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El. knyga: Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents

Edited by (Ethicon Endo-Surgery, Inc., Sommerville, NJ, U.S.A.), Edited by (Professor and Chair, Department of Comparative Medicine, Penn State University Colleg), Edited by (Associate Vice President for Research, Attending Veterinarian, University of Kentucky, USA)
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The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents is a single volume, comprehensive book sanctioned by the American College of Laboratory Animal Medicine (ACLAM), covering the rabbit, guinea pig, hamster, gerbil and other rodents often used in research. This well illustrated reference includes basic biology, anatomy, physiology, behavior, infectious and noninfectious diseases, husbandry and breeding, common experimental methods, and use of the species as a research model. With many expert contributors, this will be an extremely valuable publication for biomedical researchers, laboratory animal veternarians and other professionals engaged in laboratory animal science.

  • A new gold standard publication from the American College of Laboratory Animal Medicine series
  • One stop resource for advancements in the humane and responsible care of: rabbit, guinea pig, hamster, gerbil, chinchilla, deer mouse, kangaroo rat, cotton rat, sand rat, and degu
  • Includes up-to-date, common experimental methods
  • Organized by species for easy access during bench research

Recenzijos

"...a thorough review of the responsible use of these species in research...a well organized, easily read volume that serves as both a handy reference and as an authoritative compilation." --Anticancer Research, February 2015

"The book is easy to use, despite its size, as the information is well indexed by diseases and speciesI highly recommend this text as the editors with their 112 coauthors have met the goal to provide a comprehensive resource for laboratory rabbits, guinea pigs, hamsters, and other rodents." --Veterinary Pathology, September 2013

"The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents serves as a thorough review of the responsible use of these species in research a well organized, easily read volume that serves as both a handy reference and as an authoritative compilation." --Anticancer Research, Volume 33, issue no. 5, May 2013

Daugiau informacijos

Winner of PROSE (Single Vol. Ref/Science) 2012.This single volume reference, arranged in section by species often used in research, includes basic biology, anatomy, physiology, behavior, infectious and noninfectious diseases, husbandry and breeding, common experimental methods, and use of the species as a research model.
Preface xiii
List of Contributors
xv
List of Reviewers
xix
I GENERAL
1 Ethical Considerations and Regulatory Issues
Marilyn J. Brown
Kathleen L. Smiler
Introduction
3(1)
Ethical Concepts
4(10)
Ethical Challenges
14(6)
Institutional Animal Welfare Oversight
20(1)
Regulations and Non-regulatory Considerations
21(6)
Conclusion
27(1)
References
27(7)
2 Anesthesia and Analgesia
Patrick A. Lester
Rashida M. Moore
Katherine A. Shuster
Daniel D. Myers
Pre-anesthetic Preparation
34(1)
Controlled Substances
34(1)
Pharmacology
35(9)
Anesthesia Circuits
44(2)
Anesthesia Monitoring and Support
46(3)
Surgical Anesthesia
49(1)
Post-operative Monitoring and Pain Assessment
50(3)
References
53(6)
3 Clinical Biochemistry and Hematology
Ida M. Washington
Gerald Van Hoosier
Introduction
59(1)
