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El. knyga: Immune Mechanisms in Inflammatory Bowel Disease

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Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.

Recenzijos

From the reviews:









"This multi-author book provides a complete overview about intestinal immunology, thanks to the contribution of many of the leaders in this field. The completeness of articles allows the reader to consult the book rapidly in order to achieve direct information about the specific aspect he is interested in. This book can be recommended to both researchers interested in basic aspects of inflammatory bowel disease and clinical gastroenterologists who want to raise their awareness of the mechanisms underlying clinical manifestations ." (A. Cassinotti, Digestive and Liver Disease, Vol. 39, 2007)

Structure and Function of the Gut Mucosal Immune System
1(15)
Reinhard Pabst
Hermann J. Rothkotter
Introduction
1(1)
Intraepithelial Lymphocytes (IEL)
1(2)
Lamina Propria Lymphocytes (LPL)
3(1)
Lymphocyte-Filled Villi (LFV)
4(1)
Cryptopatches (CP)
5(1)
Isolated Lymphoid Follicies (ILF)
5(1)
Peyer's Patches (PP)
6(1)
Lymphoid Structures in the Large Intestine
7(1)
Mesenteric Lymph Nodes, Part of the Gut Immune System
7(1)
Gut Lymphatics
8(1)
Liver---Also a Part of the Gut Immune System?
8(1)
Dynamics in the Gut Immune System
9(1)
Conclusions
9(1)
Note Added in Proof
9(6)
Functional Aspects of the Mucosal Immune System
15(9)
Cathryn Nagler-Anderson
Phenotypically and Functionally Unique Lymphocyte Populations in the Gut Associated Lymphoid Tissue
15(3)
Mechanisms Governing Non-Responsiveness to Food Proteins and Commensal Bacteria
18(6)
Recent Progress in Inflammatory Bowel Disease Genetics
24(11)
Judy H. Cho
Introduction
24(1)
IBD Epidemiology
24(1)
The Human Genome Project and the Challenge of Complex Genetic Disorders
25(1)
Linkage Studies in IBD
26(1)
Association Studies in IBD
27(3)
Future Directions
30(5)
Microbial and Dietary Factors in the Pathogenesis of Chronic, Immune-Mediated Intestinal Inflammation
35(20)
R. Balfour Sartor
Introduction
35(3)
Evidence of Bacterial Induction and Maintenance of Intestinal Inflammation
38(4)
Induction of Mucosal Immune Responses by Bacterial and Dietary Antigens and Adjuvants
42(6)
Conclusion
48(7)
Experimental Models of Mucosal Inflammation
55(43)
Warren Strober
Ivan J. Fuss
Introduction
55(1)
General Features of Models of Mucosal Inflammation
56(12)
Representative Models of Mucosal Inflammation
68(12)
Tabular Summary of Models of Mucosal Inflammation
80(1)
Conclusion
80(18)
Overview of Role of the Immune System in the Pathogenesis of Inflammatory Bowel Disease
98(10)
Thomas T. MacDonald
Giovanni Monteleone
Abstract
98(1)
Introduction
98(1)
Crohn's Disease, but Not Ulcerative Colitis Bears the Stigmata of a Th1 Mediated Immune Response
99(1)
The Role of T Cells in Ulcerative Colitis
100(1)
The Role of Antibody in Ulcerative Colitis
100(2)
Nonspecific Effector Mechanisms Down-Stream of the Immune System Cause Tissue Injury in Crohn's Disease and Ulcerative Colitis
102(1)
The Immune System Fails to Negatively Regulate in CD and UC
103(5)
The Role of the Epithelial Barrier in Inflammatory Bowel Disease
108(9)
Edward E.S. Nieuwenhuis
Richard S. Blumberg
Introduction
108(1)
Bacteria and the Epithelium
108(1)
Bacteria and IBD
109(1)
The Epithelial Cell as Effector Cell in IBD
110(2)
Luminal Antigens, Fate and Processing
112(1)
IEC and Mucosal Barrier Function/Permeability
113(1)
Conclusion
113(4)
Involvement of Dendritic Cells in the Pathogenesis of Inflammatory Bowel Disease
117(16)
Francisco Leon
