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El. knyga: Myocardial Ischemia and Preconditioning

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Current evidence suggests that the ischemic preconditioning response is a multi-factorial process consisting of an initial early trigger, an intermediate mediator, and an end effector. Each of these steps in is now its own intense area of investigation. The need to render the heart ischemic for a brief period to invoke the preconditioning response is currently the major factor limiting clinical application of this powerful cardioprotective strategy. Recent research efforts have utilized brief exposures to pharmacological agents, in lieu of a brief preconditioning ischemia, to trigger/mimic the ischemic preconditioning-induced response. The World Heart Congress held in Winnipeg in July 2001 provided a forum for the presentation of new insights into the basic mechanisms of ischemia and reperfusion injury, as well as novel strategies to protect the heart from cell death, ventricular arrhythmias, and contractile dysfunction. Many pioneers in the fields of ischemia-reperfusion injury and preconditioning-induced protection presented there and the chapters in this book represent selected papers from these symposia.

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Springer Book Archives
1. PTCA Acutely Expands Perfused Myocardial Mass and Increases Flow
Homogeneity.-
2. Angiogenic Therapy by Coronary Collateral Recruitment and
Arteriogenesis.-
3. Regulatory Role of ERK-Dependent Pathways in Activity of
the Na+/H+ Exchanger in the Healthy and Ischemic Myocardium.-
4. Sodium
Overload and Mitochondrial Damage in Ischemic/Reperfused Heart.-
5.
Antisense-Induced Underexpression of Manganese Superoxide Dismutase Extends
Myocardial Ischemia-Reperfusion Injury.-
6. Phospholamban Phosphorylation
During Ischemia and Reperfusion Injury: Mechanisms and Functional
Implications.-
7. Phospholipase C-Mediated Signaling in Ischemic Heart
Disease.-
8. Effects of Sequential Ischemia-Reperfusion Cycles on Cyclic
Nucleotide Phosphodiesterase Activity in Pig Heart.-
9. Inducible Nitric
Oxide Synthase in Cardiac Adaption to Ischemia.-
10. Long Term Follow-Up of
Leukocyte Function During Myocardial Reperfusion Injury.-
11. Mechanisms of
Cellular Alterations Due to Ischemia-Reperfusion Injury in the Heart.-
12.
Mechanisms for Ischemia/Reperfusion Injury: Application of 23Na Magnetic
Resonance Spectroscopy.-
13. Is Reduced Cell Swelling a Plausible
End-Effector of Ischemic Preconditioning Protection?.-
14. Cardioprotection
by Mitochondrial KATP Channel in both Early and Late Preconditioning.-
15.
Role of Mitochondrial Membrane Potential in Cardiac Protection against
Ischemia.-
16. Hypoxic Reperfusion after Brief Ischemia Potentiates Ischemic
Preconditioning in Isolated Rat Hearts.-
17. Molecular Basis for the
Cardioprotective Effect of Herbal Drugs in Ischemic Heart Disease: An
Experimental Study.-
18. Ischaemic and Pharmacological Preconditioning is
Associated with Attenuation of p38 MAPK Activation During Sustained Ischaemia
and Reperfusion.-
19. A Role for the PhosphatidyHnositol-3-Kinase Pathway in
Preconditioning.-
20. Myofilament Calcium Responsiveness in Stunning and
Preconditioning.-
21. How to Mediate Cardioprotection in Ischemic HeartsRole
of Adenosine.-
22. On the Role of Adenosine in Classical and Interorgan
Preconditioning of the Heart.-
23. Adenosine A3 Receptor Induced Delayed
Preconditioning: Essential Role of Nuclear Factor ?B, Nitric Oxide Synthase
and Mitochondrial KATP Channels.-
24. Activation of Adenosine A1 and A3
Receptors Protects Mitochondria during Hypoxia in Cardiomyocytes by Distinct
Mechanisms.-
25. Non Ischemic Myocardial Preconditioning by Tachycardia and
Exercise.-
26. Myocardial Effects of Sodium-Hydrogen Exchange Inhibition
During Resuscitation From Ventricular Fibrillation.-
27. Na/H Exchange and
Arrhythmia.-
28. Mechanisms of Functional Disturbances of Various HERG
Mutations in Patients with Long QT Syndrome 2 (LQT2).-
29. Sensitivity to
Ischemic Injury in the Diabetic Heart: A Dichotomy between Susceptibility to
Ventricular Arrhythmias and the Size of Myocardial Infarction.-
30. Exercise
and Delayed Preconditioning in the Protection of the Heart Against
Ventricular Arrhythmias: Crucial Role of Nitric Oxide.-
31.
Myocardioprotection Against Ischemia and Reperfusion Injury by Endothelin
Receptor Antagonists.-
32. Role of Lipid Peroxidation in Myocardial Ischemic
Injury.-
33. Involvement of Na+/Ca2+ Exchange in Normal Cardiac
Excitation-Contraction Coupling and in Ca2+ Overload during Ischemia and
Reperfusion.-
34. Modulation of Sarcoplasmic Reticulum Calcium Release as a
Cardioprotective Strategy.-
35. Early Detection of Ischemic Myocardial Damage
by Glycogen Phosphorylase Isoenzyme BB: A Biomarker for Evaluation of Chest
Pain and Evolving Infarction in Patients.
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