Integrated Neuroscience argues that in order to make an intelligent diagnosis and provide a rational treatment nervous system disorders, it is necessary to answer the basic questions of clinical neurology. Where is the disease process located, and what is the nature of the disease process? For students to answer these questions, the authors first review the makeup of the cells within the central nervous system and the development of the regions within the central nervous system. A detailed anatomical overview of the nervous system, starting at the spinal cord, proceeding to the brain stem, diencephalon and cerebrum follows. This textbook focuses not only on localized diseases caused by infectious diseases, trauma, tumors, and vascular lesions within the central nervous system, but also these diseases within the systems of the brain and spinal cord. Over 250 real cases with associated MRI or CTs and any pathological findings from these patients illustrate numerous disorders and fully explain the nature of the pathology. The authors have also included six problem solving sessions in which the student must identify the ongoing disease process, what caused it, and how best to treat it. Throughout the discussion in this text the authors also correlate the neurological findings to the underlying anatomy of the region.
Preface |
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xi | |
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SECTION ONE INTRODUCTION TO BASIC NEUROBIOLOGY |
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1 Overview of the Nervous System |
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3 | (19) |
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2 Overview of Localization of Function and Neurological Diagnosis |
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22 | (23) |
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3 Neurocytology: Cells of the Central Nervous System |
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45 | (27) |
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4 Neuroembryology and Congenital Malformations |
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72 | (19) |
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5 Skeletal Muscle and Nerve-Muscle Junction |
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91 | (20) |
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SECTION TWO REGIONAL APPROACH TO NEUROANATOMY AND FUNCTIONAL LOCALIZATION |
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6 Spinal Cord: Structure and Function |
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111 | (22) |
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7 Atlas of the Spinal Cord |
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133 | (5) |
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8 A Survey of Diseases of Peripheral Nerve and Nerve Root |
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138 | (24) |
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9 Spinal Cord: Clinical Considerations |
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162 | (31) |
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10 Case History Problem Solving: Part I: Spinal Cord, Nerve Root, Peripheral Nerve, and Muscle |
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193 | (6) |
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11 Functional Anatomy of the Brain Stem |
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199 | (22) |
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221 | (31) |
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13 Brain Stem: Clinical Considerations |
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252 | (29) |
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14 Case History Problem Solving: Part II: Brain Stem and Cranial Nerves |
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281 | (7) |
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15 Diencephalic Nuclei, Functional Localization, and Atlas of the Diencephalon |
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288 | (23) |
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SECTION THREE MAJOR SYSTEMS |
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16 Hypothalamus, Neuroendocrine System, and Autonomic Nervous System |
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311 | (14) |
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17 Cerebral Cortex: Cytoarchitecture, Physiology, and Overview of Functional Localization |
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325 | (22) |
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18 Motor System and Movement: Part I: Reflex Activity, Central Pattern Generators, and Cerebral Cortical Motor Functions |
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347 | (24) |
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19 Motor Systems: Part II: Basal Ganglia and Movement Disorders |
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371 | (24) |
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20 Motor Systems: Part III: Cerebellum and Movement and Major Fiber Pathways of the Cerebellum |
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395 | (19) |
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21 Somatosensory Function and the Parietal Lobe |
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414 | (8) |
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422 | (22) |
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444 | (16) |
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24 Speech, Language, Cerebral Dominance, and the Aphasias |
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460 | (16) |
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25 Case History Problem Solving: Part IV: Cortical Localization |
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476 | (6) |
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26 Cerebral Hemispheres: Neuropathology and Clinical Correlation I. Vascular Syndromes |
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482 | (23) |
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27 Cerebral Hemispheres: Neuropathology and Clinical Correlation II. Nonvascular Syndromes |
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505 | (33) |
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28 Case History Problem Solving: Part IV: Cerebral Hemispheres |
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538 | (11) |
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SECTION FOUR COMPLEX FUNCTIONS |
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29 Alterations in Consciousness: Seizures, Sleep, and Coma |
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549 | (26) |
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30 Learning, Memory, Amnesia, Dementia, Instinctive Behavior, and the Effects of Early Experience |
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575 | (23) |
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31 Case History Problem Solving: Part V: General Cases |
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598 | (7) |
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32 Case History Problem Solving: Part VI: Case History Review with Correlation to Illustrations |
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605 | (9) |
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614 | (5) |
Index |
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619 | |
The late Elliott M. Marcus, MD, was Professor Emeritus of Neurology, University of Massachusetts School of Medicine, Lecturer in Neurology, Tufts University School of Medicine, Chairman Emeritus, Department of Neurology, Saint Vincent Hospital and Fallon Clinic, Worcester, MA.
Stanley Jacobson, PhD is Professor of Anatomy and Cellular Biology at Tufts University, Health Sciences Campus, Boston, MA. He is also a Fulbright Scholar.
Thomas D. Sabin, MD, is a Professor of Neurology at Tufts University School of Medicine, Tufts Medical Center, Boston, MA.