Lesley E. Smythies
Phillip D. Smith
Brian L. Kelsall
Introduction
117(1)
Current Views on Dendritic Cell Biology
117(2)
Intestinal Dendritic Cells
119(3)
Dendritic Cells in Inflammatory Bowel Disease
122(4)
Intestinal Macrophages
126(1)
Intestinal Macrophages in IBD
126(1)
Summary
127(6)
Alterations of T Lymphocytes in Inflammatory Bowel Diseases
133(16)
Charles O. Elson
Yingzi Cong
Casey T. Weaver
CD4+ T Cell Subsets in the Intestine
134(2)
Intestinal T Effector Cells
136(1)
Th2 Effectors in IBD
136(2)
Intestinal T Regulatory Cells
138(1)
CD4+CD45RB10 T Cells
138(1)
T-Regulatory-1 Cells (Tr1)
139(1)
T-Helper-3 Cells (Th3)
139(1)
αEβ7+ T Cells
140(1)
What Drives Effector and Regulatory T Cells in IBD?
141(2)
Conclusion
143(6)
The B-Cell System in Inflammatory Bowel Disease
149(19)
Per Brandtzaeg
Hege S. Carlsen
Trond S. Halstensen
Abstract
149(1)
Introduction
150(1)
B Cell-Mediated Mucosal Homeostasis in the Normal Gut
150(2)
Humoral Immunity and Immune Exclusion in IBD Lesions
152(1)
Local Production of Antibodies to the Indigenous Gut Flora in IBD
153(1)
Local Production of Anti-Epithelial IgG1 Autoantibodies in Ulcerative Colitis
154(2)
Local Production and Diagnostic Aid of Other (Auto)Antibodies in IBD
156(1)
Mechanisms for Induction of Local Proinflammatory B-Cell Responses
157(4)
IBD Apparently Reflects Break of Oral Tolerance against Indigenous Bacteria
161(7)
Alterations of Mesenchymal and Endothelial Cells in Inflammatory Bowel Diseases
168(9)
Claudio Fiocchi
Kenji Ina
Silvio Danese
Andre Z.A. Leite
Jon D. Vogel
Abstract
168(1)
Introduction
168(1)
Mesenchymal Cells
169(1)
Smooth Muscle Cells
169(1)
Fibroblasts and Myofibroblasts
169(1)
Endothelial Cells
170(1)
Human Intestinal Microvascular Endothelial Cells
171(1)
Integration of Intestinal Immune-Nonimmune Cell Interactions by the CD40/CD40 Ligand System
172(5)
Role of Mast Cells and Eosinophils in Neuroimmune Interactions Regulating Mucosal Inflammation in Inflammatory Bowel Disease
177(32)
Stephan C. Bischoff
Thomas Gebhardt
Introduction
177(1)
Intestinal Mast Cells and Eosinophils
178(4)
Role of Mast Cells and Eosinophils in Intestinal Inflammation
182(2)
Structure and Function of The Enteric Nervous System
184(2)
Mechansims of Mast Cell / Eosinophil-Neuroimmune-Crosstalk in the Gut
186(5)
Neurophysiological Effects of Mast Cell and Eosinophil Activation
191(3)
Alterations of Neuroimmune-Crosstalk in IBD
194(3)
Conclusions
197(12)
Multiparameter Analysis of Immunogenetic Mechanisms in Clinical Diagnosis and Management of Inflammatory Bowel Disease
209(10)
Jonathan Braun
Stephan R. Targan
Abstract
209(1)
NOD2 and Innate Anti-Microbial Processes in IBD Diagnosis
209(2)
Anti-Microbial Antibodies and Adaptive Immune Components in IBD Diagnosis
211(2)
Autoantibodies in IBD Diagnosis
213(1)
Multiparameter Analysis of Immunogenetic Traits in IBD Diagnosis
213(6)
The Role of Probiotics and Antibiotics in Regulating Mucosal Inflammation
219(8)
Rainer Duchmann
Abstract
219(1)
Probiotics: Animal Studies and Clinical Trials
219(1)
Probiotics: Mechanisms
220(1)
Antibiotics: Animal Studies and Clinical Trials
221(1)
Antibiotics: Mechanisms
221(1)
General Problems
222(1)
Perspectives
222(5)
From Immunogenic Mechanisms to Novel Therapeutic Approaches in Inflammatory Bowel Disease
227(16)
Martin H. Holtmann
Markus F. Neurath
Abstract
227(1)
Introduction
227(1)
Genetic Factors
228(1)
Physiological ``Hyporeactivity'' of the Intestinal Immune System
229(1)
Activation of the Mucosal Immune System in IBD
229(5)
Novel Therapeutic Approaches
234(4)
Concluding Remarks
238(5)
Index 243


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