This open access book offers a comprehensive review of hepatocellular carcinoma (HCC) with a particular focus on the pathobiology and clinical aspects of the disease, including diagnosis and treatment. HCC is becoming one of the most common causes of cancer-related death worldwide. It is the fifth most common malignancy in men and the ninth in women, with an estimated 500,000 to 1 million new cases annually around the world. Independent of its cause, cirrhosis is considered a major clinical and histopathological risk factor for HCC development. Five percent of all cirrhotic patients develop HCC every year. Diagnostic tools for HCC include blood tests, high-quality imaging studies and liver biopsy. The treatment of HCC depends on the size and location of the HCC and includes surgical resection, liver transplantation, endovascular approaches, percutaneous ablation, and medical treatments. The book is organized into four parts overview, diagnosis, management strategies, and recommendations and aims to provide surgeons and clinicians with a valuable resource for complete and up-to-date research on the clinical aspects and management of HCC.
PART I: OVERVIEW.
Chapter
1. Epidemiological Aspects of Hepatocellular
Carcinoma.
Chapter
2. Molecular and Genetic Mechanisms of Hepatocellular
Carcinoma.
Chapter
3. Role of the Immune System in Hepatocellular
Carcinoma.
Chapter
4. Underlying Liver Disease.- PART II: DIAGNOSIS.-
Chapter
5. Imaging of Hepatocellular Carcinoma.
Chapter
6. Pathology of
Hepatocellular Carcinoma.
Chapter
7. Hepatological Evaluation and
Biomarkers.- PART III: TREATMENT.
Chapter
8. Percutaneous and
Laparoscopic-Assisted Ablation of Hepatocellular Carcinoma.
Chapter
9.
Endovascular Treatments of Hepatocellular Carcinoma.
Chapter
10. Indications
for Surgery in Cirrhotic Patients.
Chapter
11. Laparoscopic Approach for the
Treatment of Hepatocellular Carcinoma.
Chapter
12. Robotic Approach for the
Treatment of Hepatocellular Carcinoma.
Chapter
13. Ultrasound-Guided Liver
Resection and Parenchymal-Sparing Surgery.
Chapter
14. Surgical Margins for
Hepatocellular Carcinoma.
Chapter
15. Major Hepatectomies for Hepatocellular
Carcinoma.
Chapter
16. R1-Vascular Surgery for Hepatocellular Carcinoma.-
Chapter
17. Associating Liver Partition and Portal Vein Ligation for Staged
Hepatectomy (ALPPS).
Chapter
18. Re-Do Surgery for Hepatocellular
Carcinoma: Indications and Results.
Chapter
19. Liver Transplantation for
Hepatocellular Carcinoma.
Chapter
20. Downstaging Strategies Prior to Liver
Transplantation.
Chapter
21. Hepatocellular Carcinoma Medical Therapy.- PART
IV: SPECIAL CONSIDERATIONS.
Chapter
22. Surveillance for Patients at Risk of
Developing Hepatocellular Carcinoma.
Chapter
23. Hepatocellular Carcinoma
Recurrence: How to Manage.
Chapter
24. Liver Biopsy: How and When.
Chapter
25. Anesthesiologic Management During Surgery for Hepatocellular Carcinoma.
Giuseppe Maria Ettorre is currently Chief of the Transplantation Department at the San Camillo-Forlanini Hospital and National Institute of Infectious Disease L. Spallanzani in Rome. He is an internationally renowned expert in liver surgery and transplantation, being considered one of the pioneers of laparoscopic liver surgery. He received his surgical training at Sapienza University of Rome and completed his clinical fellowships at the Service of General Surgery of Hōpital Lariboisičre in Paris, directed by Prof. Hautefeuille and Valleur, and at the Service of Hepatobiliary Surgery and Liver Transplantation of Hōpital Beaujon in Paris, directed by Prof. Jacques Belghiti. From April 2001 to 2007 he was head of the Liver Disease and Transplantation team of the Surgical Unit of Prof. Eugenio Santoro at the oncological hospital IFO - Istituto Regina Elena in Rome. Since 2009 he has been Chief of the General Surgery and Transplantation Unit of San Camillo-Forlanini Hospital of Rome,where he oversees a comprehensive surgical program for the liver, pancreas and bile ducts, including surgeries for malignant and non-malignant conditions. In the last two decades he has performed more than 2,000 complex hepatobiliary and liver transplantation procedures. He also helped pioneer minimally invasive techniques in liver resection for the treatment of cancer. He is a member of numerous scientific societies and is author of more than 350 peer-reviewed articles of surgical interest as well as serving as principal or co-investigator in more than 20 studies.
