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1 | (12) |
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Three Illustrative Problems |
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2 | (1) |
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2 | (2) |
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4 | (4) |
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Linkages of the Three Methods |
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8 | (4) |
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12 | (1) |
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13 | (20) |
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13 | (4) |
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17 | (12) |
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Cost-Effectiveness Analysis |
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29 | (4) |
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33 | (10) |
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33 | (1) |
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Developing a Study Protocol |
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34 | (6) |
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40 | (1) |
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Procuring Administrative Approvals |
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40 | (3) |
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43 | (25) |
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Overall Strategy for Retrieving Information from Published Studies |
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43 | (2) |
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Computerized Searches of Medline |
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45 | (5) |
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Other Computer-Stored Databases |
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50 | (1) |
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Limitations of Computerized Searches of Computer-Stored Databases |
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51 | (7) |
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58 | (10) |
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68 | (7) |
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68 | (1) |
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69 | (3) |
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72 | (1) |
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73 | (2) |
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Advanced Issues in Meta-Analysis |
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75 | (19) |
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Defining Eligibility Criteria and Determining Eligibility of Individual Studies |
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76 | (3) |
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79 | (1) |
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Inclusive Dates of Publication |
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80 | (1) |
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English-Language Publications |
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81 | (1) |
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Multiple Publications from the Same Study Population |
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81 | (2) |
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Restrictions on Sample Size or Length of Follow-Up |
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83 | (1) |
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Eligibility Based on Similarity of Treatments (or Exposures) or Outcomes |
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83 | (2) |
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Completeness of Information |
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85 | (2) |
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Choosing Estimates of Effect Within Eligible Studies |
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87 | (2) |
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89 | (5) |
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Statistical Methods in Meta-Analysis |
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94 | (25) |
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Goals of Meta-Analysis and the Problem of Heterogeneity |
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95 | (5) |
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100 | (1) |
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101 | (3) |
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104 | (3) |
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General Variance-Based Methods |
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107 | (4) |
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General Variance-Based Methods That Use Confidence Intervals |
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111 | (4) |
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Statistical Tests of Homogeneity |
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115 | (1) |
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DerSimonian and Laird Method |
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116 | (3) |
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118 | (1) |
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Other Statistical and Methodologic Issues in Meta-Analysis |
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119 | (21) |
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Measures on a Continuous Scale |
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119 | (8) |
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Trend or ``Dose Response'' Analysis |
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127 | (5) |
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Vote Counting and Related Methods |
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132 | (1) |
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Statistical Approaches to Publication Bias |
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133 | (2) |
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135 | (1) |
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Meta-Analysis of Individual Level Data |
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136 | (4) |
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Complex Decision Problems |
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140 | (19) |
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More Than Two Alternative Treatments or Interventions |
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141 | (1) |
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142 | (5) |
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147 | (2) |
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Estimating Life Expectancy |
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149 | (3) |
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152 | (7) |
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159 | (10) |
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159 | (2) |
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Relying on Selected Published Sources of Information on Probabilities |
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161 | (3) |
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Aggregating Information from Multiple Published Sources |
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164 | (1) |
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Experts as Sources of Probability Estimates |
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165 | (1) |
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Personal Experience and ``Guessing'' to Estimate Probabilities |
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166 | (1) |
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Accounting for Uncertainty in Probability Estimates |
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166 | (3) |
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Measuring Preferences for Health States |
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169 | (13) |
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169 | (1) |
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Conceptual Issues in the Measurement of Preferences for Health States |
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170 | (3) |
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Developing Measurement Scales in Practice |
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173 | (6) |
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Use of Generic Measures of Health-Related Quality of Life as Preference Measures |
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179 | (2) |
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Limitations of Measures of Preferences for Health States |
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181 | (1) |
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Advanced Cost-Effectiveness Analysis |
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182 | (20) |
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Types of Economic Evaluation |
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183 | (2) |
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185 | (4) |
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189 | (1) |
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Identifying Contributors to Cost |
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190 | (4) |
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194 | (2) |
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196 | (3) |
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199 | (3) |
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Utility and Cost-Utility Analysis |
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202 | (11) |
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Quality-Adjusted Life-Years |
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203 | (3) |
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Steps in a Utility or Cost-Utility Analysis |
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206 | (1) |
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Review of Approaches to Measuring Preferences (Utilities) |
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207 | (1) |
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Incorporating Preference Measures into the Analysis |
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207 | (6) |
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213 | (16) |
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214 | (1) |
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Statistical Versus Clinical Heterogeneity |
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214 | (1) |
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215 | (1) |
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Limitations of Statistical Tests of Heterogeneity |
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216 | (2) |
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Framework for Exploration of Clinical Heterogeneity |
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218 | (4) |
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Stratification as a Method for Exploring Heterogeneity |
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222 | (2) |
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224 | (1) |
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Subgroup Analysis in Decision Analysis and Cost-Effectiveness Analysis |
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225 | (2) |
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Limitations of Subgroup Analysis |
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227 | (2) |
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229 | (15) |
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Goals of Sensitivity Analysis |
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229 | (1) |
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One-way Sensitivity Analysis in Decision Analysis and Cost-Effectiveness Analysis |
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230 | (4) |
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Two-way, Three-way, and n-way Sensitivity Analysis |
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234 | (5) |
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Application of the Principles of Sensitivity Analysis to Meta-Analysis |
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239 | (5) |
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244 | (19) |
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244 | (3) |
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247 | (1) |
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Cost-Effectiveness Analysis |
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248 | (2) |
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Graphical Presentation of the Results of Meta-Analysis |
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250 | (9) |
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Graphical Presentation of the Results of Decision Analysis and Cost-Effectiveness Analysis |
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259 | (4) |
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263 | (20) |
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264 | (7) |
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271 | (2) |
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Cost-Effectiveness Analysis |
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273 | (2) |
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275 | (4) |
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Situations Where the Methods Are Most and Least Useful |
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279 | (1) |
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Improving the Methods: Recommendations of Experts |
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279 | (4) |
References |
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283 | (14) |
Subject Index |
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297 | (8) |
Index of Examples |
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305 | |