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El. knyga: Introduction to Food Toxicology

3.71/5 (12 ratings by Goodreads)
(University of California, Berkeley, USA), (University of California, Davis, USA)
  • Formatas: EPUB+DRM
  • Serija: Food Science and Technology
  • Išleidimo metai: 24-Mar-2009
  • Leidėjas: Academic Press Inc
  • Kalba: eng
  • ISBN-13: 9780080921532
Kitos knygos pagal šią temą:
  • Formatas: EPUB+DRM
  • Serija: Food Science and Technology
  • Išleidimo metai: 24-Mar-2009
  • Leidėjas: Academic Press Inc
  • Kalba: eng
  • ISBN-13: 9780080921532
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The rapidly expanding field of food safety includes many new developments in the understanding of the entire range of toxic compounds found in foods -- whether naturally occuring or having been introduced by industry or food processing methods. This second edition of Introduction to Food Toxicology explores these development while continuing to provide a core understanding of the basic principles of food toxicology.

Introduction to Food Toxicology 2nd edition includes new and updated coverage of key topics including the circulatory systems and their influence on toxicity, molecular mechanisms of absorption and excretion, the multiplicity and specificity of phase I and II reactions, toxins from marine food sources including the growing number of toxins from symbiotic bacteria, algae and plankton, focus on the occurrence and modes of action of the central mycotoxins and information on emerging problems, including fumonisins, regulations, including the Food Quality Control Act, solid-pfase extraction, immuno assay, and LC/MS, mechanisms of regulation of xenobiotic activation and deactivation, developments in the modes of action and impact of natural toxins in food plants, a comprehensive review of the issues surrounding dioxins, the function of antioxidants and their toxicological aspects, acrylamide, its occurrence, toxicity and regulation on its use, phytochemicals, their beneficial effects and the modes of action of this growing group of nutraceuticals from food plants and diet and drug interactions.

*New information on:
--Solid-phase extraction, immuno assay, and LC/MS
--Mechanisms of regulation of xenobiotic activation and deactivation
--Developments in the modes of action and impact of natural toxins in food plants
--A comprehensive review of the issues surrounding dioxins
--The function of antioxidants and their toxicological aspects
--Acrylamide, its occurrence, toxicity and regulation on its use
--Phytochemicals, their beneficial effects and the modes of action of this growing group of nutraceuticals from food plants
--Diet and drug interactions

The rapidly expanding field of food safety includes many new developments in the understanding of the entire range of toxic compounds found in foods -- whether naturally occurring or having been introduced by industry or food processing methods. This 2e of Introduction to Food Toxicology explores these developments while continuing to provide a core understanding of the basic principles of food toxicology.

*New information on:
--Solid-phase extraction, immunoassay, and LC/MS
--Mechanisms of regulation of xenobiotic activation and deactivation
--Developments in the modes of action and impact of natural toxins in food plants
--A comprehensive review of the issues surrounding dioxins
--The function of antioxidants and their toxicological aspects
--Acrylamide, its occurrence, toxicity and regulation on its use
--Phytochemicals, their beneficial effects and the modes of action of this growing group of nutraceuticals from food plants
--Diet and drug interactions

