Immunology in the Twentieth Century: From Basic Science to Clinical Application grew out of common knowledge that those who survived many of the common infectious diseases rarely contracted the same disease again. This book charts the historical development of this vital branch of medicine in a concise volume, covering both the basic science involved and the clinical applications. Immunology as a distinctive subject developed in the mid-twentieth century as researchers started to understand how the adaptive immune system aids the defense against pathogens. The subject has grown in importance and diversified into specialist fields, such as immunohistochemistry, immunogenetics and immunopathology.
- Provides a concise overhead of the history of immunology and its applications in medicine
- Includes a discussion of the scientists who were pioneers in landmark discoveries in immunology
- Summarizes the clinical applications of major discoveries
| Preface |
|
vii | |
| Acknowledgement |
|
xiii | |
|
|
|
1 | (16) |
|
1.1 The Antibody Production |
|
|
1 | (4) |
|
1.2 The Antibodies Structure |
|
|
5 | (2) |
|
1.3 The Molecular Basis of Antibodies Diversity |
|
|
7 | (2) |
|
1.4 How an Antigen Influences the Antibody Structure |
|
|
9 | (8) |
|
|
|
14 | (3) |
|
Chapter 2 The Cells of Immunity |
|
|
17 | (20) |
|
|
|
20 | (7) |
|
2.2 The Role of the "Bursa of Fabricius" and Thymus in the Immune Response |
|
|
27 | (3) |
|
2.3 The Resource of Natural Immunity and the Emergence of Regulatory Function of Cytokines |
|
|
30 | (7) |
|
|
|
34 | (3) |
|
Chapter 3 The Genetic Basis of Immune Response |
|
|
37 | (10) |
|
3.1 Antigen Recognition Controlled by Major Histocompatibility Complex |
|
|
37 | (3) |
|
|
|
40 | (2) |
|
3.3 Immune Tolerance and the Immunological Basis of Transplant Rejection |
|
|
42 | (5) |
|
|
|
46 | (1) |
|
Chapter 4 Immune System Pathologies |
|
|
47 | (18) |
|
|
|
47 | (5) |
|
|
|
52 | (2) |
|
4.3 Immediate Hypersensitivity |
|
|
54 | (2) |
|
4.4 Delayed Hypersenitivity |
|
|
56 | (2) |
|
|
|
58 | (7) |
|
|
|
62 | (3) |
|
Chapter 5 Immunity and Tumors: The Surveillance Theory |
|
|
65 | (4) |
|
|
|
68 | (1) |
|
|
|
69 | (2) |
| References |
|
71 | |
Domenico Ribatti was awarded his M.D. degree in October 1981, with full marks. In 1983, D.R. joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara (Romania). D.R. is author of 866 publications as reported in PUBmed and contributed to 50 chapters to books. Overall, his papers have been cited 51153 times.
He has published many books with both Elsevier and Springe
Daugiau apie elektronines knygas