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El. knyga: Imidazole-Based Drug Discovery

Shikha Agarwal (Department of Chemistry, University College of Science, Mohanlal Sukhadia University, Rajasthan, Udaipur, India)

Formatas: PDF+DRM
Serija: Heterocyclic Drug Discovery
Išleidimo metai: 02-Dec-2021
Leidėjas: Elsevier - Health Sciences Division
Kalba: eng
ISBN-13: 9780323903639

Kitos knygos pagal šią temą:

Organic chemistry

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Formatas: PDF+DRM
Serija: Heterocyclic Drug Discovery
Išleidimo metai: 02-Dec-2021
Leidėjas: Elsevier - Health Sciences Division
Kalba: eng
ISBN-13: 9780323903639

Kitos knygos pagal šią temą:

Organic chemistry

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Imidazole-Based Drug Discovery covers all categories of imidazole and its derivatives, synthesis, pharmacological applications and drug-based studies. Imidazole scaffolds act as a channel between organic synthesis and medicinal chemistry and compel researchers to explore new drug candidates. This book provides detailed coverage of several greener synthetic protocols and pharmacological applications of imidazole derivatives that are useful to researchers working on designing more promising clinical lead compounds with this scaffold. It also includes information on past decades of research on the synthesis and biological applications of imidazole derivatives.

This is an ideal resource for researchers in organic chemistry both in academic and industrial settings, as well as postgraduates in chemistry and medicinal chemistry.

Contributors

About the authors

xiii

Preface

xvii

Acknowledgments

xix

1 Imidazole and its derivatives: Introduction and synthetic aspects

Jay Soni

Ayushi Sethiya

Shikha Agarwal

1 Introduction

(4)

2 Synthesis of substituted imidazoles

(9)

2.1 Mono-substituted imidazole derivatives

(1)

2.2 Di-substituted imidazole derivatives

(2)

2.3 Tri-substituted imidazole derivatives

(4)

2.4 Tetra-substituted imidazole derivatives

(2)

3 Imidazole hybrids

(6)

3.1 Imidazole fused heterocycles

(3)

3.2 Benzimidazole fused heterocycles

(2)

4 Benzimidazole

(3)

4.1 Hoebrecker synthesis

(1)

4.2 Synthesis of benzimidazoles using o-phenylene diamine and acids

(1)

4.3 Synthesis of benzimidazoles using o-phenylene diamine and acid anhydride

(1)

4.4 Synthesis of benzimidazoles using o-phenylene diamine and alcohols

(1)

4.5 Synthesis of benzimidazoles using o-phenylene diamine and alkyl halides

(1)

4.6 Synthesis of benzimidazoles using ketones

(1)

4.7 Synthesis of benzimidazoles using o-phenylene diamine and aldehydes

(1)

5 Conclusion

(13)

Conflict of interest

(1)

Acknowledgments

(1)

Funding Source

(1)

References

(11)

2 Biological profile of imidazole-based compounds as anticancer agents

Ayushi Sethiya

Jay Soni

Nusmt Sahiba

Pankaj Teli

Dinesh K. Agarwal

Shikha Agarwal

1 Introduction

(2)

2 Imidazole-based heterocycles

(84)

2.1 Imidazole as the main nucleus in the anticancer compounds

(29)

2.2 Imidazole hybrids as anticancer agents

(20)

2.3 Imidazole fused heterocycles

(24)

2.4 Imidazole-based metal complexes as anticancer agents

112

(10)

3 Conclusion and future challenges

122

(12)

Conflict of interest

122

(1)

Acknowledgment

123

(1)

Funding Source

123

(1)

References

123

(11)

3 Recent advancements on imidazole containing heterocycles as antitubercular agents

Dinesh K. Agarwal

Jay Soni

Ayushi Sethiya

Nusrat Sahiba

Pankaj Teli

Shikha Agarwal

1 Introduction

134

(1)

2 Imidazole-based heterocycles

135

(26)

2.1 Substituted imidazoles

135

(5)