Daugiau informacijos

Newly revised and updated to provide complete coverage of food toxicology core concepts
Preface x
Principles of Toxicology
1(32)
Branches of Toxicology
4(1)
Dose-Response
5(3)
Potency
8(1)
Hormesis
9(1)
Margin of Safety
10(2)
Biologic Factors that Influence Toxicity
12(1)
Absorption
13(3)
Types of Membrane Transport
16(2)
Toxin Absorption in the Alimentary Tract
18(1)
Intestinal Microflora
19(1)
The Blood-Brain Barrier
20(1)
Xenobiotic Absorption into Lymph
21(1)
Translocation
22(1)
Distribution
23(2)
Storage
25(2)
Organ Storage
25(1)
Lipid Storage
26(1)
Bone Storage
26(1)
Excretion
27(1)
Kidney
27(2)
Effects of Maturation on Kidney Excretion
29(4)
Fecal Excretion of Xenobiotics
29(4)
Determination of Toxicants in Foods
33(20)
Sampling
35(1)
Qualitative and Quantitative Analyses of Toxicants in Foods
35(6)
Sample Preparation for Analysis of Toxicants
36(4)
Isolation and Identification by Chromatography
40(1)
Biological Determination of Toxicants
41(12)
Acute Toxicity
41(1)
Genetic Toxicity
42(1)
Bioassay
43(4)
Metabolism
47(1)
Subchronic Toxicity
47(1)
Teratogenesis
48(2)
Chronic Toxicity
50(3)
Biotransformation
53(32)
Phase I Reactions
54(3)
Phase II Reactions
57(4)
Phase I Enzymes
61(9)
Cytochrome P450
61(3)
CYP3A4
64(2)
CYP1B1
66(2)
CYP2E1
68(2)
Peroxidases
70(3)
Flavin-Containing Monooxygenase (FMO)
73(1)
Epoxide Hydrolase (EH)
74(2)
Esterases
76(2)
Carboxylesterases (CES)
76(1)
Paraoxonase
77(1)
Phase II Xenobiotic Metabolism
78(7)
Glucuronide Conjugation
79(1)
Sulfate Conjugation
80(1)
Glutathione Conjugation
81(4)
Chemical Carcinogenesis
85(14)
Definitions
85(1)
Phases of Carcinogenesis
86(6)
Initiation
86(2)
Promotion
88(1)
Progression
88(1)
Angiogenesis
89(3)
Cancer Epidemiology
92(3)
Dietary Guidelines for Cancer Prevention
95(4)
Natural Toxins in Animal Foodstuffs
99(24)
Natural Toxins in Land Animal Foodstuffs
99(3)
Bile Acids
100(1)
Vitamin A
100(2)
Transmissible Spongiform Encephalopathies (TSEs) and Prions
102(3)
Discovery of Bovine Spongiform Encephalopathy (BSE)
102(1)
Discovery of Toxic Principle Prion
103(1)
Mode of Action of Prion
104(1)
Natural Toxins in Marine Foodstuffs
104(1)
Tetrodotoxin---Puffer Fish Poison
105(18)
Paralytic Shellfish Poisoning (PSP)
108(3)
Ciguatera
111(2)
Neurotoxic Shellfish Poisoning (NSP)
113(2)
Amnesic Shellfish Poisoning (ASP)
115(2)
Voltage-Gated Na+ Channels
117(1)
Scombroid Fish Poisoning
118(5)
Toxic Phytochemicals
123(36)
Phytotoxins
124(28)
Goitrogens
124(3)
Environmental Antithyroid Substances
127(2)
Favism
129(4)
Neurolathyrism
133(1)
Cyanogenic Glycosides
134(4)
Lectins
138(3)
Vasoactive Amines
141(2)
Caffeine
143(3)
Curare
146(1)
Strychnine
147(2)
Atropine
149(3)
Phytoalexins
152(2)
Herb-Drug Interactions
154(5)
Toxins from Fungi
159(22)
Mycotoxins
159(17)
Ergotism
160(3)
Alimentary Toxic Aleukia
163(2)
Fumonisins
165(2)
Aflatoxin
167(9)
Mushrooms
176(5)
Amanita phalloides
176(2)
Amanita muscaria
178(2)
Psilocybe
180(1)
Food Contaminants from Industrial Wastes
181(30)
Chlorinated Hydrocarbons
181(11)
Polychlorinated Biphenyls (PCBs)
181(6)
Polychlorinated Dibenzo-p-dioxins (PCDDs)
187(5)
Heavy Metals
192(19)
Arsenic
193(3)
Lead
196(6)
Mercury
202(4)
Cadmium
206(5)
Pesticide Residues in Foods
211(18)
What is a Pesticide?
211(1)
History
212(2)
Pesticides in the Food Chain
214(2)
Regulations
216(2)
Insecticides
218(8)
DDT
218(2)
Chlorinated Cyclodiene Insecticides
220(2)
Organophosphate Insecticides
222(3)
Carbamate Insecticides
225(1)
Herbicides
226(1)
Chlorophenoxy Acid Esters
226(1)
Naturally Occurring Pesticides
227(2)
Food Additives
229(24)
Regulations
232(5)
Preservatives
237(5)
Benzoic Acid
238(2)
Sorbic Acid and Potassium Sorbate
240(1)
Hydrogen Peroxide
241(1)
AF-2 [ 2-(-furyl)-3-(5-nitro-2-furyl)acrylamide]
241(1)
Antioxidants
242(3)
L-Ascorbic Acid (Vitamin C)
243(1)
dl-α-Tocopherol (Vitamin E)
243(1)
Propyl Gallate
244(1)
Butylated Hydroxyanisol and Butylated Hydroxytoluene
244(1)
Sweeteners
245(2)
Saccharin and Sodium Saccharin
245(1)
Sodium Cyclamate
246(1)
Coloring Agents
247(3)
Amaranth (FD&C Red No. 2)
248(1)
Tartrazine (FD&C Yellow No. 4)
249(1)
Flavoring Agents
250(2)
Methyl Anthranilate
250(1)
Safrole (1-Allyl-3,4-Methylenedioxybenzene)
251(1)
Diacetyl (2,3-butane dione)
251(1)
Flavor Enhancers
252(1)
Toxicants Formed During Food Processing
253(24)
Polycyclic Aromatic Hydrocarbons (PAHs)
255(5)
Occurrence
256(1)
Benzo[ a]pyrene (BP)
257(3)
Maillard Reaction Products
260(1)
Polycyclic Aromatic Amines (PAA)
261(4)
Occurrence
261(1)
Toxicity
262(3)
N-Nitrosamines
265(4)
Precursors
265(1)
Occurrence in Various Foods
266(1)
Toxicity
267(1)
Mode of Toxic Action
267(1)
General Considerations
268(1)
Acrylamide
269(4)
Formation Mechanisms of Acrylamide in Foods
270(2)
Toxicity
272(1)
Mode of Action
272(1)
General Considerations
273(1)
Food Irradiation
273(4)
Food Factors and Health
277(16)
Probiotcs, Prebiotics, and Synbiotics
278(3)
Probiotics
278(1)
Prebiotics
278(2)
Synbiotics
280(1)
Antioxidants
281(5)
The Role of Oxygen in Living Organisms
281(1)
In vivo Balance between Oxidants and Antioxidants
282(1)
Lipid Peroxidation
283(2)
Toxicity of RCCs
285(1)
Functional Components Found in Food for Disease Prevention
286(7)
Index 293