Our immune system defends us against infection by employing multiple lines of defense. The relevance of the immune response in human health, disease prevention, and vaccinations becomes evident when the immune system is compromised as in the case of pathogenic infections or autoimmune diseases. The reader will gain a fundamental understanding of the essential principles of immunology, such as how our immune system recognizes/fights infectious agents, how our body differentiates between foreign and self-cells/molecules, and how the memory from previous infections aids in a faster and more effective immune response. The book is divided into 17 chapters, providing an overview of the immune system and its components, including its organs and cells. Chapters on the major histocompatibility complex, the complement system, hypersensitivity and tolerance, antibody diversity through DNA rearrangements, and autoimmune diseases are included in the book which further broadens the understanding of this very complex system of our body. Chapters on transplantation immunology and vaccines provide a perspective on the application of these immunological concepts and will be of great interest to readers.
Key features of the book:
Simple, direct, and lucid language
Comprehensive coverage of concepts for better understanding
Well-labeled illustrations, flowcharts, and tables for enhanced learning
Every chapter is followed up with a detailed summary and questionnaire
A detailed glossary for users to know the right words
Chapters contributed/reviewed by experienced experts in this field
The book provides broad, accessible, and up-to-date information about immunological perspectives to biotechnologists, biomedical scientists, biochemists, molecular biologists, and students from various streams of life sciences, including zoology, biotechnology, and microbiology, as well as instant access to a wealth of information.
| Preface |
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vii | |
| Contributors |
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ix | |
| Glossary |
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xi | |
| Editors |
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xxix | |
| Abbreviations |
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xxxi | |
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Chapter 1 Overview of Immune System |
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1 | (26) |
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Chapter 2 Innate Immunity |
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27 | (34) |
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Chapter 3 Adaptive Immunity |
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61 | (36) |
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97 | (12) |
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109 | (24) |
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Chapter 6 Antigen-Antibody Interactions |
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133 | (18) |
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Chapter 7 Major Histocompatibility Complex and Antigen Presentation |
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151 | (22) |
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173 | (16) |
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Chapter 9 The Complement System |
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189 | (18) |
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Chapter 10 Tolerance and Autoimmunity |
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207 | (10) |
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Chapter 11 Hypersensitivity |
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217 | (16) |
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Chapter 12 Transplantation Immunology |
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233 | (18) |
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251 | (24) |
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Chapter 14 Generation of Receptor Diversity |
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275 | (14) |
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Chapter 15 Biology of the B Lymphocyte |
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289 | (16) |
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Chapter 16 Biology of the T Lymphocytes |
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305 | (16) |
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Chapter 17 Cell-Mediated Cytotoxic Responses |
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321 | (10) |
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| Index |
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331 | |
Dr. Indrakant K. Singh received his Ph.D. in Zoology from the Department of Zoology, University of Delhi (DU). Dr. Singh is currently working as Professor (Zoology), Deshbandhu College, & Fellow, Delhi School of Public Health, Institute of Eminence, University of Delhi, New Delhi, where he enjoys teaching, Immunology, Genomics, Computation Biology, and Medical Diagnostics. He is a recipient of the Young Scientist Award/Fellowship (2013-2016) by Science & Engineering Research Board (SERB), Raman-Post Doctoral Fellowship (2016-17), Max-Planck Society Visiting Post-Doctoral Fellowship (2019) and ICMR-DHR Long Term International Fellowship for Young Bio-medical Scientists (2019-20 & 2022-23), Prestigious Delhi University Excellence Award for Teacher in Service 2021 and DHR Long Term Fellowship for Training in Indian Institute (2022). He has also been awarded with Best Researcher, 2017 and Best Teacher, 2018 by Grace India Trust India. Dr. Singh also filed two (2) patents (India & USA) on Mycobacterium tuberculosis. Prof. Singh is a life-member/Fellow/member of many prestigious academic societies including the RSB, AMCA, IBS, and AIMI, ESI, BSI. Dr. Singh has published more than 50 quality research articles in peer-reviewed journals of international repute like Scientific Reports, International Journal of Biological Macromolecules, Critical Reviews in Biotechnology, Clinica Chimica Acta, International Journal of Molecular Sciences and BBA Molecular Basis of Disease, Computational Biology and Chemistry, Phytochemistry, Anti-Cancer Agents in Medicinal Chemistry. He is an editorial board member in many international and national journals like Scientific Reports-SpringerNature etc. He has also edited four books and authored more than 30 book chapters published by Springer, Taylor & Francis and Elsevier. Dr. Singh has served as a reviewer for several international and national refereed journals. Dr. Singh has trained many post-doctoral, doctoral, post-graduate and graduate students, and currently supervises five doctoral and two post-doctoral, fore M.Tech. students. Over the years, he has pursued his research interests in the areas of Molecular biology, Cancer Biology, and Functional Genomics
Dr. Poonam Sharma, Associate Professor at Department of Zoology, Gargi College, University of Delhi, India has more than 15 years of teaching experience. Dr. Sharma received the prestigious "BOYSCAST FELLOW" award from the Department of Science and Technology of the Government of India for outstanding research in the field of environmental engineering at LIEBE, Université Paul Verlaine-Metz, France. Dr. Sharma was also a Visiting fellow at Swiss Federal Institute for Environmental Science and Technology (EAWAG), Dubendorf, Switzerland. She received her Ph.D. in Cell and Molecular Biology from the Department of Zoology, University of Delhi (DU). She has edited and written several chapters and modules for postgraduate, undergraduate, and senior secondary school students. Dr. Sharma has a number of peer-reviewed journal papers to her credit and has participated in a number of international and national conferences.
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