Clinical Biochemistry
59(11)
Rabbit
70(6)
Guinea Pig
76(4)
Hamster
80(5)
Other Rodents
85(5)
Hematology
90(7)
Rabbit
97(5)
Guinea Pig
102(2)
Hamster
104(2)
Other Rodents
106(4)
References
110(7)
4 Euthanasia and Necropsy
Mihai Gagea-Iurascu
Suzanne Craig
Introduction
117(1)
Euthanasia
117(6)
Necropsy
123(11)
Pathology Considerations
134(2)
References
136(6)
5 Zoonoses and Occupational Health
David W. Brammer
Introduction
142(1)
Viral Diseases
142(2)
Rickettsial Diseases
144(2)
Chlamydial Diseases
146(1)
Bacterial Diseases
146(3)
Fungal Diseases
149(1)
Cestode Infections
150(1)
Arthropod Infections
150(1)
Allergies
150(1)
Prevention of Allergy and Zoonotic Disease
151(1)
References
151(6)
II RABBITS
6 The Domestic Rabbit, Oryctolagus Cuniculus: Origins and History
Katherine A. Naff
Suzanne Craig
Introduction and Background
157(1)
Phylogeny and Taxonomy
158(1)
Geographic Origins and Diversity
159(1)
Domestication and Breed Development
160(1)
Ecology and Conservation
161(1)
References
162(3)
7 Rabbit Genetics and Transgenic Models
Neil D. Christensen
Xuwen Peng
Rabbit Genetics
165(9)
Transgenic Rabbits
174(11)
Conclusions
185(1)
References
185(10)
8 Anatomy, Physiology, and Behavior
Joanne Sohn
Marcelo A. Couto
Introduction
195(1)
External Features
196(1)
Osteology
197(2)
Oral Cavity
199(1)
Abdominal Viscera
200(3)
Urogenital System
203(4)
Thoracic Viscera
207(1)
Brain and Spinal Cord
208(3)
Metabolism
211(1)
Behavior
211(2)
Acknowledgment
213(1)
References
213(5)
9 Rabbit Colony Management and Related Health Concerns
Robert H. Quinn
Introduction
218(1)
Laboratory Management
218(11)
Breeding
229(3)
Nutrition
232(4)
Nutritionally Related Diseases
236(2)
References
238(5)
10 Basic Experimental Methods in the Rabbit
Cynthia A. Pekow
Introduction
243(1)
Handling and Restraint
244(2)
Sampling Techniques
246(4)
Compound Administration
250(4)
Specialized Research Techniques
254(2)
References
256(3)
11 Polyclonal Antibody Production
Harold E. Stills
Introduction
259(1)
The Immunogen
260(1)
Immunogen Dose
261(1)
Route of Immunization
262(1)
Immunization Schedule
263(1)
Adjuvants
263(7)
Summary
270(1)
References
270(5)
12 Toxicity and Safety Testing
Debra Kirchner
Susan Henwood
Introduction
275(1)
Toxicity Testing
276(4)
Safety Testing
280(14)
Metabolism and Toxicokinetics
294(2)
Acknowledgments
296(1)
References
296(7)
13 Bacterial Diseases
David Delong
Introduction
303(1)
Pasteurellosis
303(11)
Enterotoxemia
314(4)
Tyzzer's Disease
318(3)
Colibacillosis
321(5)
Salmonellosis
326(2)
Staphylococcosis
328(3)
Treponematosis
331(4)
Necrobacillosis
335(2)
Listeriosis
337(2)
Tuberculosis
339(2)
Tularemia
341(2)
Proliferative Enteropathy
343(1)
Miscellaneous Bacterial Diseases
344(4)
References
348(17)
14 Viral Diseases
Thea Brabb
Ronald E. Di Giacomo
Introduction
365(3)
DNA Virus Infections
368(18)
RNA Virus Infections
386(15)
References
401(14)
15 Parasitic Diseases
Stacy Pritt
Kimberley Cohen
Heather Sedlacek
Introduction
415(1)
Protozoa
416(12)
Arthropods
428(7)
Helminths
435(8)
References
443(5)
16 Rabbit Neoplasia
Peggy T. Tinkey
Rajesh K. Uthamanthil
Steven H. Weisbroth
Introduction
448(10)
Neoplasms of Oryctolagus cuniculus
458(29)
Neoplasms of Sylvilagus
487(2)
Neoplasms of Lepus
489(1)
References
489(15)
17 Mycoses and Non-Infectious Diseases
Kristie Brock
Laura Gallaugher
Valerie K. Bergdall
Robert C. Dysko
Introduction
504(1)
Mycotic Diseases
504(1)
Non-Infectious Diseases
505(18)
References
523(7)
18 The Rabbit as an Experimental Model
Tanya H. Burkholder
Garry Linton
Robert E. Hoyt, Jr.
