This book presents recent advancements, challenges, and clinical implications of molecular biomarkers in various cancers. This book highlights the clinical applications of biomarkers are extensive for cancer risk assessment, screening and early detection of cancer, accurate diagnosis, patient prognosis, prediction of response to therapy, and cancer surveillance and monitoring response. It also explores the progress of predictive biomarkers as an adjunctive tool to tumor immunotherapy in effectively identifying the efficacy of immune checkpoint inhibitors and discusses their future directions in achieving precision immuno-oncology. Further, the book examines the combination of next-generation sequencing and advanced computational data analysis approaches in the understanding of the genomic underpinnings of cancer development and progression. Towards the end, the chapter discusses the role of some commonly investigated phytochemicals and their epigenetic targets that are of particular interest in cancer prevention and cancer therapy. It is a must for researchers as well as advanced students and physicians in the field of cancer and clinical oncologists.
Chapter
1. Molecular Biomarkers of Cancer and their Diagnostic
Applications.
Chapter
2. Statistical Models in Cancer Management.
Chapter
3. Deep Learning Techniques for Computer Aided Diagnosis of Various Cancers.-
Chapter
4. Machine Learning Techniques in Computer Aided Diagnosis for
Effective Detection of Malignant Tissues.
Chapter
5. Molecular Mechanisms of
Oncogenesis.
Chapter
6. Application of CRISPR in Cancer Research and
Treatment.
Chapter
7. Nanobiosensing Platforms for Early Detection of
Cancer.
Chapter
8. Bionanotechnological Strategies and Tools for Cancer
Prediction, Prevention and Therapy.
Chapter
9. Central Nervous System
Tumors.
Chapter
10. Biomedical Approaches in the Research and Management of
Head and Neck Squamous Cell Carcinoma.
Chapter
11. Applications of Molecular
Biology and Biomedical Advances in Ocular Oncology.
Chapter
12. Molecular
Markers in Oral Cancer.
Chapter
13. MicroRNAs as Tools for Early Diagnosis
and Predicting Response to Therapy in Oesophageal Cancer.
Chapter
14. The
Role of Complement Regulatory Proteins during Liver Homeostasis and Hepatitis
C Virus-related Liver Disease.
Chapter
15. Metabolite based Biosignature of
Pancreatic Cancer.
Chapter
16. Molecular Pathogenesis of Lung Cancer:
Evolving Landscape based on Past Experience.
Chapter
17. Molecular Insights
and Risk Factors Associated with Small and Non-Small Cell Lung Cancer.-
Chapter
18. Deciphering the Role of Immune-Checkpoint Inhibitors in Lung
Cancer Treatment.
Chapter
19. Bone Tumors: An Overview.
Chapter
20.
Genomics in the Personalize Management of Breast Cancer.
Chapter
21.
Colorectal Cancer and Role of Biomarkers in Diagnosis, Prognostification and
Personalized Treatment.
Chapter
22. Biomarkers in Renal Cell Carcinoma.-
Chapter
23. Androgen and Estrogen Signalling Pathways in Prostate
Hyperplastic Tissues: Opportunities for Therapeutic Targeting from Multiple
Angles.
Chapter
24. Role of Circadian Rhythm in Hormonal Cancers.
Chapter
25. Recent Immunotherapeutic Approaches for Cancer Treatment.
Chapter
26.
Importance of Adme for Anticancer Prodrugs.
Chapter
27. Personalized
Medicine in Clinical Management of Breast Cancer - Where Do We Stand?.-
Chapter
28. PABPC1: A Novel Emerging Target for Cancer Prognostics and
Anti-Cancer Therapeutics.
Chapter
29. Recent Update on Pyridoxine
Derivatives as Anticancer Agents with Overview on its Patents.
Chapter
30.
Recent Advances in Iron Oxide Nanoparticles-based Nano Medicine for Prostate
Cancer: A Review.
Chapter
31. Therapeutic Applications of Snake Venom
Proteins as Anti-Cancer Agents.
Chapter
32. Revamping Anticancer Strategies
by Modulating Tumor Microenvironment using Botanicals.
Chapter
33.
Modulation of Epigenetic Regulators for Cancer Prevention by Dietary
Phytochemicals: Tools for Personalized Nutrition.
Professor Ranbir Chander Sobti is Indian National Science A Senior Scientist Indian Academy of Sciences (INSA) and Emeritus Professor at Punjab University. He is a former Vice-Chancellor of the Panjab University, Chandigarh & Babasaheb Bhimrao Ambedkar University (Central University), Lucknow. He started his career as a cytogeneticist and then moved on to molecular biology, including genomics, to understand the susceptibility and disease process of cancer, COPD, AIDS, metabolic syndrome, and kidney diseases. He has also used stem cells and nanoparticles to understand the process of tissue organ development through a designed de-cellularization protocol. He has published more than 350 research articles in the journals of international repute and has also published more than 50 books. He is a Fellow of the Third World Academy of Sciences, National Academy of Sciences India, Indian National Science Academy, National Academy of Medical Sciences, National Academy of Agricultural Sciences, Canadian Academy of Cardiovascular Diseases and few others. He was the General President of the Indian Science Congress for the 102nd session held at the University of Jammu in 2013. Dr. Sobti is the recipient of many prestigious awards like the INSA Young Scientist Medal, UGC Career Award, Punjab Rattan Award, JC Bose Oration and Sriram Oration Awards and of Life Time Achievement Awards of the Punjab Academy of Sciences, Zoological Society of India, and the Environment Academy of India.He is recipient of most prestigious civil award Padmashri of The Government of India
Professor H Sugimura has served as a Chairman and Vice Director, Hammatsu University School of Medicine for 32 years, and now a Professor Emeritus of Hamamatsu University School of Medicine. He had been a President of Japan Cancer Epidemiology and Molecular Epidemiology. He is an internationally recognized cancer biologist, molecular epidemiologist, and molecular pathologist. He had also worked at University of Tokyo and had been visiting fellow at NCI, NIH Bethesda from 1988-1990. He has published a large number of papers in journals of repute with high impact factor. Currently he serves as a Director of Sasaki Institute, a 140 years old renowned cancer institute, Tokyo
Dr. Aastha Sobti is BDS (Panjab University ) ,Masters in Clinical Dentistry (University of London ) and Ph.D (Lund University,Sweden). She carried out her research for Ph.D at the Department of Immunotechnology, Lund University, Lund, Sweden, under CanFaster, Marie Skodowska-Curie COFUND programme. She has a background in dental sciences and did a specialization in masters in Clinical Dentistry (Oral surgery) from Eastman College, UCL, London. Her core interests are head and neck cancer-based clinical research. In entirety aiding in the field to bring reforms that are required in the present multifarious surgicalas well as translational research areas. She has teaching and research experience of about 8 years and published a few papers in international journals of repute. She is a recipient of a large number of prizes and medals for her exceptional work namely the academic certificate of excellence from BAOS, UK and IADR Hatton award (India). Additionally, she has attended and presented papers in international conferences in Hong Kong, Croatia, Brazil, Sweden, UK, Japan, and other countries.
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