Remarkably, the original five editors from the first edition (1991) and two who came on board subsequently have again joined forces to keep this reference vital and current. Though journals and web-based tools proliferate, the editors still root in favor of textbooks, which distill and organize the deluge in a way that's useful to practitioners and researchers. They've avoided stagnation by engaging a big percentage of new authors and including new chapters, substantially increasing the number of color photomicrographs, providing full color throughout for the first time, and including "opinion" boxes with treatment strategies and recommendations. The publisher makes this work available as a text combined with a CD-ROM and including access to a regularly updated web site (a stand-alone text is the other option). Annotation ©2004 Book News, Inc., Portland, OR (booknews.com)
The fourth edition of this leading text reflects the new direction and growth of the field of hematology as an academic and clinical discipline. Both a state-of-the-art website and a critically acclaimed reference.
- THE WEBSITE:
- Incorporates the text with a state-of-the-art, dedicated website...featuring fully searchable contents of the 4TH Edition.
- Patient information sheets.
- Includes all of the artwork from the text downloadable into PowerPoint presentations.
- Features weekly content updates Edited by Dr. Hoffman.
- THE BOOK:
- Full color throughout for the first time (color figures in place!)
- The definitive, complete reference resource for hematologic disorders provides "one-stop shopping" for information; appeals to both practitioners and researchers
- Red "opinion" boxes contain treatment strategies and recommendations by the experts
- Clinically oriented focus
- Includes more than 15 new chapters
Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
Part I. Molecular and Cellular Basis of Hematology
Chapter 1Anatomy and Physiology of the Gene
Chapter 2Genomic Approaches to the Study of Hematologic Science NEW
Chapter 3Protein Synthesis, Processing, and Degradation REORGANIZED
Chapter 4Protein Architecture: Relationship of Form and Function
Chapter 5Regulation of Cellular Response NEW
Chapter 6Cell Adhesion
Chapter 7Control of Cell Division
Chapter 8Cell Death NEW
Chapter 9Consequences of Genetic Diversity to Hematologic Disease and Treatment NEW
Part II. Immunologic Basis of Hematology
Chapter 10B-Cell Development
Chapter 11T-Cell and NK-Cell Immunity REORGANIZED
Chapter 12Dendritic Cell Biology NEW
Chapter 13Regulation of Lymphocyte Activation
Chapter 14Lymphocyte Trafficking NEW
Chapter 15Tolerance and Autoimmunity
Part III. Biology of Stem Cells and Disorders of Hematopoiesis
Chapter 16Stem Cell Model of Hematopoiesis
Chapter 17Anatomy and Physiology of Hematopoiesis
Chapter 18Humeral Regulation of Hematopoiesis NEW
Chapter 19Biology of Erythroppoiesis, Erythroid Differentiation, and Maturation
Chapter 20Granulopoiesis and Monocytopoiesis
Chapter 21Thrombocytopoiesis
Chapter 22Defects in Platelet Production NEW
Chapter 23Inherited Forms of Bone Marrow Failure
Chapter 24Aplastic Anemia
Chapter 25Paroxysmal Nocturnal Hemoglobinuria
Chapter 26Pure Red Cell Aplasia
Part IV. Red Blood Cells
Chapter 27Pathobiology of the Human Erythrocyte and Its Hemoglobins
Chapter 28Approach to the Adult and Child with Anemia
Chapter 29Anemia of Chronic Diseases
Chapter 30Disorders of Iron Metabolism: Iron Deficiency and Overload
Chapter 31Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
Chapter 32Megablastic Anemias
Chapter 33Thalassemia Syndromes
Chapter 34Pathology of Sickle Cell Disease
Chapter 35Clinical Manifestations and Treatment of Sickle Cell Disease NEW
Chapter 36Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
Chapter 37Red Cell Enzymopathies
