The proceedings of a workshop which outlined new advances in B-cell biology, focusing on B-cell development, immunoglobulin gene rearrangement, multiple myeloma and plasmacytomas, particular lymphomas, oncogenes and transcriptional factors.
B-Cell Development.- Progenitor and Precursor B Lymphocytes of Mice.
Proliferation and Differentiation In Vitro and Population, Differentiation
and Turnover in SCID Mice In Vivo of Normal and Abnormal Cells.- Isolation
and Characterization of a Stromal Cell Line.- Growth and Differentiation of a
Bipotent Precursor of B Cells and Macrophages.- Control of Intramarrow B-Cell
Genesis by Stromal Cell-Derived Molecules.- Establishment of a Reproducible
Culture Technique for the Selective Growth of B-Cell Progenitors.- Multiple
Steps in the Regulation and Dysregulation of B-Cell Precursors in the Bone
Marrow: c-myc Expression, In Vivo Effects of Interleukins 1 and 7, and
Stromal Cell Interactions.- The Purification of B-Cell Precursors From Mouse
Fetal Liver.- BCR/ABL Enhances Growth of Multipotent Progenitor Cells But
Does Not Block Their Differentiation Potential In Vitro.- Repopulation of
SCID Mice with Fetal-Derived B-Lineage Cells.- Early B-Cell Repertoires.- In
Vitro Growth and Maturation of Human B-Cell Precursors.- Modulation of Signal
Transduction in Phosphocholine-Specific B cells from ?? Transgenic Mice.-
Immunoglobulin Gene Rearrangement.- Activities Involved in V(D)J
Recombination.- Double-Strand Breaks Associated with V(D)J Recombination at
the TCR? Locus in Murine Thymocytes.- Replication, Transcription, CpG
Methylation and DNA Topology in V(D)J Recombination.- Rearrangement and
Expression of Immunoglobulin Genes in Transgenic Mice.- Regulation of Switch
Recombination to the Murine ? 1 Gene.- Protein Recognition Motifs of S? 3 DNA
Are Statistically Correlated with Switch Recombination Breakpoints.-
Regulation of Transcription of the Germline Immunoglobulin ? Constant Region
Gene.- S?BP/BSAP/NF-S? B1, a Murine and Human B-Cell Stage Specific Nuclear
Factor with DNA Binding Specificity Implying Roles in Switch-Recombination
and Transcription.- Multiple Myeloma, Plasmacytomas.- Multidrug Resistance of
a Continuously Differentiating Monoclonal B Lineage in the Blood and Bone
Marrow of Patients with Multiple Myeloma.- Expression of Multiple Adhesion
Molecules on Circulating Monoclonal B Cells in Myeloma.- Circulating
Peripheral Blood Plasma Cells in Multiple Myeloma.- Circulating B Lymphocytes
in Multiple Myeloma Patients Contain an Autocrine IL-6 Driven Pre-Myeloma
Cell Population.- In Which Cells Does Neoplastic Transformation Occur in
Myelomatosis?.- Differential Expression of c-myc-mRNA and c-MYC-Protein
During Terminal Neoplastic B-Cell Differentiation.- Genes Expressed
Selectively in Plasmacytomas: Markers of Differentiation and Transformation.-
PCS, a Gene Related to the Immunoglobulin Super Family of Axonal
Glycoproteins is Expressed in Murine Plasma Cell Tumors.- Inhibiting IL-6 in
Human Multiple Myeloma.- Pathophysiology of Human Multiple Myeloma- Recent
Advances and Future Directions.- An Exceptional Mouse Plasmacytoma with a New
Kappa/N-myc [ T(6; 12) (C1; B)] Translocation Expresses N-myc But Not c-myc.-
Experimental Model of Human Light-Chain-Associated Disease.- Lymphomas:
B-CLL, Follicular Lymphomas BCL-2, BCL-1.- On the Role of Endogenously
Produced TNF-? and IL-6 as Regulators of Growth and Differentiation of B-Type
Chronic Lymphocytic Leukemia Cells in Vitro.- BCL-2 in B-Chronic Lymphocytic
Leukemia.- Subcellular Localization of BCL-2 Protein.- Collaboration of PIM-1
and BCL-2 in Lymphomagenesis.- The Role of bcl-2 in Lymphoid Differentiation
and Neoplastic Transformation.- Evolution of Leukemic Heterogeneity of Human
B-CLL Lymphocytes Between and Within Patients.- p53 Mutations in B-Cell
Chronic Lymphocytic Leukemia.- Burkitts Lymphoma Cells Frequently Carry
Monoallelic DJ Rearrangements.- Centrocytic Lymphoma: a B-Cell Non-Hodgkin's
Lymphoma Characterized by Chromosome 11 BCL-1 and PRAD 1 Rearrangements.- Two
Surface Antigen Targets for Immunotoxin-Mediated Elimination of Normal and
Neoplastic Murine B Cells.- Generation and Differentiation Potential of
Retrovirus-lmmortalized Mature Murine B Cells.- The Role of Growth Factors in
Human Lymphomas.- Production of Interleukin-6 in High Grade B Lymphomas.-
Lymphomas: EBV, AIDS Associated Lymphomas.- Mutational Analysis of the
Transforming Function of the EBV Encoded LMP-1.- Integration of EBV in
Burkitt's Lymphoma Cells.- The Oncogenic Potential of Epstein-Barr Virus
Nuclear Antigen 1 in Transgenic Mice.- AIDS Associated Non-Hodgkin's
Lymphomas Represent a Broad Spectrum of Monoclonal and Polyclonal
Lymphoproliferative Processes.- Lymphomas in Mice with Retrovirus-lnduced
Immunodeficiency.- Does HIV Infection of B Lymphocytes Initiate AIDS
Lymphoma? Detection by PCR of Viral Sequences in Lymphoma Tissue.- Oncogenes
and Transcriptional Factors.- Lymphocyte Activation and the Family of NF-?B
Transcription Factor Complexes.- Transactivation of the c-myc Gene by HTLV-1
tax is Mediated by NF-?B.- Cloning and Characterization of DNA Binding
Factors Which Bind Sequences Required for Proper c-myc Initiation.-
Transcriptional Activities of the Myc and Max Proteins in Mammalian Cells.-
c-myc Transactivates the Ornithine Decarboxylase Gene.- v-Raf/v-Myc Synergism
in Abrogation of IL-3 Dependence: v-Raf Suppresses Apoptosis.- Cyclins in the
Cell Cycle: An Overview.- The Localization of the Products of the c-cbl and
v-cbl Oncogenes During Mitosis and Transformation.- V-rel and C-rel Modulate
the Expression of Both Bursal and Non-Bursal Antigens on Avian B-Cell
Lymphomas.- Why Don't Germline Mutations in RB1 Predispose to Leukemia?.-
Loss of p53 Expression in Myc-induced B Lineage Tumors.
