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Infertility in Practice 5th edition [Kietas viršelis]

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(Professor of Reproductive Medicine and Surgery, Leeds Teaching Hospitals, UK)
  • Formatas: Hardback, 442 pages, aukštis x plotis: 254x178 mm, weight: 1180 g, 32 Tables, black and white; 20 Line drawings, color; 101 Line drawings, black and white; 32 Halftones, color; 53 Halftones, black and white; 52 Illustrations, color; 154 Illustrations, black and white
  • Serija: Reproductive Medicine and Assisted Reproductive Techniques Series
  • Išleidimo metai: 21-Dec-2022
  • Leidėjas: CRC Press
  • ISBN-10: 0367557444
  • ISBN-13: 9780367557447
Kitos knygos pagal šią temą:
Infertility in Practice 5th editionDidesnis paveikslėlis
  • Formatas: Hardback, 442 pages, aukštis x plotis: 254x178 mm, weight: 1180 g, 32 Tables, black and white; 20 Line drawings, color; 101 Line drawings, black and white; 32 Halftones, color; 53 Halftones, black and white; 52 Illustrations, color; 154 Illustrations, black and white
  • Serija: Reproductive Medicine and Assisted Reproductive Techniques Series
  • Išleidimo metai: 21-Dec-2022
  • Leidėjas: CRC Press
  • ISBN-10: 0367557444
  • ISBN-13: 9780367557447
Kitos knygos pagal šią temą:
Pastovi nuoroda: https://www.kriso.lt/db/9780367557447.html
Raktažodžiai:
"This text has been written as a practical guide, based on the author's experience over the last 40 years of daily clinical practice and aiming to place the modern approach to the management of infertility in the context of sound theory and evidence-based therapy. It provides the reader with a comprehensive classification of the causes of infertility, their investigation, and their management. This new edition covers many advances in the understanding and management of infertility and other updates to practice - for example, a greater understanding of the pathophysiology of ovarian aging and ovarian reserve testing, the classification of disorders of ovulation and management of polycystic ovary syndrome, the refinement of regimens for superovulation, improved embryo culture systems and the use of artificial intelligence for the selection of embryos, assessments for endometrial receptivity and management of recurrent implantation failure, and pre-implantation genetic testing (PGT) as a therapeutic tool opening up the possibility for aneuploidy screening, as well as the latest thoughts on nutritional health, periconception care, and the exciting new world of the microbiome"--

This text has been written as a practical guide, based on the author’s experience over the last 40 years of daily clinical practice and aiming to place the modern approach to the management of infertility in the context of sound theory and evidence-based therapy. It provides the reader with a comprehensive classification of the causes of infertility, their investigation, and their management. This new edition covers many advances in the understanding and management of infertility and other updates to practice - for example, a greater understanding of the pathophysiology of ovarian aging and ovarian reserve testing, the classification of disorders of ovulation and management of polycystic ovary syndrome, the refinement of regimens for superovulation, improved embryo culture systems and the use of artificial intelligence for the selection of embryos, assessments for endometrial receptivity and management of recurrent implantation failure, and pre-implantation genetic testing (PGT) as a therapeutic tool opening up the possibility for aneuploidy screening, as well as the latest thoughts on nutritional health, periconception care, and the exciting new world of the microbiome.



This text is a practical guide, based on the author’s experience over the last 40 years of daily clinical practice, aiming to place modern approach to management of infertility in the context of sound theory and evidence-based therapy.

Recenzijos

"...packed with dense knowledge, advice and experience...a superb resource" - Pavilion Health Today

Foreword xiii
Richard S. Legro
Preface xv
About the Author xviii
1 Epidemiology of Infertility, 21st-Century Considerations and the Covid-19 Pandemic
1(11)
1.1 Introduction
1(1)
1.2 Ovarian Ageing
2(2)
1.3 At What Age Should Couples Start Trying for a Family?
4(1)
1.4 Fertility Education
4(1)
1.5 Measuring Infertility and Response to Treatment
5(1)
1.6 Definition of Infertility
6(1)
1.7 Is Infertility Becoming More Common?
6(2)