Chapter 38Red Cell Membrane Disorders
Chapter 39Autoimmune Hemolytic Anemias
Chapter 40Extrinsic Nonimmune Hemolytic Anemias
Part V. Host Defense and Its Disorders
Chapter 41Immunoglobulins and Complement Biology REORGANIZED
Chapter 42Normal Phagocyte Structure and Function
Chapter 43Eosinophilia, Eosinophil-Associated Diseases, and the Hypereosinophilic Syndrome
Chapter 44Disorders of Phagocyte Function and Number
Chapter 45Disorders of Lymphocyte Function
Chapter 46Histiocytic Disorders
Chapter 47Lysosomal Storage Diseases: Perspective and Principles
Chapter 48Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
Chapter 49The Spleen and Its Disorders
Chapter 50Basophils, Mast Cells, and Systemic Mastocytosis
Part VI. Hematologic Malignancies
Chapter 51Cytogenetics and Neoplasia
Chapter 52The Molecular Basis of Neoplasia
Chapter 53Pharmacology and Molecular Mechanism of Action or Resistance of Antineoplastic Agents: Current Status and Future Potential
Chapter 54Principles of Radiation Oncology for Hematologic Malignancies NEW
Chapter 55Clinical Application of Cytokines
Chapter 56Biologic Response Modifiers NEW
Chapter 57Pathobiology of Acute Myeloid Leukemia
Chapter 58Clinical Manifestations of Acute Myeloid Leukemia
Chapter 59Therapy for Acute Myeloid Leukemia
Chapter 60Acute Myeloid Leukemia in Children
Chapter 61Pathobiology of Acute Lymphoblastic Leukemia
Chapter 62Clinical Manifestations of Acute Lymphoblastic Leukemia
Chapter 63Treatment of Childhood Acute Lymphoblastic Leukemia
Chapter 64Acute Lymphoblastic Leukemia in Adults
Chapter 65Myelodysplastic Syndrome
Chapter 66Polycthemia Vera
Chapter 67Chronic Myelogenous Leukemia
Chapter 68Agnogenic Myeloid Metaplasia
Chapter 69Primary Thrombocythemia
Chapter 70Myelodysplastic Syndromes and Myeloproliferative Syndromes in
Children
Chapter 71Pathobiology of Non-Hodgkin Lymphomas
Chapter 72Pathology and Histogenesis of Hodgkin Disease
Chapter 73Hodgkin Disease: Clinical Manifestations, Staging, and Therapy
Chapter 74The Pathologic Basis for the Classification of Non-Hodgkin
Lymphomas
Chapter 75Clinical Manifestations, Staging, and Treatment of Non-Hodgkin
Lymphoma
Chapter 76Malignant Lymphomas in Childhood
Chapter 77Chronic Lymphocytic Leukemia
Chapter 78Hairy Cell Leukemia
Chapter 79Cutaneous T-Cell Lymphomas
Chapter 80AIDS-Related Lymphomas
Chapter 81Multiple Myeloma and Other Plasma Cell Disorders
Chapter 82Amyloidosis
Chapter 83Atypical Immune Lymphoproliferations
Chapter 84Clinical Approaches to Infections in the Compromised Host
Chapter 85Nutritional Support of Patients with Hematologic Malignancies
Chapter 86Psychosocial Aspects of Hematologic Disorders
Chapter 87Pain Management and Antiemetic Therapy in Hematologic Disorders
Chapter 88Palliative Care NEW
Chapter 89Indwelling Access Devices
Chapter 90Late Complications of Hematologic Disease and Their Therapies NEW
Part VII. Transplantation
Chapter 91Transplant for Bone Marrow Failure and Autoimmune Disorders NEW
Chapter 92Hematopoietic Stem Cell Transplantation for Genetic Diseases and
Immune Deficiencies NEW
Chapter 93Results of Allogeneic Stem Cell Transplantation for Malignant
Disorders
Chapter 94Results of Autologous Stem Cell Transplantation for Malignancies
Chapter 95Unrelated Donor Stem Cell Transplantation Therapy
Chapter 96Placental and Umbilical Cord Blood Transplantation
Chapter 97Preparative Regimens for Stem Cell Transplantation
Chapter 98Graft-versus-Host Disease and Graft-versus- Leukemia Effect
Chapter 99Achievement of Tolerance NEW
Chapter 100Graft Engineering to Enhance Engraftment, Reduce Graft-versus-
Host Disease, and Provide a Graft-versus-Tumor Effect
Chapter 101Gene Therapy for Hematologic Disorders
Chapter 102Experimental Cell Therapy
(include NK-, T-, and dendric cells)
