|
PART I MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY |
|
|
1 | (77) |
|
Chapter 1 Anatomy and Physiology of the Gene |
|
|
2 | (14) |
|
|
|
|
Chapter 2 Genomic Approaches to Hematology |
|
|
16 | (11) |
|
|
Chapter 3 Regulation of Gene Expression, Transcription, Splicing, and RNA Metabolism |
|
|
27 | (8) |
|
|
|
|
Chapter 4 Protein Synthesis, Processing, and Trafficking |
|
|
35 | (13) |
|
|
|
Chapter 5 Protein Architecture: Relationship of Form and Function |
|
|
48 | (7) |
|
|
|
|
|
Chapter 6 Signaling Transduction and Regulation of Cell Metabolism |
|
|
55 | (10) |
|
|
Chapter 7 Pharmacogenomics and Hematologic Diseases |
|
|
65 | (13) |
|
|
|
PART II CELLULAR BASIS OF HEMATOLOGY |
|
|
|
Chapter 8 Hematopoietic Stem Cell Biology |
|
|
78 | (10) |
|
|
Chapter 9 Hematopoietic Microenvironment |
|
|
88 | (9) |
|
|
|
|
97 | (8) |
|
|
|
Chapter 11 Hematopoietic Cell Trafficking and Chemokines |
|
|
105 | (12) |
|
|
|
|
Chapter 12 Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization |
|
|
117 | (9) |
|
|
|
|
|
|
|
Chapter 13 Vascular Growth in Health and Disease |
|
|
126 | (10) |
|
|
Chapter 14 Principles of Cytokine Signaling |
|
|
136 | (11) |
|
|
|
Chapter 15 Control of Cell Division |
|
|
147 | (11) |
|
|
|
|
158 | (13) |
|
|
|
PART III IMMUNOLOGIC BASIS OF HEMATOLOGY |
|
|
171 | (86) |
|
Chapter 17 Overview and Compartmentalization of the Immune System |
|
|
172 | (10) |
|
|
|
|
Chapter 18 B-Cell Development |
|
|
182 | (11) |
|
|
|
Chapter 19 T-Cell Immunity |
|
|
193 | (17) |
|
|
|
|
Chapter 20 Natural Killer Cell Immunity |
|
|
210 | (7) |
|
|
|
Chapter 21 Dendritic Cell Biology |
|
|
217 | (11) |
|
|
|
Zbigniew M. Szczepiorkowski |
|
|
|
Chapter 22 Complement and Immunoglobulin Biology |
|
|
228 | (19) |
|
|
|
|
Chapter 23 Tolerance and Autoimmunity |
|
|
247 | (10) |
|
|
PART IV DISORDERS OF HEMATOPOIETIC CELL DEVELOPMENT |
|
|
257 | (148) |
|
Chapter 24 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation |
|
|
258 | (22) |
|
|
|
Chapter 25 Granulocytopoiesis and Monocytopoiesis |
|
|
280 | (12) |
|
|
|
Chapter 26 Thrombocytopoiesis |
|
|
292 | (15) |
|
|
Chapter 27 Inherited Forms of Bone Marrow Failure |
|
|
307 | (43) |
|
|
|
Chapter 28 Aplastic Anemia |
|
|
350 | (23) |
|
|
|
Chapter 29 Paroxysmal Nocturnal Hemoglobinuria |
|
|
373 | (10) |
|
|
Chapter 30 Acquired Disorders of Red Cell, White Cell, and Platelet Production |
|
|
383 | (22) |
|
|
|
|
405 | (235) |
|
Chapter 31 Pathobiology of the Human Erythrocyte and Its Hemoglobins |
|
|
406 | (12) |
|
|
|
|
|
Chapter 32 Approach to Anemia in the Adult and Child |
|
|
418 | (9) |
|
|
Chapter 33 Pathophysiology of Iron Homeostasis |
|
|
427 | (10) |
|
|
Chapter 34 Disorders of Iron Homeostasis: Iron Deficiency and Overload |
|
|
437 | (13) |
|
|
Chapter 35 Anemia of Chronic Diseases |
|
|
450 | (7) |
|
|
|
|
Chapter 36 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias |
|
|
457 | (16) |
|
|
|
Chapter 37 Megaloblastic Anemias |
|
|
473 | (32) |
|
|
Chapter 38 Thalassemia Syndromes |
|
|
505 | (31) |
|
|
|
Chapter 39 Pathobiology of Sickle Cell Disease |
|
|
536 | (12) |
|
|
Chapter 40 Sickle Cell Disease: Clinical Features and Management |
|
|
548 | (25) |
|
|
|
Chapter 41 Hemoglobin Variants Associated With Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias |
|
|
573 | (8) |
|
|
|
Chapter 42 Red Blood Cell Enzymopathies |
|
|
581 | (11) |
|
|
|
|
Chapter 43 Red Blood Cell Membrane Disorders |