1.8 Is Infertility on the Rise?
8(1)
1.9 Principles of Infertility Treatment
9(1)
1.10 Covid-19 and Fertility
9(3)
2 Prevention of Infertility
12(9)
2.1 Introduction
12(1)
2.2 Impact of Age on Male and Female Fertility
12(2)
2.3 Can Women Protect Fertility against Ageing?
14(1)
2.4 Contraception
14(1)
2.5 Environmental Pollutants
15(1)
2.6 Are Sperm Counts Falling?
16(1)
2.7 Hypospadias, Cryptorchidism and Testicular Cancer
17(1)
2.8 Conclusion
18(3)
3 Planning a Pregnancy and Preconception Care
21(25)
3.1 Introduction
21(1)
3.2 A Preconception Healthcare Programme
21(1)
3.3 Body Weight
22(1)
3.4 Dietary Advice for Women Wishing to Conceive
23(1)
3.5 Folic Acid (Folate)
24(1)
3.6 Exercise
25(1)
3.7 Supplements for Male Fertility
25(1)
3.8 Special Diets for Sex Selection
26(1)
3.9 The Microbiome
26(1)
3.10 Oral Health
27(1)
3.11 Smoking, Alcohol and Recreational Drugs
27(2)
3.12 Anabolic Androgenic Steroids
29(1)
3.13 Acquired Infections
29(1)
3.14 Medical Conditions and Drugs
30(1)
3.15 Endocrine Disorders
30(3)
3.16 Diabetes
33(1)
3.17 Psychiatric Disorders
33(1)
3.18 Neurological Disorders
34(1)
3.19 Gastrointestinal Disease
35(1)
3.20 Renal Disease
36(1)
3.21 Cardiovascular Disease
36(1)
3.22 Respiratory Disease
37(1)
3.23 Antibiotics and Anti-Infective Agents
37(2)
3.24 Haematological Problems
39(1)
3.25 Connective Tissue Disorders
40(1)
3.26 Chemotherapy
41(5)
4 Obesity and Reproduction
46(10)
4.1 Introduction
46(1)
4.2 Defining Obesity and the Extent of the Problem
46(2)
4.3 Influence of Obesity on Natural Fertility
48(1)
4.4 Obesity and Polycystic Ovary Syndrome
49(1)
4.5 Effect of Obesity on Treatment of Anovulatory Infertility
49(1)
4.6 Effect of Obesity on IVF and Related Treatments
50(1)
4.7 Effect of Obesity on Pregnancy
51(1)
4.8 Provision of Support in Achieving Weight Loss
51(1)
4.9 Guidelines for Accessing Treatment
52(4)
5 Investigating Infertility
56(60)
5.1 Introduction
56(1)
5.2 General Investigations
56(1)
5.3 Investigating the Female Partner
57(4)
5.4 Diagnosis of Anovulatory Infertility
61(3)
5.5 Endocrine Profile
64(2)
5.6 Progesterone
66(1)
5.7 Follicle-Stimulating Hormone
66(1)
5.8 Ovarian Reserve Tests
66(2)
5.9 Luteinising Hormone
68(1)
5.10 Androgens
69(1)
5.11 Thyroid Function
70(1)
5.12 Prolactin
71(1)
5.13 Oestrogen
71(1)
5.14 Glucose Tolerance
71(1)
5.15 Other Investigations
72(1)
5.16 Pelvic Ultrasound
72(1)
5.17 Ovarian Morphology
73(1)
5.18 Differentiating between PCOM and PCOS
74(5)
5.19 Ovarian Cysts
79(3)
5.20 Endometrial Assessment
82(1)
5.21 Doppler Ultrasound in Assisted Conception
83(1)
5.22 Assessment of Tubal Patency and the Uterine Cavity
83(6)
5.23 Ultrasound Contrast Hysterosalpingography or Hysterosalpingo Contrast Sonography
89(4)
5.24 Selective Salpingography and Falloposcopy
93(1)
5.25 Laparoscopy and Hysteroscopy
94(4)
5.26 Transvaginal Hydroculdoscopy/Hydrolaparoscopy/Salpingoscopy
98(1)
5.27 Choosing between HSG and Laparoscopy
98(1)
5.28 MRI/Computed Tomography Scans
98(1)
5.29 Investigating the Male Partner
98(3)
5.30 Semen Analysis
101(3)
5.31 Reduced Sperm Concentration (Oligozoospermia)
104(1)
5.32 Impaired Sperm Morphology (Teratozoospermia)
104(1)
5.33 Reduced Sperm Motility (Asthenozoospermia)
104(2)
5.34 Sperm Dysfunction and DNA Fragmentation
