MicroRNA: From Bench to Bedside provides an in-depth, expansive overview of microRNA from fundamentals to clinical practice. It presents researchers with detailed insights on the topic of microRNA, exploring foundational knowledge that is followed by methodologies and the latest technologies for research and potential theragnostic and therapeutic applications for specific diseases. The book consists of eight parts, beginning with an introduction to microRNA and the current state of the field, followed by sections on biogenesis and maturation of microRNA, and methodology and bioinformatics, where chapters focus on isolation and detection techniques.
Sections then move on to molecular mechanisms and gene regulation, considering topics such as transcriptional regulation and epigenetic regulation, as well as the role of microRNA as biomarkers. Additionally, microRNA and human disease and microRNA-based therapeutics are explored, focusing on a wide range of diseases such as cancer, age-related disease, cardiovascular disease, microRNA targeted therapy in hepatitis and therapeutic strategies for diabetes. The book concludes with a discussion on advances and future perspectives in microRNA investigation.
- Covers the topic of microRNA in detail, from foundational knowledge to clinical application
- Explores the physiological and pathological roles of microRNAs in various human diseases, including neurological, cardiovascular and age-related diseases
- Discusses future directions and challenges in the field
- Includes chapters on methodology and bioinformatics for microRNA research
Part I: Overview
1. An overview of microRNAs
Part II: Methodology and Bioinformatics
2. MicroRNA isolation
3. Detection of microRNA
4. MicroRNA Interference
5. Target prediction and validation of microRNA
6. Online databases for microRNA Research
Part III: Biogenesis and Maturation
7. Biogenesis of microRNAs
8. Molecular basis for microRNA processing
9. Maturation of microRNAs
Part IV: Molecular Mechanisms and gene regulation
10. Function microRNA in cytoplasm
11. Mechanisms of miRNA Nuclear Localization
12. MiRNA-Mediated Transcriptional Regulation
13. Epigenetic Regulation and microRNA Expression
14. RNA m6A modification and microRNAs
Part V: MicroRNA as biomarkers
15. Detection Methodologies for microRNA biomarker profiling
16. Circulating microRNAs
17. MicroRNA Profiling of Exosomes
18. MicroRNAs and biomarkers
Part VI: MicroRNAs and human diseases
19. MicroRNAs and Cancers
20. MicroRNAs and the Immune System
21. MicroRNAs in Cardiovascular Diseases
22. MicroRNAs in aging and age-related Diseases
23. MicroRNAs in Neurological Diseases
24. MicroRNAs in Muscle Atrophy
25. MicroRNAs in Respiratory Diseases
26. MicroRNAs in Liver Diseases
Part VII: MicroRNA Based Therapeutics
27. Overview of MicroRNA Based Therapeutics
28. MicroRNA Based Therapeutic Strategies for Cancer
29. MicroRNA Targeted Therapy in Cardiovascular disease
30. MicroRNA Targeted Therapy in Hepatitis
31. MicroRNA Based Therapeutic Strategies for Diabetes
32. Clinical studies involving microRNAs
Part VIII: Concluding Perspectives
33. Prospective advances in microRNAs investigation
Dr. Junjie Xiao is Professor and Vice Dean of School of Life Science, and also the Vice Dean of School of Medicine, at Shanghai University, People's Republic of China. Dr. Xiao is the Associate Editor of the Journal of Cardiovascular Translational Research, BMC Sports and Science, Medicine and Rehabilitation, and Frontiers in Cardiovascular Medicine. He is also the member of the editorial board of BMC Medicine, Journal of Molecular and Cellular Cardiology, Journal of Sport and Health Science, Cell Transplantation, Current Stem Cell Research & Therapy, Journal of Thoracic Disease, and Biomedical and Environmental Sciences. He is the author or co-author of 140 scientific articles in various journals and his major research interest is studying the comprehensive intervention and risk warning of heart failure, especially using exercise as a platform to identify novel targets, including non-coding RNAs and functional proteins, for enhancing cardiac regeneration and combating heart failure.
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