Richard Young
Introduction
530(1)
Cardiovascular Diseases
530(7)
Ophthalmic Diseases
537(5)
Central Nervous System Diseases
542(1)
Respiratory Diseases
542(3)
Urogenital Diseases
545(1)
Gastrointestinal Diseases
546(2)
Musculoskeletal Diseases
548(2)
Multisystemic Diseases
550(2)
Acknowledgments
552(1)
References
552(11)
III GUINEA PIGS
19 Taxonomy and History
Stacy Pritt
Introduction
563(1)
Taxonomy and Geographical Distribution
564(2)
Origin and Domestication
566(2)
Genetics
568(4)
References
572(4)
20 Anatomy, Physiology, and Behavior
Maureen Hargaden
Laura Singer
Introduction
576(1)
External Anatomy
576(2)
Musculoskeletal System
578(3)
Digestive System
581(2)
Cardiovascular System
583(3)
Pulmonary System
586(4)
Genitourinary System
590(6)
Nervous System
596(1)
Special Senses
596(2)
Behavior
598(1)
References
599(4)
21 Management, Husbandry, and Colony Health
Vincent C. Gresham
Vicky L. Haines
Introduction
603(1)
Handling
604(1)
Housing
604(7)
Reproduction and Breeding
611(1)
Nutrition
612(2)
Colony Health
614(1)
Record Keeping
615(2)
References
617(4)
22 Basic Experimental Methods
Richard B. Huneke
Introduction
621(1)
Handling and Restraint
621(1)
Sampling Techniques
622(2)
Compound Administration
624(1)
Specialized Research Techniques
624(8)
References
632(6)
23 Infectious Diseases
Thea Brabb
Denise Newsome
Andrew Burich
Martha Hanes
Introduction
638(1)
Viral Diseases
638(7)
Bacterial Infections
645(16)
Fungal Infections
661(4)
Protozoa Infections
665(4)
Parasitic Infections
669(7)
References
676(10)
24 Non-Infectious Diseases
Bruce H. Williams
Introduction
686(1)
Cardiovascular System
686(1)
Respiratory System
687(1)
Gastrointestinal System
688(3)
Urinary System
691(1)
Endocrine System
692(1)
Reproductive System
693(3)
Musculoskeletal System
696(2)
Integumentary System
698(2)
Special Senses
700(1)
Hematolymphatic System
700(1)
Multisystemic Conditions
701(1)
References
702(3)
25 Guinea Pigs as Experimental Models
Douglas K. Taylor
Vanessa K. Lee
Introduction
705(1)
Models of Disease
706(22)
References
728(19)
IV HAMSTERS
26 Taxonomy and History
Gerald D. Smith
Taxonomy
747(1)
Geographical Distribution
747(1)
Origin and Domestication
748(2)
Genetics
750(1)
Acknowledgments
751(1)
References
751(2)
27 Anatomy, Physiology, and Behavior
Kathleen A. Murray
Introduction
753(1)
External Features
753(1)
Musculoskeletal System
754(1)
Digestive System
754(2)
Circulatory System
756(1)
Pulmonary System
757(1)
Genitourinary System
757(3)
Nervous System
760(1)
Special Senses
761(1)
Behavior
762(1)
References
762(3)
28 Management, Husbandry, and Colony Health
Guy B. Mulder
Introduction
765(1)
Housing
765(1)
Environmental Conditions
766(2)
Nutrition
768(2)
Breeding
770(1)
Colony Health
771(3)
Record Keeping
774(1)
References
775(4)
29 Biomedical Research Techniques
Jerald Silverman
Introduction
779(1)
General Non-Surgical Procedures
780(3)
Injections and Intubations
783(3)
Biological Specimen Collections
786(3)
Other Surgical Procedures
789(4)
References
793(5)
30 Bacterial and Fungal Diseases
Craig S. Frisk
Introduction
798(1)
Bacterial Diseases
798(18)
Fungal Diseases
816(1)
References
817(5)
31 Viral Diseases
Amy Cassano
Skye Rasmussen
Felix R. Wolf
Introduction
822(1)
DNA Viruses
822(6)
RNA Viruses
828(5)
Miscellaneous Viruses
833(1)
References
833(6)
32 Parasitic Diseases
Holly N. Burr
Lee-Ronn Paluch
Gordon S. Roble
Neil S. Lipman
Introduction
839(1)
Protozoa
840(7)
Nematodes
847(7)
Cestodes
854(3)
Arthropods
857(6)
References
863(4)
33 Non-Infectious Diseases
Brian Karolewski
Thomas W. Mayer
Gaye Ruble
Introduction
867(1)
Diseases Associated with Aging
867(4)
Nutritional Disorders
871(1)
Genetic, Traumatic, Environmental and Other Non-Infectious
Diseases
871(1)
Neoplasms
872(1)
References
872(4)
34 The Experimental Use of Syrian Hamsters
Helen Valentine
Erin K. Daugherity
Bhupinder Singh
Kirk J. Maurer