106(1)
5.35 Leukospermia
106(1)
5.36 Cervical Mucus Penetration and the Post-Coital Test
107(1)
5.37 Antisperm Antibodies
107(1)
5.38 Serum Endocrinology in the Male
107(1)
5.39 Chromosomal Analysis
108(1)
5.40 Imaging in Male Infertility
108(1)
5.41 Testicular Exploration and Biopsy
109(7)
6 Anovulatory Infertility and Ovulation Induction
116(54)
6.1 Introduction
116(1)
6.2 Primary and Secondary Amenorrhoea
117(3)
6.3 Pituitary and Hypothalamic Causes of Anovulation
120(1)
6.4 Hypogonadotrophic Hypogonadism
120(5)
6.5 Weight-Related Amenorrhoea
125(3)
6.6 Systemic Disorders Leading to Anovulation
128(1)
6.7 Exercise-Related Amenorrhoea
129(1)
6.8 Hyperprolactinaemia
130(5)
6.9 Polycystic Ovary Syndrome
135(27)
6.10 Summary
162(8)
7 Polycystic Ovary Syndrome
170(33)
7.1 Introduction
170(1)
7.2 What Is PCOS?
171(1)
7.3 Pathophysiology of PCOS
172(1)
7.4 Ovarian Biochemistry
173(3)
7.5 Hypothalamic-Pituitary-Ovarian Axis
176(3)
7.6 Hyperinsulinaemia
179(1)
7.7 Definitions and Heterogeneity of PCOS
180(3)
7.8 Prevalence of PCOS and Ethnic Variations
183(2)
7.9 PCOS in Adolescence
185(1)
7.10 Management of Non-Fertility Aspects of PCOS
186(1)
7.11 Psychological Support and Quality of Life
186(1)
7.12 Obesity
186(2)
7.13 Menstrual Irregularity
188(1)
7.14 Hyperandrogenism and Hirsutism
188(2)
7.15 Reproductive Health in PCOS
190(1)
7.16 Health Consequences of PCOS
191(3)
7.17 PCOS and Cancer
194(1)
7.18 Conclusion
195(8)
8 Premature Ovarian Insufficiency and Oocyte Donation
203(12)
8.1 Introduction
203(1)
8.2 Control of Ovarian Ageing
203(2)
8.3 Incipient POI ("Resistant Ovary Syndrome")
205(1)
8.4 Diagnosis of POI
205(1)
8.5 Causes of POI
206(3)
8.6 Management of POI
209(1)
8.7 Oocyte Donation
210(1)
8.8 Experimental Approaches to Combatting POI
211(4)
9 Endometriosis
215(16)
9.1 Introduction
215(1)
9.2 Diagnosis
215(3)
9.3 Non-Invasive Testing for Biomarkers of Endometriosis
218(1)
9.4 Classification of Endometriosis
218(1)
9.5 Biopsy
218(1)
9.6 Cysts
219(3)
9.7 Management of Endometriosis
222(1)
9.8 Medical Therapy for Fertility
223(1)
9.9 Surgical Therapy
224(2)
9.10 Endometriosis and IVF
226(1)
9.11 Adenomyosis
227(1)
9.12 Proposed Strategy for Management of Endometriosis
227(4)
10 Tubal Infertility, Fibroids and Uterine Factors
231(23)
10.1 Introduction
231(12)
10.2 Uterine Problems: Congenital Anomalies, Septa, Fibroids, Polyps, Adhesions and Uterine Anomalies
243(11)
11 Male Factor Infertility
254(24)
11.1 Introduction
254(1)
11.2 General Lifestyle Factors
255(1)
11.3 Drugs
255(1)
11.4 Chemotherapy and Radiotherapy
256(1)
11.5 Occupational Factors
256(1)
11.6 Anabolic Steroids
256(1)
11.7 Cannabis and Other Recreational Drugs
256(1)
11.8 Hypospadias, Cryptorchidism and Testicular Cancer
256(1)
11.9 Orchitis and Prophylactic Mumps, Measles, Rubella Vaccination
257(1)
11.10 Sexually Transmitted Infections
258(1)
11.11 Testicular Trauma
258(1)
11.12 Hypogonadism
258(1)
11.13 Oligoasthenozoospermia
259(1)
11.14 Frequency of Intercourse
260(1)
11.15 Leukospermia
260(1)
11.16 Oxidative Stress and ROS
260(1)
11.17 Varicocele
261(1)
11.18 Antisperm Antibodies
262(2)
11.19 Obstructive Azoospermia
264(1)
11.20 Congenital Bilateral Absence of the Vasa Deferentia
264(1)
11.21 Young's Syndrome
