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Molecular Hematology 5th edition [Kietas viršelis]

Edited by (Ireland Cancer Center, Case Western Reserve University, Cleveland, OH), Edited by (St Barts & the Royal London Hospital, London, UK)
  • Formatas: Hardback, 448 pages, aukštis x plotis x storis: 279x221x31 mm, weight: 1383 g
  • Išleidimo metai: 18-Apr-2024
  • Leidėjas: Wiley-Blackwell
  • ISBN-10: 1394180454
  • ISBN-13: 9781394180455
Kitos knygos pagal šią temą:
  • Formatas: Hardback, 448 pages, aukštis x plotis x storis: 279x221x31 mm, weight: 1383 g
  • Išleidimo metai: 18-Apr-2024
  • Leidėjas: Wiley-Blackwell
  • ISBN-10: 1394180454
  • ISBN-13: 9781394180455
Kitos knygos pagal šią temą:
"The new and fully-revised volume of hematologic molecular biology for practicing and trainee hematologists Molecular Hematology is a comprehensive resource for hematologists to increase their understanding of the molecular basis of various blood diseases, their pathogeneses, and current and emerging molecular research and therapies. The impact of molecular research on the field of hematology is significant--molecular techniques are continuing to play a central role in in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has increased our comprehension of the causes of hematological diseases and led to the development of new drug therapies and recombinant proteins"--

Provides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated

Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more.

Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout.

  • Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies
  • Illustrates the impact of molecular research on hematologic investigations and therapeutics
  • Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders
  • Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma
  • Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools

Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.

Foreword

1

Beginnings: The Molecular Pathology of Hemoglobin

2

Stem Cells

3

The Genetics of Acute Myeloid Leukemias

4

Molecular diagnostics and risk assessment in myeloid malignancies

5

Molecular basis of acute lymphoblastic leukemia

6

Chronic Myeloid Leukemia

7

Myeloproliferative neoplasms

8

Lymphoma genetics

9

Molecular basis of chronic lymphocytic leukemia

10

The Molecular Biology of Multiple Myeloma

11

The Molecular Basis of Bone Marrow Failure Syndromes and Red Cell Enzymopathies

12

Anemia of chronic disease

13

Molecular Basis of Iron Metabolism

14

Hemoglobinopathies due to Structural Mutations

15

Molecular Coagulation and Thrombophilia

16

The Molecular Basis of Hemophilia

17

The Molecular basis of von Willebrand Disease

18

Platelet Disorders

19

The Molecular Basis of Blood Cell Alloantigens

20

Functions of Blood Group Antigens

21

Autoimmune hematologic disorders

22

Molecular Therapeutics in Hematology: gene therapy

23

Pharmacogenomics

24

Cancer stem cells

25

CAR-T cell therapy

26

Molecular basis of transplantation

DREW PROVAN MD, FRCP, FRCPATH, Emeritus Reader in Autoimmune Hematology, Centre for Immunology, Blizard Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.



HILLARD M. LAZARUS, MD, FACP, Professor of Hematology-Oncology, Full Professor of Medicine, The Department of Medicine, Division of Hematology-Oncology, Case Western Reserve University, Cleveland, Ohio 44106.