Introduction
876(1)
Cancer Research
876(3)
Metabolic Diseases
879(4)
Non-Cancerous Respiratory Diseases
883(2)
Cardiovascular
885(2)
Infectious Disease Research
887(7)
Other Models
894(4)
References
898(9)
35 The Chinese or Striped-Back Hamster
William P. Feeney
Introduction
907(1)
Biology
908(1)
Care and Husbandry
909(1)
Cytogenetics and Fetal Development
910(1)
Diseases
910(3)
Research Uses
913(5)
Summary
918(1)
References
919(4)
36 The European Hamster
Judy Fenyk-Melody
Taxonomy
923(1)
History
923(1)
Biology
924(4)
Behavior
928(1)
Diseases
929(1)
Management, Husbandry, and Colony Health
930(1)
Experimental Methodology
930(1)
Use in Biomedical Research
930(1)
References
931(4)
37 Other Hamsters
Beth A. Bauer
Cynthia Besch-Williford
Introduction
935(1)
Phodopus sungorus (Djungarian Hamster)
935(4)
Mesocricetus brandti (Turkish Hamster)
939(2)
Cricetulus migratorius (Armenian Hamster)
941(1)
Mesocricetus newtoni (Romanian Hamster)
942(1)
References
943(6)
V CHINCHILLAS
38 Taxonomy and History
Brent J. Martin
Introduction
949(1)
Taxonomy
949(2)
History
951(1)
References
952(3)
39 Anatomy, Physiology, and Behavior
Leanne C. Alworth
Stephen B. Harvey
Introduction
955(1)
External Features
955(2)
Unique Biological Characteristics
957(6)
Behavior
963(2)
References
965(2)
40 Management, Husbandry, and Colony Health
Stephen I. Levin
Diana M.P. Berger
Tracy L. Gluckman
Introduction
967(1)
Housing Systems
967(2)
Environmental Conditions
969(1)
Nutrition
970(1)
Breeding
971(2)
Colony Health
973(1)
Record Keeping
973(2)
References
975(2)
41 Basic Experimental Methods
Charlie C. Hsu
Jeleen A. Briscoe
Angela B. Keffer
Introduction
977(1)
Handling and Restraint
978(2)
Mechanical Methods
980(2)
Sampling Techniques
982(6)
Compound Administration
988(2)
Specialized Research Techniques
990(1)
References
990(3)
42 Diseases and Veterinary Care
John N. Norton
Randall P. Reynolds
Introduction
993(1)
Infectious Diseases
994(6)
Gastrointestinal and Metabolic Diseases
1000(1)
Traumatic Lesions
1001(1)
Management-Related Disorders
1002(1)
Neoplastic Diseases
1002(1)
Miscellaneous Conditions
1002(4)
References
1006(3)
43 Chinchillas as Experimental Models
Lisa Martin
Introduction
1009(1)
Models Related to Aural Disease
1010(7)
Models Related to Hearing Loss
1017(9)
Future of Chinchilla Models
1026(1)
References
1026(6)
VI OTHER RODENTS
44 Degu
Lesley A. Colby
Howard G. Rush
Megan M. Mahoney
Theresa M. Lee
Introduction
1032(1)
History and Taxonomy
1032(1)
Anatomy, Physiology, and Behavior
1033(5)
Management, Husbandry, and Colony Health
1038(5)
Handling and Restraint
1043(1)
Sampling Techniques
1044(1)
Compound Administration
1044(1)
Anesthesia and Analgesia
1044(2)
Euthanasia and Necropsy
1046(1)
Diseases
1046(1)
The Degu as an Experimental Model
1047(2)
References
1049(6)
45 Naked Mole Rat
Rochelle Buffenstein
Thomas Park
Martha Hanes
James E. Artwohl
History
1055(1)
Taxonomy
1056(1)
General Description
1056(1)
Natural Habitat
1057(1)
Behavior
1058(1)
Reproductive Behavior
1059(1)
General Physiology
1060(1)
Anatomy and Physiology of Organ Systems
1061(4)
Aging
1065(1)
Husbandry
1066(1)
Colony Health
1067(2)
Use in Research
1069(2)
References
1071(4)
46 Deer Mice, White-Footed Mice, and their Relatives
Peter C. Smith
Jodi A. Carlson Scholz
Steven R. Wilson
Introduction
1075(3)
Biology
1078(2)
Husbandry
1080(1)
Captive Breeding
1081(1)
Diseases
1081(3)
Anesthesia/Analgesia
1084(1)
References
1085(4)
47 Dormouse
John P. Long
Cheri L. West
Introduction
1089(1)
Taxonomy and History
1089(1)
Anatomic Characteristics
1090(1)
Husbandry
1090(1)
Nutrition
1091(1)
Housing
1091(1)
Environmental Conditions
1092(1)
Handling
1092(1)
Breeding
1092(1)
Diseases and Zoonoses
1092(1)
Colony Health Monitoring
1092(1)
Experimental Applications
1092(1)
Biomethodology
1093(1)
References
1093(2)
48 Kangaroo Rat
Denise M. Newsom
Gerald L. Van Hoosier, Jr.