Chapter 103Complications After Stem Cell Transplantation
Part VIII. Hemostasis and Thrombosis
Chapter 104Megakaryocyte and Platelet Structure
Chapter 105The Molecular Basis for Platelet Function
Chapter 106The Molecular Basis for Platelet Activation
Chapter 107The Blood Vessel Wall
Chapter 108Molecular Basis of Blood Coagulation
Chapter 109Molecular and Cellular Basis of Fibrinolysis
Chapter 110Regulatory Mechanisms in Hemostasis: Natural Anticoagulants
Chapter 111Clinical Evaluation of Hemorrhagic Disorders: The Bleeding History
and Differential Diagnosis of Pupura
Chapter 112Laboratory Evaluation of Hemostatic Disorders REORGANIZED
Chapter 113Structure, Biology, and Genetics of Factor VIII
Chapter 114Biochemistry of Factor IX and Molecular Biology of Hemophilia B
Chapter 115Clinical Aspects and Therapy of Hemophilia
Chapter 116Inhibitors in Hemophilia
Chapter 117Other Clotting Factor Deficiencies
Chapter 118Quantitative and Qualitative Disorders of Fibrinogen
Chapter 119Structure, Biology, and Genetics of von Willebrand Factor
Chapter 120Clinical Aspects of and Therapy for von Willebrand Disease
Chapter 121Vitamin K: Metabolism and Disorders
Chapter 122Inhibitors of Blood Coagulation
Chapter 123Disseminated Intrvascular Coagulation
Chapter 124Hemostatic Defects Associated with Dysproteinemias
Chapter 125Disorders of Coagulation and Platelets in the Neonate
Chapter 126Hypercoagulable States
Chapter 127Venous Thromboembolism
Chapter 128Arterial Thromboembolism
Chapter 129Anticoagulation and Thrombolytic Therapy REORGANIZED
Chapter 130Immune Thrombocytopenic Purpura, Neonatal Alloimmune
Thrombocytopenia, and Posttransfusion Purpura
Chapter 131Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic
Syndrome
Chapter 132Thrombocytopenia Due to Platelet Destruction and Hypersplenism
Chapter 133Hereditary Disorders of Platelet Function
Chapter 134Acquired Disorders of Platelet Function
Part IX. Transfusion Medicine
Chapter 135Human Blood Group Anitgens and Antibodies
Part 1: Carbohydrate Determinants
Part 2: Protein Determinants
Chapter 136Human Platelet Antigens
Chapter 137HLA and Neutrophil Antigen and Antibody Systems
Chapter 138Principles of Red Blood Cell Transfusion
Chapter 139Principles of Platelet Transfusion Therapy
Chapter 140Principles of Neutrophil (Granulocyte) Transfusions
Chapter 141Transfusion of Plasma Derivatives: Fresh-Frozen Plasma,
Cryoprecipitate, Albumin, and Immunoglobulins
Chapter 142Intravenous Immunoglobulin NEW
Chapter 143Preparation of Plasma-Derived and Recombinant Human Plasma
Proteins
Chapter 144Transfusion Principles for Congenital Coagulation Disorders
Chapter 145Hemapheresis and Cellular Therapy NEW
Chapter 146Practical Aspects of Stem Cell Collection
Chapter 147Transfusion Reactions
Chapter 148Transfusion-Transmitted Diseases
Chapter 149Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ
Transplantation
Part X. Consultative Hematology
Chapter 150Hematologic Manifestations of Systemic Disease: Liver and Renal
Disease REORGANIZED
Chapter 151Hematologic Manifestations of Systemic Disease: Infection,
Chronic Inflammation, and Cancer
Chapter 152Hematologic Manifestations of Systemic Disease: HIV Infection
Chapter 153Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
Chapter 154Hematologic Aspects of Pregnancy
Chapter 155Hematologic Manifestations of Childhood Illness
Part XI. Special Tests and Procedures
Chapter 156Bone Marrow Aspiration and Morphology
Chapter 157Automated Analysis of Blood Cells
Chapter 158Laboratory Detection of Hemoglobinopathies and Thalassemias
Chapter 159Antenatal Diagnosis of Hematologic Disorders
Chapter 160Use of Molecular Techniques in the Analysis of Hematologic Diseases
Chapter 161Special Imaging Applications in Hematology NEW
Chapter 162Coagulation Studies and Their Interpretation NEW
