Microextraction Techniques in Analytical Toxicology provides the information readers need to include about cutting-edge sample preparation techniques into their everyday analytical practice, including comprehensive information about principles and state-of-the-art microextraction sample preparation techniques for the analysis of drugs and poisons in biological specimens, especially in forensic and clinical settings.
This book also focuses on theoretical discussions of solid-based and liquid-based microextraction techniques, their method development, validation, and applications. A detailed compilation of analytical protocols based on published microextraction procedures to aid in method development, synthesis, and the application of green solvents (ionic liquids and deep eutectic solvents) and new sorbents, such as molecularly imprinted polymers, and their application in microextraction techniques are also covered.
Features:
Provides a systematic review of microextraction techniques applied in analytical toxicology
A comprehensive guide for the practical implementation of microextraction techniques in forensic, clinical, and analytical laboratories
Contains figures and tables for easy understanding and quick adaptation of the parameters of microextraction techniques
Fundamentals, development, and applications of microextraction techniques as a sample preparation procedure are discussed in detail
Extremely useful for the researchers and academicians engaged in analytical method development using microextraction techniques
This book appeals to a wide readership of forensic, clinical, and analytical toxicologists, as well as academicians and researchers. Written by eminent scientists and leading experts on sample preparation techniques, this book serves as a desk reference for routine laboratory analysis and as an indispensable teaching tool in the classroom for graduate and Ph.D. students.
| Preface |
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ix | |
| Editors' Biographies |
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xi | |
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xiii | |
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1 Microextraction Techniques in Analytical Toxicology: An Overview |
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1 | (10) |
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2 Application of Solid-Phase Microextraction in Analytical Toxicology |
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11 | (12) |
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3 Applications of Micro Solid-Phase Extraction in Analytical Toxicology |
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23 | (38) |
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4 Stir Bar Sorptive Extraction in Analytical Toxicology Studies |
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61 | (10) |
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Elisave-Ioanna Diamantopoulou |
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5 Microextraction by Packed Sorbent |
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71 | (46) |
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6 Thin-Film Solid-Phase Microextraction: Applications in Analytical Toxicology |
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117 | (14) |
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7 Application of Single Drop Microextraction in Analytical Toxicology |
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131 | (16) |
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8 Applications of Liquid-Phase Microextraction in Analytical Toxicology |
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147 | (12) |
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9 Dispersive Liquid-Liquid Microextraction and Its Variants |
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159 | (12) |
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10 Electromembrane Extraction in Analytical Toxicology |
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171 | (12) |
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11 Fabric Phase Sorptive Extraction in Analytical Toxicology |
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183 | (10) |
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12 Sorbent-Based Microextraction Using Molecularly Imprinted Polymers |
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193 | (12) |
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13 Applications of Ionic Liquids in Microextraction |
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205 | (16) |
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14 Deep Eutectic Solvent-Based Microextraction |
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221 | (18) |
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15 Hyphenation of Derivatization with Microextraction Techniques in Analytical Toxicology |
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239 | (10) |
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| Index |
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249 | |
Dr. Rajeev Jain is Senior Scientist of Forensic Toxicology at Central Forensic Science Laboratory, Ministry of Home Affairs, Govt. of India. He has more than 10 years of research experience in the field of analytical toxicology. During his tenure as Forensic Toxicologists, he has examined post-mortem samples of more than 500 medico-legal cases pertaining to drug overdose and poisoning. He has obtained his Ph.D. degree in Analytical Toxicology from CSIR-Indian Institute of Toxicology Research (India). His research work is focused on Development of simple, rapid, eco-friendly, cost-effective, sensitive and selective analytical methods based on microextraction techniques (such as SPME and DLLME etc.) for the determination of chemical analytes for forensic toxicological, clinical and environmental importance in various complex samples such as blood, saliva, plasma, urine, tissue etc. using GC-MS, GC-FID, HPLC, GC-ECD and TLC-image processing technique. He has published many research papers, review papers and book chapters in various referred journals on this subject. He was one of the first scientists to explore the possibility of coupling dispersive liquid-liquid microextraction with injector port silylation for rapid analysis of polar toxicants. He is also acting as invited reviewer in various referred journals and on the editorial board of various open access journals of Toxicology and Chromatography.
Dr. Ritu Singh is an Assistant Professor in Department of Environmental Science, School of Earth Sciences, Central University of Rajasthan, Rajasthan, India. Her research interest includes analytical method development, microextraction techniques, nano-remediation, environmental monitoring and assessment. She received her doctorate degree in Environmental Science from Babasaheb Bhimrao Ambedkar University, Lucknow. She worked as research fellow in CSIR-Indian Institute of Toxicology Research for five years and made significant contribution in the field of nano-remediation. She has published her work in several international journals of repute and has contributed several chapters in international and national books. She also has one international book to her credit. She is the recipient of DEF-Young Scientist Award in the field of Environmental Science. She is an editorial board member of Journal of Nanoscience, Nanoengineering and Applications, Journal of Water Pollution & Purification Research & Eurasian Journal of soil science. and invited reviewer of several refereed journals. She is also serving as life member of various academic bodies.
