433 | (2) |
|
Purpura Associated with Infection |
|
|
435 | (2) |
|
Platelet Bleeding Disorders |
|
|
437 | (4) |
|
|
|
437 | (1) |
|
Immune Thrombocytopenic Purpura |
|
|
438 | (1) |
|
Drug-Induced Immune Thrombocytopenia |
|
|
439 | (1) |
|
Disseminated Intravascular Coagulation, Thrombotic Thrombocytopenic Purpura, and Hemolytic-Uremic Syndrome |
|
|
440 | (1) |
|
Disorders of Platelet Function |
|
|
441 | (4) |
|
|
|
441 | (2) |
|
|
|
443 | (2) |
|
The Inherited and Acquired Coagulation Disorders |
|
|
445 | (16) |
|
|
|
445 | (1) |
|
Hereditary Coagulation Disorders |
|
|
446 | (10) |
|
|
|
446 | (9) |
|
|
|
455 | (1) |
|
Other Hereditary Coagulation Disorders |
|
|
456 | (1) |
|
Acquired Coagulation Disorders |
|
|
456 | (5) |
|
|
|
457 | (1) |
|
Overdosage with Anticoagulants |
|
|
457 | (1) |
|
Disseminated Intravascular Coagulation |
|
|
458 | (1) |
|
Acquired Coagulation Factor Inhibitor |
|
|
458 | (2) |
|
Thromboelastometry and Thromboelastography |
|
|
460 | (1) |
|
|
|
461 | (16) |
|
|
|
461 | (1) |
|
|
|
462 | (1) |
|
|
|
462 | (3) |
|
|
|
463 | (1) |
|
|
|
464 | (1) |
|
|
|
465 | (1) |
|
|
|
465 | (1) |
|
|
|
465 | (1) |
|
|
|
465 | (1) |
|
|
|
465 | (1) |
|
Acquired Risk Factors for Venous Thrombosis |
|
|
465 | (1) |
|
Antiphospholipid Syndrome |
|
|
466 | (1) |
|
Diagnosis of Venous Thrombosis |
|
|
466 | (1) |
|
Clinical Probability Assessment |
|
|
466 | (1) |
|
|
|
466 | (1) |
|
Ultrasound and Radiologic Imaging |
|
|
466 | (2) |
|
Diagnosis of Pulmonary Embolus |
|
|
468 | (1) |
|
|
|
468 | (1) |
|
|
|
469 | (1) |
|
|
|
469 | (1) |
|
|
|
469 | (1) |
|
|
|
469 | (1) |
|
|
|
469 | (1) |
|
|
|
469 | (1) |
|
Glycoprotein IIb/IIIa Inhibitors |
|
|
469 | (1) |
|
|
|
469 | (1) |
|
|
|
470 | (3) |
|
|
|
470 | (1) |
|
|
|
471 | (1) |
|
|
|
471 | (1) |
|
Direct Thrombin Inhibitors |
|
|
472 | (1) |
|
|
|
473 | (1) |
|
|
|
473 | (4) |
|
Secondary Anemia and Bone Marrow in Nonhematopoietic Disorders |
|
|
477 | (24) |
|
Anemia of Chronic Disorders |
|
|
477 | (1) |
|
Malignant Diseases (Other Than Leukemias, Lymphomas, and Histiocytic/Myeloproliferative Disorders) |
|
|
478 | (7) |
|
Rheumatoid Arthritis and Other Connective Tissue Diseases |
|
|
485 | (1) |
|
|
|
486 | (1) |
|
|
|
487 | (1) |
|
|
|
487 | (1) |
|
|
|
488 | (2) |
|
|
|
488 | (1) |
|
|
|
489 | (1) |
|
Parasitic Infections Diagnosed in Blood |
|
|
490 | (1) |
|
Marrow Involvement in Other Infections |
|
|
490 | (1) |
|
Granulomatous Inflammation |
|
|
490 | (1) |
|
|
|
491 | (1) |
|
|
|
491 | (1) |
|
|
|
491 | (4) |
|
Osteopetrosis (Albers-Schonberg or Marble Bone Disease) |
|
|
495 | (2) |
|
Paget's Disease of Bone (Osteitis Deformans) |
|
|
497 | (1) |
|
|
|
498 | (1) |
|
|
|
499 | (1) |
|
|
|
499 | (2) |
|
|
|
501 | (8) |
|
|
|
501 | (5) |
|
Effects of Malaria on Various Organs |
|
|
504 | (1) |
|
Comparative Methods for Malaria Diagnosis |
|
|
505 | (1) |
|
|
|
506 | (1) |
|
|
|
506 | (1) |
|
|
|
506 | (1) |
|
|
|
507 | (1) |
|
|
|
507 | (1) |
|
|
|
508 | (1) |
|
|
|
508 | (1) |
|
|
|
509 | (10) |
|
|
|
509 | (1) |
|
|
|
510 | (1) |
|
|
|
510 | (1) |
|
|
|
511 | (1) |
|
Blood Grouping and Cross-Matching |
|
|
511 | (1) |
|
|
|
511 | (1) |
|
Clinical Blood Transfusion |
|
|
512 | (1) |
|
Complications of Blood Transfusion |
|
|
512 | (5) |
|
|
|
513 | (2) |
|
|
|
515 | (1) |
|
Transfusion-Related Acute Lung Injury |
|
|
516 | (1) |
|
Craft-Versus-Host Disease |
|
|
517 | (1) |
|
|
|
517 | (2) |
|
|
|
517 | (1) |
|
|
|
517 | (1) |
|
|
|
517 | (1) |
|
|
|
518 | (1) |
| Index |
|
519 | |
