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Lentiviral Vectors: Applications for Basic and Clinical Neuroscience [Kietas viršelis]

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  • Formatas: Hardback, 318 pages, aukštis x plotis: 254x178 mm, 57 Illustrations, color; 4 Illustrations, black and white; Approx. 320 p. 61 illus., 57 illus. in color., 1 Hardback
  • Serija: Methods in Molecular Biology 2974
  • Išleidimo metai: 22-Oct-2025
  • Leidėjas: Springer-Verlag New York Inc.
  • ISBN-10: 1071648063
  • ISBN-13: 9781071648063
Kitos knygos pagal šią temą:
Lentiviral Vectors: Applications for Basic and Clinical NeuroscienceDidesnis paveikslėlis
  • Formatas: Hardback, 318 pages, aukštis x plotis: 254x178 mm, 57 Illustrations, color; 4 Illustrations, black and white; Approx. 320 p. 61 illus., 57 illus. in color., 1 Hardback
  • Serija: Methods in Molecular Biology 2974
  • Išleidimo metai: 22-Oct-2025
  • Leidėjas: Springer-Verlag New York Inc.
  • ISBN-10: 1071648063
  • ISBN-13: 9781071648063
Kitos knygos pagal šią temą:
Pastovi nuoroda: https://www.kriso.lt/db/9781071648063.html

This volume provides readers with an overview of lentiviral vector applications and includes detailed laboratory protocols relevant to neuroscience research. The chapters are organized into five sections: Section I provides an overview of lentiviral vector properties, including practical methods for vector preparation and delivery into the brains of rodents and non-human primates, as well as delivery into non-human primate embryos for transgenic animal production. Sections II to IV explore basic neuroscience covering anatomical, molecular and developmental, and behavioral and physiological neuroscience. Section V focuses on clinical neuroscience, offering protocols related to gene therapy for motor neuron and ocular diseases. Written in the highly successful Methods in Molecular Biology series format, each chapter includes an introduction to the topic, a list of required materials and reagents, step-by-step protocols that are easy to reproduce, and expert tips for troubleshooting and avoiding common pitfalls.

Cutting-edge and thorough, Lentiviral Vectors: Application for Basic and Clinical Neuroscience is a valuable resource for any researcher looking to learn more about this important and advancing field.

Properties and Application of Pseudotyped Lentiviral
Vectors.- Production and Purification of Lentiviral Vectors.- Lentiviral
Vector Administration into the Mouse Brain.- Stereotaxic Injection of
Lentiviral Vectors into the Primate Brain.- Optimized Lentiviral Vector
Production Using Dual-Pseudotyping with VSV-G and Sendai Virus HN
Glycoproteins for Enhanced Gene Delivery in Diverse Cell Types.- Preparation
of Lentiviral Vectors for the Generation of Transgenic Cynomolgus
Monkeys.- Ubiquitous and Brain Cell-Type-Specific Promoters and Enhancers in
Lentiviral Vectors.- Efficient Labeling of Somatodendritic Membranes of the
Central Neurons.- Visualization of Selective Neural Pathways by Double Viral
Infection Method.- Lentivirus-Mediated Measurement of Transcription Factor
Activity in the Brain.- Birth Date-Dependent Tracing of Neuronal Cell
Lineage.- Application of Lentivirus Vectors to Adult Neurogenesis and
Manipulation of Neural Stem Cells.- Direct Reprogramming of Microglia into
Neurons.- Selective Neural Pathway Targeting by Using Lentiviral Vectors.-
Synaptic Silencing with Transactivation of Tetanus Neurotoxin for
Pathway-Selective Manipulation.- Optogenetic Approach for In Vivo
Manipulation of Neural Circuits Using Lentiviral Vectors.- Selective
Chemogenetic Blockade of Cerebello-Rubral Pathway by Double-Virus Infection
Method Using Lentivirus and Adeno-Associated Virus in Rats.- Development of a
Gene Therapy with Lentiviral Vectors for Spinocerebellar Ataxias.- Lentiviral
Vector-Mediated Gene Delivery for iPSC-Related Neuroscience Research.- Phase
1/2a Clinical Trial Protocol for Lentiviral Vector-Based Retinal Gene Therapy
to Slow the Progression of Retinitis Pigmentosa.- CAR-T Cell Therapy for
Central Nervous System Tumors.