Following recent developments in hypofractionated stereotactic radiation therapy (SRT) for brain and spine tumors, this new edition offers a fully updated and comprehensive "how-to" guidance on hypofractionated SRT for brain and spine metastases, glioma, benign tumors, and other tumor types. Presenting the state of the art of the technology and practice, this book:
Discusses the pros and cons of hypofractionated SRT compared to single-fraction radiosurgery, providing a deeper understanding of radiosurgery and radiobiology
Explains the toxicity and adverse effects of hypofractionated SRT including the dosage of 24 Gy in two spine SBRT fractionation schemes, aiding practitioners in communicating the risks and benefits of treatment and in obtaining consent from their patients
Outlines the current standards for safe practice, including checklists for implementation
Explores new technologies for brain and spine tumors including LITT, MR-guided focused ultrasound, and Zap technology, with chapters authored by well-recognized experts in the radiation, oncology, and neurosurgery communities; this book delivers a level of technological and clinical detail not available in journal papers
This book is suitable for radiation oncologists, neurosurgeons, and medical physicists who specialize in brain and/or spine radiosurgery or want to start a program and need a comprehensive reference with key checklists for practice.
Following recent developments in hypofractionated stereotactic radiation therapy for brain and spine tumours, this new edition offers a fully updated and comprehensive, how-to guidance on hypofractionated SRT for brain and spine metastases, glioma, benign tumors, and other tumor types.
1. Tumor Vascular Modulation: Role of Endothelial cells, Ceramide and
Vascular Targeted Therapies
2. Gamma Knife: From single fraction SRS to
IG-HSRT
3. CyberKnife image-guided hypofractionated stereotactic radiotherapy
4. Li5. nac-based IG-HSRT technology
5. Advanced MRI for brain metastases
6.
From frame to frameless: Brain radiosurgery
7. Principles of image-guided
hypofractionated stereotactic radiosurgery for brain tumors
8. Principles of
image-guided hypofractionated radiotherapy of spine metastases
9. Spine
stereotactic body radiotherapy for the treatment of de novo spine metastasis
10. Image-guided hypofractionated stereotactic radiotherapy for reirradiation
of spinal metastases I1. G-HSRT for benign tumors of the spine
12.
Postoperative spine IG-HSRT outcomes
13. Postoperative cavity image-guided
stereotactic radiotherapy outcomes
14. Brain metastases image-guided
hypofractionated radiation therapy: Rationale, approach, outcomes
15.
Image-guided hypofractionated stereotactic whole-brain radiotherapy and
simultaneous integrated boost for brain metastases
16. Image-guided
hypofractionated radiation therapy for high-grade glioma
17.
Hypo-fractionated stereotactic radiotherapy for meningiomas, vestibular
schwannomas and pituitary adenomas
18. Radiation Necrosis
19. Vertebral
compression fracture post-spine SBRT
20. Spinal cord dose limits for
stereotactic body radiotherapy
21. Summary of image-guided hypofractionated
stereotactic radiotherapy (IG-HSRT): Serious Late Toxicities and Strategies
to Mitigate Risk
22. MR-guided focused ultrasound for brain tumors
23. Laser
Thermal Therapy for Brain Tumors
24. Updates on laser interstital therapy for
metastatic tumors of the spine
25. Stereotactic Radiotherapy & Intracranial
Leptomeningeal Disease
26. Minimally invasive percutaneous treatment in the
palliation of painful bone metastases
27. Proton stereotactic radiosurgery
for brain metastases
28. The Zap-X: A Novel 3 Megavolt Linear Accelerator for
Dedicated Intracranial Stereotactic Radiosurgery
29. Immunotherapy and
Radiosurgery for Brain and Spine Metastases
30. 24 Gy in 2 Daily Spine SBRT
Fractions as Developed by the Sunnybrook Health Sciences Centre
31. MRI for
spinal metastases and response determination
32. Stereotactic Body
Radiotherapy (SBRT) for Metastatic Disease to the Sacrum
33. Radiomics and
its Role in Predicting Radiotherapy Response and Outcome in Brain Metastasis
Arjun Sahgal, MD (chief editor), is a leader in the field of high-precision stereotactic radiation to the brain and spine. After training at the University of Toronto, Ontario, Canada, in radiation oncology, he completed a fellowship at the University of California, San Francisco, in brain and spine radiosurgery with Dr. David Larson. Since then he has been recognized as a national and international clinical expert and research leader in radiosurgery. His main focus is on developing spine stereotactic body radiotherapy as an effective therapy for patients with spinal tumors. He has published numerous book chapters on the subject and more than 200 peer-reviewed papers in high-impact journals, including Journal of Clinical Oncology and The Lancet Oncology. He has edited or written several books specific to research on brain and bone metastases and is an editorial board member for several journals. He was chairman of the International Stereotactic Radiosurgery Society meeting (June 2013) and was a board member for the Brain Tumour Foundation of Canada and the International Stereotactic Radiosurgery Society. He has been invited to speak at several international meetings, has been a visiting professor at various universities, and leads several research groups. His further research activities involve integrating MRI into radiotherapy delivery, combining novel pharmacologic therapies with radiosurgery, and MRI-guided focused ultrasound.
