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El. knyga: Hyperthermic Oncology from Bench to Bedside

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  • Formatas: PDF+DRM
  • Išleidimo metai: 07-Jun-2016
  • Leidėjas: Springer Verlag, Singapore
  • Kalba: eng
  • ISBN-13: 9789811007194
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  • Formatas: PDF+DRM
  • Išleidimo metai: 07-Jun-2016
  • Leidėjas: Springer Verlag, Singapore
  • Kalba: eng
  • ISBN-13: 9789811007194
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This comprehensive work broadens readers' understanding of the rudimentary mechanism of the anti-cancer effect of hyperthermia. It also presents state-of-the-art clinical outcomes by hyperthermia treatment of cancer.

In the past few decades, basic and clinical research have shown through in vitro experiments that hyperthermia inhibits epithelial-mesenchymal transition (EMT), resulting in the prevention of metastasis. It also has been learned that hyperthermia shows its superior benefit when applied in combination with radiation therapy, chemotherapy, or various immunotherapies as treatments of several types of carcinoma. The chapters here from expert contributors describe the details of their research for each type of cancer.

This book provides not only an overview and the current status of hyperthermia but also its future perspectives. Therefore this volume will greatly benefit oncologists, radiologists and radiology technologists, and chemotherapists who are involved in immunotherapy for all kinds of cancer.
Part I Basic Science in Cultured Cells
1 Introduction
3(4)
Satoshi Kokura
2 Induction of Oxidative Stress by Hyperthermia and Enhancement of Hyperthermia-Induced Apoptosis by Oxidative Stress Modification
7(12)
Yoshiaki Tabuchi
Kanwal Ahmed
Takashi Kondo
3 Molecular Damage: Hyperthermia Alone
19(14)
Akihisa Takahashi
4 Roles of HSF1 and Heat Shock Proteins in Cancer
33(16)
Kenzo Ohtsuka
5 Cellular Responses in Signal Transduction Pathways Induced by Hyperthermia
49(12)
Takeo Ohnishi
6 Cell Cycle Responses to Hyperthermia
61(16)
Yukihiro Furusawa
7 Thermo-Tolerance
77(6)
Ken Ohnishi
8 Enhancement of Hyperthermia on Radio-Sensitivity
83(8)
Ken Ohnishi
9 Inhibition of DNA Repair System Activity
91(18)
Akihisa Takahashi
10 Enhancement of Hyperthermia on Anti-tumor Drug Sensitivity
109(6)
Takeo Ohnishi
11 Inhibition of Epithelial-to-Mesenchymal Transition (EMT) by Hyperthermia
115(12)
Satoshi Kokura
Part II Basic Science in Whole Body
12 Potentiating Immune System by Hyperthermia
127(10)
Hiroshi Terunuma
13 Magnetic Nanoparticle-Mediated Hyperthermia and Induction of Anti-Tumor Immune Responses
137(14)
Takeshi Kobayashi
Akira Ito
Hiroyuki Honda
14 Tumor Microenvironment and Hyperthermia
151(22)
Shin-ichiro Masunaga
Part III Clinical Science in Cancer Patients
15 Hyperthermia Alone
173(4)
Takayuki Ohguri
16 Combination Therapy with Hyperthermia and Chemoradiotherapy: Oral Cancer
177(16)
Kenji Mitsudo
Iwai Tohnai
17 Combination by Hyperthermia and Radiation (and Chemotherapy): Lung Cancer
193(8)
Takayuki Ohguri
18 Efficacy of Hyperthermia in Combination with Radiation Therapy for Breast Cancer
201(8)
Daigo Yamamoto
Chizuko Yamamoto
Satoru Iwase
Hiroki Odagiri
19 Combination by Hyperthermia and Radiation: Esophageal Cancer
209(6)
Takayuki Ohguri
20 Combination by Hyperthermia and Radiotherapy and/or Chemo-radiotherapy: Gyneology Cancer
215(12)
Yoko Harima
21 Combination by Hyperthermia and Radiation and Chemotherapy: Soft Tissue Sarcoma
227(18)
Hisaki Aiba
Hiroaki Kimura
Takanobu Otsuka
22 Combination by Hyperthermia and Chemotherapy: Lung Cancer
245(4)
Takayuki Ohguri
23 Efficacy of Hyperthermia in Combination With Chemotherapy for Breast Cancer
249(8)
Daigo Yamamoto
Chizuko Yamamoto
Satoru Iwase
Hiroki Odagiri
24 Combination by Hyperthermia and Chemotherapy: Esophageal Cancer
257(4)
Takayuki Ohguri
25 Combination with Hyperthermia and Chemotherapy: Liver Cancer
261(14)
Satoshi Kokura
26 Hyperthermia Combined with Chemotherapy: Pancreatic Cancer
275(12)
Takeshi Ishikawa
27 Effect of Hyperthermia in Combination with Chemotherapy and Radiation Therapy for Treatment of Urological Cancer: Prostate Cancer and Urothelial Cancer
287(8)
Kosuke Ueda
Fumiko Maeda
Mayumi Oota
28 Combination by Hyperthermia and Surgery
295(14)
Takayuki Asao
Hiroyuki Kuwano
Takeo Takahashi
Takashi Nakano
29 Combining Hyperthermia and Immunotherapy: NK Therapy and Hyperthermia
309(10)
Hiroshi Terunuma
Noriyuki Nishino
Tsuyoshi Abe
Akiko Yoshimura
Atsushi Toki
Tatsuaki Ishiguro
Xuewen Deng
Atsushi Terunuma
30 Combination by Hyperthermia and Immunotherapy: DC Therapy and Hyperthermia
319(10)
Tsutomu Takeda
Takashi Takeda
31 Effects of Fever-Range Hyperthermia on T Cell-Mediated Immunity: Possible Combination of Hyperthermia and T Cell-Based Cancer Immunotherapy
329(12)
Keishi Tanigawa
Yusuke Ito
Yasunobu Kobayashi
32 Combination of Hyperthermia and Immunotherapy: Hyperthermia and Naive T-cell Therapy
341(14)
Satoshi Kokura
33 High-Temperature Hyperthermic Intraperitoneal Chemotherapy (H-HIPEC) with Cytoreductive Surgery for Patients with Peritoneal Metastases of Colorectal Cancer and Appendiceal Pseudomyxoma
355(16)
Kanji Katayama
Mitsuhiro Morikawa
Kenji Koneri
Makoto Murakami
Yasuo Hirono
Takanori Goi
Akio Yamaguchi
34 A New Comprehensive Treatment for Peritoneal Metastases Using Cytoreductive Surgery Combined with Hyperthermic Intraperitoneal Chemoperfusion
371(26)
Yutaka Yonemura
Akiyoshi Mizumoto
Haruaki Ishibashi
Kazuyoshi Takeshita
Oliver Glehen
Paul H. Sugarbaker
35 Noninvasive Temperature Monitoring
397(24)
Kagayaki Kuroda
36 Development of Heating Device
421(18)
Masahiro Kuroda
Kazuyuki Saito
Koichi Ito
Shin-ichiro Umemura
37 Epilogue
439
Takeo Ohnishi
Dr. Satoshi Kokura





KOKURA Lab, Health and Medical Sciences, Kyoto Gakuen University





Kyoto, Japan







Dr. Toshikazu Yoshikawa





President





Kyoto Prefectural University of Medicine





Kyoto, Japan







Dr. Takeo Ohnishi

Department of Radiation Oncology

Nara Medical University

















Nara, Japan