2.2 Hybrid Imidazoles

140

(2)

2.3 Fused imidazoles

142

(10)

2.4 Linker imidazole

152

(3)

2.5 Benzimidazole

155

(6)

3 Conclusion

161

(7)

Conflict of interest

161

(1)

Acknowledgments

162

(1)

Funding Source

162

(1)

References

162

(6)

4 Imidazole derivatives: Impact and prospects in antiviral drug discovery

Pankaj Teli

Nusrat Sahiba

Ayushi Sethiya

Jay Soni

Shikha Agarwal

1 Introduction

168

(2)

2 Imidazole derivatives and their action against different viruses

170

(17)

2.1 Zika virus

170

(2)

2.2 Influenza

172

(3)

2.3 SARS-COVID

175

(2)

2.4 Dengue

177

(1)

2.5 Hepatitis

178

(3)

2.6 HIV

181

(2)

2.7 Miscellaneous

183

(4)

3 Conclusion

187

(8)

Acknowledgments

188

(1)

Conflict of interest

188

(1)

Funding Source

188

(1)

References

188

(7)

5 Imidazole heterocycles: Therapeutically potent lead compounds as antimicrobials

Nusrat Sahiba

Ayushi Sethiya

Shikha Agarwal

1 Introduction

195

(2)

2 Imidazole-based antimicrobial compounds

197

(52)

2.1 Based on imidazole ring generation

197

(26)

2.2 Based on linked moieties

223

(15)

2.3 Based on metal complex

238

(8)

2.4 Based on imidazolium salt or ionic liquids

246

(2)

2.5 Based on polymer

248

(1)

3 Conclusion and future perspectives

249

(14)

Acknowledgments

250

(1)

Conflict of interest

250

(1)

Funding Source

250

(1)

References

250

(13)

6 Imidazole containing heterocycles as antioxidants

Nusrat Sahiba

Ayushi Sethiya

Pankaj Teli

Shikha Agarwal

1 Introduction

263

(1)

2 Imidazole-based antioxidant compounds

264

(21)

2.1 Imidazole

265

(13)

2.2 Benzimidazole

278

(7)

3 Conclusion and future perspectives

285

(6)

Conflict of interest

285

(1)

Acknowledgments

286

(1)

Funding Source

286

(1)

References

286

(5)

7 Miscellaneous biological activity profile of imidazole-based compounds: An aspirational goal for medicinal chemistry

Nusrat Sahiba

Pankaj Teli

Dinesh K. Agarwal

Shikha Agarwal

1 Introduction

291

(2)

2 Imidazole-based bioactive compounds

293

(22)

2.1 Antiparasitic activity

293

(7)

2.2 Anti-Alzheimer's activity

300

(4)

2.3 Antiinflammatory activity

304

(2)

2.4 Antidiabetic activity

306

(2)

2.5 Antihypertensive activity

308

(2)

2.6 Antidepressant activity

310

(1)

2.7 Miscellaneous activities

310

(5)

3 Conclusion and future perspectives

315

(8)

Conflict of interest

316

(1)

Acknowledgments

316

(1)

Funding Source

316

(1)

References

316

(7)

8 Imidazole-based drugs and drug discovery: Present and future perspectives

Ayushi Sethiya

Jay Soni

Dinesh K. Agarwal

Shikha Agarwal

1 Introduction

323

(1)

2 Imidazole-based market available drugs

324

(6)

3 Pharmacokinetics and pharmacodynamic profiles of a drug

330

(1)

4 Synergy between imidazole-based compounds and drug development

330

(13)

4.1 Rational approaches to find imidazole-based drugs

330

(2)

4.2 Imidazole hybrids as a hit for several diseases

332

(2)

4.3 Clinical trials on imidazole-based compounds

334

(1)

4.4 Patents on imidazole-based compounds

334

(9)

5 Conclusion and future prospects

343

(6)

Conflict of interest

344

(1)

Acknowledgment

344

(1)

Funding Source

344

(1)

References

344

(4)

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