265(1)
11.22 Kartagener's Syndrome
265(1)
11.23 Surgical Trauma and Vasectomy
265(1)
11.24 Microsurgical Reconstruction of the Vasa
265(2)
11.25 Idiopathic Male Factor Infertility
267(2)
11.26 Paternal Ageing
269(1)
11.27 Coital Dysfunction and Psychosexual Problems
269(1)
11.28 Hypergonadotrophic Testicular Failure
270(1)
11.29 IUI, IVF and ICSI
271(1)
11.30 Androgen Insensitivity Syndrome
271(1)
11.31 Donor Insemination
271(7)
12 Unexplained Infertility
278(7)
12.1 Introduction
278(1)
12.2 Assessing the Cause of Infertility
278(2)
12.3 Management of Unexplained Infertility
280(1)
12.4 Clomifene Citrate
280(1)
12.5 Letrozole
280(1)
12.6 IUI
281(1)
12.7 Gamete Intrafallopian Transfer
282(1)
12.8 IVF
282(1)
12.9 Strategy for Management of Unexplained Infertility
283(2)
13 In Vitro Fertilisation
285(44)
13.1 Introduction
285(1)
13.2 Indications for IVF
285(1)
13.3 Viral Screening before Assisted Conception Therapies
286(1)
13.4 IVF
286(1)
13.5 Regimens for IVF
287(4)
13.6 Dosing of Stimulation for IVF
291(1)
13.7 Monitoring the IVF Cycle and Ovarian Response to Stimulation
292(2)
13.8 Ovarian Reserve and Prediction of Response to Stimulation
294(1)
13.9 Poor Responders
294(1)
13.10 Response of the Polycystic Ovary to Stimulation for IVF
295(6)
13.11 Oocyte Retrieval
301(1)
13.12 Embryo Culture and Embryo Transfer
301(5)
13.13 Number of Embryos for Transfer
306(3)
13.14 ICSI for Severe Male Factor Infertility
309(3)
13.15 The Embryo Transfer Procedure
312(1)
13.16 Endometrial Assessment
312(1)
13.17 The Endometrial Scratch
313(1)
13.18 Luteal-Phase Support after IVF
313(1)
13.19 The Frozen Embryo Replacement Cycle
314(1)
13.20 Pregnancy Rates after IVF
315(1)
13.21 Oocyte Donation
316(1)
13.22 Surrogacy
317(1)
13.23 The Human Fertilisation and Embryology Authority and Regulation in the United Kingdom
318(11)
14 Fertility Preservation
329(6)
14.1 Cryopreservation of Gametes and Embryos
329(3)
14.2 In Vitro Growth of Follicles
332(1)
14.3 Protection of the Ovaries against Chemotherapy
332(1)
14.4 Testicu lar Tissue Freezi ng
332(1)
14.5 Transgender Fertility Preservation
333(2)
15 Pre-Implantation Genetic Testing and Emerging Technologies
335(13)
15.1 Pre-Implantation Genetic Testing
335(2)
15.2 Modes of Inheritance
337(1)
15.3 The Process of PGT
337(3)
15.4 PGT-A
340(3)
15.5 Supernatant Testing
343(1)
15.6 Emerging Technologies
344(4)
16 Complications of Ovarian Stimulation
348(16)
16.1 Introduction
348(1)
16.2 Drug-Specific Side Effects
348(2)
16.3 The Ovarian Hyperstimulation Syndrome
350(8)
16.4 Multiple Pregnancy
358(1)
16.5 The Risk of Cancers in Subfertile Populations and after Fertility Treatment
359(5)
17 Counselling and Modern Families
364(8)
17.1 Introduction
364(1)
17.2 Infertility and Subfertility
364(1)
17.3 Psychosexual Problems
365(1)
17.4 How to Deal with Work
366(1)
17.5 Special Needs of the Male Partner
366(1)
17.6 Adjustment to Parenthood
367(1)
17.7 How to Tell Children of Donated Gametes
367(1)
17.8 Surrogacy
367(1)
17.9 Modern Families
368(1)
17.10 Transgender Pregnancies
368(1)
17.11 Emotional Support for Clinic Staff
369(1)
17.12 The Infertility Counsellor
369(1)
17.13 Welfare of the Child
370(2)
18 Ethical and Religious Issues
372(10)
18.1 Introduction
372(1)