|
|
592 | (22) |
|
|
Chapter 44 Autoimmune Hemolytic Anemia |
|
|
614 | (14) |
|
|
|
Chapter 45 Extrinsic Nonimmune Hemolytic Anemias |
|
|
628 | (12) |
|
|
|
|
|
Chapter 46 Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia |
|
|
640 | (7) |
|
|
|
Chapter 47 Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia |
|
|
647 | (8) |
|
|
Chapter 48 Disorders of Phagocyte Function |
|
|
655 | (19) |
|
|
|
Chapter 49 Congenital Disorders of Lymphocyte Function |
|
|
674 | (12) |
|
|
|
Chapter 50 Histiocytic Disorders |
|
|
686 | (15) |
|
|
Alexandra Hult Filipovich |
|
|
Chapter 51 Lysosomal Storage Diseases: Perspectives and Principles |
|
|
701 | (7) |
|
|
|
Chapter 52 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases |
|
|
708 | (13) |
|
|
|
|
PART VII HEMATOLOGIC MALIGNANCIES |
|
|
721 | (654) |
|
Chapter 53 Progress in the Classification of Myeloid Neoplasms: Clinical Implications |
|
|
722 | (6) |
|
|
|
Chapter 54 Conventional and Molecular Cytogenetic Basis of Hematologic Malignancies |
|
|
728 | (53) |
|
|
Chapter 55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies |
|
|
781 | (63) |
|
|
|
|
|
|
|
Chapter 56 Radiation Therapy in the Treatment of Hematologic Malignancies |
|
|
844 | (9) |
|
|
|
Chapter 57 Pathobiology of Acute Myeloid Leukemia |
|
|
853 | (10) |
|
|
|
Chapter 58 Clinical Manifestations and Treatment of Acute Myeloid Leukemia |
|
|
863 | (19) |
|
|
|
Chapter 59 Myelodysplastic Syndromes: Biology and Treatment |
|
|
882 | (22) |
|
|
|
Chapter 60 Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults |
|
|
904 | (9) |
|
|
|
|
Chapter 61 Acute Myeloid Leukemia in Children |
|
|
913 | (13) |
|
|
|
|
Chapter 62 Myelodysplastic and Myeloproliferative Neoplasms in Children |
|
|
926 | (9) |
|
|
|
Chapter 63 Pathobiology of Acute Lymphoblastic Leukemia |
|
|
935 | (16) |
|
|
|
|
Chapter 64 Clinical Manifestations and Treatment of Acute Lymphoblastic Leukemia in Children |
|
|
951 | (9) |
|
|
|
Chapter 65 Acute Lymphoblastic Leukemia in Adult |
|
|
960 | (21) |
|
|
|
|
|
Chapter 66 Chronic Myeloid Leukemia |
|
|
981 | (17) |
|
|
Chapter 67 The Polycythemias |
|
|
998 | (36) |
|
|
|
|
|
Chapter 68 Essential Thrombocythemia |
|
|
1034 | (19) |
|
|
|
|
|
Chapter 69 Primary Myelofibrosis |
|
|
1053 | (24) |
|
|
|
|
|
Chapter 70 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes |
|
|
1077 | (18) |
|
|
|
|
|
|
Chapter 71 Mast Cells and Systemic Mastocytosis |
|
|
1095 | (17) |
|
|
|
|
|
Chapter 72 Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas |
|
|
1112 | (18) |
|
|
|
|
Chapter 73 Origin of Hodgkin Lymphoma |
|
|
1130 | (8) |
|
|
Chapter 74 Hodgkin Lymphoma: Clinical Manifestations, Staging, and Therapy |
|
|
1138 | (19) |
|
|
|
|
Chapter 75 Origin of Non-Hodgkin Lymphoma |
|
|
1157 | (13) |
|
|
|
Chapter 76 Chronic Lymphocytic Leukemia |
|
|
1170 | (22) |
|
|
|
|
Chapter 77 Hairy Cell Leukemia |
|
|
1192 | (12) |
|
|
Chapter 78 Clinical Manifestations and Treatment of Marginal Zone Lymphomas (Extranodal/Malt, Splenic, and Nodal) |
|
|
1204 | (11) |
|
|
Chapter 79 Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma |
|
|
1215 | (11) |
|
|
Chapter 80 Mantle Cell Lymphoma |
|
|
1226 | (10) |
|
|
|
|
|
|
|
|
|
Chapter 81 Diagnosis and Treatment of Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma |
|
|
1236 | (9) |
|
|
|
Chapter 82 Virus-Associated Lymphoma |
|
|
1245 | (10) |
|
|
|
Chapter 83 Malignant Lymphomas in Childhood |
|
|
