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Life's Blueprint: The Science and Art of Embryo Creation [Kietas viršelis]

  • Formatas: Hardback, 192 pages, aukštis x plotis x storis: 229x178x16 mm, weight: 617 g, 71 color illus.
  • Išleidimo metai: 23-Oct-2014
  • Leidėjas: Yale University Press
  • ISBN-10: 0300196636
  • ISBN-13: 9780300196634
Kitos knygos pagal šią temą:
  • Formatas: Hardback, 192 pages, aukštis x plotis x storis: 229x178x16 mm, weight: 617 g, 71 color illus.
  • Išleidimo metai: 23-Oct-2014
  • Leidėjas: Yale University Press
  • ISBN-10: 0300196636
  • ISBN-13: 9780300196634
Kitos knygos pagal šią temą:
A uniquely accessible way of looking at recent major advances in the science of embryonic development   In the span of just three decades, scientific understanding of the formation of embryos has undergone a major revolution. The implications of these new research findings have an immediate bearing on human health and future therapies, yet most nonscientists remain quite unaware of the exciting news.   In this engaging book, a distinguished geneticist offers a clear, jargon-free overview of the field of developmental biology. Benny Shilo transforms complicated scientific paradigms into understandable ideas, employing an array of photographic images to demonstrate analogies between the cells of an embryo and human society. Shilos innovative approach highlights important concepts in a way that will be intuitive and resonant with readers own experiences.   The author explains what is now known about the mechanisms of embryonic development and the commanding role of genes. For each paradigm under discussion, he provides both a scientific image and a photograph he has taken in the human world. These pairs of images imply powerful metaphors, such as the similarities between communication among cells and among human beings, or between rules embedded in the genome and laws that govern human society. The book concludes with a glimpse of promising future possibilities, including the generation of tissues and organs for use as spare parts.   Supported by a grant from the Alfred P. Sloan Foundation Public Understanding of Science and Technology Program

Recenzijos

Readers will come away from Shilos book with a better feel for how a developing embryo can organise itself. In later chapters, he also hints at the practical implications, such as the growth of tumours, stem cells and developmental abnormalities. Thisplus the appealing visual analogiesmake the book worthwhile for anyone with even a passing interest in the subject.Bob Holmes, New Scientist

Benny Shilo has had a distinguished career as a scientist seeking to understand how embryos develop, but he hasnt lost the sense of wonder we all have when we first learn how each of us developed from a single egg. In Lifes Blueprint, Shilo uses wonderfully lucid explanations, elegant metaphors, and lovely illustrations to bring the marvel of development to light.Carl Zimmer, coauthor of Evolution: Making Sense of Life

Shilo provides a broad and informative overview of the field of developmental biology. A timely and engaging introduction to the field for a non-specialist audience.James Briscoe, MRC-National Institute for Medical Research, UK

This is a wonderful, as well as beautiful, book; using the immediately recognizable imagery of photography to convey deep concepts in embryology in a medium that makes it intuitively understandable to a wide audience.Cliff Tabin, Harvard Medical School

Shilos explorations for making the complexities of the microscopic and submicroscopic world accessible through the use of everyday visual metaphors succeeds brilliantly. One can only hope that this book will represent the precedent for other similar ones that make modern biology accessible to a general public deeply interested in these topics. A bold and creative venture.Robert A. Weinberg, Whitehead Institute for Biomedical Research & Department of Biology, MIT

This superb book, which reflects Benny Shilos creativity and his profound understanding of organismal development, uses the eloquence of visual metaphors from common day life to convey the essence developmental processes and concepts. Public understanding of science is absolutely critical now and will be even more so in the future. This project in science communication is an exemplary one.Anne Ephrussi, European Molecular Biology Laboratory This superb book, which reflects Benny Shilos creativity and his profound understanding of organismal development, uses the eloquence of visual metaphors from common day life to convey the essence developmental processes and concepts. Public understanding of science is absolutely critical now and will be even more so in the future. This project in science communication is an exemplary one.Anne Ephrussi, European Molecular Biology Laboratory -- Anne Ephrussi

Preface ix
Acknowledgments xv
1 Introduction: Exploring the Principles of Embryo Creation
1(8)
2 It's All in the Genes
9(10)
3 How an Embryonic Cell "Decides" Its Future Destiny
19(6)
4 How Cells Talk and Listen to Each Other
25(10)
5 How Do Simple Modules Lead to Complex Patterns?
35(24)
6 How Can a Single Substance Generate Multiple Responses?
59(11)
7 How Do Patterns Evolve Rapidly?
70(10)
8 How Are Cells Programmed to Follow Predictable Routes to Specification?
80(6)
9 Ensuring That Embryo Development Is on the Right Track
86(14)
10 Shaping the Tissues
100(19)
11 Stem Cells
119(16)
12 What's Next?
135(8)
Glossary of Scientific Terms 143(6)
Glossary of Scientific Images 149(16)
Recommended Reading and Web Resources 165(4)
Index 169
Benny Shilo is professor of molecular genetics at the Weizmann Institute of Science, where he has served in a variety of leadership, research, and teaching roles for over 30 years. He is also a photographer. He lives in Rehovot, Israel.