18.2 Does Everyone Have a Right to Treatment?
373(1)
18.3 Biological Considerations
373(1)
18.4 Moral Status of the Embryo
374(1)
18.5 Is IVF Ethical?
374(1)
18.6 Experiments on Human Embryos, Cloning and Stem Cell Research
375(1)
18.7 Donors and Donation
376(1)
18.8 Sex Selection
377(1)
18.9 Fetal Reduction
378(1)
18.10 Should Older Women Be Offered IVF?
378(1)
18.11 Rel igious Perspectives
379(1)
18.12 Conclusion
380(2)
19 Health Outcomes of Children Born after Assisted Conception
382(6)
19.1 Introduction
382(1)
19.2 Manipulated Gametes
382(1)
19.3 IVF
382(2)
19.4 ICSI
384(1)
19.5 Imprinting Disorders
385(1)
19.6 Cryopreserved Gametes or Embryos
385(3)
20 Miscarriage and Ectopic Pregnancy
388(12)
20.1 Introduction
388(1)
20.2 Incidence of Miscarriage
388(1)
20.3 Parental Age
388(1)
20.4 Health Conditions, Lifestyle Factors and Risks of Miscarriage
389(1)
20.5 Diagnosis of Pregnancy
390(1)
20.6 Prevention of Miscarriage
391(1)
20.7 Management of Miscarriage
391(1)
20.8 Ectopic Pregnancy
391(1)
20.9 Diagnosis of Ectopic Pregnancy
392(1)
20.10 Management of Ectopic Pregnancy
392(5)
20.11 Counselling and Support
397(3)
21 Recurrent Miscarriage and Recurrent Implantation Failure
400(10)
21.1 Introduction
400(1)
21.2 Classification of Recurrent Miscarriage
400(1)
21.3 Nutritional Causes
401(1)
21.4 Environmental Factors
401(1)
21.5 Genetic Causes
402(1)
21.6 Anatomical Abnormalities
402(1)
21.7 Infection and the Microbiome
403(1)
21.8 Endocrine Abnormalities
403(1)
21.9 Luteal-Phase Defects and Progesterone Therapy
403(1)
21.10 Thrombophilias
404(1)
21.11 Immunological Causes of Recurrent Miscarriage
405(1)
21.12 Summary of the Investigation and Management of Couples with Recurrent Miscarriage
406(1)
21.13 Recurrent Implantation Failure
406(4)
22 Alternative Therapies and "Add-Ons"
410(3)
23 When to Stop Treatment and Other Options
413(4)
23.1 Introduction
413(1)
23.2 Adoption
414(1)
23.3 Adopting a Child from Overseas
415(1)
23.4 Fostering
415(1)
23.5 Respite Care
416(1)
Appendix: Daily Vitamin and Mineral Requirements (See
Chapter 3)		 417(3)
Books for Further Reading 420(2)
Index 422
Adam Balen MB, BS, MD, DSc, FRCOG is a full time Consultant in Reproductive Medicine at Leeds Teaching Hospitals NHS Trust, Professor of Reproductive Medicine and Surgery at St. James University Hospital, Consultant and the Clinical Lead at Leeds Fertility, a partner at Balance Fertility, former Chair of the British Fertility Society, and the Royal College of Obstetricians and Gynaecologist's spokesperson for fertility.