Describes the way causal pathogens of diseases interact with the vectors that transmit them.
Several billion people are at daily risk of life-threatening vector-borne diseases such as malaria, trypanosomiasis and dengue. This volume describes the way in which the causal pathogens of such diseases interact with the vectors that transmit them, detailing the biological adaptations that enable pathogens to live with their vectors and, in some circumstances, to control them. This knowledge has led to novel preventative strategies in the form of antibiotics and new vaccines which are targeted not at the pathogen itself but at its specific vector.
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'The authors describe the advantages of insects as vectors and their numerous barriers to infection, including physico-chemical barriers, the gut, haemolymph, and the salivary glands themselves.' ASM News
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Describes the way causal pathogens of diseases interact with the vectors that transmit them.
| Contributors |
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vii | |
| Editors' Preface |
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xi | |
| B.W.J. Mahy |
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1 | (18) |
| S.E. Randolph |
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Evolution of tick-borne disease systems |
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19 | (24) |
| S. Blanc |
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Insect transmission of viruses |
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43 | (20) |
| R. Lu, H. Li, W.-X. Li and S.-W. Ding |
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RNA-based immunity in insects |
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63 | (12) |
| A. Barbour |
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Specificity of Borrelia-tick vector relationships |
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75 | (16) |
| R.M. Elliott and A. Kohl |
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Bunyavirus/mosquito interactions |
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91 | (12) |
| S. Higgs |
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How do mosquito vectors live with their viruses? |
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103 | (36) |
| S.C. Weaver, L.L. Coffey, R. Nussenzveig, D. Ortiz and D. Smith |
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139 | (42) |
| R.S. Mellor |
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Environmental influences on arbovirus infections and vectors |
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181 | (18) |
| N.A. Ratcliffe and M.M.A. Whitten |
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199 | (64) |
| S.A. MacFarlane and D.J. Robinson |
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Transmission of plant viruses by nematodes |
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263 | (24) |
| M.J. Taylor |
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Wolbachia host-symbiont interactions |
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287 | (14) |
| J.A. Carlyon and E. Fikrig |
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Pathogenic strategies of Anaplasma phagocytophilum, a unique bacterium that colonizes neutrophils |
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301 | (30) |
| B.J. Hinnebusch |
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Interactions of Yersinia pestis with its flea vector that lead to the transmission of plague |
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331 | (14) |
| P.W. Atkinson and D.A. O'Brochta |
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345 | (18) |
| G.A.T. Targett |
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Vaccines targeting vectors |
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363 | (16) |
| Index |
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379 | |
Stephen H. Gillespie is Professor of Medical Microbiology in the Department of Infectious Diseases at University College London, UK. Geoffrey L. Smith is a Wellcome Trust Principal Research Fellow and Head of Department of Virology at Imperial College London, UK. Anne Osbourn is a Group leader in the Sainsbury Laboratory, John Innes Centre, Norwich,UK.
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