This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc.
Role of leukemia stem cells in pathogenesis of hematologic
malignancies.- Leukemia stem cells in chronic myeloid leukemia.- Leukmeia
stem cells in MLL-rearranged acute myeloid leukemia.- Interaction between
leukmeia stem cells and bone marrow environment.- Molecular signatures of
leukemia stem cells.- Metabolic regulation of leukemia stem cell
function.- Epigenetic regulation of leukmeia stem cell function.- DNA
instability and leukemia stem cell function.- Tumor suppressor genes in
leukemia stem cells.- Targeting leukemia stem cells.- Leukemia stem cells and
drug resistance.- Hypoxia and leukemia.
Dr. Haojian ZhangDr. Shaoguang Li
