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El. knyga: Molecular Mechanisms of Basal Cell and Squamous Cell Carcinomas

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  • Formatas: PDF+DRM
  • Serija: Medical Intelligence Unit
  • Išleidimo metai: 25-Jun-2007
  • Leidėjas: Springer-Verlag New York Inc.
  • Kalba: eng
  • ISBN-13: 9780387350981
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  • Formatas: PDF+DRM
  • Serija: Medical Intelligence Unit
  • Išleidimo metai: 25-Jun-2007
  • Leidėjas: Springer-Verlag New York Inc.
  • Kalba: eng
  • ISBN-13: 9780387350981
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apid progress in the understanding of carcinogenesis and pathology of epitheUal skin cancer has led to new strategies for the prevention Rand treatment of these malignancies. The goal of this volume is to comprehensively cover in a highly readable overview our present knowledge of pathogenetic mechanisms and molecular biology of Basal Cell and Squamous Cell Carcinomas. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in epidemiology, histology, photobiology, immunology, cytogenetics, and molecular pathol­ ogy to new concepts for prophylaxis and treatment. Experts in the field as well as health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for clinicians and scientists interested in the biology of Basal Cell and Squamous Cell Carcinomas. The chapters are written by authors who are experts in their respective research areas, and I am gratefixl for their willingness to contribute to this book. I would also like to express my thanks to Ron Landes, Cynthia Conomos, Sara Lord and all the other members of the Landes Bioscience staff for their expertise, diligence and patience in helping me complete this work. Jorg Reichrathy Prof, Dn med. CHAPTER 1 The Epidemiology of Basal Cell and Squamous Cell Carcinoma Hao Wang and Thomas L.
Preface xv
The Epidemiology of Basal Cell and Squamous Cell Carcinoma
1(9)
Hao Wang
Thomas L. Diepgen
Incidence of Nonmelanoma Skin Cancer (NMSC)
1(2)
Trends in Incidence of BCC and SCC
3(1)
Risk Factors
3(1)
Ultraviolet Radiation (UVR)
3(1)
Ageing
4(1)
Smoking
4(1)
Alcohol
4(1)
Diet
4(1)
Medical Conditions
5(1)
Ionizing Radiation
5(1)
Occupation
5(1)
Chemical Carcinogens
6(1)
History and Precursor Lesions
6(1)
Skin Cancer Prevention Strategies
6(4)
Histology of Epithelial Skin Tumors
10(8)
Jorg Reichrath
Kerstin Querings
Squamous Cell Carcinoma
10(5)
Basal Cell Carcinoma
15(1)
Basosquamous Carcinoma
16(2)
UV Damage and DNA Repair in Basal Cell and Squamous Cell Carcinomas
18(13)
Knuth Rass
UV Damage and DNA Repair
19(4)
UV-Induced Carcinogenesis in Squamous Cell Carcinoma (SCC)
23(2)
UV-Induced Carcinogenesis in Basal Cell Carcinoma (BCC)
25(6)
Papillomavirus Infections and Cancerogenesis of Squamous Cell and Basal Cell Carcinomas
31(12)
Guido Bens
Basal Cell Carcinomas
39(4)
The Immune System and Nonmelanoma Skin Cancers
43(6)
Elma D. Baron
Epidemiologic Evidence from Organ Transplant Recipients
43(1)
Evidence from Studies on UV-Induced Immune Suppression and Nonmelanoma Cancer Formation
44(1)
Mechanisms Involved in Immune Suppression and Carcinogenesis of Nonmelanoma Skin Tumors
45(4)
Cytogenetics of Basal Cell Carcinoma and Squamous Cell Carcinomas
49(9)
Melanie A. Carless
Kevin J. Ashton
Lyn R. Griffiths
Cytogenetic Analysis
49(1)
Ploidy Analysis
50(1)
Classical Karyotypic Analysis
51(1)
Fluorescence in Situ Hybridization Analysis and Comparative Genomic Hybridization Analysis
51(2)
Implications of Cytogenetic Findings and Future Developments
53(5)
The Hedgehog Signaling Pathway and Epithelial Skin Cancer
58(8)
Julia Reifenberger
The Hedgehog Signaling Pathway
59(1)
Alterations of Hedgehog Signaling in Skin Tumors
60(2)
Mouse Models for Basal Cell Carcinoma
62(1)
Novel Pathogenesis-Based Approaches for Prevention and Therapy of Basal Cell Carcinomas
63(3)
p53 Protein and Nonmelanoma Skin Cancer
66(14)
Vladislava O. Melnikova
Honnavara N. Ananthaswamy
p53 Tumor Suppressor Gene
66(3)
Induction of p53 Protein by UV and Biologic Consequences
69(1)
A Model of UV-Induced Initiation and Progression of Squamous Cell Carcinomas
69(1)
p53 Mutations in Nonmelanoma Skin Cancers
69(3)
p53 Mutations in Mouse Skin Cancers
72(8)
TGF-β Pathway and Cancerogenesis of Epithelial Skin Tumors
80(14)
Miguel Quintanilla
Eduardo Perez-Gomez
Diana Romero
Mar Pons
Jaime Renart
TGF-β Signalling
80(2)
Role of TGF-β in Epidermal Development
82(2)
Role of TGF-β in Epidermal Proliferation and Homeostasis
84(2)
Role of TGF-β in Epithelial Skin Cancer
86(8)
PDGF Pathways and Growth of Basal Cell and Squamous Cell Carcinomas
94(14)
Jingwu Xie
Signal Transduction by PDGFs and Their Receptors
94(1)
In Vivo Functions of PDGFs and Their Receptors
95(2)
PDGF Alterations in Cancer
97(2)
The Role of PDGF for Cell Proliferation in BCCs
99(3)
The Role of PDGF/VEGF Signaling in Angiogenesis of SCCs
102(2)
PDGF Signaling in Dermatofibrosarcoma Protuberans and Giant Cell Fibroblastoma
104(1)
Perspectives
104(4)
Apoptosis and Cancerogenesis of Basal Cell and Squamous Cell Carcinoma
108(7)
Peter Erb
Jingmin Ji
Marion Wernli
Stanislaw A. Buchner
Gene Mutations Lead to NMSCs
109(1)
Apoptosis Is Pivotal for the Removal of DNA Damaged and Transformed Cells
110(1)
UV-Light Changes the Expression Pattern of Apoptosis-Inducing and -Preventing Molecules in Skin Epidermis
110(1)
FasL, the Double-Edged Sword
111(1)
Downregulation of FasL on BCC by Antisense Oligonucleotides or Small Interfering RNAs (siRNAs)
112(1)
Outlook
113(2)
The Role of Telomerase for Cancerogenesis of Basal Cell and Squamous Cell Carcinomas
115(20)
Eva-Maria Fabricius
Interaction of Telomeres and Telomerase
116(3)
Telomerase Activating in Normal Skin
119(2)
Telomerase Activation in the Nonmelanoma Skin Tumors BCC and SCC and in Their Tumor-Free Margins
121(14)
Index 135