Introduction
1095(2)
Biology
1097(3)
Diseases
1100(1)
Use in Research
1101(1)
Laboratory Care
1102(1)
References
1103(2)
49 Cotton Rat
Joseph E. Curlee
Dale M. Cooper
Introduction
1105(1)
Biology
1106(2)
Husbandry
1108(1)
Diseases
1109(1)
Experimental Methods
1110(1)
Use in Research
1110(1)
Acknowledgments
1111(1)
References
1111(4)
50 Pocket Gopher
M. Susan Devries
Introduction
1115(4)
Biology
1119(3)
Diseases
1122(1)
References
1123(2)
51 White-Tailed Rat
Beth A. Bauer
Cynthia L. Besch-Williford
Introduction
1125(1)
Taxonomy, History, and Genetics
1125(1)
Anatomy, Physiology, and Behavior
1126(1)
Management, Husbandry, and Colony Health
1127(1)
Basic Experimental Methods
1127(1)
Diseases and Veterinary Care
1128(1)
Experimental Models
1129(1)
References
1129(3)
52 Gerbils
Margaret Batchelder
Lynn S. Keller
Mary Ball Sauer
Wanda L. West
Introduction
1132(1)
Taxonomy and History
1132(1)
Anatomy, Physiology, and Behavior
1133(5)
Management, Husbandry, and Colony Health
1138(3)
Basic Experimental Methods
1141(3)
Veterinary Care and Diseases
1144(2)
Gerbils as Experimental Models
1146(3)
References
1149(9)
53 Egyptian Fat-Tailed Jird
Stephen A. Felt
Nancy L. Merrill
Fady I. Guirguis
Hussein I. Hussein
Introduction
1158(1)
Anatomy, Physiology, and Behavior
1159(1)
Management, Husbandry, and Colony Health
1160(4)
Diseases
1164(3)
Anesthesia/Analgesia, Euthanasia, and Necropsy
1167(1)
Use in Research
1167(1)
Basic Experimental Methods
1168(1)
References
1169(2)
54 Sand Rat
Rony Kalman
Ehud Ziv
Galila Lazarovici
Eleazar Shafrir
Introduction
1171(1)
Selection of Reliable Diets and Psammomys Lines for Diabetes Research
1172(1)
Metabolic Efficiency
1173(3)
Morphology, Physiology, Breeding Performance, and Husbandry
1176(3)
The Basis of Diabetes in Psammomys
1179(6)
The Relevance of Psammomys to Diabetes Research
1185(1)
The Genetic Basis of Psammomys Diabetes
1186(1)
Worldwide Research Using Psammomys
1187(1)
Complications of Diabetes in Psammomys
1187(1)
Concluding Remarks
1188(1)
References
1188(5)
VII FORMULARY AND NORMATIVE VALUES
55 Formulary
Sean Maguire
C. Terrance Hawk
Introduction
1193(1)
Rabbit (Oryctolagus cuniculus)
1194(14)
Guinea Pig (Cavia porcellus)
1208(9)
Hamster (Mesocricetus auratus)
1217(5)
Degu (Octodon degus)
1222(2)
Other Species
1224(1)
References
1225(7)
56 Normative Values
Jolaine M. Wilson
Diane J. Gaertner
James O. Marx
E. Claire Hankenson
Rabbits (Oryctolagus cuniculus)
1232(1)
Guinea pigs (Cavia porcellus)
1233(1)
Hamsters
1234(2)
Gerbils (Meriones unguiculatus)
1236(1)
Chinchillas (Chinchilla laniger)
1237(1)
Other rodents
1238(5)
References
1243
Mark Suckow received his DVM from the University of Wisconsin in 1987 and subsequently completed a post-doctoral residency in laboratory animal medicine at the University of Michigan in 1990. He spent 8 years as a clinical laboratory animal veterinarian at Purdue University and then 17 years at the University of Notre Dame where he served as Director of the Freimann Life Science Center and later as Associate Vice President for Research Compliance. Prior to coming to the University of Kentucky, he was Professor of Veterinary Population Medicine and Director, Research Animal Resources at the University of Minnesota. With an interest in cancer models, biomaterials models, and vaccines, Dr. Suckow has functioned as an independent and collaborative investigator and has published in refereed journals and has seven issued patents related to vaccine adjuvants and cancer vaccines. He has written or edited over 20 books on topics related to research and laboratory animal medicine. Further, he served as the 2006 President of the American Association for Laboratory Animal Science and the 2011 President of the American Society of Laboratory Animal Practitioners; and currently he serves on the AVMA Council on Research and is a member of the Council on Accreditation of AAALAC, International. Ronald P. Wilson, VMA, MS, DACLAM, is the Professor and Chair of Comparative Medicine at Pennsylvania State University. Research interests are related to experimental surgery, pain, analgesia and anesthesia of laboratory animals.