1255 | (12) |
|
|
|
|
Chapter 84 T-Cell Lymphomas |
|
|
1267 | (36) |
|
|
|
|
|
|
|
|
Chapter 85 Plasma Cell Neoplasms |
|
|
1303 | (35) |
|
|
|
Chapter 86 Waldenstrom Macroglobulinemia and Lymphoplasmacytic Lymphoma |
|
|
1338 | (12) |
|
|
|
Chapter 87 Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis) |
|
|
1350 | (25) |
|
|
|
|
|
PART VIII COMPREHENSIVE CARE OF PATIENTS WITH HEMATOLOGIC MALIGNANCIES |
|
|
1375 | (94) |
|
Chapter 88 Clinical Approach to Infections in the Compromised Host |
|
|
1376 | (15) |
|
|
|
Dimitrios P. Kontoyiannis |
|
|
Chapter 89 Indwelling Access Devices |
|
|
1391 | (14) |
|
|
|
Chapter 90 Nutritional Issues in Patients With Hematologic Malignancies |
|
|
1405 | (13) |
|
|
Chapter 91 Psychosocial Aspects of Hematologic Disorders |
|
|
1418 | (11) |
|
|
|
Chapter 92 Pain Management and Antiemetic Therapy in Hematologic Disorders |
|
|
1429 | (15) |
|
|
|
|
|
Chapter 93 Palliative Care |
|
|
1444 | (8) |
|
|
|
|
Chapter 94 Late Complications of Hematologic Diseases and Their Therapies |
|
|
1452 | (17) |
|
|
|
PART IX CELL-BASED THERAPIES |
|
|
1469 | (72) |
|
Chapter 95 Overview and Historical Perspective of Current Cell-Based Therapies |
|
|
1470 | (2) |
|
|
|
Chapter 96 Practical Aspects of Hematologic Stem Cell Harvesting and Mobilization |
|
|
1472 | (14) |
|
|
|
Chapter 97 Preclinical Process of Cell-Based Therapies |
|
|
1486 | (6) |
|
|
|
|
|
Chapter 98 Graft Engineering and Cell Processing |
|
|
1492 | (11) |
|
|
Chapter 99 Principles of Cell-Based Genetic Therapies |
|
|
1503 | (10) |
|
|
Chapter 100 Mesenchymal Stromal Cells |
|
|
1513 | (8) |
|
|
Chapter 101 T-Cell Therapy of Hematologic Diseases |
|
|
1521 | (6) |
|
|
|
Chapter 102 Natural Killer Cell-Based Therapies |
|
|
1527 | (7) |
|
|
|
|
Chapter 103 Dendritic Cell Therapies |
|
|
1534 | (7) |
|
|
|
|
1541 | (86) |
|
Chapter 104 Overview of Hematopoietic Stem Cell Transplantation |
|
|
1542 | (4) |
|
|
Chapter 105 Indications and Outcome of Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults |
|
|
1546 | (11) |
|
|
|
Chapter 106 Unrelated Donor Hematopoietic Cell Transplantation |
|
|
1557 | (12) |
|
|
|
Chapter 107 Haploidentical Hematopoietic Cell Transplantation |
|
|
1569 | (11) |
|
|
|
Chapter 108 Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies |
|
|
1580 | (12) |
|
|
|
Chapter 109 Graft-Versus-Host Disease and Graft-Versus-Leukemia Responses |
|
|
1592 | (20) |
|
|
|
Chapter 110 Complications After Hematopoietic Stem Cell Transplantation |
|
|
1612 | (15) |
|
|
|
PART XI TRANSFUSION MEDICINE |
|
|
1627 | (146) |
|
Chapter 111 Human Blood Group Antigens and Antibodies |
|
|
1628 | (14) |
|
|
|
|
Chapter 112 Principles of Red Blood Cell Transfusion |
|
|
1642 | (11) |
|
|
|
Chapter 113 Principles of Platelet Transfusion Therapy |
|
|
1653 | (6) |
|
|
Chapter 114 Human Leukocyte Antigen and Human Neutrophil Antigen Systems |
|
|
1659 | (17) |
|
|
|
|
|
Chapter 115 Principles of Neutrophil (Granulocyte) Transfusions |
|
|
1676 | (7) |
|
|
Chapter 116 Principles of Plasma Transfusion: Plasma, Cryoprecipitate, Albumin, and Immunoglobulins |
|
|
1683 | (12) |
|
|
|
|
Chapter 117 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins |
|
|
1695 | (10) |
|
|
Chapter 118 Transfusion Therapy for Coagulation Factor Deficiencies |
|
|
1705 | (11) |
|
|
|
|
|
1716 | (11) |
|
|
|
Chapter 120 Transfusion Reactions to Blood and Cell Therapy Products |
|
|
1727 | (11) |
|
|
|
|
|
|
