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Molecular Hematology 4th edition [Kietas viršelis]

Edited by (Barts and The London School of Medicine), Edited by (St Barts & the Royal London Hospital, London, UK)
  • Formatas: Hardback, 432 pages, aukštis x plotis x storis: 279x213x25 mm, weight: 1406 g
  • Išleidimo metai: 28-Nov-2019
  • Leidėjas: Wiley-Blackwell
  • ISBN-10: 1119252873
  • ISBN-13: 9781119252870
Kitos knygos pagal šią temą:
  • Formatas: Hardback, 432 pages, aukštis x plotis x storis: 279x213x25 mm, weight: 1406 g
  • Išleidimo metai: 28-Nov-2019
  • Leidėjas: Wiley-Blackwell
  • ISBN-10: 1119252873
  • ISBN-13: 9781119252870
Kitos knygos pagal šią temą:
Molecular Hematology is a comprehensive resource for hematologists to increase their understanding of the molecular basis of various blood diseases, their pathogeneses, and current and emerging molecular research and therapies. The impact of molecular research on the field of hematology is significant-molecular techniques are continuing to play a central role in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has increased our comprehension of the causes of hematological diseases and led to the development of new drug therapies and recombinant proteins.

Now in its fourth edition, Molecular Hematology has been thoroughly revised and updated to reflect current advances in molecular research. Chapters introduce and summarize specific disorders, such as hemophilia, anemia, and multiple myeloma, and illustrate the impact of molecular research on their diagnoses and treatments. Contributions written by respected clinicians and researchers offer accessible coverage of topics including lymphoma genetics, molecular coagulation and thrombophilia, platelet disorders, pharmacogenomics, and many others.

Demonstrates the clinical relevance of molecular biology in hematology.

Provides overviews of recent advances in cancer cell biology, with an emphasis on leukemia and lymphoma.

Offers new and updated chapters written by an international team of experts.

Presents new full-color charts, graphs, and illustrations.

Includes access to a Wiley Companion Digital Edition providing search across the book, downloadable illustrations and notation tools.

Drew Provan, MD, FRCP, FRCPath, is Emeritus Reader in Autoimmune Haematology, Department of Haematology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.

John G. Gribben, MD, DSc, FRCP, FRCPath, FMedSci, is The Gordon Hamilton Fawley Professor of Medical Oncology, Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.

The new and fully-revised volume of hematologic molecular biology for practicing and trainee hematologists

Molecular Hematology is a comprehensive resource for hematologists to increase their understanding of the molecular basis of various blood diseases, their pathogeneses, and current and emerging molecular research and therapies. The impact of molecular research on the field of hematology is significant—molecular techniques are continuing to play a central role in in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has increased our comprehension of the causes of hematological diseases and led to the development of new drug therapies and recombinant proteins.

Now in its fourth edition, Molecular Hematology has been thoroughly revised and updated to reflect current advances in molecular research. Chapters introduce and summarize specific disorders, such as hemophilia, anemia, and multiple myeloma, and illustrate the impact of molecular research on their diagnoses and treatments. Contributions written by respected clinicians and researchers offer accessible coverage of topics including lymphoma genetics, molecular coagulation and thrombophilia, platelet disorders, pharmacogenomics, and many others.

  • Demonstrates the clinical relevance of molecular biology in hematology
  • Provides overviews of recent advances in cancer-cell biology, with an emphasis on leukemia and lymphoma
  • Offers new and updated chapters written by an international team of experts in the field
  • Presents new full-color charts, graphs, and illustrations
  • Includes access to a Wiley Companion Digital Edition providing search across the book, downloadable illustrations and notation tools

Molecular Hematology is an essential volume for both trainee and practicing hematologists and oncologists, molecular biologists, and research scientists working in the field of hematology.

Contributors ix
Preface to the fourth edition xiii
Further reading xv
Acknowledgments xvi
1 Beginnings: the molecular pathology of hemoglobin 1(20)
David Weatherall
2 Stem cells 21(16)
David T. Scadden
3 The genetics of acute myeloid leukemias 37(12)
Amy M. Trottier
Carolyn J. Owen
4 Molecular diagnostics and risk assessment in myeloid malignancies 49(10)
Christian Scharenberg
Torsten Haferlach
5 Molecular basis of acute lymphoblastic leukemia 59(12)
Bela Patel
Fiona Fernando
6 Chronic myeloid leukemia 71(16)
Hagop Kantarjian
Jorge Cortes
Elias Jabbour
Susan O'Brien
7 Myeloproliferative neoplasms 87(14)
Jyoti Nangalia
Anthony J. Bench
Anthony R. Green
Anna L. Godfrey
8 Lymphoma genetics 101(10)
Jennifer L. Crombie
Anthony Letai
John G. Gribben
9 The molecular biology of chronic lymphocytic leukemia 111(10)
John G. Gribben
10 The molecular biology of multiple myeloma 121(10)
Wee Joo Chng
P. Leif Bergsagel
11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 131(24)
Deena Iskander
Lucio Luzzatto
Anastasios Karadimitris
12 Anemia of chronic disease 155(6)
Tomas Ganz
13 The molecular basis of iron metabolism 161(12)
Nancy C. Andrews
Tomas Ganz
14 Hemoglobinopathies due to structural mutations 173(20)
D. Mark Layton
Steven Okoli
15 Molecular pathogenesis of malaria 193(14)
David J. Roberts
Arnab Pain
Chetan E. Chitnis
16 Molecular coagulation and thrombophilia 207(14)
Bjorn Dahlback
Andreas Hillarp
17 The molecular basis of hemophilia 221(14)
Daniel P. Hart
Paul L.F. Giangrande
18 The molecular basis of von Willebrand disease 235(16)
Luciano Baronciani
19 Platelet disorders 251(16)
Kenneth J. Clemetson
20 The molecular basis of blood cell alloantigens 267(18)
Cristina Navarrete
Louise Tilley
Winnie Chong
Colin J. Brown
21 Functions of blood group antigens 285(12)
Jonathan S. Stamler
Marilyn J. Telen
22 Autoimmune hematological disorders 297(22)
Drew Provan
John W. Semple
23 Molecular therapeutics in hematology: gene therapy 319(20)
William M. McKillop
Jeffrey A. Medin
24 Pharmacogenomics 339(14)
Leo Kager
William E. Evans
25 History and development of molecular biology 353(10)
Paul Moss
26 Cancer stem cells 363(10)
Sara Ali
Dominique Bonnet
27 Molecular basis of transplantation 373(16)
Francesco Dazzi
Antonio Galleu
Index 389
DREW PROVAN, MD, FRCP, FRCPath, is Emeritus Reader in Autoimmune Haematology, Department of Haematology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.

JOHN G. GRIBBEN, MD, DSc, FRCP, FRCPath, FMedSci, is The Gordon Hamilton Fairley Professor of Medical Oncology, Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.