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El. knyga: Mechanisms in B-Cell Neoplasia: Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD,USA,March 24-26,1986

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Mechanisms in B-Cell Neoplasia: Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD,USA,March 24-26,1986Didesnis paveikslėlis
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The papers in this book were presented at the 6th Workshop on Mechanisms in B-Cell Neoplasia, held in Bethesda, March 23-25, 1988. On alternate years this meeting is sponsored by the . ;. Basel Institute of Immunology in Basel, Switzerland and by the National Cancer Institute in Bethesda, and is attended by 100 to 150 parti­ cipants. This 6th workshop, like the preceding five, was characterized by intense and enthusiastic discussion which reflects, we think, the exciting growth and development of this field. It is quite clear, however, that despite many general advances an understanding of the precise underlying mechanisms in B-cell tumor development is not yet defined. Probably, there is no single mechanism for all the various forms of B-cell neo­ plastic development. Many different forms of B-cell neoplasms are known, and these are distinguished by several characteristics: 1) the stage of development attained by the tumor stem cells; 2) mode of growth (slow or fast); 3) association with natural or inductive etiologic agents and 4) specific and consistent mutational mechanisms such as retroviral insertion, chromosomal rearrangement. Those charac­ teristic forms which arise naturally in relatively high frequency or those tumors with hallmark properties which can be induced consistently are the models most frequently studied, e. g. , endemic Burkitt's lymphoma, follicular lymphoma, acute and chronic lymphocytic leukemia and mUltiple myeloma in man; bursal lymphoma in chickens; Abelson virus induced pre B cell lymphomas and plasmacytomas in mice and immunocytomas in rats. Each model system, has special problems and advantages.
B-cell Tumors in Transgenic Mice Carrying c-mycSequences.- c-Myc-Induced
Lymphomagenesis in Transgenic Mice and the Role of the Pvt-1 Locus in
Lymphoid Neoplasia..- Lymphohematopoietic and Other Malignant Neoplasms
Occurring Spontaneously in Transgenic Mice Carrying and Expressing MTV/myc
Fusion Genes.- Induction of B-cell Tumors with Retroviral Constructs
Containing Oncogenes.- Tumors of Newborn NFS/N Mice Infected with Murine
Retroviruses Containing Avian v-Myc.- Induction of Clonal Monocyte/Macrophage
Tumors invivo by a Mouse c-myc Retroviruses: Evidence for Secondary
Transforming Events.- Induction of Hematopoietic Tumors Using a Viral
Construct Containing c-myc cDNA from Normal Mouse Spleen.- Rapid Induction of
Plasmacytomas in Mice by Pristane and a Murine Recombinant Retrovirus
Containing an Avian v-myc and a Defective raf Oncogene.- Transformation and
Insertional Mutagenesis in Vitro of Primary Hematopoietic Stem Cell
Cultures.- Induction of B-cell and Other Tumors in Vitro.- Mammalian Cell
Transformation by a Recombinant Murine Retrovirus Containing the Avian
Erythroblastosis Virus erbB Gene.- Determinants of Abelson Murine Leukemia
Virus Pathogenesis.- An In Vitro Model for Tumor Progression in Murine
Lymphoid Cells.- Structural Modification of c-abl in Lymphoma and Leukemia.-
Transposable Elements and Cancer.- B-Lymphocyte/Plasma Cell Growth Factors,
Receptors.- Alpha-type B Cell Growth Factor and Complement Component C3:
Their Possible Structural Relationship.- A Growth-Factor Dependent B-Cell
Hybridoma.- A Growth Factor Required by Plasmacytoma Cells In Vitro.- Genes
Affecting the Production or Action of B Cell-Active Lymphokines.- Lymphokine
Regulation of Murine IgE Production.- Interleukin-4 (B Cell Growth
Factor-II/Eosinophil Differentiation Factor) is a Mitogen and Differentiation
Factor for Preactivated Murine B Lymphocytes.- Role of the LFA-1 Molecule in
B Cell Differentiation.- Studies on Transferrin Receptor Expression in Mouse
Plasmacytoma Cells.- Structure and Expression of c-myb Protooncogene mRNA in
Murine B-Cells.- Chromosome Translocations, Breaks.- Genomic Activity and
Translocation in Lymphocytes.- Possible Role of Immunoglobulin Recombination
Sequences in the Genesis of Variant t (2;8) Translocations of Burkitt
Lymphoma.- C-Myc Activation in Spontaneous Rat Immunocytomas Containing a 6;7
Chromosomal Translocation.- The Molecular Genetics of Human T Cell Leukemias
and Lymphomas.- Molecular Genetics of Human B-cell Neoplasia.- C-myc and
Functionally Related Oncogenes Induce Both High Rates of Sister Chromatid
Exchange and Abnormal Karyotypes in Rat Fibroblasts.- Chromosomal
Radiosensitivity During G2 Phase and Susceptibility to Plasmacytoma Induction
in Mice.- Biology of B Cell Tumor Development.- Normal and Neoplastic B Cell
Development in the Bursa of Fabricius.- Restrictions That Influence Avian
Leukosis Virus-Induced Lymphoid Leukosis.- Benign Monoclonal Gammapathy
(BMG).- DNA Rearrangement and Expression of the c-myc Gene in a Human
Myeloma.- Inbred Strain Differences Influence the Focal Proliferation of
Plasma Cells in Pristane Induced Oil Granuloma.- Molecular Analysis of myc
Gene Mutants.- EBV-Virus, Burkitt's Lymphoma.- Induction of fgr
Proto-oncogene mRNA in B Lymphocytes as a Consequence of Epstein- Barr Virus
Infection.- Epstein-Barr Virus Induced Differentiation of Early B-Lineage
Cells.- Epstein-Barr Virus Gene Expression During Primary B-Lymphocyte
Infection, in Transformed and Burkitt Lymphoma-Derived Cell Lines.- Structure
and Expression of Translocated c-myc Oncogenes: Specific Differences in
Endemic, Sporadic and AIDS-Associated Forms of Burkitt Lymphomas.-
EBV-Activation of Human B-Lymphocytes.- Regulation of c-myc Expression.- Myc
Expression in vivo During Human Embryogenesis.- Expression of c-myc and c-fos
During Phorbol Ester Induced Differentiation of B-type Chronic Lymphocytic
Leukemia Cells.- Regulation of c-myc mRNA and Protein Levels During
Activation of Normal Human B Cells.- Differential Expression of N-myc, c-myc
and c-src Proto-oncogenes During the Course of Induced Differentiation of
Murine Embryonal Carcinoma Cells.- Complex Regulation of c-myc Gene
Expression in a Murine B Cell Lymphoma.- Activation of Proto-oncogene
Expression by Growth Regulatory Signals.- Biological Effects of High Level
c-myc Expression in FR3T3 Fibroblasts.- A Transfected c-myc Oncogene Inhibits
Mouse Erythroleukemic Differentiation.- Myc Transcription, Post
Transcription.- Altered c-myc RNA Metabolism in Burkitt's Lymphomas and Mouse
Plasmacytomas.- Mutations Which Stabilize myc Transcripts and Enhance myc
Transcription in Two Mouse Plasmacytomas.- Studies on c-myc Regulation in
Normal and Transformed Cells.- Myc Gene Product.- Characterization and
Nuclear Localization of the v- and c-myc Proteins.- Characterisation of Human
myc Proteins.- Indexed in Current Contents.
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