Chapter 121 Transfusion-Transmitted Diseases |
|
|
1738 | (17) |
|
|
|
Chapter 122 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation |
|
|
1755 | (10) |
|
|
Chapter 123 Pediatric Transfusion Medicine |
|
|
1765 | (8) |
|
|
|
PART XII HEMOSTASIS AND THROMBOSIS |
|
|
1773 | (358) |
|
Chapter 124 Overview of Hemostasis and Thrombosis |
|
|
1774 | (10) |
|
|
Chapter 125 The Blood Vessel Wall |
|
|
1784 | (13) |
|
|
|
Chapter 126 Megakaryocyte and Platelet Structure |
|
|
1797 | (12) |
|
|
|
Chapter 127 Molecular Basis for Platelet Function |
|
|
1809 | (12) |
|
|
|
Chapter 128 Molecular Basis of Blood Coagulation |
|
|
1821 | (21) |
|
|
|
Chapter 129 Regulatory Mechanisms in Hemostasis |
|
|
1842 | (5) |
|
|
|
Chapter 130 Clinical Approach to the Patient With Bleeding or Bruising |
|
|
1847 | (10) |
|
|
Chapter 131 Laboratory Evaluation of Hemostatic and Thrombotic Disorders |
|
|
1857 | (10) |
|
|
Chapter 132 Acquired Disorders of Platelet Function |
|
|
1867 | (16) |
|
|
|
Chapter 133 Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura |
|
|
1883 | (12) |
|
|
|
|
|
|
|
Chapter 134 Thrombocytopenia Caused by Platelet Destruction, Hypersplenism, or Hemodilution |
|
|
1895 | (18) |
|
|
Chapter 135 Heparin-Induced Thrombocytopenia |
|
|
1913 | (12) |
|
|
Chapter 136 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome |
|
|
1925 | (15) |
|
|
|
|
Chapter 137 Hemophilia A and B |
|
|
1940 | (21) |
|
|
|
|
Chapter 138 Inhibitors in Hemophilia A and B |
|
|
1961 | (10) |
|
|
|
|
Chapter 139 Rare Coagulation Factor Deficiencies |
|
|
1971 | (16) |
|
|
|
Chapter 140 Structure, Biology, and Genetics of von Willebrand Factor |
|
|
1987 | (14) |
|
|
|
Chapter 141 Disseminated Intravascular Coagulation |
|
|
2001 | (12) |
|
|
Chapter 142 Hypercoagulable States |
|
|
2013 | (12) |
|
|
|
Chapter 143 Antiphospholipid Syndrome |
|
|
2025 | (14) |
|
|
|
Chapter 144 Venous Thromboembolism |
|
|
2039 | (9) |
|
|
Chapter 145 Mechanical Interventions in Arterial and Venous Thrombosis |
|
|
2048 | (9) |
|
|
|
Chapter 146 Atherothrombosis |
|
|
2057 | (10) |
|
|
|
2067 | (9) |
|
|
|
|
Chapter 148 Acute Coronary Syndromes |
|
|
2076 | (10) |
|
|
|
Chapter 149 Atrial Fibrillation |
|
|
2086 | (8) |
|
|
|
Chapter 150 Peripheral Artery Disease |
|
|
2094 | (8) |
|
|
|
Chapter 151 Antithrombotic Drugs |
|
|
2102 | (18) |
|
|
Chapter 152 Disorders of Coagulation in the Neonate |
|
|
2120 | (11) |
|
|
|
|
PART XIII CONSULTATIVE HEMATOLOGY |
|
|
2131 | |
|
Chapter 153 Hematologic Changes in Pregnancy |
|
|
2132 | (12) |
|
|
Chapter 154 Hematologic Manifestations of Childhood Illness |
|
|
2144 | (23) |
|
|
|
|
Chapter 155 Hematologic Manifestations of Liver Disease |
|
|
2167 | (6) |
|
|
|
Chapter 156 Hematologic Manifestations of Systemic Disease: Renal Disease |
|
|
2173 | (3) |
|
|
|
|
Chapter 157 Hematologic Manifestations of Cancer |
|
|
2176 | (7) |
|
|
|
|
Chapter 158 Integrative Therapies in Patients With Hematologic Diseases |
|
|
2183 | (8) |
|
|
|
|
Chapter 159 Hematologic Manifestations of HIV/AIDS |
|
|
2191 | (17) |
|
|
|
Chapter 160 Hematologic Aspects of Parasitic Diseases |
|
|
2208 | (26) |
|
|
Chapter 161 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis |
|
|
2234 | (18) |
|
|
|
Chapter 162 The Spleen and Its Disorders |
|
|
2252 | (14) |
|
|
|
|
Chapter 163 Hematology in Aging |
|
|
2266 | |
|
|
|
Chapter 164 (online only) Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations |
|
|
|
|