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El. knyga: Medical Biosensors for Point of Care (POC) Applications

Edited by (Joint Department of Biomedical Engineering, North Carolina State University, NC, USA)
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Medical Biosensors for Point of Care (POC) Applications discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care. Part 1 covers the fundamentals of medical biosensors for point-of-care applications. Chapters in part 2 go on to look at materials and fabrication of medical biosensors while the next part looks at different technologies and operational techniques. The final set of chapters provide an overview of the current applications of this technology.

Traditionally medical diagnostics have been dependent on sophisticated technologies which only trained professionals were able to operate. Recent research has focused on creating point-of-care diagnostic tools. These biosensors are miniaturised, portable, and are designed to be used at the point-of-care by untrained individuals, providing real-time and remote health monitoring.

  • Provides essential knowledge for designers and manufacturers of biosensors for point-of-care applications
  • Provides comprehensive coverage of the fundamentals, materials, technologies, and applications of medical biosensors for point-of-care applications
  • Includes contributions from leading international researchers with extensive experience in developing medical biosensors
  • Discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care

Daugiau informacijos

This cutting-edge book offers comprehensive coverage of the fundamentals, materials, fabrication, technologies, and operational techniques of using medical biosensors for point-of-care applications, including contributions from leading researchers with extensive experience in the emerging field of developing medical biosensors
List of contributors
ix
Woodhead Publishing Series in Biomaterials xi
Part One Fundamentals of medical biosensors for POC applications
1(66)
1 Introduction to medical biosensors for point of care applications
3(24)
K. Baryeh
S. Takalkar
M. Lund
G. Liu
1.1 Biosensors and medical biosensors
3(1)
1.2 Biosensors for point of care testing
3(1)
1.3 Biorecognition elements of medical biosensors
4(7)
1.4 Medical biosensors for point of care applications
11(3)
1.5 Overview of types of point of care techniques
14(8)
1.6 Conclusion
22(5)
References
23(4)
2 Validation and regulation of point of care devices for medical applications
27(18)
S. Misra
J. Huddy
G. Hanna
N. Oliver
2.1 Introduction
27(1)
2.2 Analytical method validation
28(8)
2.3 Clinical validation methodology
36(5)
2.4 Regulation of POCT devices
41(4)
Acknowledgement
42(1)
References
42(3)
3 Materials for improved point of care biosensor-tissue interfaces
45(22)
P. Vadgama
3.1 Introduction
45(1)
3.2 Materials for in vitro sensors
46(5)
3.3 Biocompatibility
51(3)
3.4 Materials for in vivo sensors
54(5)
3.5 Materials for ex vivo sensors
59(1)
3.6 Conclusion
59(8)
Acknowledgement
60(1)
References
60(7)
Part Two Materials, fabrication and types of biosensors for POC applications
67(114)
4 Screen printing and other scalable point of care (POC) biosensor processing technologies
69(30)
L. Gonzalez-Macia
A.J. Killard
4.1 Introduction
69(3)
4.2 Printing techniques
72(13)
4.3 Thin-film deposition
85(1)
4.4 Other POC prototyping techniques
86(3)
4.5 Conclusions
89(10)
References
90(9)
5 Lab-on-chip (LOC) devices for point of care (POC) applications
99(34)
S. Mukherji
D. Mondal
5.1 Introduction
99(1)
5.2 Optical detection
99(13)
5.3 Electrochemical method
112(6)
5.4 Other detection techniques
118(3)
5.5 Miscellaneous
121(4)
5.6 Conclusion
125(8)
References
125(8)
6 Intelligent tattoos, patches, and other wearable biosensors
133(18)
X. Zhu
W. Liu
S. Shuang
M. Nair
C.-Z. Li
6.1 Introduction
133(1)
6.2 Detection mechanism
134(2)
6.3 Fabrications
136(8)
6.4 Application
144(4)
6.5 Conclusions and perspectives
148(3)
Acknowledgment
148(1)
References
149(2)
7 Wireless biosensors for POC medical applications
151(30)
M.S. Arefin
J.-M. Redoute
M.R. Yuce
7.1 Introduction
151(2)
7.2 Electrical measurements using biosensors
153(11)
7.3 Wireless telemetry systems
164(1)
7.4 Applications
165(6)
7.5 Conclusion and future trends
171(10)
References
173(8)
Part Three POC biosensors for particular clinical applications
181(112)
8 Point of care (POC) medical biosensors for cancer detection
183(20)
L. Bueno
W.R. de Araujo
T.R.L.C. Paixao
8.1 Introduction
183(1)
8.2 Definition of cancer
183(1)
8.3 Cancer biomarkers
184(1)
8.4 Types of cancer
185(18)
References
197(6)
9 Point of care (POC) blood coagulation monitoring technologies
203(26)
L. Harris
R.S. Lakshmanan
V. Efremov
A.J. Killard
9.1 Introduction
203(1)
9.2 Development of point of care coagulation monitoring devices
204(9)
9.3 Novel point of care coagulation tests and recent innovations
213(5)
9.4 Resonator-based methods
218(3)
9.5 Future perspectives and challenges
221(8)
References
222(7)
10 Nanostructured materials and nanoparticles for point of care (POC) medical biosensors
229(26)
L.C. Brazaca
L. Ribovski
B.C. Janegitz
V. Zucolotto
10.1 Introduction
229(3)
10.2 Synthesis, characterization, and application of nanomaterials
232(8)
10.3 Biological recognition elements
240(2)
10.4 Electroanalytical techniques
242(4)
10.5 Conclusion
246(9)
References
246(9)
11 Microfluidic platforms for point of care (POC) medical diagnostics
255(20)
M. Azhar
D. Dendukuri
11.1 Introduction and background
255(1)
11.2 Categories of in vitro diagnostic tests
256(8)
11.3 Commercialization of platforms and challenges
264(11)
References
267(8)
12 Electrochemical medical biosensors for POC applications
275(18)
U. Anik
12.1 Introduction
275(1)
12.2 General approach to electrochemical biosensors
275(7)
12.3 Portable decentralized devices based on electrochemical biosensors for medical applications
282(5)
12.4 Conclusions and future prospects
287(6)
References
288(5)
Index 293
Roger J. Narayan is a professor at the Joint Department of Biomedical Engineering, North Caroline State University, USA. He has authored numerous publications on micro- and nanoscale processing of biological and biomedical materials, and is Editor-in-Chief of Materials Science and Engineering: C.
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