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El. knyga: Mechanisms of Lymphocyte Activation and Immune Regulation

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Mechanisms of Lymphocyte Activation and Immune RegulationDidesnis paveikslėlis
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During the past 5 years rapid progress has been made in the understanding of biochemical pathways for signal transduction in lymphocyte activation. Gene cloning technology has been instrumental in defining and making available in pure form of a number of growth and differentiation factors, in the characterization of their receptors, and in the delineation of genes for the T cell receptor. This book is divided into 6 sections. Section 1 deals with the molecular structure of the T cell receptor. Section 2 discusses the role of the T cell receptor, membrane ion channels and biochemical pathways of signal transduction in T cell activation. The molecular structures and biological and immunological effects of interleukin 1, interleukin 2 and interleukin 3 are presented in Section 3. This section also details the structure of interleukin 2 receptor and its use as a target for therapy for certain leukemias. Section 4 includes the biochemical events which occur following the delivery of the signal for B cell activation, proliferation, and differentiation by antigen, growth/differentiation factors. The molecular structure of B cell stimulating factors is also discussed. The role of oncogene expression in cellular activation and differentiation is included in Section 5. The cellular and molecular basis of natural killing and the molecular basis of cyc1osporin A-mediated immunosuppression are discussed in detail in Section 6. We hope this book will serve as a reference work on basic mechanisms of lymphocyte activation, proliferation, and differentiation for immunologists and molecular biologists.

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Springer Book Archives
T Cell Receptor.- The T cell receptor: Its repertoire and role in
thymocyte development.- Murine T-cell receptor genes.- Correspondence between
functionally significant sequences in immunoglobulin and the T cell receptor
for antigen.- T Cell Activation.- The early mitogenic pathway in mouse
thymocytes: An analysis of the dual signal hypothesis.- The role of the
antigen receptor/T3 complex in T-cell activation.- Early events in lymphocyte
activation triggered via CD3/Ti or CD2.- Human T lymphocyte activation.-
Transmembrane signals in the activation of T lymphocytes.- Ion channels in T
lymphocytes.- Interleukins and their Receptors.- The multiple biological
properties of interleukin-1 influencing immunocompetent cells.- Autocrine
growth function of interleukin-1-like molecules secreted by neoplastic human
B cells.- Dissection of the molecular events occuring during T cell cycle
progression.- The Interleukin-2 receptor on normal and malignant
lymphocytes.- IL-2 receptor gene activation by ATL-derived factor (ADF).-
Mechanisms in interleukin 3 regulated growth and differentiation.- B
Lymphocyte Activation, Proliferation and Differentiation.- The activation,
proliferation, and differentiation of human B lymphocytes.- Delineation of
human B cell differentiation: Immunological and molecular characterization of
human B cell differentiation factor (BSF-2).- Transmembrane signaling
reactions generated in B cells in response to anti-IgM or
lipopolysaccharide.- Coupling of B cell surface Ig, Ia and BSF1 receptors to
intracellular second messengers.- B lymphocyte activation The roles of
receptor cross-linkage and BSF-1.- B cell growth factor interactions.- IgGl
induction factor: A single molecular entity with multiple biological
functions.- Inhibition of human B cellproliferation by ion channel blockers.-
Proto-Oncogenes and Cellular Activation and Differentiation.- Cell growth
associated regulation of c-myc and c-fos in normal human T cells.- Regulation
of proto-oncogene expression during T lymphocyte activation and
proliferation.- Expression of the c-fos gene during differentiation.- Natural
Killing and Cyclosporin A.- Activation of natural killer (NK) cells and
mechanism of their cytotoxic effects.- Regulation of activation and
proliferation of human natural killer cells.- Molecular mechanism of natural
killer cell-mediated cytotoxicity.- Mechanism of action of cyclosporine.-
Contributors.
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