This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases.
Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.
Part
1. Historical Aspects of Drug Discovery.
Chapter
1. The Great
Pharmacologists and Their Revolutionary Discoveries.
Chapter
2. Indian
Contributions to Pharmacology.- Part
2. General Pharmacological Principles.-
Chapter
3. Sources and Nature of Drugs.
Chapter
4. Principles and Modes of
Drug Administration.
Chapter
5. Drug Absorption and Bioavailability.-
Chapter
6. Drug Distribution.
Chapter
7. Drug Metabolism.
Chapter
8. Drug
Elimination.
Chapter
9. Mechanisms of Drug Action.
Chapter
10. Drug
Transporters.
Chapter
11. Adverse Effects and Pharmacovigilance.
Chapter
12. Drug Interactions.
Chapter
13. Structure-Activity Relationships.- Part
3. Special Topics in Pharmacology.
Chapter
14. Drug Information.
Chapter
15. Pharmacogenetics, Pharmacogenomics and Personalized Medicine.
Chapter
16. Chronopharmacology.
Chapter
17. Pharmacoepidemiology.
Chapter
18.
Ethnopharmacology.
Chapter
19. Pharmacoeconomics.
Chapter
20. Orphan
Diseases and Drugs.
Chapter
21. Fixed-DoseCombinations.
Chapter
22.
Translational and Reverse Pharmacology.
Chapter
23. Gene Therapy.
Chapter
24. Stem Cell Therapy.
Chapter
25. Principles of Prescription Writing.- Part
4. Toxicology.
Chapter
26. Environmental Toxicology.
Chapter
27. Basic
Principles of Management of Drug Poisoning.- Part
5. Molecular Biology in
Pharmacology.
Chapter
28. Regulation of Gene Expression.
Chapter
29.
Proteomics.
Chapter
30. Techniques Involved in Studying Receptor Dynamics.-
Chapter
31. Polymerase Chain Reaction.
Chapter
32. Southern, Western and
Northern Blotting.
Chapter
33. Antisense Oligonucleotides.
Chapter
34.
Recombinant DNA Technology.
Dr. Gerard Marshall Raj. D holds an M.B.B.S. and M.D. in Pharmacology. Currently, he is working as an Assistant Professor at the Dept. of Pharmacology, Sri Venkateshwaraa Medical College Hospital & Research Centre, Puducherry, India. He has published two book chapters, one on Intellectual Property Rights in Drug Development and Biotechnology in the book Intellectual Property Issues in Biotechnology (CABI; ISBN: 9781780646534) and the other on Intellectual Property Issues Surrounding Antimicrobial Agents in the book Intellectual Property Issues in Microbiology (Springer-Nature; ISBN: 9789811374654). He was awarded the Prof. M. N. Ghosh Gold Medal for outstanding performance during the M.D. Pharmacology course at JIPMER, Puducherry and has published many research articles, reviews, commentaries, case reports and letters-to-the-editor in peer-reviewed and indexed journals.
Dr. Ramasamy Raveendran, Dean (Research) -cum- Professor (Senior Scale) and Head of Pharmacology, JIPMER, Puducherry, graduated from the University of Madras and obtained his M.D. degree in Pharmacology from JIPMER, Puducherry and his Diploma in Clinical Pharmacology from St Bartholomews Medical College, London, UK. With over 34 years of research and teaching experience, his main interests include Computer Assisted Learning (CAL) and toxicology. He has authored 55 research papers, 7 CAL software packages and 1 book. He has also conducted more than 50 workshops on research methodologies, biomedical communication and biostatistics throughout India. He was chief editor of the Indian Journal of Pharmacology from 2001 to 2006 and is currently editor-in-chief of the Journal of Pharmacology and Pharmacotherapeutics (since 2010). Further, as the Dean (Research) of JIPMER, he is coordinating all research activities at the premier institute.
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